Investigation of an extensive outbreak of HIV infection among children in Sindh, Pakistan: protocol for a matched case–control study by Victoria Simms, Rashida Ferrand, Baseer Achakzai, Iqbal Azam, Amna R Siddiqui, Apsara Ali Nathwani, Syed H Abidi, Syed Faisal Mahmood, Sobiya Sawani, Abdul M Kazi, Aneeta Hotwani, Sikander Ali Memon, Jamila Soomro, Saqib Ali Shaikh, Quaid Saeed, Palwasha Khan, Fatima Mir

“…Following written informed consent from the guardian, a structured questionnaire will be administered to collect data on sociodemographic indices and exposure to risk factors for parenteral, vertical and sexual (only among those aged above 10 years) HIV transmission. …”
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Optimising Paediatric Transition to Intensive Care for Adults (OPTICAL): study protocol for a mixed method study by Padmanabhan Ramnarayan, Louise Rose, Julie Taylor, Christina Pagel, Jo Wray, Sarah E Seaton, Kate Oulton, Sonya Crowe, Rum Thomas, Qi Huang, Paul R Mouncey, Katherine Malbon, Anjalika Mallick, Charmaine Kohn, Sue Ben Abraham, Clare Windsor

“…To do this, we will: (1) link and analyse UK national data (years 2017–2024) on paediatric and adult ICU admissions, hospital inpatient, outpatient and emergency care visits and survival status, to determine the clinical characteristics and healthcare resource utilisation from teenage years to early adulthood of people admitted to an ICU as a young person (admission aged 14 and 15), and how these relate to ICU admissions after age 16; (2) conduct semistructured interviews, online forums and surveys with TYA patients, carers and health professionals to understand their experience of transition in ICU services; and (3) synthesise these strands of evidence and use a structured process of stakeholder engagement to propose potential targeted improvements as appropriate.Ethics and dissemination This study was approved by the East of England - Cambridge South Research Ethics Committee on 1 August 2024 (research ethics committee number 24/EE/0108), and the Health Research Authority Confidentiality Advisory Group (CAG) on 7 October 2024 (CAG number 24/CAG/0068). …”
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Vulvovaginal candidiasis: knowledge, practices and occurrence among pregnant women receiving antenatal care in a teaching hospital, Ghana by Florence Shine Edziah, Florence Shine Edziah, Princess Ruhama Acheampong, Philip Apraku Tawiah, Cedric Dzidzor Amengor, Godsway Edem Kpene, Grace Otobea Amponsah, Priscilla Appiah Baffoe, Georgina Korankye, John Gameli Deku

“…This study assessed the knowledge, practices and occurrence of Vulvovaginal candidiasis among pregnant women accessing antenatal care at a teaching hospital in Ghana.MethodsA cross-sectional study was conducted among 336 pregnant women receiving antenatal care at the Ho Teaching Hospital. A structured questionnaire was used to assess their knowledge of the infection and practices on vaginal hygiene. …”
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The experience of immersive virtual reality in patients with heart failure during cardiac rehabilitation: a qualitative study by Valentina Micheluzzi, Valentina Micheluzzi, Gavino Casu, Gavino Casu, Francesco Burrai, Antonella Canu, Antonio Sircana, Pierluigi Merella, Pierluigi Merella, Angelo Laconi, Angelo Laconi, Andrea Chelo, Andrea Chelo, Piero Cozzula, Michela Piredda, Ercole Vellone, Ercole Vellone

“…The intervention group experienced iVR in natural settings, while the control group received standard care. Semi-structured individual interviews were conducted in person after the intervention group’s eighth rehabilitation session. …”
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Сontent of cytokines and growth factors in the intraocular fluid of patients with primary open-angle glaucoma by V. V. Chernykh, V. I. Konenkov, O. V. Ermakova, N. B. Orlov, O. O. Obukhova, A. V. Eremina, A. N. Trunov

