The mediating role of self-compassion in the relationship between childhood trauma and the symptoms of body dysmorphic disorder by Motahhareh Kargar Shooroki, Azadeh Choobforoushzadeh, Azra Mohammadpanah Ardakan

“…Methods A cross-sectional design employing structural equation modeling (SEM) was utilized to construct an optimal model for BDD symptoms, where the mediating role of self-compassion was tested in the relationship between childhood trauma and BDD symptoms. …”
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Skeletal Muscle‐Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength by Hye Rim Jang, Shi‐Young Park, Yeonmi Lee, Dongjin Lee, Jongjun Lee, Yoonil Cho, Cheol Soo Choi, Hui‐Young Lee

“…Notably, desmin, a protein critical for structural integrity and mitochondrial function, was identified as a target protein of the ASB2 E3 ligase. …”
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CATHODOLUMINESCENCE AND RAMAN SPECTROSCOPY AS A BASIS FOR THE SELECTION OF REFERENCE SAMPLES FOR LA-ICP-MS ANALYSIS OF ZIRCON by S. L. Votyakov, M. V. Chervyakovskaya, Yu. V. Shchapova, E. A. Pankrushina, G. B. Mikhalevsky, V. S. Chervyakovsky

“…The Аi–Вi–Сi diagram is compared with similar data on the cathodoluminescence of the reference samples.…”
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Increased Brain Iron Deposition in the Putamen in Patients with Type 2 Diabetes Mellitus Detected by Quantitative Susceptibility Mapping by Jing Li, Qihao Zhang, Nan Zhang, Lingfei Guo

“…The underlying brain structural changes in type 2 diabetes mellitus (T2DM) patients have attracted increasing attention. …”
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Coverage of HPV Vaccination and Influencing Factors Among Female College Students in Northern China by Li Yang, Chen Xing, Xue Yu, Yanrui Xu, Weibing Wang, Caiyun Chang, Qingbin Lu

“…Notably, increased knowledge was associated with vaccine hesitancy in the WTG group (<i>OR</i> = 0.45, <i>p</i> < 0.001), indicating that information overload may adversely affect decision-making processes. Structural barriers, such as cost (42.63%), safety concerns (46.59%), and misconceptions (e.g., 57.76% cited “no sexual activity” as a reason for refusal), significantly impeded vaccine uptake. …”
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Geographic variations and determinants of ever-tested for HIV among women aged 15–49 in Sierra Leone: a spatial and multi-level analysis by Lovel Fornah, Mulugeta Shegaze Shimbre, Augustus Osborne, Alieu Tommy, Agumas Fentahun Ayalew, Wei Ma

“…Method The study utilized data from the 2008, 2013, and 2019 Sierra Leone Demographic Health Surveys, comprising 39,606 women aged 15–49. …”
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Application of Statistical Methods for the Characterization of Radon Distribution in Indoor Environments: A Case Study in Lima, Peru by Rafael Liza, Félix Díaz, Patrizia Pereyra, Daniel Palacios, Nhell Cerna, Luis Curo, Max Riva

“…Additionally, analysis of variance (ANOVA) was used to evaluate the influence of environmental and structural factors on radon variability. Non-normally distributed data were normalized using a Box–Cox transformation to improve statistical assumptions, enabling subsequent geostatistical analyses. …”
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Deep dive into hydrologic simulations at global scale: harnessing the power of deep learning and physics-informed differentiable models (<i>δ</i>HBV-globe1.0-hydroDL) by D. Feng, D. Feng, D. Feng, H. Beck, J. de Bruijn, J. de Bruijn, R. K. Sahu, Y. Satoh, Y. Wada, J. Liu, M. Pan, K. Lawson, C. Shen

“…Nevertheless, relative to LSTM, the differentiable model was hampered by structural deficiencies for cold or polar regions, highly arid regions, and basins with significant human impacts. …”
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Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microg... by Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao

“…Through this approach, four new (<b>1</b>–<b>4</b>) and nine known (<b>5</b>–<b>13</b>) PUFA analogues were obtained from large-scale cultures of the marine dinoflagellate <i>Prorocentrum lima</i>, with lipidomic profiling identifying FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and FA22:6 methyl ester (<b>11</b>) as major constituents of the algal oil extract. Structural elucidation was achieved through integrated spectroscopic analyses of IR, 1D and 2D NMR, and HR-ESI-MS data. …”
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E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness by Alf Spitschak, Prabir Dhar, Krishna P. Singh, Rosaely Casalegno Garduño, Shailendra K. Gupta, Shailendra K. Gupta, Julio Vera, Luca Musella, Nico Murr, Anja Stoll, Brigitte M. Pützer, Brigitte M. Pützer

“…To explore E2F1’s role in immune regulation in presence of aggressive melanoma cells, we established a coculture system and utilized transcriptome and cytokine arrays combined with bioinformatics and structural modeling. We identified an E2F1-dependent gene regulatory network with IL6 as a central hub. …”
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Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits by Dennis Witt, Marc Sturm, Antje Stäbler, Benita Menden, Lisa Ruisinger, Kristin Bosse, Ines Gruber, Andreas Hartkopf, Silja Gauß, German Demidov, Nicolas Casadei, Elena Buena Atienza, Kira Mehnert, Janna Witt, Caspar Gross, Leon Schütz, Christopher Schroeder, Stephan Ossowski, Andreas Dufke, Tobias B. Haack, Olaf Riess, Ulrike Faust

