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52281
Application of high-throughput sequencing in citrus virus identification and analysis of population diversity
Published 2025-03-01“…This technology uses the principle of sequencing by synthesis, which can sequence a large number of RNA and DNA molecules in a short time without prior knowledge of the virus's biological characteristics or genome structure, thus obtaining its nearly complete genomic sequence. …”
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52282
EFFECT OF FREQUENT GENERIC IMATINIB SWITCHING ON TREATMENT RESPONSE IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA
Published 2024-12-01“…Methodology: We retrospectively analyzed data from patients diagnosed with CML-CP treated with imatinib from 2010 - 2024. …”
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52283
Multi-scenario Dynamic Simulation and Optimization of Urban Ventilation Environment: A Case Study of Taiyuan Metropolitan Area
Published 2025-05-01“…From 2030 to 2050, the villages and towns located in the southern plains transform from early isolated islands to a grid-like structure, and the ventilation environment level of the surrounding roads, rivers and other linear spaces gradually increases. …”
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52284
Genetic Diversity and Construction of Salt-Tolerant Core Germplasm in Maize (<i>Zea mays</i> L.) Based on Phenotypic Traits and SNP Markers
Published 2025-07-01“…Whole-genome genotyping was conducted using the Maize6H-60K liquid phase chip. Population structure analysis, principal component analysis, and cluster analysis divided the 588 accessions into six subgroups. …”
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52285
The mediating role of biological age in the association between dietary index for gut microbiota and sarcopenia
Published 2025-03-01“…Alterations in muscle structure are closely linked to DNA methylation-based biological age assessments and individual dietary patterns. …”
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52286
Impact of different genomic relationship matrix construction methods on the accuracy of genomic prediction in different species
Published 2025-05-01“…The learning curve for bull data showed the choice of G-matrix had minimal impact on prediction accuracy when the reference population size and genetic marker density reached a certain threshold.DiscussionThe study concluded that the optimal G-matrix construction method varies across species, with population structure being a key factor. …”
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52287
SURGERY OF BRAIN STEM CAVERNOUSES MALFORMATION
Published 2020-03-01“…Cavernous malformations (CM), also known as cavernous angiomas or cavernomas, are benign vascular hamartomas having a sinusoidal type of wall structure.CM occurs in the brain stem with a frequency of 9–35 % of cases. …”
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52288
Distribution Characteristics of Nutrients and Eutrophication Assessment in Yueqing Bay
Published 2024-09-01“…Based on the Marine environment monitoring data of Yueqing Bay in spring, summer, autumn and winter from 2018 to 2019, the spatial and temporal distribution characteristics of nutrient salts (dissolved inorganic nitrogen, DIN) and active phosphate (DIP) in the sea were analyzed, and the pollution degree, eutrophication degree and nutrient structure of the sea area were evaluated by single factor index method, eutrophication index method and potential eutrophication model. …”
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52289
Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes
Published 2025-07-01“…Across ten genes encoding voltage-gated sodium channels and 22 expert-curated disorders, we identify cross-paralog correlated phenotypes based on 3D structure spatial position. For example, multiple established loss-of-function related disorders across SCN1A, SCN2A, SCN5A, and SCN8A show overlapping spatial variant clusters. …”
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52290
Functional Analysis of <i>Penicillium expansum</i> Glucose Oxidase-Encoding Gene, <i>GOX2</i>, and Its Expression Responses to Multiple Environmental Factors
Published 2025-07-01“…It is either an integrated membrane protein (such as a receptor or channel) that is directly anchored to the membrane through a transmembrane structure or a non-classical secreted protein that is secreted extracellularly. …”
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52291
Some issues of local drinking water supply of the population during martial law (using the example of Ukrainian cities with a population of over 100 thousand people). Part 2
Published 2025-06-01“…Considering the high potential risks of damage from massive weapons to urban agglomerations with a high population density and infrastructure facilities within residential areas, reliable supply of drinking water to the social structure is one of the most important factors in the life support of the population. …”
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52292
Extending isolation by resistance to predict genetic connectivity
Published 2022-11-01“…Our empirical example highlights that the SAMC better predicts population structure than circuit theory and least‐cost analysis by acknowledging asymmetric environmental gradients (i.e. slope) and migration mortality in this species. …”
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52293
Whole genome insights into genetic diversity, introgression, and adaptation of Yunnan indigenous cattle of Southwestern China
Published 2025-03-01“…Results Herein, we employed 140 whole-genome sequencing data from Yunnan indigenous cattle across eight breeds to elucidate their genetic diversity and population structure. …”
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52294
A Systematic Analysis of Meteorological Parameters in Predicting Rainfall Events
Published 2025-01-01“…However, due to the complexity and dynamic structure of climate systems, rainfall prediction is a difficult task. …”
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52295
Synthesis of <i>bis</i>-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines
Published 2024-10-01“…In this study, we synthesized chalcone compounds with <i>bis</i>-chalcone’s chemical structure under microwave (MW) and microwave–ultrasound (MW-US) conditions and compared them to chalcones produced using the classical synthesis method. …”
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52296
Exploring the feasibility of integrating ultra‐high field magnetic resonance imaging neuroimaging with multimodal artificial intelligence for clinical diagnostics
Published 2024-10-01“…The superior spatial resolution of 7TMRI provides detailed visualizations of brain structure, which are crucial forunderstanding complex central nervous system diseases and tumors. …”
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52297
Quantitative risk assessment and eco-engineering mitigation strategies for debris flows utilizing dynamic process simulation in Shuzheng gully, Jiuzhaigou valley scenic and histori...
Published 2025-08-01“…The PPGD raises the erosion base level to dissipate impact energy and features a stepped gabion structure that promotes progressive solid-liquid separation, thereby reducing sediment concentration and enhancing ecological resilience. …”
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52298
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52299
Global trends in thermal burn burden, 1990–2021: a comprehensive analysis for the global burden of disease study 2021
Published 2025-07-01“…Decomposition analysis was performed to quantify the relative contributions of epidemiological changes, age structure shifts, and population growth to the thermal burn burden. …”
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52300
Proteomic study of the inhibitory effects of tannic acid on MRSA biofilm
Published 2024-12-01“…Differentially expressed proteins (DEPs) were screened using proteomic and biological information analyses, and their transcriptional levels were verified using real-time quantitative polymerase chain reaction.ResultsThe MIC of TA was 0.625 mg/mL, whereas 1/2 MIC (0.3125 mg/mL) of TA significantly inhibited biofilm formation without affecting the bacterial growth (p < 0.01) and prevented the formation of a complete three-dimensional biofilm structure. Using 1/2 MIC of TA, 208 DEPs were identified, of which 127 were upregulated and 81 were downregulated. …”
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