Smart Digital Solutions for EARLY Treatment of COGNitive Disability (EARLY-COGN^3): A Study Protocol by Maria Cotelli, Francesca Baglio, Elena Gobbi, Elena Campana, Ilaria Pagnoni, Giovanna Cannarella, Alessandro Del Torto, Federica Rossetto, Angela Comanducci, Gennaro Tartarisco, Rocco Salvatore Calabrò, Simona Campisi, Raffaela Maione, Claudia Saraceno, Elisa Dognini, Sonia Bellini, Marta Bortoletto, Giuliano Binetti, Roberta Ghidoni, Rosa Manenti

“…Neurophysiological markers and biomolecular data will be collected at T0 and T1. <b>Conclusions:</b> EARLY-COGN^3 project could lead to a complete paradigm shift from the traditional therapeutic approach, forcing a reassessment on how CNDs could take advantage of a digital solution. …”
Get full text

Flares on TRAPPIST-1 Reveal the Spectrum of Magnetic Features on Its Surface by Valeriy Vasilyev, Nadiia Kostogryz, Alexander I. Shapiro, Astrid M. Veronig, Benjamin V. Rackham, Christoph Schirninger, Julien de Wit, Ward Howard, Jeff Valenti, Adina D. Feinstein, Olivia Lim, Sara Seager, Laurent Gizon, Sami K. Solanki

“…Our analysis rules out lingering flare decay as the cause of the flux enhancement and thus, points to structural changes on the stellar surface induced by flares. …”
Get full text

International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Through initiatives led by the Quality Control and Accreditation Committee, educational programs, and multidisciplinary stakeholder workshops, ISLB provides a structured framework to promote standardization and foster innovation. …”
Get full text

Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
Get full text

Pre-Implementation Assessment of a Sexual Health eClinic in Canadian Oncology Care by Taylor Incze, Dalia Peres, Steven Guirguis, Sarah E. Neil-Sztramko, Jackie Bender, Dean Elterman, Shabbir M. H. Alibhai, Antonio Finelli, Phil Vu Bach, Emily Belita, Gerald Brock, Julia Brown, Jeffrey Campbell, Trustin Domes, Andrew Feifer, Ryan Flannigan, Celestia Higano, Jesse Ory, Premal Patel, Monita Sundar, Luke Witherspoon, Andrew Matthew

“…Data were analyzed using a hybrid deductive–inductive thematic approach guided by the Consolidated Framework for Implementation Research (CFIR) 2.0. …”
Get full text

Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice by Tao Lu, Huan Liu, Xiaoqing Yuan, Desheng Li, Guanqing Zhang, Yue Wang, Qiqiang Xie, Xinhao Wang, Jingjian Chi, Zhenzhen Wang, Shaoping Wang, Yanling Gao, Ling Zhou, Maolei Xu

“…The results confirmed, for the first time, that PET MPs can induce oxidative stress, lipid accumulation, and apoptosis in liver cells, resulting in structural damage and functional abnormalities in the liver. …”
Get full text

Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
Get full text

Treatment of loiasis: a review of clinical management recommendations by Dorothea Ekoka Mbassi, Rike Dreeßen, Rella Zoleko Manego, Saskia Dede Davi, Tamara Nordmann, Johannes Mischlinger, Michael Ramharter

“…Renowned tropical medicine textbooks were also consulted. Data were extracted with a detailed table collaboratively developed and reviewed by multiple researchers to ensure consistency and accuracy. …”
Get full text

AI-based thematic exploration to understand patients with myasthenia gravis by serological subtype by Louis Jackson, Caroline Brethenoux, Alyssa DeLuca, Jacqueline Pesa, Zia Choudhry, Patrick Furey, Rosario Alvarez, Laura Gonzalez, Alex Lorenzo, Raghav Govindarajan, Ashley E. L. Anderson

“…Advanced search techniques and AI-powered algorithms were used to extract/organize data by topics into a large, unstructured dataset. …”
Get full text

Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus by Ling Wang, Yu Zhang, Rui Zhao, Yan Huang, Xinghao Wang, Yuyou Huang, Jiancheng Zhang, Han Lv, Pengfei Zhao, Zhenghan Yang, Qian Chen, Zhenchang Wang

“…Objective: To examine structural and functional changes in auditory cortex(AC) subregions of patients with tinnitus and identify potential predictive indicators for sound therapy. …”
Get full text

