Extracting Multifaceted Characteristics of Patients With Chronic Disease Comorbidity: Framework Development Using Large Language Models by Junyan Zhang, Junchen Zhou, Liqin Zhou, Zhichao Ba

“…In addition, we demonstrated the strengths and limitations of this framework. MethodsWe used data sourced from a grassroots community health service center in China. …”
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Advances in diffuse glial tumors diagnosis by Luis Filipe de Souza Godoy, Vitor Ribeiro Paes, Aline Sgnolf Ayres, Gabriela Alencar Bandeira, Raquel Andrade Moreno, Fabiana de Campos Cordeiro Hirata, Frederico Adolfo Benevides Silva, Felipe Nascimento, Guilherme de Carvalho Campos Neto, Andre Felix Gentil, Leandro Tavares Lucato, Edson Amaro Junior, Robert J. Young, Suzana Maria Fleury Malheiros

“…This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. …”
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Key motor and non-motor features in early dementia with Lewy bodies by Anna Planas-Ballvé, Anna Planas-Ballvé, José Rios, Lourdes Ispierto, Mireia Gea, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vilas, Dolores Vilas

“…Demographic and clinical data were collected, and motor and non-motor symptoms were assessed using structured interviews and validated scales and questionnaires.ResultsA total of 107 participants were included (23 DLB, 27 PD, 26 AD, and 31 controls). …”
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Deep dive into hydrologic simulations at global scale: harnessing the power of deep learning and physics-informed differentiable models (<i>δ</i>HBV-globe1.0-hydroDL) by D. Feng, D. Feng, D. Feng, H. Beck, J. de Bruijn, J. de Bruijn, R. K. Sahu, Y. Satoh, Y. Wada, J. Liu, M. Pan, K. Lawson, C. Shen

“…Nevertheless, relative to LSTM, the differentiable model was hampered by structural deficiencies for cold or polar regions, highly arid regions, and basins with significant human impacts. …”
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Behavioural activation in nursing homes to treat depression (BAN-Dep): study protocol for a pragmatic randomised controlled trial by Simon Gilbody, Christopher Etherton-Beer, Kathryn A Ellis, Leon Flicker, Diana Velasquez Reyes, Hema Patel, Nicola Lautenschlager, Andrew H Ford, Eleanor Curran, Rachael Kelly, Rhoda Lai, Terence Chong, David Ekers, Dina Lo Giudice, Angelita Martini, Osvaldo P Almeida

“…Only de-identified group data will be presented.Trial registration ACTRN12618000634279.…”
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Design and methods of an adaptive trial to test comparative effectiveness of readmission reduction approaches following infection and sepsis hospitalizations (ACCOMPLISH) by Kristin Mayes, Victor B. Talisa, Adelina Malito, Florian B. Mayr, Kelly Williams, Kalpana Char, Richard Wadas, Elizabeth Lorenzi, Kert Viele, Rana Awdish, Derek C. Angus, Chung-Chou Ho Chang, Sachin Yende

“…Methods: Adults admitted to the hospital with sepsis or lower respiratory tract infection (index admission) are recruited and randomized to usual care (structured telephonic support [STS]) or one of four post-discharge RPM care models in addition to STS. …”
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Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microg... by Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao

“…Through this approach, four new (<b>1</b>–<b>4</b>) and nine known (<b>5</b>–<b>13</b>) PUFA analogues were obtained from large-scale cultures of the marine dinoflagellate <i>Prorocentrum lima</i>, with lipidomic profiling identifying FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and FA22:6 methyl ester (<b>11</b>) as major constituents of the algal oil extract. Structural elucidation was achieved through integrated spectroscopic analyses of IR, 1D and 2D NMR, and HR-ESI-MS data. …”
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Implementation of a Patient Navigation Program to Support Representative Participation in Cancer Clinical Trials by Sukh Makhnoon, Fabian Robles, Jessica L. Lee, D'Angelo Grant, Marisol Rojas, Ang Gao, Carla Pezzia, Venkata Eluri, Navid Sadeghi, Song Zhang, Thomas Hulsey, Rebecca Renn, Erin L. Williams, Heather Kitzman, David E. Gerber

“…Evaluation was guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework and incorporated programmatic data, structured surveys of patients and staff, and qualitative patient interviews. …”
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E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness by Alf Spitschak, Prabir Dhar, Krishna P. Singh, Rosaely Casalegno Garduño, Shailendra K. Gupta, Shailendra K. Gupta, Julio Vera, Luca Musella, Nico Murr, Anja Stoll, Brigitte M. Pützer, Brigitte M. Pützer

“…To explore E2F1’s role in immune regulation in presence of aggressive melanoma cells, we established a coculture system and utilized transcriptome and cytokine arrays combined with bioinformatics and structural modeling. We identified an E2F1-dependent gene regulatory network with IL6 as a central hub. …”
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Australian treatment outcome study: protocol for the 18–20-year follow-up of a prospective longitudinal cohort examining the natural history of heroin dependence and associated mor... by Maree Teesson, Paul S Haber, Christina Marel, Katherine Mills, Rachel Visontay, Jack Wilson, Shane Darke, Joanne Ross, Tim Slade, Katherine Haasnoot, Madeleine Keaveny, Chris Tremonti

“…The 18–20-year follow-up will consist of: (1) a structured interview; (2) physical health assessment; and (3) data linkage. …”
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Prevalence of tick-borne pathogens in feeding and questing Ixodes ricinus ticks from Southern Sweden by Chiara Cialini, Alessandra Cafiso, Mattias Waldeck, Åsa Lundgren, Johan Fält, Bo Settergren, Phimphanit Choklikitumnuey, Giulia Chiappa, Eleonora Rosso, Laura Roveri, Elisa Fesce, Nicola Ferrari, Per-Eric Lindgren, Chiara Bazzocchi, Giulio Grandi