“…Increase concentrations of IL-7 in the intraocular fluid of patients with primary open-angle glaucoma allows us to assume participation in the pathogenesis of the primary open-angle glaucoma of this autocrine mediator of activation of the growth of lymphatic structures.…”
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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…The interviews were conducted by two researchers who have extensive experience interviewing KOA patients, and data were gathered through face-to-face, semi-structured interviews to ensure a high level of information power. …”
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Effects of timely case conferencing between general practitioners and specialist palliative care services on symptom burden in patients with advanced chronic disease: results of th... by Tina Mallon, Josefine Schulze, Nadine Pohontsch, Thomas Asendorf, Jan Weber, Silke Böttcher, Uta Sekanina, Franziska Schade, Nils Schneider, Judith Dams, Michael Freitag, Christiane Müller, Friedemann Nauck, Tim Friede, Martin Scherer, Gabriella Marx

“…Methods The cluster-randomised controlled trial compared a structured palliative care nurse visit followed by an interprofessional case conference to usual care. …”
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Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China by Yongqiang Yang, Yanxian Yang, Guanping Chen, Minmin Lin, Yuan Chen, Ruowen He, Klibs N. Galvão, Mohamed Abd El-Gawad El-Sayed Ahmed, Adam P. Roberts, Yiping Wu, Lan-Lan Zhong, Xiaoxue Liang, Mingyang Qin, Xin Ding, Wenbin Deng, Songyin Huang, Hong-Yu Li, Min Dai, Ding-Qiang Chen, Liyan Zhang, Kang Liao, Yong Xia, Guo-Bao Tian

“…We described 29 KPC-2 plasmids showing diverse structures, two virulence plasmids in two KPC-2-producing Kp, and two novel multidrug-resistant (MDR)-virulent plasmids. …”
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Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an International Register "Dynamics Analysis of Comorbiditi... by G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, D. S. Polyakov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigoryeva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, H. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Ayypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, O. Yu. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchaeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. .A. Vinnikova, V. V. Vustina, E. A. Elena A. Galova, V. V. Genkel, D. B. Giller, E. D. Gordeychuk, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova48, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Yuliya S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, C. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Yuliya V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A/ Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu. Shishkov, S. Yu Shcherbakov, G. V. Shcherbakova, E. A. Yausheva

“…Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. …”
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Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs by Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai

“…In the DrugBank database, 98 structurally novel candidate compounds with potential senolytic activity were identified. …”
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Artificial Intelligence in Breast Cancer Diagnosis and Treatment: Advances in Imaging, Pathology, and Personalized Care by Petar Uchikov, Usman Khalid, Granit Harris Dedaj-Salad, Dibya Ghale, Harney Rajadurai, Maria Kraeva, Krasimir Kraev, Bozhidar Hristov, Mladen Doykov, Vanya Mitova, Maria Bozhkova, Stoyan Markov, Pavel Stanchev

“…However, challenges include data variability, ethical concerns, and real-world validation. …”
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Human lung cancer neutrophils generate NETs with preserved anti-tumor cytotoxicity but impaired anti-migratory activity by Nuha Alsharif, Nuha Alsharif, Mohamad Qaisi, Merav Shaul, Naomi Kaisar-Iluz, Naomi Kaisar-Iluz, Dan Padawer, Dan Padawer, Osnath Bouhanna, Osnath Bouhanna, Yael Volman, Yael Volman, Zvi G. Fridlender, Zvi G. Fridlender

“…Neutrophil extracellular traps (NETs) are DNA-protein structures released during a form of programmed neutrophil death known as NETosis. …”
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The evolution of sprinting performance: Technological and regulatory influences from 1976 to 2024 by Dariusz Tadeusz SKALSKI, Magdalena PROŃCZUK, Kinga ŁOSIŃSKA, Ewelina LULIŃSKA, Joanna MOTOWIDŁO, Petr STASTNY, Adam MASZCZYK, Grzegorz TRYBEK

