Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…Currently, the identification of effective therapies for KRAS-mutant NSCLC is difficult for reasons of the structural and biochemical characteristics of the KRAS protein. …”
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Assessing the Validity of Claims-Based Diagnostic Codes for Psychotic and Affective Disorders and the Influence of the Coding Transition from the ICD-9 to the ICD-10 in Taiwan&... by Wang YW, Liu CC, Chen HC, Wu CS, Chan JH, Chen CC, Huang WL, Liao SC, Hwang T, Chen WJ

“…The validity indices of claims-based diagnoses using the ICD-10-CM tended to be better than those using the ICD-9-CM.Conclusion: This first-ever study validating psychiatric diagnoses in Taiwan’s NHIRD using a structured chart review suggests that the diagnostic codes of narrow categories of schizophrenia or other broad categories are recommended for high-performing validity indices. …”
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CONCEPÇÕES DE PROFESSORES SOBRE A INCLUSÃO DE ALUNOS COM DEFICIÊNCIA VISUAL NA EDUCAÇÃO SUPERIOR by Joice Fernanda Pinheiro, Silvana Maria Moura da Silva

“…Sixteen professors from visually impaired students, enrolled in the 2019 school year and attending courses at the Center of Social Sciences of the referred university at the Dom Delgado campus participated in this research. The data collection was based on a semi-structured interview, whose analysis was focused on the selection of each participant's speech, with a phenomenological analysis (eidetic reduction) in significant units. …”
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COOLFACADE by Alejandro Prieto Hoces

“…Introduction and conclusions aside, the research body is structured on three sequential parts, with 2-3 chapters each. …”
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Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis by Hisako Akatsuka, Tomohiro Kashikawa, Kaori Masuhara, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Chisa Okada-Yamaguchi, Yoshinori Okada, Masayuki Tanaka, Takahiro Suzuki, Norio Yamamoto, Katsuto Hozumi, Tomoaki Tanaka, Hirofumi Nakaoka, Kazuyoshi Hosomichi, Yu Hamaguchi, Michiaki Hamada, Yoshiki Shiraishi, Akihide Kamiya, Yoshihiko Nakamura, Kaito Harada, Abd Aziz Ibrahim, Takashi Yahata, Masato Ohtsuka, Naoya Nakamura, Hiroyuki Hosokawa, Minoru Kimura, Ituro Inoue, Takehito Sato

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MODULATION AS A MULTIMODAL TRANSLATION STRATEGY OF GRAPHIC NOVEL PERSEPOLIS BY M. SATRAPI by Anna V. Khodorenko

“…The study then proceeds to evaluate the data obtained from the selected corpus, carefully comparing the translated versions with the original and drawing conclusions based on the findings of the descriptive analysis. …”
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Innovation and diversity in public health team engagement in local alcohol premises licensing: qualitative interview findings from the ExILEnS study by Richard Purves, Andrea Mohan, Rachel O’Donnell, Matt Egan, Nason Maani, Niamh Fitzgerald

“…Firstly, representatives of each public health team with experience of licensing activity took part in structured face-to-face or telephone interviews (n = 41) and provided documentation to identify how and when their team engaged with alcohol premises licensing. …”
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The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation by Janire Castelo, Sarai Araujo-Aris, Diego Barriales, Samuel Tanner Pasco, Iratxe Seoane, Ainize Peña-Cearra, Ainhoa Palacios, Carolina Simó, Virginia Garcia-Cañas, Muthita Khamwong, Itziar Martín-Ruiz, Monika Gonzalez-Lopez, Laura Barcena, José Ezequiel Martín Rodríguez, José Luís Lavín, Naiara Gutiez, Raquel Marcos, Estibaliz Atondo, Arantza Cobela, Laura Plaza-Vinuesa, Adrián Plata, Eneko Santos-Fernandez, Alberto Fernandez-Tejada, Mari Carmen Villarán, José Miguel Mancheño, Juana Maria Flores, Ana María Aransay, Aize Pellón, Blanca de las Rivas, Rosario Muñoz, Abelardo Margolles, Patricia Ruas-Madiedo, Maria Victoria Selma, Mercedes Gomez de Agüero, Leticia Abecia, Juan Anguita, Héctor Rodríguez

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THE IMPORTANCE OF HIGH-RESOLUTION COMPUTED TOMOGRAPHY IN EVALUATING THE EFFICACY OF RITUXIMAB IN PATIENTS WITH INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS by O. A. Koneva, O. V. Desinova, L. P. Ananyeva, N. V. Kovaleva

“…Semiquantitative assessment of structural changes by chest MSCT in SSc patients and ILD did not reveal any changes in their total scores for a sufficiently long follow-up period. …”
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Epitope mapping of SARS-CoV-2 Spike protein using naturally-acquired immune responses to develop monoclonal antibodies by Rubén López-Aladid, Leticia Bueno-Freire, Roc Farriol-Duran, Eduard Porta-Pardo, Ruth Aguilar, Marta Vidal, Alfons Jiménez, Roberto Cabrera, Nil Vázquez, Alexandre López-Gavín, Gemma Moncunill, Montserrat Carrascal, Teresa García, Miquel Lozano, Alberto L. García-Basteiro, Carlota Dobaño, Martalu D. Pazos, M.-Carmen Estevez, Laura M. Lechuga, Antoni Torres, Laia Fernández-Barat

