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52181
Systematic review of dietary salt reduction policies: Evidence for an effectiveness hierarchy?
Published 2017-01-01“…To facilitate comparisons between the interventions, the extracted data were categorised using nine stages along the agentic/structural continuum, from "downstream": dietary counselling (for individuals, worksites or communities), through media campaigns, nutrition labelling, voluntary and mandatory reformulation, to the most "upstream" regulatory and fiscal interventions, and comprehensive strategies involving multiple components.…”
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52182
From reality to virtuality: Unveiling Gen Z's purchasing behavior through virtual influencers in the metaverse
Published 2025-12-01“…Utilizing judgmental sampling, a sample of 352 individuals with prior experience as VIs was selected to address the research objectives. The data were analyzed using a mixed-method approach, incorporating fuzzy-set Qualitative Comparative Analysis (fsQCA), Partial Least Squares Structural Equation Modeling (PLS-SEM), and Artificial Neural Networks (ANN techniques). …”
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52183
Identification of multiple genomic alterations and prediction of neoantigens from circulating tumor cells at the single-cell level
Published 2025-07-01“…In the PDX model, integrating data from seven CTCs captures 88.7% of SNPs and INDELs, and 75.0% of structural variants present in tumor tissue. …”
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52184
Tackling Paradoxes and Double Binds for a Healthier Workplace: Insights from the Early COVID-19 Responses in Quebec and Ontario
Published 2025-04-01“…We argue that PDBs represent a significant occupational health hazard for precarious workers. Addressing these structural contradictions through proactive management strategies could help mitigate workplace tensions, reduce stress, and enhance resilience in both crisis situations and regular organisational contexts. …”
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52185
Prevalence and environmental abundance of the TSET complex in cosmopolitan algal groups
Published 2025-06-01“…Finally, diatom TSET genes are detectable in meta-transcriptomic data from Tara Oceans, suggesting functional roles in the wild. …”
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52186
Multimodal gradients unify local and global cortical organization
Published 2025-04-01“…Here, we present an approach to integrate inter- and intra-areal similarities of microstructure, structural connectivity, and functional interactions. …”
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52187
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52188
Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow
Published 2025-02-01“…A selected subset of the identified antigens is then expressed recombinantly to isolate antigen-specific IgG, followed by characterization of the structural and functional properties of these antibodies. …”
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52189
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52190
Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics
Published 2025-07-01“…Very little is understood about the underlying pathogenesis underpinning injury at this location, especially the contribution of keratinocytes and other structural skin cells. We performed single-cell RNA sequencing to compare the transcriptome of epidermal and dermal chronic GVHD samples with that of healthy control samples. …”
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52191
Food parenting stress among caregivers receiving government food assistance: a study from the United States
Published 2025-09-01“…Nutrition education should be paired with supports that address structural barriers.…”
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52192
ODEP-Based Robotic System for Micromanipulation and In-Flow Analysis of Primary Cells
Published 2025-01-01“…The induced responses obtained under time-variant ODEP stimulation reflect the cells’ chemical, morphological, and structural characteristics in an automated, flexible, and label-free manner. …”
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52193
Evaluation of dengue virus seroprevalence in four boroughs of Mexico City among persons aged 5-35 years in 2022
Published 2025-02-01“…However, it is important to note that the structural conditions of the dwellings in these boroughs, which offer minimal barriers to vector infestation, could facilitate the establishment of local transmission under favorable conditions. …”
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52194
Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies
Published 2025-06-01“…Nevertheless, challenges persist regarding hepatic safety, pharmacodynamic variability, and limited long-term outcome data. This review integrates current structural, pharmacological, and clinical evidence, highlights key mechanistic innovations—including biased agonism, covalent binding strategies, and allosteric modulation—and discusses future directions for this rapidly evolving therapeutic class in metabolic disease management.…”
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52195
Comprehensive Dissolution Study on Two Double Ce(IV) Phosphates with Evidence of Secondary CeO<sub>2</sub> Nanoparticle Formation
Published 2025-05-01“…In contrast, the nanophase NaCe<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> exhibits exceptional structural and chemical stability, showing no signs of recrystallisation, phase transformation, or CeO<sub>2</sub> formation, even after extended ageing. …”
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52196
USP7 V517F mutation as a mechanism of inhibitor resistance
Published 2025-03-01“…We discovered a key treatment-emergent heterozygous mutation (V517F) in USP7 in the binding pocket of compounds as the primary cause of resistance to the USP7 inhibitor USP7-797. Our structural analysis, supported by AlphaFold2 predictions, indicates that the V517F mutation altered the conformation of the compound binding pocket, causing steric hindrance and reducing the affinity between USP7 and its inhibitors. …”
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52197
Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors
Published 2025-01-01“…We conducted a global survey involving healthcare professionals (n =204) to understand the role of various determinants in adopting ICTs and their implications for organizational performance. Data was analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) and multiple regression for micro-level constructs. …”
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52198
The Expression and Molecular Roles of MAMDC2 in MSS Colorectal Cancer with a High Tumor Stromal Ratio
Published 2025-05-01“…The meprin/A5/PTPmu (MAM) domain, a conserved structural motif in transmembrane proteins, remains undercharacterized in CRC pathogenesis. …”
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52199
Anthropogenic and natural influence on vegetation ecosystems from 1982 to 2023
Published 2025-01-01“…In addition, frequent land cover changes promoted the growth of greening trends (∼23%), which is linked to enhanced structural plasticity of vegetation. This effect has become more pronounced since 2000, with 92% of such changes occurring during this period. …”
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52200
TET dioxygenases localize at splicing speckles and promote RNA splicing
Published 2025-12-01“…This study explores the relationship between RNA splicing and the TET dioxygenase activity, shedding light on the role of hm5C (RNA 5-hydroxymethylcytosine), and TET proteins in RNA metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, and different functional assays, including in vitro splicing, TET proteins were found to regulate splicing. …”
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