Utilizing computational approaches for the prediction of alpha-PPAR inhibitors from baobab (Adansonia digitata) against non-alcoholic fatty liver disease by Asia Awad AbdelGader, Afra M. Al Bakry, Hind A. Elnasri, Dawelbiet Abdelaal Yahia, Mona Abdelrahman Mohamed Khaier

“…Then, Molecular Operating Environment (MOE) software was used to prepare these compounds as ligands for docking simulations. The 3D structure of the PPAR-alpha receptor was retrieved from the Protein Data Bank (PDB) database for docking simulations. …”
Get full text

Nutrient cycling characteristics along a chronosequence of forest primary succession in the Hailuogou Glacier retreat area, eastern Tibetan Plateau by Danli Yang, Ji Luo, Shumiao Shu, Yan Hu, Hongsong Tang, Xuemei Li

“…Nutrient cycling and utilization are the foundation to forest succession processes and dynamic changes, directly influencing the structure and stability of ecosystems. However, our understandings on the characteristics of ecosystem nutrient accumulation and recycling during succession, especially in the context of primary succession within glacier retreat areas, remain limited. …”
Get full text

Antimicrobial and antifungal activity of some (5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthiols substitutes by V. M. Odyntsova

“…The study of biological and pharmacological activity of the synthesized compounds, and also the determination of the regularities between structure and activity create a favorable basis for the search of new medicines in a number of 1,2,4-triazole derivatives.…”
Get full text

Economic damage associated with excess salt intake of Russian people in 2016 by Yu. A. Balanova, A. V. Kontsevaya, A. O. Myrzamatova, D. K. Mukaneeva, M. B. Khudyakov

“…The largest contribution of excess salt intake is in the damage associated with CVD (122,8 billion rubles), where half (68,1 billion rubles) is attributable to the ED associated with stroke. In the structure of the ED of each nosology, excess salt intake cause from 4,5% (CVD in general) to 17% (for T2D) and 16,1% (stroke) of the entire damage.Conclusion. …”
Get full text

Ricin and Abrin as Possible Agents of Bioterror by D. V. Pechenkin, A. S. Gorshkov, M. A. Sablina, A. V. Eremkin, S. S. Ipatov, G. V. Kuklina

“…Both toxins have a similar molecular structure and mechanism of action. They consist of two subunits – A and B, resistant to high temperatures and extreme pH values. …”
Get full text

Epigenetic analysis of KSHV latent and lytic genomes. by Zsolt Toth, Dennis T Maglinte, Sun Hwa Lee, Hye-Ra Lee, Lai-Yee Wong, Kevin F Brulois, Stacy Lee, Jonathan D Buckley, Peter W Laird, Victor E Marquez, Jae U Jung

“…The genomic region encoding the IE genes ORF50 and ORF48 possesses the features of a bivalent chromatin structure characterized by the concomitant presence of the activating H3K4me3 and the repressive H3K27me3 marks during latency, which rapidly changes upon reactivation with increasing AcH3 and H3K4me3 marks and decreasing H3K27me3. …”
Get full text

Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Retinal morphology, vascular structure, and cell counts were assessed ex vivo. Results We identified common molecular aging signatures across the nine mouse strains, which included genes associated with photoreceptor function and immune activation. …”
Get full text

Characterisation of coastal reef fish assemblages across an estuarine-urbanisation gradient using underwater visual census and environmental DNA metabarcoding by Yu-De Pei, Joseph Heard, Wenqian Xu, Shara K.K. Leung, Charmaine C.M. Yung, Alex S.J. Wyatt

“…In many places, baseline data on fish communities are inadequate for understanding and managing the ecological impacts of this urbanisation. …”
Get full text

Comparative analysis of bacterial communities and environmental interactions in seawater and saline-alkali aquaculture ponds for Scylla paramamosain in northern China by Dongping Zhou, Dongping Zhou, Yuanyuan Fu, Lei Liu, Weichuan Lin, Zhibin Lu, Yangfang Ye, Minglei Zhang

“…Redundancy analysis (RDA) identified salinity, pH, and dissolved oxygen as the principal environmental factors influencing bacterial community structure. Using the IndVal method, we identified strong associations between specific bacterial species and pond types, such as Sphingoaurantiacus and Cobetia in seawater ponds, and Roseivivax, Tropicimonas, and Thiobacillus in saline-alkali ponds. …”
Get full text

Evaluation Methods for the Human–Land Coupling Coordination Relationship in a Metro Station Area: A Case Study of Chengdu Metro Line 1 by Zhiyue Qiu, Shirui Wen, Hong Yuan, Ziyi Liu, Yao Wei, Siqi Yanling, Runlong Dai, Xiang Li, Yuxin Gu

“…By collecting multi-source data, the coupling coordination degree model (CCDM) is used to quantitatively evaluate the human–land coupling coordination relationship in the station area. …”
Get full text

PROFESSIONAL AND APPLIED PHYSICAL TRAINING FOR STUDENTS OF COMPUTER ENGINEERING SPECIALTY IN THE TEMPORARILY OCCUPIED TERRITORY WITH USING DISTANCE LEARNING by Shuba Liudmyla, Shuba Victor, Shuba Victoria

