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53461
Case report: pomalidomide as maintenance after salvage autologous stem cell transplantation in a patient with relapsed multiple myeloma
Published 2023-12-01“…Pomalidomide is a third-generation IMiD approved for the treatment of relapsed and refractory multiple myeloma, which is efficient in patients with resistance to lenalidomide and proteasome inhibitors. Structurally, lenalidomide and pomalidomide are similar, and therefore the latter can also be considered as a drug for maintenance, however, there are no relevant phase 3 randomized trials. …”
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53462
Video-based telemedicine utilization patterns and associated factors among racial and ethnic minorities in the United States during the COVID-19 pandemic: A mixed-methods scoping r...
Published 2025-07-01“…Despite increased attention and efforts to address access barriers, our findings highlight the need for more targeted, culturally and structurally tailored interventions to improve digital inclusion.…”
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53463
Assessment of Youth Water Polo Players’ Swimming Sprint Potential: A New Approach to Building an International Model
Published 2025-05-01“…Factor analysis indicated that swimming with and without the ball are structurally distinct technical skills, highlighting the specificity of these water polo players’ abilities. …”
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53464
Obstacle shape determination by mobile robot sensor system using GP2Y0A (Sharp) type IR distance sensors
Published 2024-04-01“…When using analog sensors, it is necessary to convert an output signal into digital form using analog-to-digital converters (ADCs) in an integrated design, structurally bringing the ADC as close as possible to the signal source.…”
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53465
Applicability of Adults 2015 American Thyroid Association Differentiated Thyroid Cancer Guidelines for Postoperative Risk Stratification and Postradioiodine Treatment Dynamic Risk...
Published 2022-06-01“…Forty-seven patients were classified as responders (excellent and indeterminate responses) and incomplete responders (biochemical and structurally incomplete responses) by assessing the RTT at 1.5 years follow-up similar to recommendation of 2015 adult DTC ATA guidelines. …”
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53466
Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms
Published 2025-03-01“…The effects of fasudil are mostly related to ROCK inhibition, which we have shown using two structurally different ROCK inhibitors and knockdown data, and further supported by using RT-QuiC.…”
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53467
Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. VI. Confirmation of a Long-period Giant Planet Discovered with a Single TESS Transit
Published 2025-01-01“…Based on giant planet structure models, TOI-4465 b appears to be enriched in heavy elements at a level consistent with late-stage accretion of icy planetesimals. …”
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53468
Psychodrama: implementation, study design and effectiveness: a systematic review
Published 2025-07-01“…However, the methodological design of psychodrama needs improvement: RCTs and quasi-experimental designs, larger sample sizes, follow-up evaluations, and effect size measurement. Additionally, structuring interventions and their manualization in specific populations can help establish evidence-based treatments.…”
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53469
Algorithms of diagnosis and therapy of a primary depressive episode
Published 2023-07-01“…An algorithm for the PDE diagnosis has been developed based upon four stages: the first one – the symptomatic state diagnosis; the second – clinical-ethological analysis of depressive phenomenon signs and a neurophysiological electroencephalographic (EEG) examination; the third – psycho-experimental examinations using appropriate tools; the fourth – structuring of the obtained diagnostic data, diagnosis verification and development of therapeutic intervention tactics. …”
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53470
The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.
Published 2014-10-01“…Plant nucleotide-binding leucine-rich repeat (NB-LRR) disease resistance (R) proteins recognize specific "avirulent" pathogen effectors and activate immune responses. NB-LRR proteins structurally and functionally resemble mammalian Nod-like receptors (NLRs). …”
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53471
Correlation with viruses enhances network complexity and stability of co-occurrence prokaryotes across the oceans
Published 2025-07-01“…However, the mechanisms behind the association and structuring of microbiomes with viruses still remain largely unknown. …”
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53472
Metagenomics-assembled genomes reveal microbial metabolic adaptation to athalassohaline environment, the case Lake Barkol, China
Published 2025-06-01“…Overall, this study reveals extensive taxonomic novelty and functional plasticity among microbial communities in Lake Barkol and underscores the influence of salinity in structuring microbial assemblages and metabolic pathways in athalassohaline ecosystems.…”
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53473
Examination of Inter‐α Inhibitor Proteins in Permanent and Transient Focal Ischemia
Published 2025-02-01“…Inter‐α inhibitor proteins (IαIPs) are a family of structurally related glycoproteins with 2 major forms (inter‐α inhibitor and pre‐α inhibitor) in blood. …”
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53474
Ability to form duplexes as a factor of intracellular microRNA distribution
Published 2018-11-01“…The regulation of the content of mature microRNAs (miRNAs) in different cell compartments – the nucleus (N) and the cytoplasm (C) – makes it possible to control their availability for participation in RNA-mediated interference processes. Structurally different miRNAs, processed from different precursors (pre-miRNA), can form duplexes between molecules containing complementary sequences. …”
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53475
UAV-OVD: Open-Vocabulary Object Detection in UAV Imagery via Multi-Level Text-Guided Decoding
Published 2025-07-01“…First, at the training level, we design a region–text contrastive loss to replace conventional classification loss, allowing the model to align visual regions with textual descriptions beyond fixed category sets. Structurally, building on this, we introduce a multi-level text-guided fusion decoder that integrates visual features across multiple spatial scales under language guidance, thereby improving overall detection performance and enhancing the representation and perception of small objects. …”
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53476
Qalification assessment practices: new possibilities and constraints
Published 2021-09-01“…The methodological framework of the research is based on the principles of the activity approach and the concept of structuration, in which the practice of qualifications assessment is viewed as a combination of social relations between individual and collective actors in the space of social and labour relations. …”
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53477
Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis
Published 2024-09-01“…It is theory driven because it uses evidence to iteratively develop and test structurally coherent explanations (i.e. theories) of complex interventions. …”
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53478
Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol
Published 2024-12-01“…The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. …”
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53479
Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression
Published 2025-02-01“…Analysis was inductive using thematic analysis of transcribed interview data. Neuroimaging Participants’ baseline and 16-week MRI scans (the London site underwent scanning at the baseline time point only), were carried out at the same site and using the same scanner platform (all 3T), using a core protocol across the treatment sites (scanner sites Nottingham for Nottingham and Northampton; Newcastle, London, and Manchester for Oldham). rsfMRI and structural MRI was conducted at all sites and Mesher-Garwood Point Resolved Spectroscopy (MEGA-PRESS) magnetic resonance spectroscopy (MRS) scans in the DlPFC at Nottingham and Newcastle only. …”
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53480
Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region
Published 2021-09-01“…The high heterogeneity of lymphomas in the head and neck area requires structuring knowledge about their epidemiology and clinical manifestations.Objective: to study the epidemiological and clinical features of the head and neck lymphoproliferative diseases, which will lead to an improvement in diagnostic quality of this nosology’s.Materials and methods. …”
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