Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Several alpha and beta-diversity metrics assessed biodiversity within-sample and population structure between different microbiota datasets, respectively. …”
Get full text

The COMBAT Project: study protocol for the development of a core outcome set for morbidity following surgery in paediatric brain tumour patients by Sandhya Trichinopoly Krishna, Nicola Harman, Conor Mallucci, Barry Pizer, Michael D. Jenkinson, Kristian Aquilina, Kim Bull, Jon Foss-Skiftesvik, Helen Hartley, James Hayden, Colin Kennedy, Ulrich W. Thomale, Sophie Wilne, Jeffrey H. Wisoff, Faris Bouaouiche, Liz Hull, John Robinson, Hannah L. Vickers, Carrol Gamble

Get full text

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial by Jean-Yves Reginster, J Badurski, N Bellamy, W Bensen, R Chapurlat, X Chevalier, C Christiansen, H Genant, F Navarro, E Nasonov, P N Sambrook, T D Spector, C Cooper

“…Treatment with strontium ranelate 1 and 2 g/day is associated with a significant effect on structure in patients with knee osteoarthritis, and a beneficial effect on symptoms for strontium ranelate 2 g/day.Additional supplementary data are published online only. …”
Get full text

Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
Get full text

QTL mapping associated with Verticillium wilt resistance in cotton based on MAGIC population by Muhammad Ayyaz, Zewei Chang, Shugen Ding, Peng Han, Lin Xu, Abudurezike Abudukeyoumu, Irfan Ali Siddho, Zhibo Li, Hairong Lin, Jianwei Xu, Yuanlong Wu, Xinhui Nie

“…Single nucleotide polymorphism (SNP) markers and phenotypic data can be used to identify genetic markers and loci associated with cotton resistance to Verticillium wilt. …”
Get full text

Stakeholder perspectives on the effects of environmental and socio-economic factors on children's health and learning: a qualitative study in Greater Manchester, England by Sarah Daniels, Hua Wei, Anne Clayson, Martie van Tongeren, Thomas Bannan, Melanie Carder, Luke Munford, Nicola Gartland

“…This study aimed to explore stakeholders' views on the impact of environmental and socio-economic factors on children's health and learning, and the effectiveness of local air quality initiatives.MethodsBetween April and June 2024, we conducted 15 semi-structured interviews with primary school teachers, local government and transport representatives from Greater Manchester (GM), a city region with high levels of deprivation in the Northwest of England. …”
Get full text

Patient and public involvement in the SPRUCE methodology study investigating electronic patient reported outcomes in oncology clinical trials by Morgaine Stiles, Monisha Dewan, Georgina Manning, Jessica Maudsley, Diana King, Jacqui Gath, Andy Deutsch, Esme Radin, Kim Watson, Franko Kowalczuk, Stephanie Foster, Alexa Gillman, Joanne Haviland, Elizabeth Hill, Lisa Lloyd, Robert Huddart, Emma Hall, Lara Philipps, Rebecca Lewis

“…The first committee meeting saw PPI members testing the electronic PRO (ePRO) system and giving feedback on this and the patient-facing documents, for which we provided structured feedback forms. Members also provided feedback on the meeting itself. …”
Get full text

Analysis of the changes and correlation of soft and hard tissues in the lower facial third before and after BSSRO with genioplasty in patients with unilateral mandibular asymmetry by HU Shuangyu, HE Shixi, MA Cheng, LIU Liyuan, HUANG Xuanping

“…Objective To investigate the effects and alterations in soft and hard tissues in the lower third of the facial structure in patients exhibiting facial asymmetry following bilateral sagittal split ramus osteotomy (BSSRO) with genioplasty, and to examine the correlation between the changes observed in soft and hard tissues. …”
Get full text

Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
Get full text

Explanatory models and coping with alcohol misuse among conflict-affected men in Ukraine by Sergiy Bogdanov, Kateryna Koss, Kimberly Hook, Quincy Moore, Catharina Van der Boor, Alessandro Masazza, Daniela C. Fuhr, Bayard Roberts, Carl May, Olha Fedorets, Oxana Bayer, Andrii Karachevskyy, Abhijit Nadkarni

“…Qualitative data received from each subgroup were analysed separately. …”
Get full text

PSYCHOSOCIAL FACTORS AND LIFE QUALITY IN CORONARY HEART DISEASE PATIENTS: RESULTS OF THE RUSSIAN PART OF INTERNATIONAL MULTICENTER STUDY EUROASPIRE IV by N. V. Pogosova, R. G. Oganov, S. A. Boytsov, A. K. Ausheva, O. Yu. Sokolova, A. A. Kursakov, Yu. M. Pozdnyakov, A. O. Salbieva, I. N. Lelchuk, T. A. Gusarova, N. V. Gomyranova, A. V. Karpova, N. A. Eliseeva, E. B. Akhmedova, K. K. Bedeynikova, M. N. Korneeva

“…To the study protocol, the analysis of medical charts was included, with following visit and structured interview. During the study, long-term results were evaluated, presence and level of the risk factors, including psychosocial, life quality parameters, adequacy of the acquired by patients recommendations and the grade of adherence. …”
Get full text

Tungsten solubility and speciation in hydrothermal solutions revealed by in situ X-ray absorption spectroscopy by M. Borchert, M. Borchert, M. A. Kokh, M. A. Kokh, M. Louvel, M. Louvel, E. F. Bazarkina, E. F. Bazarkina, A. Loges, E. Welter, D. Testemale, R. Al Abed, S. Klemme, M. Wilke

