Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease by Zachary Gaertner, Cameron Oram, Amanda Schneeweis, Elan Schonfeld, Cyril Bolduc, Chuyu Chen, Daniel Dombeck, Loukia Parisiadou, Jean-Francois Poulin, Rajeshwar Awatramani

“…We developed an optimized pipeline for single-nuclear RNA sequencing (snRNA-seq) and generated a high-resolution hierarchically organized map revealing 20 molecularly distinct DA neuron subtypes belonging to three main families. We integrated this data with spatial MERFISH technology to map, with high definition, the location of these subtypes in the mouse midbrain, revealing heterogeneity even within neuroanatomical sub-structures. …”
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De Novo Reconstruction of 3D Human Facial Images from DNA Sequence by Mingqi Jiao, Jiarui Li, Bingxu Zhong, Siyuan Du, Shuning Li, Manfei Zhang, Qibin Zhang, Zhongming Liang, Fan Liu, Chunman Zuo, Sijia Wang, Luonan Chen

“…Difface can generate 3D facial images of individuals solely from their DNA data, projecting their appearance at various future ages. …”
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Ultradiffuse Dwarf Galaxies Hosting Pseudobulges by Yu Rong, Hong-Xin Zhang, Cheng Cheng, Qi Guo, Weiyu Ding, Zichen Hua, Huiyuan Wang, Xu Kong

“…We propose that these UDGs likely formed through mergers of dwarf galaxies lacking old stars in their progenitors, resulting in the development of central bulge-like structures during starbursts triggered by the mergers while also enhancing their halo spin. …”
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Differentiable Modeling of Planet and Substellar Atmosphere: High-resolution Emission, Transmission, and Reflection Spectroscopy with ExoJAX2 by Hajime Kawahara, Yui Kawashima, Shotaro Tada, Hiroyuki Tako Ishikawa, Ko Hosokawa, Yui Kasagi, Takayuki Kotani, Kento Masuda, Stevanus K. Nugroho, Motohide Tamura, Hibiki Yama, Daniel Kitzmann, Nicolas Minesi, Brett M. Morris

“…We derive a C/O ratio for GL 229B consistent with its host star, constrain WASP-39 b’s radial velocity from molecular line structures, and infer Jupiter’s metallicity in line with previous estimates.…”
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International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Through initiatives led by the Quality Control and Accreditation Committee, educational programs, and multidisciplinary stakeholder workshops, ISLB provides a structured framework to promote standardization and foster innovation. …”
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Pre-Implementation Assessment of a Sexual Health eClinic in Canadian Oncology Care by Taylor Incze, Dalia Peres, Steven Guirguis, Sarah E. Neil-Sztramko, Jackie Bender, Dean Elterman, Shabbir M. H. Alibhai, Antonio Finelli, Phil Vu Bach, Emily Belita, Gerald Brock, Julia Brown, Jeffrey Campbell, Trustin Domes, Andrew Feifer, Ryan Flannigan, Celestia Higano, Jesse Ory, Premal Patel, Monita Sundar, Luke Witherspoon, Andrew Matthew

“…This study used a qualitative descriptive design to examine barriers and facilitators influencing the integration of SHAReClinic into oncology care across nine Canadian health care centres. Semi-structured interviews were conducted with 17 knowledge users, including health care providers and institutional leaders. …”
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Evaluation of Screening Tool of Older People’s Prescriptions (STOPP) Criteria in an Urban Cohort of Older People with HIV by Lauren F. O’Connor, Jenna B. Resnik, Sam Simmens, Vinay Bhandaru, Debra Benator, La’Marcus Wingate, Amanda D. Castel, Anne K. Monroe

“…Negative binomial models were used to evaluate factors associated with PIP and structural equation modeling was used to evaluate whether symptom burden mediates the relationship between PIP and quality of life. …”
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Pathways Between Parental Attitudes and Early Childhood Caries in Preschool Children by Apolinaras Zaborskis, Aistė Kavaliauskienė, Jaunė Razmienė, Augustė Razmaitė, Vilija Andruškevičienė, Julija Narbutaitė, Eglė Aida Bendoraitienė

“…For the children, the following variables were considered: sex, age, dental caries experience (dmf-t index in the primary dentition), oral hygiene index (Silness–Löe Plaque Index), toothbrushing frequency, and parental assistance with toothbrushing. Structural Equation Modeling (SEM) was applied for the data analysis. …”
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Cerium doped superparamagnetic Mn–Zn ferrite particles as a promising material for self-regulated magnetic hyperthermia by Mattheus Torquato, Eliel Gomes da Silva Neto, Magno de Assis Verly Heringer, Elisa Maria Baggio-Saitovich, Emilson Ribeiro Viana, Ronaldo Sergio de Biasi

“…A comprehensive characterization was performed in order to investigate the influence of this replacement on the magnetic and structural properties of the ferrite. The samples were synthesized by the sol-gel auto-combustion method and the properties were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), Raman spectroscopy (RS), Mössbauer spectroscopy (MS), vibrational sample magnetometry (VSM), and ferromagnetic resonance (FMR). …”
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The Role of P‐Wave Variables in Enhancing Prediction of New‐Onset Atrial Fibrillation in Patients With Acute Myocardial Infarction by Na Yang, Xiaoyan Li, Bo Wu, Longhao Dai, Shaobin Yang, Qinning Zhang, Shaobin Jia

“…Some P‐wave variables (P‐wave duration [PWD], P‐wave amplitude, and interatrial block [IAB]), reflecting the process of electrical and structural remodeling, could predict the risk of atrial fibrillation (AF). …”
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Subaqueous multiscale bedform morphology dynamics in a mountainous macrotidal estuary by Ruiqing Liu, Ruiqing Liu, Heqin Cheng, Jinfeng Chen, Lizhi Teng, Zhongda Ren, Zhongda Ren, Qian Yang, Heshan Fan, Heshan Fan, Alice Lefebvre

