Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study by Ruiyi Qian, Xue Zhao, Dongbin Lyu, Qingqing Xu, Kai Yuan, Xin Luo, Wanying Wang, Yang Wang, Yutong Liu, Yu Cheng, Yingting Tan, Fan Mou, Chengmei Yuan, Shunying Yu

“…Molecular docking was used to visualize the binding structure and fine affinity for <i>MAN1A2</i> and the drugs predicted by DSigDB. …”
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Genome-Wide Identification Analysis of the 4-Coumarate: Coa Ligase (4CL) Gene Family in <i>Brassica</i> U’s Triangle Species and Its Potential Role in the Accumulation of Flavonoid... by Mengzhen Zhang, Mengjiao Tian, Ziwuyun Weng, Yaping Yang, Nian Pan, Shulin Shen, Huiyan Zhao, Hai Du, Cunmin Qu, Nengwen Yin

“…Based on phylogenetics, gene structure, conserved motifs, chromosome localization and collinearity analysis, <i>4CLs</i> were relatively conserved in the evolution of <i>Brassica</i> U’s triangle species. …”
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Forest birds maintain body condition in Alder-leaf Birch (Betula alnoides) plantations in subtropical Asia by Wenyi Zhou, Alexandra A. Grossi, Daniel R. Gustafsson, Zhengzhen Wang, Zhuyang Zhang, Yuqing Han, Xinyi Wang, Anru Zuo, Miguel A. Acevedo, Yang Liu, Scott K. Robinson

“…Plantation forestry alters avian community assembly by creating homogeneous habitats with simplified vegetation structure. However, its effects on avian body condition remain poorly understood, despite the influence body condition has on survival and reproduction. …”
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Polar lights optimizer: A novel algorithm for accurate parameter estimation in proton exchange membrane fuel cells by Mohammad Aljaidi, Pradeep Jangir, Arpita, Sunilkumar P. Agrawal, Sundaram B. Pandya, Anil Parmar, G. Gulothungan, Ali Fayez Alkoradees, Mohammad Khishe, Reena Jangid

“…The complex multivariate structure together with nonlinear behavior of these systems makes it parameter estimation a challenging task, which negatively affects operational reliability and system lifespan. …”
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MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway by Cong Liu, Jinjin Xiang, Yueqin Chen, Chang He, Jun Tong, Yinglin Liao, Huangyi Lei, Lingyun Sun, Genhong Yao, Zhenggao Xie

“…MSC-sEVs decreased the accumulation of ROS and improved the structure and function of mitochondria of Müller cells with AGEs treatment. …”
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Symbiotic microalgae and microbes: a new frontier in saline agriculture by Cheng-Gang Ren, Cun-Cui Kong, Si-Ming Li, Xiao-Jing Wang, Xiao Yu, Yin-Chu Wang, Yin-Chu Wang, Song Qin, Song Qin, Hong-Li Cui

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Development and Evaluation of Hydrogel-Based Sulfasalazine-Loaded Nanosponges for Enhanced Topical Psoriasis Therapy by Sunil Kumar, Anroop B. Nair, Varsha Kadian, Pooja Dalal, Babu Lal Jangir, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Nouf Alwadei, Rekha Rao

“…<b>Results:</b> Physiochemical data confirms nanoscale architecture, drug inclusion in nanosponges, crystalline structure, and formulation stability. …”
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AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis by M. Niiranen, M. Niiranen, P. Bendel, P. Bendel, J. Koikkalainen, J. Lötjönen, T. Selander, E. Solje, E. Solje, P. Hartikainen, S. Simula, R. Vanninen, R. Vanninen, A. M. Portaankorva

“…Based on this study, the corpus callosum is a crucial structure in monitoring disease progression in BRRMS.…”
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Long term emission and simulation on air quality from residential coal burning in China by Qin Yan, Tingyu Xiao, Wenjie Zhang, Shaofei Kong, Yuzhe Zhang, Qingxian Gao, Yun Shu, Hui Li, Han Wang

“…To address this, a suite of control policies has been implemented, leading to a shift in the energy structure and a limitation in pollution emission within RCB sector. …”
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SIGnature Libraries: A roadmap for the formation of special interest group libraries by Young‐Min Kim, Eric M. Chin, Michael Fahey, Rose Gelineau‐Morel, Kate Himmelmann, Jennifer O'Malley, Maryam Oskoui, Bruce Shapiro, Michael Shevell, Jenny L. Wilson, Max Wiznitzer, the Child Neurology Society Cerebral Palsy Special Interest Group Consortium, Bhooma Aravamuthan

“…A final review by an 11‐member international advisory group determined threshold ratings for resource inclusion and the library's final structure. Results Seventy‐nine articles were submitted for the first Delphi round and 22 articles for the second Delphi round. …”
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Threshold of kurtosis on occupational hearing loss associated with non-steady noise by Yang LI, Haiying LIU, Linjie WU, Jinzhe LI, Jiarui XIN, Hua ZOU, Xin SUN, Wei QIU, Changyan YU, Meibian ZHANG