“…Additionally, the study highlights the narrowing gender performance gap, driven by advancements in sports science, improved access to elite training, and evolving competition structures. Conclusions: Regulatory measures, particularly in anti-doping enforcement, have played a crucial role in preserving fair competition and influencing performance trends. …”
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Understanding community pharmacists’ intentions to report adverse drug reactions in Saudi Arabia: a theory of planned behavior analysis by Fahad T. Alsulami, Yousef Saeed Alqarni, Wadia Saad Alruqayb, Mohammed S. Alharthi, Mohammad S. Alzahrani, Majed A. Algarni, Musaad M. Althobaiti, Saad Mohammed Almalki, Nawaf Abid Altowarqi, Hussain Ali Mathkur, Anas Muslih Althumali, Ayman Mohammed Alharthi, Haifa Abdulrahman Fadil, Adel A. Altowairqi, Mubarak S. Alharthi

“…Strategies such as structured training, institutional support, and promoting moral responsibility may bridge the gap between awareness and actual reporting practices among community pharmacists in Saudi Arabia.…”
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Discriminant analysis of occupational performance characteristics in patients with major depressive disorders and healthy individuals by Tomonari Hayasaka, Izumi Nagashima, Miku Hoshino, Koji Teruya, Yasuyuki Matumoto, Masami Murao, Taku Maruki, Masako Watanabe, Takeshi Katagiri, Yayoi Imamura, Mariko Kurihara, Yuki Oe, Yoshikazu Takaesu, Takashi Tsuboi, Koichiro Watanabe, Hitoshi Sakurai

“…Abstract Aim Assessing symptoms and daily functioning in patients with major depressive disorder (MDD) can be challenging, as their limited self‐monitoring abilities may result in behavior observed during structured interviews not accurately reflecting their daily lives. …”
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Operational considerations for approximating molecular assembly by Fourier transform mass spectrometry by Gabriella M. Weiss, Gabriella M. Weiss, Gabriella M. Weiss, Silke Asche, Hannah McLain, Angela H. Chung, Angela H. Chung, Angela H. Chung, S. Hessam M. Mehr, Leroy Cronin, Heather V. Graham

“…Because AT makes no assumptions about the chemistry of life, it is an agnostic tool that identifies molecular structures that are probabilistically more likely to have arisen via selection and therefore biological processes. …”
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Cognition and experience of surgical incisions in patients undergoing laparoscopic surgery with enhanced recovery after surgery protocol: A qualitative study by Hongxia Xu, Yihong Xu, Gongjie Shi, Jiaqi Lu, Liping Zhu, Guibing He, Xiao Liang

“…The data were analyzed via the framework method to identify themes related to incision experiences. …”
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Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells by Verena Schlösser, Helen Louise Lightfoot, Christine Leemann, Seyedeh Elnaz Banijamali, Aathma Merin Bejoy, Shashank Tiwari, Jeffrey L. Schloßhauer, Valentina Vongrad, Andreas Brunschweiger, Jonathan Hall, Karin J. Metzner, Jochen Imig

“…Results: We established that Enoxacin, but not the structurally similar compound nalidixic acid, exhibits strong anti-HIV-1 effects in the T-cell line CEM-SS, but not MT-4. …”
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The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial by R.D. Singh, J.T.J.M. van Dijck, T.A. van Essen, H.P. Nix, R.J.G. Vreeburg, H.F. den Boogert, G.C.W. de Ruiter, B. Depreitere, W.C. Peul

“…Furthermore, non-structured interviews with involved clinical research personnel were conducted. …”
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Retention of medical officers in the district health services of the Western Cape, South Africa: An exploratory descriptive qualitative study by Robert J. Mash, Werner Viljoen, Steve Swartz, Mumtaz Abbas, Leigh Wagner, Herma Steyn, Gavin Hendricks, Dusica Stapar, Andrew Williams, Adeloye Adeniji, Johan Schoevers, Paul Kapp

“…Medical officers were purposefully selected in terms of districts, facility types, gender, seniority and perceived likelihood of leaving in the next four years. Semi-structured interviews were performed by family physicians, and the qualitative data were analysed using the framework method. …”
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