Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Abstract Background 3D-spatial interaction between cancer cells influences tumor behavior, making it essential to replicate tumor structures for predicting patient outcomes. Methods We collected data from three multicenter prospective studies to evaluate the ability to establish Patient-Derived Organoids (PDOs) from different biological samples and timepoints, correlating their characteristics and drug sensitivity with clinical outcomes. …”
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ANALYSIS OF STUDENTS' MATHEMATICAL CREATIVE THINKING ABILITIES WITH CROSS-CULTURAL EXPERIENCES FROM DIFFERENT COUNTRIES AT SEKOLAH INDONESIA KUALA LUMPUR (SIKL) by Nafisyah Alfiyanti Nabilah, Siti Lailiyah, Taufik Taufik, Dewi Mariani

“…The subject of this research is students of class X at SIKL, Malaysia, in the 2023/2024 academic year, a total of 6 people will be categorized into two criteria that is students graduated from secondary school in Indonesia and graduated from secondary school outside Indonesia. The data collection technique in this research uses a written test on exponents and unstructured interviews. …”
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Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods by Xianzong Ma, Changwei Duan, Xiaoying Wang, Yurong Tao, Lang Yang, Yongsheng Teng, Yuanming Pan, Mingjie Zhang, Junfeng Xu, Jianqiu Sheng, Xin Wang, Peng Jin

“…In summary, acute high-altitude exposure caused dramatic changes in gut microbiota, while prolonged exposure led to structural and functional reshaping. These findings enhance our understanding of how high-altitude environments reshape gut microbiota.IMPORTANCEThis study is the first to investigate the impact of high-altitude exposure on gut microbiota adaptation in a large-scale longitudinal cohort. …”
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Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep by Samantha J. Murray, Mustafa M. Almuqbel, Simon A. Felton, Nickolas J. Palmer, Ashley R. Deane, Daniel J. Myall, Reza Shoorangiz, Arsène Ella, Matthieu Keller, David N. Palmer, Tracy R. Melzer, Nadia L. Mitchell

“…Method Sheep treated at a pre‐symptomatic timepoint underwent five T1‐weighted structural MRI scans between 5 and 18 months of age. …”
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Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design by Xuanming Hong, Hui Cao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Ruqin Gao, Min Yu, Jinyi Zhou, Xianping Wu, Yu Liu, Shengli Yin, Wenjing Gao, Liming Li

“…Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in these associations are limited. Results Using data from 1,074 twins in the Chinese National Twin Registry and bivariate structural equation models (SEMs), we investigated the phenotypic (Rph), genetic (Ra), and environmental (Re) correlations between genome-wide DNAm and three obesity indices: BMI, waist circumference (WC), and waist-to-hip ratio (WHR). …”
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An inner membrane complex protein IMC1g in Plasmodium berghei is involved in asexual stage schizogony and parasite transmission by Yinjie Liu, Shitong Cheng, Gang He, Dawei He, Duo Wang, Sicong Wang, Lumeng Chen, Liying Zhu, Yonghui Feng, Liwang Cui, Yaming Cao, Xiaotong Zhu

“…Together, this work reveals an essential role of IMC1g in the parasite life cycle and suggests that IMC1 family members likely contribute to parasite gliding and invasion.IMPORTANCEThe malaria parasite’s inner membrane complex is critical to maintain its structural integrity and motility. Here, we identified the function of the IMC1g protein, a member of the IMC1 family, in invasive and proliferative stages of P. berghei. …”
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Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma by Qiwei Zhao, Qiwei Zhao, Yu Wang, Yu Wang, Long Ding, Long Ding, Zhuang Li, Zhuang Li, Mengyang Wang, Yueqing Huang, Qiushi Cao, Qiushi Cao, Yaqin Sun, Yaqin Sun, Xiaohong Guo, Xiaohong Guo

“…In this study, we aimed to validate whether CAP induces ferroptosis in TSCC and to elucidate the underlying mechanisms.MethodsCell viability in HN6 and CAL27 cells was assessed using CCK-8 assays. Mitochondrial structural changes were observed via transmission electron microscopy (TEM). …”
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Relative vacuum reduction innovative processes applied in primary magnesium production—Comprehensive analysis of thermodynamics, resource, energy flow, and carbon emission by Xiaolong Li, Tingan Zhang, Yan Liu, Junhua Guo, Jingzhong Xu, Yuanyuan Liang

“…Magnesium and magnesium alloys, serving as crucial lightweight structural materials and hydrogen storage elements, find extensive applications in space technology, aviation, automotive, and magnesium-based hydrogen industries. …”
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A Comparative Analysis of European Media Coverage of the Israel–Gaza War Using Hesitant Fuzzy Linguistic Term Sets by Walaa Abuasaker, Mónica Sánchez, Jennifer Nguyen, Nil Agell, Núria Agell, Francisco J. Ruiz