Influencing Factors and Paths of the Coupling Relationship Between Ecosystem Services Supply–Demand and Human Well-Being in the Hexi Regions, Northwest China by Yongge Li, Wei Liu, Meng Zhu, Qi Feng, Linshan Yang, Jutao Zhang, Zhenliang Yin, Xinwei Yin

“…Here, we assessed dynamic changes in ecosystem services supply–demand, human well-being, their coupling relationships and influencing factors in the Hexi Regions by integrating remote sensing data, ecological model, ecosystem services supply–demand ratio (ESDR), coupling coordination degree (CCD) model, and the partial least squares structural equation modeling (PLS-SEM). …”
Get full text

Diagnosis, evaluation and management of osteoporosis in chronic kidney disease: navigating treatment approaches – Indian consensus statement by Vijay Kher, Rajkumar Sharma, Georgi Abraham, Bharat Shah, Sishir Gang, Sanjeev Gulati, Manisha Sahay, Jatin Kothari, Anil Kumar BT, Raja Ramachandran, Sanjay Kalra, Rakesh Kumar Sahay, Om Lakhani, Jay Kumar Sharma, Deepak Bunger, Thomas L. Nickolas

“…Given the lack of robust clinical trial data and a notable knowledge gap exists among nephrologists regarding an optimal management in this population, an expert consensus is crucial for developing tailored management strategies. …”
Get full text

High prevalence of fecal carriage of extended-spectrum beta-lactamase producing Enterobacterales among patients with urinary tract infections in rural Tanzania by Magreth Erick Macha, Magreth Erick Macha, Magreth Erick Macha, Weihong Qi, Salome N. Seiffert, Anja Bösch, Philipp Kohler, Honorathy Msami Urassa, Sabine Haller, Erin West, Maja Weisser Rohacek, Maja Weisser Rohacek, Maja Weisser Rohacek, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury

“…Francis Regional Referral Hospital, Ifakara, Tanzania, from October 2021 to August 2023, involving 326 UTI patients. Demographic data and resistance risk factors were collected via structured questionnaires. …”
Get full text

Ecotype-specific responses of Typha domingensis to microplastics: Antioxidant defense and biochemical adaptations in wetland ecosystems by Muhammad Aqeel, Ali Noman, Saher Nawaz, Noreen Khalid, Muhammad Kashif Irshad, Muhammad Faisal Iqbal, Modhi O. Alotaibi, Motirh Al-Mutairi, Mohamed O. Alshahrani, Nahaa M. Alotaibi, Fahad Mohammed Alzuaibr

“…Data were analyzed using one-way ANOVA and PCA (n = 6), with significance at P ≤ 0.05. …”
Get full text

Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). Subsequently, the structural, textural, and surface chemistry properties of these biochars were assessed. …”
Get full text

snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

“…Subsequently, we employed single-nucleus RNA sequencing (snRNA-seq) to comprehensively characterize iWAT cellular dynamics during cold stimulation and the subsequent two-week period after the return to thermoneutrality.ResultsOur findings revealed that while iWAT phenotypically reverts to a white state after 2 weeks of rewarming, as evidenced by structural, functional, and bulk transcriptomic characteristics, significant cold-induced molecular and cellular signatures persist. …”
Get full text

Mediation of nutritional status between the number of teeth and depressive symptoms in multi-ethnic older adults from Western China by Xin Tian, Xin Xia, Huixian Li, Yuexia Hu, Yuqing Xie, Xiuying Hu, Jirong Yue, Birong Dong, Bei Wu, Yanyan Wang

“…This study aimed to investigate the role of nutritional status in mediating the number of teeth and depressive symptoms.MethodA prospective multi-ethnic baseline data of 6,632 adults aged 50 years and older was derived from the 2018 West China Health and Aging Trend study. …”
Get full text

Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) by Paloma Kiwan, Morena Gasparine, Dorine Decarreaux, Lisandru Capai, Shirley Masse, Miša Korva, Tatjana Avšič-Županc, Jean Canarelli, Marie-Helene Simeoni, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi

“…Sociodemographic and epidemiological data were collected using a structured questionnaire in the high-risk group. …”
Get full text

The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens by Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu

“…By analysing the polymorphism of this residue in various subtype viruses, we found that PA-X 100 was highly variable in H7N9 viruses. Structural analysis revealed that 100 V was generally close to the PA-X endonuclease active site, which may account for its host shutoff activity. …”
Get full text

Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

“…Background: Outdoor air pollution exposure is associated with structural and functional brain differences and an increased risk for psychopathology. …”
Get full text