Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia by Karima Schwab, Lianne Robinson, Anne Annschuetz, Eline Dreesen, Mandy Magbagbeolu, Valeria Melis, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel

“…We measured the abundance of tau and synaptic proteins (VAMP-2, SNAP-25, SNTX-1, SYNPY-1, SYN-1, A-SYN) immunohistochemically to reveal structural synaptic alterations in these mice. Tau and synaptic markers were also examined in L66 mice treated with hydromethylthionine mesylate (HMTM) (15 mg/kg) and rivastigmine (0.5 mg/kg) administered singly and in combination. …”
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Comparative analysis of corpus callosum lipidome and transcriptome in schizophrenia and healthy brain by Maria S. Osetrova, Olga I. Efimova, Marina D. Zavolskova, Elena A. Stekolschikova, Gleb N. Vladimirov, Dmitry A. Senko, Tatiana A. Zhuravleva, Anna Y. Morozova, Yana A. Zorkina, Denis S. Andreyuk, George P. Kostyuk, Evgeniy N. Nikolaev, Philipp E. Khaitovich

“…BACKGROUND: Functional and structural studies of the brain highlight the importance of white matter alterations in schizophrenia. …”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…The secondary outcome assessed the association between demographic factors (age, gender, income, education, smoking status) and KAP scores using structural equation modelling (SEM).Results The mean KAP scores were 1.26±2.85 for knowledge, 30.46±3.63 for attitudes and 34.58±5.55 for practices. …”
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Innovative strategies for bone organoid: Synergistic application and exploration of advanced technologies by Xu Lou, Qirong Zhou, Zhenglin Dong, Long Bai, Jiacan Su, Hua Yue

“…While 3D bioprinting enhances spatial precision and structural complexity, artificial intelligence accelerates organoid optimization through data-driven approaches. …”
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A Multidata Approach to Open Clusters: Roslund 3 and Ruprecht 174 in CCD UBV and Gaia DR3 Context by Hülya Karagöz, Talar Yontan, Selçuk Bilir, Olcay Plevne, Tansel Ak, Serap Ak, Remziye Canbay, Timothy Banks

“…A detailed analysis of the structural, astrophysical, kinematic, and dynamical properties of the open clusters Roslund 3 and Ruprecht 174 is carried out using CCD UBV photometry in conjunction with astrometric and photometric data from Gaia DR3. …”
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Fostering achievement of sustainable development goals through green culture and digital transformation: Empirical evidence from an Indonesian education human resources university by Indah Prabawati, Wiwik Sri Utami, Harmanto, Meirinawati, Suci Megawati, Artanti Indrasetianingsih, Sud Sudirman

“…Utilizing a quantitative approach, a survey was conducted with 435 students from State University of Surabaya, a leading IEHRU. Data were analyzed using partial least squares structural equation modeling (PLS-SEM) with SmartPLS 4. …”
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Quantitative Characterization and Determination of the Main Factors That Control Fracture Development in the Lower Paleozoic Shale in Southeastern Chongqing, China by Zhiping Zhang, Xiangye Kong, Qing Chen, Ye Zhang, Zhi Deng, Chuan Yu, Zhian Lei, Haijie Zhang, Xiaofeng Wang, Guanghua Yao, Licheng Yang, Xianfeng Tan

“…The results obtained showed that there are three types of fractures in the lower Paleozoic shale in southeastern Chongqing, which are structural, diagenetic, and abnormal high-pressure fractures. …”
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Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy by Zhibo Hu, Yu Zhou, Cailing Gao, Junfen Liu, Congqing Pan, Jun Guo

“…Results In vitro, AS-IV led to a significant reduction in blood urea nitrogen (BUN), urine albumen-to-creatinine ratio (UACR), serum creatinine (CREA), and hyperglycemia in db/db mice and lessen the pathological alterations in the kidney. Moreover, pyrin structural domain of the NLR family pyrin domain containing 3 (NLRP3), cleaved-caspase-1, gasdermin D (GSDMD), IL-18, and IL-1β were down-expressed and podocyte markers podocin and nphs1 were up-regulated following AS-IV intervention. …”
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Concerns of Novice Nurses in the First Year of Work: A Qualitative Content Analysis by Bahareh Najafi BScN, MScN, PhD, Ahmad Nasiri BScN, MScN, PhD