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La construction sociale de la “déscolarisation” : examen d’un dispositif départemental de signalement de l’absentéisme by Jean-Paul Géhin

“…The strenght of interpretations in terms of psychological weakness and breaking up of family structure contributes to minimise social dimensions and to underestimate the role of school itself in the process of “deschooling”.…”
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La réserve autochtone « transfrontalière » d’Akwesasne entre Canada et États-Unis, zone de contrebande et faille dans la sécurisation de la frontière by Guillaume Poiret, Pierre-Alexandre Beylier

“…New nation-wide networks operating there are creating changes in the local daily life of both the inhabitants of the reservation and those living around. Using datas collected from the police archives and interviews with local authorities, this paper aims to explain those evolutions and determine the nature and structure of the new traffics including their spatial extension, also describing the new policies implemented at the border to counter the traffics.…”
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Political Order and Nomadic Life in Iran: From the Afsharid Period to the End of the Qajar Dynasty by Shahram Gholami, Siavash Gholipour

“…The resulting insecurity prompted a transformation in village morphology, evolving into more complex structures resembling castles. Nomadism offered several advantages, including military strength, security, and a sense of freedom. …”
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Human capital development plan (HCDP) sebagai strategi komunikasi untuk meningkatkan kompetensi pegawai by Rosavella Nabila Yusriana, Ratna Ekawati

“…However, the manual management of HCDP data and unstructured training socialization schedules hinder optimal program implementation. …”
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THE INFLUENCE OF HEART RATE VARIABILITY ON CLINICAL COURSE OF CHRONIC HEART FAILURE AND RENAL FUNCTION IN ATRIAL FIBRILLATION PATIENTS by E. A. Polyanskaya, S. V. Mironova, N. A. Koziolova

“…Aim. Evaluation of structural and functional condition of the left ventricle (LV) and kidneys in permanent atrial fibrillation patients (AF) with ischemic chronic heart failure (CHF) according to mean 24 hour heart rate and heart rate variability.Material and methods. …”
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Impact of job crafting and work engagement on the mental and physical health of palliative care nurses by Ateya Megahed Ibrahim, Donia Elsaid Fathi Zaghamir, Mohamed Gamal Elsehrawy, Hassanat Ramadan Abdel-Aziz, Samia Eaid Elgazzar, Fathia Gamal Elsaid Hassabelnaby, Heba Ahmed Osman Mohamed, Nahed Abd Elazeem Abd Elsalam

“…Results The study revealed a positive correlation between job crafting behaviours and physical health (r = 0.52, p < 0.001) and a negative correlation between job crafting behaviors and mental health distress (r = -0.56, p < 0.001). The structural equation modeling (SEM) results demonstrated significant paths from job crafting to both physical health (β = 0.40) and mental health distress (β = -0.45), indicating that job crafting positively affects physical health and negatively affects mental health distress. …”
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Safety and Tolerability of Implanted Subcutaneous Cardioverter-Defibrillator Systems by A. V. Vereshchagina, T. M. Uskach, O. V. Sapelnikov, V. A. Amanatova, I. R. Grishin, A. A. Kulikov, V. S. Kostin, R. S. Akchurin

“…The use of S-ICD, even in patients with structural myocardial disease who do not require antibradycardia pacing, is effective in preventing SCD. …”
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Revision and validation of the Chinese version of the interpersonal reactivity index for couples for expectant couples by Juju Huang, Tengfei Liang, Jinzhi Li, Qiankun Liu, Jiaxue Pang, Yang Xu, Hui Xie

“…The reliability of the translated scale was assessed using Cronbach’s α coefficient, split-half reliability, and test-retest reliability. The structural validity of the scale was examined through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). …”
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Conception de l’artefact, conception du collectif : dynamique d’un processus de conception ouvert et continu dans une communauté de développement de logiciels libres by Flore Barcellini

“…These analyses combine:- structural analyses of design and use oriented mailing-lists. …”
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Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling by Xiarui Fan, Xiaomin Li, Tong Li, Bing Shao, Shan Niu, Wenhong Fan, Qi Wang, Lv Zhong, Xiangrui Wang, Ziwei Wang, Fujun Ma, Guomao Zheng, Hui Peng, Lili Chen, Zhaomin Dong

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Safety and efficacy of standard vs. tubeless percutaneous nephrolithotomy in pediatric populations: an updated systematic review and meta-analysis by Honggang Fang, Zihan Wang, Kuan Wei, Xing Liu, Shengde Wu, Yi Hua, Tao Lin, Dawei He, Guanghui Wei, Deying Zhang

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