Predicting leakage of the VERCORS mock-up and concrete containment buildings - a digital twin approach by Laurent Charpin, Jessica Haelewyn, Anass Cherki El Idrissi, Julien Niepceron, Benoît Masson, Charles Toulemonde, Guillaume Boulant, Jean-Philippe Mathieu, François Hamon, Sylvie Michel-Ponnelle, Jean-Marie Hénault, Frédéric Taillade, Jean-Luc Adia, Florian Escoffier

“…An important numerical effort has also been made to implement structural computations of the mock-up and to capitalize these computations as well as their post-processing (so as to compare automatically with the monitoring data) in what can be called a digital twin of the mock-up. …”
Get full text

Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein by Clare R. Harwood, Clare R. Harwood, David A. Sykes, David A. Sykes, David A. Sykes, Theo Redfern-Nichols, Owen Underwood, Colin Nicholson, Colin Nicholson, Armin N. Khoshgrudi, Armin N. Khoshgrudi, Eline J. Koers, Eline J. Koers, Graham Ladds, Graham Ladds, Stephen J. Briddon, Stephen J. Briddon, Dmitry B. Veprintsev, Dmitry B. Veprintsev, Dmitry B. Veprintsev

“…The β2AR is a prototypical GPCR for structural and biophysical studies. However, the molecular basis of agonist efficacy at the β2AR is not understood. …”
Get full text

MtDNA genetic diversity and phylogeographic insights into giant domestic pigeon (Columba livia domestica) breeds: connections between Central Europe and the Middle East by K. Balog, A.S. Wadday, B.A. Al-Hasan, G. Wanjala, Sz. Kusza, P. Fehér, V. Stéger, Z. Bagi

“…The highest genetic diversity was found in the Carpathian Basin, and the lowest in the Iraqi region. STRUCTURE analysis revealed low structurality, K=3 was the most likely. …”
Get full text

FEASTS Combined with Interferometry. III. The Low Column Density H i Around M51 and Possibility of Turbulent-mixing Gas Accretion by Xuchen Lin, Jing Wang, Lister Staveley-Smith, Suoqing Ji, Dong Yang, Xinkai Chen, Fabian Walter, Hsiao-Wen Chen, Luis C. Ho, Peng Jiang, Nir Mandelker, Se-Heon Oh, Bo Peng, Céline Péroux, Zhijie Qu, Q. Daniel Wang

“…With simple models, we find that these low N _H _i structures could survive the background ultraviolet photoionization, but are susceptible to the thermal evaporation. …”
Get full text

Systemic inflammation is an important risk factor and predictor of graft loss and mortality one year after kidney transplantation by Torbjørn F. Heldal, Torbjørn F. Heldal, Torbjørn F. Heldal, Anders Åsberg, Anders Åsberg, Anders Åsberg, Thor Ueland, Thor Ueland, Thor Ueland, Anna V. Reisæter, Anna V. Reisæter, Søren E. Pischke, Søren E. Pischke, Tom E. Mollnes, Tom E. Mollnes, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Finn P. Reinholt, Anders Hartmann, Anders Hartmann, Kristian Heldal, Kristian Heldal, Kristian Heldal, Trond G. Jenssen, Trond G. Jenssen

“…BackgroundAn inflammatory environment following kidney transplantation is associated with increased risk of graft loss and mortality, however, evaluation of systemic inflammation is not implemented in structured risk assessment in kidney transplant recipients. …”
Get full text

Postnatal care could be the key to improving the continuum of care in maternal and child health in Ratanakiri, Cambodia. by Kimiyo Kikuchi, Junko Yasuoka, Keiko Nanishi, Ashir Ahmed, Yasunobu Nohara, Mariko Nishikitani, Fumihiko Yokota, Tetsuya Mizutani, Naoki Nakashima

“…Overall, 377 women were included, and data were collected via face-to-face interviews using a semi-structured questionnaire. …”
Get full text

Sources of uncertainty in DNA metabarcoding of whole communities: Implications for its use in biomonitoring by J. Iwan Jones, Amanda Arnold, Dominik Buchner, John F. Murphy, Jasmine N. Childress, Pedro Beja, Florian Altermatt, Kristian Meissner, Ian Adams, Meri Anderson, Yaisel J. Borrell, Andrew G. Briscoe, Kat Bruce, Cátia Chaves, Chris Conyers, Kristy Deiner, Vasco Elbrecht, Álvaro Fueyo, Tim Goodall, Javier Granero‐Castro, Cristina Hartmann‐Fatu, Eleanor Jones, Elvira Mächler, Filipa M. S. Martins, Sam McGreig, Lyndall Pereira‐da‐Conceicoa, James L. Pretty, Daniel S. Read, Ben Price, Florian Leese, Rosetta C. Blackman