“…X-ray spectroscopic data measured in situ – with X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) – were applied to characterize the symmetry and the type of atoms of the first coordination shell of W aqueous complexes present in the fluid at given temperatures and pressures. …”
Get full text

Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…An additional total cost was calculated, which also included inpatient events (planned surgery due to musculoskeletal condition). Data were available on 348 complete data sets at all time points for total costs. …”
Get full text

Monitoring spatiotemporal changes in global change drivers and their effects on semiarid woodlands and forests - fieldwork protocol [version 2; peer review: 2 approved] by Alice Nunes, Helena C. Serrano, Pedro Pinho, Adriana Principe, Juliana Monteiro, Silvana Munzi, Mana Gharun, Rocío Alonso, Rossella Guerrieri, Cristina Branquinho, Sami Ullah, Bernardo Rocha, Elena Vanguelova, Maria Alexandra Oliveira

“…Participants applied these methodologies in real-world scenarios, conducting measurements (forest structure assessment, lichen diversity sampling, shrub and herbaceous diversity estimation, deadwood measurement and soil physico-chemical analysis) in different grazing management settings to assess their effects on tree growth, biodiversity, and soil properties. …”
Get full text

Changes in Lung Ultrasound in Systemic Sclerosis Before and After Rehabilitation: A Comparative Study Between People with and Without Interstitial Lung Disease by Samantha Gomes de Alegria, Matheus Mello da Silva, Jéssica Gabriela Messias Oliveira, Beatriz Luiza Pinheiro Alves de Azevedo, Nathália Alves de Oliveira Saraiva, Isabelle da Nóbrega Ferreira, Joana Acar Silva, Thiago Thomaz Mafort, Cláudia Henrique da Costa, Agnaldo José Lopes

“…There is limited research on the impact of a physiotherapy-guided rehabilitation program (PGRP) on lung structure in systemic sclerosis (SSc). Lung ultrasound (LUS) has been used for over a decade to identify interstitial lung disease associated with SSc (SSc-ILD). …”
Get full text

Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer by Vladimira Zlinska, Zuzana Feketova, Aleksandra Czyrek, Julia Chudzian, Martina Lenarcic Zivkovic, Vlad-Constantin Ursachi, Pooja Dudeja, Bohumil Fafilek, Jan Rynes, Gustavo Rico-Llanos, Adolf Koudelka, Tanaya Roy, Martyna Biadun, Vendula Raskova, Katerina Svozilova, Michaela Stroblova, Mateusz Krzyscik, Kalina Hristova, Daniel Krowarsch, Silvie Foldynova-Trantirkova, Malgorzata Zakrzewska, Lukas Trantirek, Pavel Krejci

“…We show that the VZ23 inhibits FGFR1 signaling in the presence of cognate fibroblast growth factor (FGF) ligands and its inhibitory activity is linked to its capacity to form unusual G-quadruplex structure. Our data suggest that targeting FGFR1 with DNA aptamers could be an effective alternative to TKIs for treating impaired FGFR1 signaling in human craniosynostoses.…”
Get full text

Quality of Life after Brain Injury in children aged six and seven years (QOLIBRI-KIDDY) – development and scale analysis of the first disease-specific self-report instrument for yo... by Nicole von Steinbuechel, Marina Zeldovich, Fabian Bockhop, Ugne Krenz, Dagmar Timmermann, Anna Buchheim, Inga K. Koerte, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Sven Greving, Axel Neu, Ulrike Wartemann, Joachim Suss, Christian Auer, Holger Muehlan, Katrin Cunitz

“…After item reduction based on a confirmatory scale analysis considering the six-factor structure of the questionnaire versions for older children, adolescents, and adults (Cognition, Self, Daily Life & Autonomy, Social Relationships, Emotions, Physical Problems), its reliability and validity were investigated. …”
Get full text

Serological Vulnerability and Active Infection Detection Among Recently Arrived Migrants in Spain: Results from a Targeted Screening Program by Guillermo Lens-Perol, Olalla Vázquez-Cancela, Magdalena Santana-Armas, Angeles Bouzas-Rodriguez, Victoria Tuñez-Bastida, Adrián Domínguez-Lago, Hugo Pérez-Freixo, Cristina Peiteado-Romay, Juan Manuel Vázquez-Lago, Cristina Fernández-Pérez

“…Sociodemographic and clinical data were collected, and individuals were offered vaccination according to an accelerated immunization schedule. …”
Get full text

Urgent natural foci infections transmitted by ticks in Saint-Petersburg by V. V. Nechaev, A. A. Yakovlev, A. N. Uskov, L. E. Boburina, N. V. Lavrova, M. N. Pogromskaya, B. I. Aslanov, A. O. Shapar, S. V. Pavlenko, L. N. Pozhidaeva, A. K. Ivanov, A. I. Kravtsova, S. A. Leppik, E. I. Vitovich, M. I. Fedunyak

“…The clinical forms of both diseases did not differ in their structure from the country data, however after 2012 subclinical forms were more common in women. …”
Get full text

Nurses' experiences of participating in employee assistance program and factors influencing its effectiveness: a qualitative study by Xuanhao Fan, Xuanhao Fan, Jiehao Zhuang, Jiehao Zhuang, Zhongqing Chen, Ziyi Xiong, Niu Yang, Jiangfeng Pu, Jiangfeng Pu, Peng Xu, Lifang Chen, Huigen Huang, Huigen Huang

“…The themes of the interview data were distilled through thematic analysis using NVivo 15 software. …”
Get full text