“…We mapped the SARS-CoV-2 S protein epitopes most likely to be recognised by human neutralizing antibodies. Linear and structural epitope predictions were included and were further refined considering accessibility factors influencing their binding to antibodies like glycosylation status, localization in the viral membrane and accessibility on the 3D-surface of S. …”
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DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model by Xin Yang, Chi Ho Chan, Shanshan Yao, Hang Yin Chu, Minchuan Lyu, Ziqi Chen, Huan Xiao, Yuan Ma, Sifan Yu, Fangfei Li, Jin Liu, Luyao Wang, Zongkang Zhang, Bao-Ting Zhang, Lu Zhang, Aiping Lu, Yaofeng Wang, Ge Zhang, Yuanyuan Yu

“…Trained on comprehensive SELEX data, DeepAptamer outperformed existing models in accuracy as substantiated by experimental evidence. …”
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Experiences of support to return to work after stroke: longitudinal case studies from RETAKE trial by Diane Trusson, Katie Powers, Kathryn Radford, Audrey Bowen, Kristelle Craven, Jain Holmes, Rebecca Lindley, Christopher McKevitt, Julie Phillips, Ellen Thompson, Caroline Watkins, David J Clarke

“…Objectives This article aims to understand participants’ experiences of being supported to return to work and explores the social and structural factors which support, or act as barriers to, implementation of the Early Stroke Specialist Vocational Rehabilitation intervention. …”
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Research On Calculation of Longitudinal Deformation of The Underlying Shield Tunnel Caused By Excavation of The Foundation Pit Considering Consolidation Effects by LYU Linhai, DONG Cheng, ZHAO Zhe, JIANG Mingjie, JI Yongkai, QIU Shizheng, ZHANG Zhendong, MEI Guoxiong

“…The proposed theoretical methodology was employed to calculate the tunnel uplift displacement, with its predictive accuracy rigorously validated against field monitoring data. In this case study, the rebound modulus of each soil layer was determined as four times its compression modulus, following established engineering practice for cohesive soils. …”
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Petrology and Geochemistry of the Aroud Granitoid Pluton, North of Alam Kuh, Central Western Alborz by Shadi Noori KHeymehsari, Nematollah Rashidnejad Omran, Mohammadreza Ghorbani, Huai-jen yang

“…Whole-rock and mineral chemistry data classify the Aroud samples within the shoshonitic series. …”
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The effects of computerised decision support systems on nursing and allied health professional performance and patient outcomes: a systematic review and user contextualisation by Carl Thompson, Teumzghi Mebrahtu, Sarah Skyrme, Karen Bloor, Deidre Andre, Anne Maree Keenan, Alison Ledward, Huiqin Yang, Rebecca Randell

“…Risk of bias Assessed using structured risk of bias guidelines; almost all included studies were at high risk of bias. …”
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Desenvolvimento de carreiras e perceção de fatores para a excelência do árbitro de futebol em Portugal (Desarrollo profesional y percepción de factores a la excelencia del árbitro... by Sérgio Miguel Cardoso Mendes, Bruno Travassos, Ema Patrícia Oliveira

“…After finishing the data collection, an inductive analysis was carried out and a several personal and environmental common factors were identified. …”
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Geochemistry and emplacement environment of intrusive bodies of Shele Boran Mo-Cu deposit (Northeast of Ahar, East Azarbaijan) by Seyed Ghafour Alavi, Mansour Kazemi rad, Mohsen Moayyed, Mohammad Reza Hosseinzadeh

“…The change process of these samples is compatible with the characteristics of the geo-structural environment related to subduction.Discussion and Conclusion The parent magma of the intrusion bodies has shoshonite and high-K calc-alkaline affinity.  …”
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Consequências do comportamento sedentário no bem-estar psicossocial: estudo qualitativo com idosos residentes em Portugal (Consequences of sedentary behavior on psychosocial well-... by André Ramalho, João Petrica, João Serrano, Rui Paulo, Pedro Duarte-Mendes, António Rosado

“…Questionnaires were used to determine the average daily time spent in different sedentary behaviors and the usual level of physical activity. Data were also collected through semi-structured interviews and analyzed using thematic analysis techniques. …”
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Effect of grinding wheel type and cooling method on grinding quality of SiCf/SiC ceramic matrix composites by Ben WANG, Jiajie TANG, Hongdi CHU, Qi ZHANG

“…ObjectivesSiCf/SiC fiber-reinforced ceramic matrix composites have been widely used in aerospace, nuclear energy, and high temperature structural parts due to their excellent high-temperature resistance, high specific strength, and oxidation resistance. …”
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從前瞻因應理論觀點探討翻轉教學策略應用 於退休準備課程在不同需求程度上之 教學成效 Exploring the Application of Flipped Teaching Strategies in Retirement Preparation Courses: An Analysis of Educational Effectiveness From... by 胡夢鯨 Menq-Jing Hwu, 施宇澤 Yu-Ze Shih, 劉霽瑈 Ji-Rou Liu, 陳雅雯 Ya-Wen Chen

“…An initial needs survey grounded in active aging principles was conducted, gathering structured data to shape the curriculum. The 11-week experimental course applied flipped teaching strategies such as pre-class reading, classroom discussions, self-directed learning, and field-based activities. …”
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