Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Regression analysis and structural equation modelling were used to examine longitudinal relationships. …”
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Livestock rearing as a key component of mitigation efforts for non-CO2 greenhouse gas emissions in global crop-livestock system by Li Zheng, Qingwen Zhang, Ji Chen, Baojing Gu, Xiaoying Zhan, Bowei Yu, Yulong Shi, Hafiz Athar Hussain, Xuekai Jing

“…The Logarithmic Mean Divisia Index (LMDI) was used to decompose drivers and six scenarios (BAU (Baseline), RSA (Rearing Structure Adjustment), LMO (Livestock Management Optimization), BMPs-30% and BMPs-50% (best management practices with a manure substitution ratio of 30% or 50%), and NMA (No Manure Application)) were developed to assess mitigation potential. …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…Cardiovascular magnetic resonance were utilized to assess RV structure, function, and global myocardial strain [including peak strain (PS), peak systolic (PSSR) and diastolic strain rate (PDSR) in longitudinal, circumferential, and radial directions]. …”
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The potential spatiotemporal distribution patterns of Avena nuda and Avena sativa from global perspective provide new insights for the cultivation of commonly cultivated oats by Huanhuan Lu, Yuying Zheng, Ting Zhao, Liuban Tang, Fan Zhang, Wengang Xie

“…Abstract Background Commonly cultivated oats (Avena nuda and Avena sativa) play an important role in agricultural planting structure adjustment, ecological environment protection and grassland animal husbandry development, and their effective cultivation is conducive to food security and grassland degradation restoration. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Analogs of Precambrian microbial communities formed de novo in Caucasian mineral water aquifers by Daria G. Zavarzina, Alexey A. Maslov, Alexander Y. Merkel, Nataliya A. Kharitonova, Alexandra A. Klyukina, Ekaterina I. Baranovskaya, Elena A. Baydariko, Evgeniy G. Potapov, Kseniya S. Zayulina, Andrey Y. Bychkov, Nikolay A. Chernyh, Elizaveta A. Bonch-Osmolovskaya, Sergey N. Gavrilov

“…Their structure and the metabolic traits of their prokaryotic populations were similar to those presumed to have dominated the Earth’s biosphere during several critical periods of its evolutionary history, that is, the Early Archean, the period of banded iron formations accumulation, and the Great Oxidation Event. …”
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Intra-host genomic variation of serologically nontypeable Haemophilus influenzae isolates from otitis media by Randall J. Olsen, S. Wesley Long, Yuvanesh Vedaraju, Sandra Tomasdottir, Helga Erlendsdottir, Karl G. Kristinsson, James M. Musser, Gunnsteinn Haraldsson

“…While research has begun advancing our understanding of the population genomic structure of H. influenza strains infecting humans, little is known about intra-host genomic variation. …”
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Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Several alpha and beta-diversity metrics assessed biodiversity within-sample and population structure between different microbiota datasets, respectively. …”
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Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial by Jean-Yves Reginster, J Badurski, N Bellamy, W Bensen, R Chapurlat, X Chevalier, C Christiansen, H Genant, F Navarro, E Nasonov, P N Sambrook, T D Spector, C Cooper

“…Treatment with strontium ranelate 1 and 2 g/day is associated with a significant effect on structure in patients with knee osteoarthritis, and a beneficial effect on symptoms for strontium ranelate 2 g/day.Additional supplementary data are published online only. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
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QTL mapping associated with Verticillium wilt resistance in cotton based on MAGIC population by Muhammad Ayyaz, Zewei Chang, Shugen Ding, Peng Han, Lin Xu, Abudurezike Abudukeyoumu, Irfan Ali Siddho, Zhibo Li, Hairong Lin, Jianwei Xu, Yuanlong Wu, Xinhui Nie

“…Single nucleotide polymorphism (SNP) markers and phenotypic data can be used to identify genetic markers and loci associated with cotton resistance to Verticillium wilt. …”
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Analysis of the changes and correlation of soft and hard tissues in the lower facial third before and after BSSRO with genioplasty in patients with unilateral mandibular asymmetry by HU Shuangyu, HE Shixi, MA Cheng, LIU Liyuan, HUANG Xuanping

“…Objective To investigate the effects and alterations in soft and hard tissues in the lower third of the facial structure in patients exhibiting facial asymmetry following bilateral sagittal split ramus osteotomy (BSSRO) with genioplasty, and to examine the correlation between the changes observed in soft and hard tissues. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
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Tungsten solubility and speciation in hydrothermal solutions revealed by in situ X-ray absorption spectroscopy by M. Borchert, M. Borchert, M. A. Kokh, M. A. Kokh, M. Louvel, M. Louvel, E. F. Bazarkina, E. F. Bazarkina, A. Loges, E. Welter, D. Testemale, R. Al Abed, S. Klemme, M. Wilke