“…This study highlights a feedback mechanism where structural geology shapes channel morphology, influencing energy distribution and bedform evolution. …”
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The Importance of Community-Based and Community-Partnered COVID-19 Testing for Reducing Disparities Among African American Populations by Chavon Hamilton-Burgess, Jannette Berkley-Patton, Jenifer Allsworth, Carole Bowe Thompson, Frank E. Thompson, Tacia Burgin, Eric D. Williams, Kathryn P. Derose

“…The merging of resources and relationships among well-equipped, safety-net providers and other health care institutions and culture-rich, community-centered organizations, to jointly address structural and systemic inequities, is key to cultivating health equity in the distribution of COVID-19 testing and other essential public health services.…”
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Understanding the triacylglycerol-based carbon anabolic differentiation in Cyperus esculentus and Cyperus rotundus developing tubers via transcriptomic and metabolomic approaches by Honglin Zhang, Zhitao Zhu, Yining Di, Jixun Luo, Xianyue Su, Yong Shen, Qing Liu, Tao Liu, Xiaoyu Xu

“…Our findings indicate distinct expression patterns of key regulatory genes involved in TAG biosynthesis and lipid droplet formation, including transcriptional factors and structural genes such as ABI3 transcriptional factor, rate-limiting enzymes GPAT3/6/9 and DGAT2/3, and oleosin and caleosin homologs. …”
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Mortality trends among Indigenous women of reproductive age in Brazil: a time series analysisResearch in context by Guilherme A.T. Ferreira, Mariângela L. Cherchiglia, Márcio Valk, Flávia B. Pilecco

“…Summary: Background: Reports on Brazilian Indigenous peoples highlight mortality disparities, yet little is known about death aetiology—particularly among women of reproductive age—or how structural discrimination based on race/skin colour influences mortality rates in this group. …”
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3-O Sulfated Heparan Sulfate (G2) Peptide Ligand Impairs the Infectivity of <i>Chlamydia muridarum</i> by Weronika Hanusiak, Purva Khodke, Jocelyn Mayen, Kennedy Van, Ira Sigar, Balbina J. Plotkin, Amber Kaminski, James Elste, Bajarang Vasant Kumbhar, Vaibhav Tiwari

“…The observed neutralization effect of G2 peptide on <i>C. muridarum</i> entry suggests the possibility of sulfated-like domains being present on the EBs. In addition, data generated from our in silico computational structural modeling indicated that the G2 peptide ligand had significant affinity towards the <i>C. muridarum</i> lipid bilayer. …”
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Measuring the One Health impacts associated with creating access to veterinary care before and during the COVID-19 pandemic by Sloane M. Hawes, Kaleigh M. O’Reilly, Tess M. Mascitelli, Jordan Winczewski, Romi Dazzio, Amanda Arrington, Kevin N. Morris

“…Integrating community perceptions into One Health assessments is critical to understanding the structural barriers that create disproportionate health outcomes for community members, their pets, and the ecosystems that encompass them, particularly in historically marginalized and under-resourced communities. …”
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RNAi of Neuropeptide CCHamide-1 and Its Receptor Indicates Role in Feeding Behavior in the Pea Aphid, <i>Acyrthosiphon pisum</i> by Sohaib Shahid, Muhammad Bilal Amir, Tian-Bo Ding, Tong-Xian Liu, Guy Smagghe, Yan Shi

“…The docking analysis revealed that the <i>CCHa1</i> peptide binds to its receptor <i>CCHa1R</i> through specific amino acid residues, which are critical for maintaining the structural and functional integrity of the peptide–receptor complex. …”
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The association of internet use and cognition among older adults: mediating roles of social networks and depressive symptoms by Xiuyuan Zhu, Zihan Ni, Xiaoying Zhu, Xiaoying Zhu, Yi Yang, Shiyu Xie, Xinguo Wang, Xiaoguang Yang

“…Structural equation modeling (SEM) was employed to analyze the potential mediating roles of social networks and depressive symptoms. …”
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Pathway analysis of the impact of family function and self-efficacy on depression and anxiety in patients undergoing in vitro fertilization-embryo transfer by Fangliang Zou, Yi Fang, Yanshan Lin, Zikai Feng, Shiying Cai, Jiliang Huang, Shaoyan Zheng, Jue Li

“…Descriptive analysis, Pearson correlation analysis, and multiple linear regression analysis were performed. A Structural Equation Model (SEM) was utilized for pathway analysis to evaluate the direct and indirect influences of family function and self-efficacy on anxiety and depression. …”
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Duration of frontline therapy and impact on clinical outcomes in newly diagnosed multiple myeloma patients not receiving frontline stem cell transplant by Sikander Ailawadhi, Augustina Ogbonnaya, Sharanya Murty, Dasha Cherepanov, Bridgette Kanz Schroader, Dorothy Romanus, Eileen Farrelly, Ajai Chari

“…Methods Adults with NDMM not undergoing stem cell transplant (SCT) from January 1, 2012 toMarch 31, 2018 from the Integrated Oncology Network were included; 300 were randomly selected for chart review. 1LT DOT, time to next treatment (TTNT), progression‐free survival (PFS), and overall survival (OS) were estimated using Kaplan–Meier analysis. Marginal structural models evaluated relationships between DOT and TTNT, PFS, and OS at 2 years accounting for confounders and survival bias from the time‐dependent nature of DOT. …”
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