“…This study highlights the presence of several zoonotic TBPs in Skåne, emphasizing the need for a structured monitoring plan and preventive strategies within a One Health framework.…”
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Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China by Bo Qu, Hui Chen, Xuhua Tan, Xiaohang Wu, Haotian Lin, Zhenzhen Liu, Lixia Luo, Bo Zhang, Erping Long, Duoru Lin, Weirong Chen, Yizhi Liu, Haofeng Jiang, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Jinzhu Tang, Yingfen Lin

“…In this study, participants who underwent free cataract surgery between January and August 2014 received a telephone interview based on a structured questionnaire. Data were collected on patient demographics, resources, health conditions, reasons for undergoing the free surgery and overall evaluation of the free cataract surgery programme.Results Among the 833 participants, the mean surgical age was 76.85±7.46 years (95% CI 76.34 to 77.36), and the male to female ratio was 385:448. …”
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Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study by Yi Tao, Yongjia Li, Tianyi Zhou, Lei Zhao, Pan Li, Minghong Sun, Lijuan Zhang, Lihong Yang, Ting Chen, Xuemei Lian, Xiaoni Zhong

“…Finally, we constructed a structural equation model to elucidate the complex pathogenic mechanisms and interactions among genetic risks, lifestyle factors, dietary habits, comorbidities, and immune metabolism in the progression of IBD. …”
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Unlocking the therapeutic potential of Pelargonium sidoides natural extract: A scoping review by Bárbara Donadon Reina, Samuel Santana Malheiros, Sâmmea Martins Vieira, Paula Ferreira de Andrade, Lívia Nordi Dovigo

“…Out of 4367 publications identified, 134 studies were included in this review. A structured form was applied for data extraction. PRISMA-ScR was used to guide reporting of this review. …”
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Facial Expression Recognition and Digital Images Infosecurity for Prevention Care System Application in Sudden Infant Death Syndrome Monitoring by Chih-Te Tsai, Chia-Hung Lin, Hsiang-Yueh Lai, Yu-En Cheng, Ping-Tzan Huang, Neng-Sheng Pai, Chien-Ming Li

“…For image infosecurity testing, the number of pixel changing rate (NPCR), unified averaged changed intensity (UACI), and structural similarity index measurement (SSIM) were employed to evaluate the performances for encryption and decryption processes, ensuring confidentiality, recoverability, and availability of transmitted images. …”
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Creation and validation of a roadside rescue skills scale for training pre-hospital medical teams: the RoadRes-Q scale by Killien Lavabre, Nicolas Marjanovic, Denis Oriot, Mathilde Chenu, Adrien Gransagne, Michel Gentilleau, Anthony Moreau, Paul Contal, Olivier Mimoz, Bertrand Drugeon, Road Rescue Study Group

“…While internal consistency was strong, improvements are needed in inter-observer reliability. Structured training for assessors and video-based assessments could enhance reproducibility. …”
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Pharmacists’ knowledge, attitudes, and practices toward preventing congenital disabilities: a cross sectional study in Saudi Arabia by Fahad S. Alshehri, Nasser M. Alorfi, Ahmed M. Ashour, Ammar Abdulrahman Jairoun, Saad M. Wali, Mohammed M. Aldurdunji, Shaker T. Alsharif, Reem Hasaballah Alhasani, Nasser M. Aldekhail, Abdullah S. Alshehri, Alqassem Y. Hakami

“…To enhance congenital disability prevention efforts in Saudi Arabia, these findings emphasize the need for improved pharmacist knowledge, structured training programs, and more extensive integration of pharmacists within maternal healthcare teams.…”
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For-profit growth and academic decline: a retrospective nationwide assessment of Brazilian medical schools by Bruno B. Andrade, Bruno B. Andrade, Klauss Villalva-Serra, Klauss Villalva-Serra, Rodrigo C. Menezes, Rodrigo C. Menezes, Luiz F. Quintanilha, Katia de Miranda Avena, Katia de Miranda Avena

“…These patterns suggest a structural misalignment between the commercial logic of expansion and the core educational mission of medical training. …”
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Does a waiting room increase same-day treatment for sexually transmitted infections among pregnant women? A quality improvement study at South African primary healthcare facilities by Ranjana M. S. Gigi, Mandisa M. Mdingi, Lukas Bütikofer, Chibuzor M. Babalola, Jeffrey D. Klausner, Andrew Medina-Marino, Christina A. Muzny, Christopher M. Taylor, Janneke H. H. M. van de Wijgert, Remco P. H. Peters, Nicola Low

“…A subset of women answered structured questions about factors influencing their decision to wait for results. …”
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Evaluating knowledge, awareness, attitudes, and practices regarding vitamin D in pregnant and postnatal Ghanaian women: a cross-sectional study by Benedicta Appiah, Alfred Effah, Samuel Ankomah Danso, Abraham Ameyaw Kwabena, Samuel Kwame Sopuruchi Agomuo, Samuel Kwarteng, Bismark Opoku Mensah, Ebenezer Senu, Enoch Ofori Awuah, Linda Ahenkorah Fondjo

“…Methods This cross-sectional study recruited 310 pregnant women and postnatal women from a Municipal Hospital between January to August 2024. A well-structured questionnaire was used to obtain data on demographic, clinical and lifestyle characteristics of participants. …”
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