“…X-ray spectroscopic data measured in situ – with X-ray absorption near-edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) – were applied to characterize the symmetry and the type of atoms of the first coordination shell of W aqueous complexes present in the fluid at given temperatures and pressures. …”
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Monitoring spatiotemporal changes in global change drivers and their effects on semiarid woodlands and forests - fieldwork protocol [version 2; peer review: 2 approved] by Alice Nunes, Helena C. Serrano, Pedro Pinho, Adriana Principe, Juliana Monteiro, Silvana Munzi, Mana Gharun, Rocío Alonso, Rossella Guerrieri, Cristina Branquinho, Sami Ullah, Bernardo Rocha, Elena Vanguelova, Maria Alexandra Oliveira

“…Participants applied these methodologies in real-world scenarios, conducting measurements (forest structure assessment, lichen diversity sampling, shrub and herbaceous diversity estimation, deadwood measurement and soil physico-chemical analysis) in different grazing management settings to assess their effects on tree growth, biodiversity, and soil properties. …”
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Changes in Lung Ultrasound in Systemic Sclerosis Before and After Rehabilitation: A Comparative Study Between People with and Without Interstitial Lung Disease by Samantha Gomes de Alegria, Matheus Mello da Silva, Jéssica Gabriela Messias Oliveira, Beatriz Luiza Pinheiro Alves de Azevedo, Nathália Alves de Oliveira Saraiva, Isabelle da Nóbrega Ferreira, Joana Acar Silva, Thiago Thomaz Mafort, Cláudia Henrique da Costa, Agnaldo José Lopes

“…There is limited research on the impact of a physiotherapy-guided rehabilitation program (PGRP) on lung structure in systemic sclerosis (SSc). Lung ultrasound (LUS) has been used for over a decade to identify interstitial lung disease associated with SSc (SSc-ILD). …”
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Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer by Vladimira Zlinska, Zuzana Feketova, Aleksandra Czyrek, Julia Chudzian, Martina Lenarcic Zivkovic, Vlad-Constantin Ursachi, Pooja Dudeja, Bohumil Fafilek, Jan Rynes, Gustavo Rico-Llanos, Adolf Koudelka, Tanaya Roy, Martyna Biadun, Vendula Raskova, Katerina Svozilova, Michaela Stroblova, Mateusz Krzyscik, Kalina Hristova, Daniel Krowarsch, Silvie Foldynova-Trantirkova, Malgorzata Zakrzewska, Lukas Trantirek, Pavel Krejci

“…We show that the VZ23 inhibits FGFR1 signaling in the presence of cognate fibroblast growth factor (FGF) ligands and its inhibitory activity is linked to its capacity to form unusual G-quadruplex structure. Our data suggest that targeting FGFR1 with DNA aptamers could be an effective alternative to TKIs for treating impaired FGFR1 signaling in human craniosynostoses.…”
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Quality of Life after Brain Injury in children aged six and seven years (QOLIBRI-KIDDY) – development and scale analysis of the first disease-specific self-report instrument for yo... by Nicole von Steinbuechel, Marina Zeldovich, Fabian Bockhop, Ugne Krenz, Dagmar Timmermann, Anna Buchheim, Inga K. Koerte, Michaela Veronika Bonfert, Steffen Berweck, Matthias Kieslich, Knut Brockmann, Maike Roediger, Sven Greving, Axel Neu, Ulrike Wartemann, Joachim Suss, Christian Auer, Holger Muehlan, Katrin Cunitz

“…After item reduction based on a confirmatory scale analysis considering the six-factor structure of the questionnaire versions for older children, adolescents, and adults (Cognition, Self, Daily Life & Autonomy, Social Relationships, Emotions, Physical Problems), its reliability and validity were investigated. …”
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Urgent natural foci infections transmitted by ticks in Saint-Petersburg by V. V. Nechaev, A. A. Yakovlev, A. N. Uskov, L. E. Boburina, N. V. Lavrova, M. N. Pogromskaya, B. I. Aslanov, A. O. Shapar, S. V. Pavlenko, L. N. Pozhidaeva, A. K. Ivanov, A. I. Kravtsova, S. A. Leppik, E. I. Vitovich, M. I. Fedunyak

“…The clinical forms of both diseases did not differ in their structure from the country data, however after 2012 subclinical forms were more common in women. …”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…In this study, we employed bioinformatics methods to identify eight TaAkPHY genes in the Aikang58 wheat variety. Based on gene structure, conserved domains, and phylogenetic relationships, the TaAkPHY gene family exhibits a high degree of conservation. …”
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