“…However, the routine application of DNA‐based methods to monitor whole communities using a metabarcoding approach and derive ecosystem status continues to be limited. We undertook a structured experiment to assess factors influencing the precision and accuracy of molecular methods for freshwater macroinvertebrate community assessment. …”
Get full text

Observational Comparison between Confined and Eruptive Flares: Magnetohydrodynamics Instability Parameters in a Similar Magnetic Configuration by Kouhei Teraoka, Daiki Yamasaki, Yusuke Kawabata, Shinsuke Imada, Toshifumi Shimizu

“…Unstable states of the solar coronal magnetic field structure result in various flare behaviors. In this study, we compared the confined and eruptive flares that occurred under similar magnetic circumstances in the active region 12673, on 2017 September 6, using the twist number, decay index, and height of magnetic field lines to identify observational behaviors of the flare eruption. …”
Get full text

Cluster-Based Flight Path Construction for Drone-Assisted Pear Pollination Using RGB-D Image Processing by Arata Kuwahara, Tomotaka Kimura, Sota Okubo, Rion Yoshioka, Keita Endo, Hiroyuki Shimizu, Tomohito Shimada, Chisa Suzuki, Yoshihiro Takemura, Takefumi Hiraguri

“…Flower detection is performed using a YOLO (You Only Look Once)-based object detection algorithm, and three-dimensional flower positions are estimated by integrating depth information with the drone’s positional and orientation data in the east-north-up coordinate system. To enhance pollination efficiency, the method applies the OPTICS (Ordering Points To Identify the Clustering Structure) algorithm to group detected flowers based on spatial proximity that correspond to branch-level distributions. …”
Get full text

Ante-Mortem Clinical Characterization with Post-Mortem Family Interview and Medical Record Abstraction in a Traumatic Brain Injury Brain Donor Program by Amelia J. Hicks, Enna Selmanovic, Ariel Pruyser, Carley R. Trentman, Joshua C. Klein, Kaitlyn Wilkey, Miguel X. Escalon, Natalia Bernal-Fernández, Belinda Yew, Kristen Dams-O’Connor

“…We describe the content development and structure of the LETBI PFI; interviewer training and qualifications; and considerations regarding interview duration, informant selection, and interview timing, as well as PFI inter-rater reliability. …”
Get full text

Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment by Toby Landeryou, Rosie Maddren, Jack Hearn, Mahlet Belachew, Santiago Rayment Gomez, Ewnetu Firdawek Liyew, Kathryn Forbes, Birhan Mengistu, Scott P. Lawton, Jude Eze, Geremew Tasew, Ufaysa Angulo, Roy Anderson

“…We found that fine-scale population structure exists in spatially distinct clusters of infected individuals with reinfection occurring within or between geographically close households. …”
Get full text

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA as novel biomarkers for multi-cancer detection by Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Miao Dang, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Huanqin Zhang, Wenjie Song, Jinliang Xing

“…Furthermore, region-specific fragmentomic features of ccf-mtDNA were observed, which was associated with protein binding, base composition and special structure of mitochondrial DNA. When comparing to non-cancer controls, six types of cancer patients exhibited aberrant fragmentomic features. …”
Get full text

Impact of Anthropomorphic Shape and Skin Stratification on Absorbed Power Density in mmWaves Exposure Scenarios by Silvia Gallucci, Martina Benini, Marta Bonato, Valentina Galletta, Emma Chiaramello, Serena Fiocchi, Gabriella Tognola, Marta Parazzini

“…As data exchange demands increase also in widespread wearable technologies, transitioning to higher bandwidths and mmWave frequencies (30–300 GHz) is essential. …”
Get full text

First Assembly of a Draft Genome of the Critically Endangered Northern Muriqui (Brachyteles hypoxanthus, Primates, Atelidae) Including Non‐Invasive Genotyping Strategies for the Sp... by Amanda Alves de Melo‐Ximenes, Romina Batista, Leonardo Carlos Jeronimo Corvalán, Tomas Marques‐Bonet, Lukas Kuderna, Kyle Farh, Jeffrey Rogers, Mariane da Cruz Kaizer, Jean Philippe Boubli, Fabiano Rodrigues de Melo, Rhewter Nunes, Mariana Pires de Campos Telles

“…The complete 16,635 bp mitochondrial genome retains the conserved mammalian structure with 22 tRNAs, 2 rRNAs, 13 CDS, and an origin of replication. …”
Get full text