“…GS offers a wealth of information, including the improved detection of structural variants, copy number variants, and parallel detection of complex genetic markers. …”
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The antioxidant property of CAPE depends on TRPV1 channel activation in microvascular endothelial cells by Miltha Hidalgo, Bárbara Railef, Vania Rodríguez, Carolina Navarro, Vanessa Rubio, Jorge Meneses-Pacheco, Sandra Soto-Alarcón, Christine Kreindl, Carolina Añazco, Leandro Zuñiga, Omar Porras

“…Herein, we hypothesized that a subfamily of TRP ion channels works as the molecular entity that recognizes CAPE at the plasma membrane and allows a fast shift in the antioxidant capacity of intact endothelial cells (EC).By monitoring cytoplasmic Ca2+ in a microvascular EC model, we compared the calcium responses evoked by three structurally related compounds: caffeic acid phenethyl ester, neochlorogenic acid and caffeic acid. …”
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Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy by Jiahui Mai, Jing Duan, Xiaoyu Chen, Liqin Liu, Dachao Liang, Tao Fu, Gang Lu, Wai Yee Chan, Xufeng Luo, Feiqiu Wen, Jianxiang Liao, Zhuo Li, Xinguo Lu

“…We used the optical genome mapping (OGM) technology to detect and analyze uncommon mutations or structural variations (SVs) within the DMD gene, thus contributing to more precise clinical diagnoses. …”
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CTV-MIND: A cortical thickness-volume integrated individualized morphological network model to explore disease progression in temporal lobe epilepsy by Xinyan Liu, Jiaqi Han, Xiating Zhang, Boxuan Wei, Lu Xu, Qilin Zhou, Yuping Wang, Yicong Lin, Jicong Zhang

“…This study aimed to investigate progressive changes in TLE by constructing a novel individualized morphological brain network based on T1-weighted structural magnetic resonance imaging (MRI). MRI data were collected from 34 postoperative seizure-free TLE patients and 28 age- and sex-matched healthy controls (HC), with patients divided into LONG-TERM and SHORT-TERM groups. …”
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Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study by Ken-ei Sada, Shuhei Yoshida, Kenji Saito, Yuya Fujita, Eisuke Inoue, Kiyoshi Migita, Naoki Matsuoka, Hiroshi Kajiyama, Ryusuke Yoshimi, Kunihiro Ichinose, Yoshia Miyawaki, Shigeru Ohno, Nobuyuki Yajima, Yasuhiro Shimojima, Shuzo Sato, Michio Fujiwara, Keisuke Nishimura, Takashi Kida, Yuya Sumichika, Haruki Matsumoto, Jumpei Temmoku, Tomoyuki Asano, Shotaro Ogawa, Jumpei Fukita, Yusuke Matsuo, Takahisa Onishi

“…Statistical analyses employed marginal structural models with stabilised inverse probability of treatment weighting to adjust for confounders.Results The analysis included 1004 patients; the incidence of severe infections was 6.5% in the MMF group and 7.5% in the non-MMF group, with no significant difference (OR 0.69, 95% CI 0.34 to 1.39). …”
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The mediating role of physical activity avoidance in the association between weight stigma and physical activity by Po-Ching Huang, Hung-Ching Wu, Ji-Kang Chen, Xavier C.C. Fung, Nadia Bevan, Daniel Kwasi Ahorsu, Mark D. Griffiths, Jung-Sheng Chen, Kuo-Hsin Lee, Amir H. Pakpour, Chung-Ying Lin

“…Results: Structural equation modeling showed that weight-related self-stigma was significantly associated with PA avoidance (standardized coefficient [β] = 0.67, p < 0.01), and negatively associated with PA (β = −0.14, p < 0.01). …”
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Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia by Melanie A. Matyi, Hamsanandini Radhakrishnan, Christopher A. Olm, Jeffrey S. Phillips, Philip A. Cook, Emma Rhodes, James C. Gee, David J. Irwin, Corey T. McMillan, Lauren Massimo

“…Given that behavioral variant frontotemporal degeneration (bvFTD) is a neurodegenerative disease associated with executive dysfunction and selective vulnerability of the salience network, we tested the hypotheses that bvFTD structural networks are de-differentiated compared to cognitively normal controls (CNC) and that network de-differentiation relates to worse executive function. …”
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Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains by Yue Xiang, Saixian Zhang, Yi Huang, Zhuqing Zheng, Jiahui Sun, Qiulin Zhao, Peng Zhou, Xiaolong Qi, Jingjin Li, Fuyang Xiong, Jing Xu, Shengquan Wang, Liangliang Fu, Xinyun Li

“…Abstract Background Pig brains serve as a valuable biomedical model for studying brain-related diseases due to their significant structural similarities to the human brain. Furthermore, the long-term domestication and artificial selection of domestic pigs have profoundly shaped their brains, making them an interesting subject for research. …”
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Flares on TRAPPIST-1 Reveal the Spectrum of Magnetic Features on Its Surface by Valeriy Vasilyev, Nadiia Kostogryz, Alexander I. Shapiro, Astrid M. Veronig, Benjamin V. Rackham, Christoph Schirninger, Julien de Wit, Ward Howard, Jeff Valenti, Adina D. Feinstein, Olivia Lim, Sara Seager, Laurent Gizon, Sami K. Solanki

“…Our analysis rules out lingering flare decay as the cause of the flux enhancement and thus, points to structural changes on the stellar surface induced by flares. …”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
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