“…On the other hand, negative aspects include: social isolation, reduced motivation, lack of stimulating environment, difficulty concentrating, insufficient physical activity, technical difficulties, challenges with assessment and reporting, lack of teacherstudent interaction, an increased self-discipline level, need for support and structure, and limited access to resources and opportunities for collaboration and group work. …”
Get full text

Development, validation and assessment of reproducibility of a modern version of semi-quantitative food frequency questionnaire for the adult population by N. S. Karamnova, S. A. Maksimov, S. A. Shalnova, O. B. Shvabskaia, O. V. Izmailova, E. I. Ivanova, O. V. Molchanova, A. V. Kontsevaya, O. M. Drapkina

“…The changing structure of food consumption requires updating the nutrition assessment tool, taking into account modern dietary patterns.Aim. …”
Get full text

Coupling coordination relationship between health resource allocation and regional economic development: an empirical study based on five provinces in eastern China by Yongqiang Wang, Xiaochen Feng, Yulin Chai, Kexuan Chen, Shilan Yang, Wei Li, Yuqing Mi

“…Furthermore, the levels of economic development, economic structure, technological investment, as well as the allocation of health human and material resources, all serve as critical drivers in enhancing the coordinated development of the system.ConclusionThe coordinated development of eastern China’s provinces produces substantial spillover effects, and the realization of a Healthy China initiative must strategically harness their radiative and demonstrative effects. …”
Get full text

Clinical and Laboratory Characteristic of Acute Stenosic Laryngotraceitis in Children Hospitalized into Diagnostic Department of Lviv Regional Hospital of Infectious Diseases durin... by Hladchenko O.

“…According to statistics, acute respiratory viral infections (ARVIs) occupy a leading place in the structure of the morbidity of children. The importance of this problem lies in the fact that 1.0-5.0% of children of early age with acute respiratory infections are accompanied by acute stenotic laryngotracheitis syndrome (ASLS), in case of which the risk of an unfavorable course of the disease is significantly increased in early childhood. …”
Get full text

Construction of an AI Literacy General Education Curriculum Based on "Knowledge-Skills" Navigation by Baiyang LI, Rong SUN

Get full text

Assessing correlation between different temporary restorative materials for microleakage following endodontic treatment: an in-vitro study by Qamar Hashem, Mohammed Mustafa, Mohammed A.S. Abuelqomsan, Ahmed Altuwalah, Ahmed A. Almokhatieb, Mohammad Fareed, Mohmed Isaqali Karobari

“…Abstract Background Coronal microleakage, the passage of fluids and bacteria through the interface between the temporary restoration and the tooth structure, can potentially result in endodontic treatment failure. …”
Get full text

INTER-ILEAL-ABDOMINAL DISSECTION IN THE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED BONY AND SOFT TISSUE SARCOMAS by V. A. Derzhavin, V. Yu. Karpenko, A. V. Bukharov, M. V. Ivanova

“…Depending on the morphological structure, 16 (61%) had chondrosarcoma, 4 (15%) had osteosarcoma and 3 (11%) had a malignant fibrous histiocytoma. …”
Get full text

Development of an Online Scenario-Based Tool to Enable Research Participation and Public Engagement in Cystic Fibrosis Newborn Screening: Mixed Methods Study by Louise Moody, Samantha Clarke, Matt Compton, Rachael Hughson-Gill, Felicity Boardman, Corinna Clark, Pru Holder, James R Bonham, Jane Chudleigh

“…MethodsAround 4 development workshops with policymakers, parents, and other stakeholders informed the design of an interactive activity, including the structure, content, and questions posed. Stakeholders were recruited to take part in the development workshops via purposeful and snowball sampling methods to achieve a diversity of views across roles and organizations, with email invitations sent to representative individuals with lived, clinical, and academic experience related to CF and screening. …”
Get full text

Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case–control study by Neil A Harrison, Hugo D Critchley, Anthony S David, Kevin A Davies, Hannah McCarthy, Jessica A Eccles, Lisa Quadt, Rod Bond

“…Objective To test whether variant connective tissue structure, as indicated by the presence of joint hypermobility, poses a developmental risk for mood disorders in adolescence.Design Cohort-based case–control study.Setting Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were interrogated.Participants 6105 children of the ALSPAC cohort at age 14 years old, of whom 3803 also were assessed when aged 18 years.Main outcome measures In a risk analysis, we examined the relationship between generalised joint hypermobility (GJH) at age 14 years with psychiatric symptoms at age 18 years. …”
Get full text

Remediation potential of biochar for As and Cd by modifying soil physicochemical properties: a conceptual model elucidating stabilization mechanism based on conditional probability... by Yan Ma, Fan Zhang, Lu Cheng, Dading Zhang, Xinyi Wu, Yue Ma, Xueyu Liu, Baoshan Xing

“…Biochar addition improved soil particle size distribution and pore structure and increased soil pH and organic matter content but decreased cation exchange and total reducing substances. …”
Get full text