“…This was a qualitative study using conventional content analysis. Methods Unstructured in-depth open individual interviews were used for data collection. …”
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‘A good decision is the one that feels right for me’: Codesign with patients to inform theoretical underpinning of a decision aid website by Kelly Kohut, Kate Morton, Karen Hurley, Lesley Turner, The CanGene‐CanVar Patient Reference Panel, Caroline Dale, Susan Eastbrook, Rochelle Gold, Kate Henwood, Sonia Patton, Reshma Punjabi, Helen White, Charlene Young, Julie Young, Elizabeth Bancroft, Lily Barnett, Sarah Cable, Gaya Connolly, Beth Coad, Andrea Forman, Helen Hanson, Grace Kavanaugh, Katherine Sahan, Katie Snape, Bethany Torr, Rosalind Way, Elizabeth Winchester, Alice Youngs, The International Lynch Decision Aid Stakeholder Panel, Diana Eccles, Claire Foster

“…Patient discussions were the primary data source. Facilitators provided a semi‐structured guide, but they did not influence the patient discussions or provide clinical advice. …”
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Understanding Care‐Seeking Behavior for Reproductive Tract Infections Among Afghan Women: A Cross‐Sectional Study by Cecilia Acuti Martellucci, Nooria Mohammady, Fawzia Negin, Sayed Hamid Mousavi, Adriana Viola Miranda, Husna Safa, Bibi Qudsia Qasimi, Khaterah Mosavi, Basira Bek, Alisina Azimi, Zahra Annabi, Saddiqa Noorzai, Aabidullah Rahimee, Taha Balaghat, Fatema Rezaie, Fardına Temory, Mirwais Ramozi, Mosè Martellucci, Rahila Bek, Shabanah Noorzai, Madina Niro, Husna Sultani, Palwasha Farooqi, Ehsan Shayan, Mohammadgul Zhwand, Qasem Rezaee, Farzana Torgani, Bibi Shakiba Hussaini, Shaqaiq Akhtiyari, Farah Qaderi, Shohra Qaderi

“…Methods From September 16, 2022 to November 26, 2022, a structured questionnaire was administered to women presenting at multi‐specialist clinics in the major cities of Afghanistan. …”
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‘It’s the perfect storm’: why are people with eating disorders at risk of suicide? A qualitative study by Una Foye, Saakshi Kakar, Niamh McNamara, Agnieszka Musial, Tom Jewell, Jessica R. Griffiths, Carol Kan, Gerome Breen, Rachel Rowan Olive, T. Suratwala, Aman Sidhu, Lizzie Mitchell, George Mycock, Katie Graden, Saskia Evans Perks, Elia Chitwa, Holly Whitehead, Ulrike Schmidt, Rina Dutta, Moritz Herle

“…Methods Using a qualitative design, we conducted semi-structured interviews with people with lived experience of an ED (n = 30), and clinicians who work with people with EDs (n = 19). …”
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Adherence to Mediterranean diet in Moroccan school-age adolescents: sociodemographic, socioeconomic and lifestyle determinants by Halima Belaoufi, Sanaa El-Jamal, Khadija Sahel, Abdelghani Aboukhalaf, Firdaous Friki, Hamid Chamlal, Jamila Elbiyad, Soumaya Atouife, Abdellah El Habazi, Rekia Belahsen