EVALUATION OF RATIONALITY OF EXPENSES ON TREATMENT OF SEVERE COMMUNITY-ACQUIRES PNEUMONIA IN MULTI-PROFILE HOSPITAL by I. V. Demko, N. V. Gordeeva, E. N. Bochanova, N. I. Golovina, A. Yu. Kraposhina, I. A. Soloveva, E. A. Sobko, T. V. Gaygolnik, S. V. Chubarova

“…The frequency analysis was applied to studying the structure of the carried-out drug treatment and identification of frequency of the separate medicinal preparations. …”
Get full text

Analysis of the Influence of Different Turbulence Models on the Prediction of Vehicle Aerodynamic Performance by Luwei Wang, Xingjun Hu, Peng Guo, Zirui Wang, Jingyu Wang, Yuqi Wang, Yan Ma, Ying Li, Jing Zhao, Xu Yang, Ruixing Ma, Yinan Zhu, Jianjiao Deng

“…These models predict vehicle aerodynamic resistance, lift, and wake flow structure. The k-ε model best predicts the steady-state drag coefficient (Cd) (error 0.0009). …”
Get full text

Physiologically based pharmacokinetic model of sodium-glucose cotransporter 2 inhibitors predicted pharmacokinetics and pharmacodynamics to explore dosage regimen for patients with... by Guimu Guo, Guimu Guo, Meng Ke, Meng Ke, Jianwen Xu, Jianwen Xu, Wanhong Wu, Wanhong Wu, Jiarui Chen, Jiarui Chen, Chengjie Ke, Chengjie Ke, Pinfang Huang, Pinfang Huang, Cuihong Lin, Cuihong Lin

“…ObjectiveThis study aimed to compare the hypoglycemic effects of four SGLT2 inhibitors (dapagliflozin, canagliflozin, empagliflozin, and ipragliflozin), simulate the 24-h urinary glucose excretion (UGE) of these inhibitors in T2DM patients with renal insufficiency, and investigate optimal dosage regimen for the SGLT2 inhibitor in these patients.MethodWe established a physiologically based pharmacokinetic (PBPK) model of SGLT2 inhibitors using the PK-Sim software, and the renal physiological tissue structure was expanded to include renal tubules using the MoBi software. …”
Get full text

Evaluating analytic strategies to obtain high-resolution, vertex-level measures of cortical neuroanatomy in children in low- and middle-income countries by Charlotte M. Pretzsch, František Váša, Michael Brammer, Lucy Brink, Mandy Potter, Wendy Mackay, Petrusa Smit, Carolina Du Plessis, Marcelle Wagner, Deborah Jonker, Kirsten A. Donald, Freda Scheffler, Cindy Pham, Viola Hollestein, Eva Loth, Declan GM Murphy, Hein J. Odendaal, Elizabeth R. Sowell, Priscilla E. Springer, Dan J. Stein, Christine Ecker

“…Abstract High-field magnetic resonance imaging to explore brain structure and function remains limited to high-resource settings. …”
Get full text

Optical Coherence Tomography Angiography, Elastography, and Attenuation Imaging for Evaluation of Liver Regeneration by Svetlana Rodimova, Ekaterina Gubarkova, Nikolai Bobrov, Ilya Shchechkin, Vera Kozlova, Natalia Zolotova, Arseniy Potapov, Elena Kiseleva, Grigory Gelikonov, Natalia Gladkova, Vladimir Zagainov, Elena Zagaynova, Daria Kuznetsova

“…In this study, we used multimodal optical coherence tomography (MM OCT), a combination of three optical coherence tomography modalities—OCT–angiography (OCTA), attenuation coefficient mapping, and OCT–elastography (OCE) to provide real-time three-dimensional and label-free assessment of changes in microcirculation, and in the structure and stiffness of the liver during regeneration. …”
Get full text

Quantifying of spatio-temporal variations in the regional gravity field and the effectiveness of earthquake prediction: A case study of MS ≥ 5.0 earthquakes in the Sichuan-Yunnan r... by Weimin Xu, Shi Chen, Yongbo Li, Jiangpei Huang, Bing Zheng, Yufei Han, Zhaohui Chen, Qiuyue Zheng, Hongyan Lu, Linhai Wang, Honglei Li, Dong Liu

“…Reportedly, crustal mass transfer, which is affected by stress state and structural environment, alters the characteristics of the regional gravity field, thus serving as an indicator for locations of moderate to strong earthquakes and a seismology-independent predictor for regions at risk for strong earthquakes. …”
Get full text