“…Material and methods A cross-sectional survey was conducted in a school setting among 386 students (148 boys and 238 girls), aged 14 to 18 years, randomly selected and from different socioeconomic strata. A structured questionnaire was used to collect sociodemographic, socioeconomic and lifestyle data. …”
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Knowledge, attitudes, and practices of people living in artisanal mining areas on water pollution in Siguiri, Guinea, 2023 by Aly Badara Toure, Aly Badara Toure, Mariama Sadjo Diallo, Mariama Sadjo Diallo, Sidikiba Sidibe, Sidikiba Sidibe, Salifou Talassone Bangoura, Salifou Talassone Bangoura, Fassou Mathias Grovogui, Fassou Mathias Grovogui, Fassou Mathias Grovogui, Maladho Diaby, Maladho Diaby, Mohamed Aly Bangoura, Yamoussa Youla, Mory Kourouma, Alexandre Delamou, Alexandre Delamou, Alexandre Delamou

“…The objective of this study was to analyze the knowledge, attitudes, and practices (KAP) of the population regarding water pollution in the mining areas of Siguiri, Guinea.MethodsA cross-sectional study was conducted from May 15 to June 15, 2023, on the population of Doko, Siguiri. Data were collected using a structured questionnaire that assessed knowledge, attitudes, and practices related to water pollution in artisanal mining areas. …”
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ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke by Ivan B. Filippenkov, Yana Yu. Shpetko, Vasily V. Stavchansky, Alina E. Denisova, Leonid V. Gubsky, Lyudmila A. Andreeva, Nikolay F. Myasoedov, Svetlana A. Limborska, Lyudmila V. Dergunova

“…Thus, our results may be useful for selecting more effective structures for future anti-stroke drugs and appropriate post-stroke time points for their testing.…”
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Characterization of the 1966 Camp Century subglacial core: a multiscale analysis by C. M. Collins, N. Perdrial, N. Perdrial, P.-H. Blard, P.-H. Blard, N. Keulen, W. C. Mahaney, H. Mastro, J. Souza, D. M. Rizzo, Y. Marrocchi, P. C. Knutz, P. R. Bierman

“…Microscale grain size and shape analysis, conducted using scanning electron microscopy, showed an abundance of fine-grained materials in the lower part of the core and no correspondence between grain shape parameters and sedimentary structures. These multiscale data define five distinct stratigraphic units within the core based on sedimentary process; <span class="inline-formula"><i>k</i></span>-means clustering analysis supports this unit delineation. …”
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Spatial Characteristics and Influencing Factors of Human Settlement Environment in the Kuye River Basin by Zhonghua ZHANG, Hao WU

“…Utilizing ArcSWAT 2012 software, hydrological simulations are conducted for the Kuye River Basin. Input data includes DEM (digital elevation model) data, soil type data, and meteorological information specific to the basin, enabling the simulation and acquisition of hydrological factors such as sub-basin boundary and river network grade. …”
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Precision Target Spraying System Integrated with Remote Deep Learning Recognition Model for Cabbage Plant Centers by ZHANG Hui, HU Jun, SHI Hang, LIU Changxi, WU Miao

“…A Ghost-Backbone lightweight network structure was introduced, integrating remote sensing technologies along with the sprayer's forward speed and the frequency of spray responses. …”
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Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis by Xudong Xin, Xudong Xin, Xudong Xin, Xudong Xin, Haidong Zhou, Song Huang, Wenzhao Zhang, Jiahou Xu, Wei Wang, Jihua Wei, Jihua Wei, Jihua Wei, Jihua Wei, Liqing Li

“…Molecular docking studies revealed that quercetin exhibits a lower binding energy with the target protein binding site, forming a stable structure. Single-cell analysis indicated that SAMHD1 is predominantly expressed in macrophages, whereas DPYSL2 is expressed not only in macrophages but also significantly in vascular endothelial cells and other cell types. …”
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Non-specific effects of different sham acupuncture methods and their impact on true acupuncture effectiveness in migraine: a protocol for systematic review and network meta-analysi... by Fan Jiang, Haifeng Zhang, Lun Li, Qinhong Zhang, Meng Lin, Yongjian Liu, Yong Fu, Jiahui Yang, Qilin Liu, Meiyi Zhu, Xiumei Yan

“…A frequentist NMA will be executed using Stata (V.18.0). The network structure will comprise: acupuncture as a single node (or multiple nodes if heterogeneity warrants), different SA methods as separate nodes, and waiting-list/no-treatment as a single node. …”
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