“…BackgroundKurtosis reflecting noise's temporal structure is an effective metric for evaluating noise-induced hearing loss (NIHL), and its threshold is still unclear. …”
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Older people and stroke: a machine learning approach to personalize the rehabilitation of gait by Elvira Maranesi, Federico Barbarossa, Leonardo Biscetti, Marco Benadduci, Elisa Casoni, Ilaria Barboni, Fabrizia Lattanzio, Lorenzo Fantechi, Daniela Fornarelli, Enrico Paci, Sara Mecozzi, Manuela Sallei, Mirko Giannoni, Giuseppe Pelliccioni, Giovanni Renato Riccardi, Valentina Di Donna, Roberta Bevilacqua

“…Gait analysis was conducted using the GaitRite system, measuring 39 spatio-temporal parameters.ResultsStatistical tests revealed no significant differences, but Principal Component Analysis identified a dominant structure. Machine learning (ML) algorithms—Random Forest (RF), Support Vector Machine (SVM), and k-Nearest Neighbors (KNN)—were employed for classification, with RF demonstrating superior performance in accuracy, precision, recall (all exceeding 85%), and F1 score compared to SVM and KNN. …”
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Effect of pretreatment type on the physico-chemical properties of activated carbons derived from an invasive weed Prosopis juliflora: potential applications by Subramaniyasharma Sivaraman, Saravanan Ramiah Shanmugam, Ponnusami Venkatachalam, Ratheeshkumar Shanmugam, Arul Chan Basha, Noori M Cata Saady

“…Results from this study revealed that the choice of activation agent significantly influences the material’s structure and chemistry. The activation process of activated carbon (AC) is significantly influenced by temperature and the agent used. …”
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Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites by Wisam A. Dawood, Gillian M. Fisher, Josefa Kremeyer, Fabian Fischer, Jessica L. Home, Christopher D. Goodman, Kwong Sum Lam, Alexander G. Maier, Thomas Kurz, Katherine T. Andrews

“…Furthermore, 4o was found to stabilise PfHDAC1 in P. falciparum protein lysates using solvent-induced protein stability Western blot assays with anti-PfHDAC1 antibody. Together, these data provide new structure-activity relationship and mechanistic insights on pentyloxyamide-based HDAC inhibitors as potential therapeutic starting points for malaria.…”
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Accounting for temporal and spatial autocorrelation to examine the effects of climate change on vegetation greenness trend in China by Lingwei Chen, Likai Zhu, Cuiyutong Yang, Zizhen Dong, Rui Huang, Jijun Meng, Min Liu

“…This method considers temporal and spatial autocorrelation structure, and aggregates pixel information to rigorously test the hypotheses about regional patterns. …”
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Molecular epidemiology of Neisseria gonorrhoeae isolates in Russia, 2015–2023: current trends and forecasting by Ilya Kandinov, Boris Shaskolskiy, Dmitry Kravtsov, Anatoliy Larkin, Alexei Kubanov, Marina Shpilevaya, Julia Shagabieva, Nikita Nosov, Dmitry Gryadunov

“…Two clusters of isolates pose a particular threat to Russia: NG-MAST G2212, linked to MLST 1901/1902, carries a mosaic structure in the penA gene; G12302, linked to MLST 9363, contains mosaic alleles in the mtrR and mtrD genes. …”
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A life cycle thinking-based environmental risk framework for screening sustainable feedstocks in early-stage bioeconomy projects by George Bishop, Carmen Girón-Domínguez, James Gaffey, Maeve Henchion, Réamonn Fealy, Jesko Zimmermann, Wriju Kargupta, David Styles

“…Criteria are proposed to structure evaluation of (i) probability and (ii) severity of environmental impact, in relation to four categories of feedstock: primary (determining product), high-value by-product, low-value by-product, and waste. …”
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Charting the path to the implementation of universal health coverage policy in Nigeria through the lens of Delphi methodology by Jibril M. Bashar, Sulaiman Hadiza, Ozoilo J. Ugochi, Lawal S. Muhammad, Adeoye Olufemi, Ukoh Eberechi, Yakubu Agada-Amade, Alhassan Yusuf, Abdulhamid H. Abdullahi, Hassan S. Musa, Ahmad A. Ibrahim, Kalu-Umeh Nnennaya, Jennifer Anyanti, Dayyabu Yusuf, Kenneth Okoineme, Jennifer Adebambo, Samuel O. Ikani, Dennis Aizobu, Musa Abubakar, Babandi S. Zaharaddeen, Lawal Aminu, Yusuf H. Wada

“…These seven priority areas that have been identified include enrolment, equity, organizational health and structure, data and technology, quality, market efficiency, and citizen engagement. …”
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Genomic investigation of NDM-1 producing Enterobacterales transmission in a South Korean hospital by Jeong-Ih Shin, Sun Hee Park, Chulmin Park, Seung-Hyun Jung, Dong-Gun Lee

“…These plasmids contained conserved mobile genetic elements, including the IS26-dsbD-trpF-ble-blaNDM-1 structure. Conclusions: This study highlights the dual roles of clonal spread and plasmid-mediated horizontal gene transfer in the dissemination of blaNDM-1 in hospital settings. …”
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Isolation, Identification, and Molecular Genetic Characteristics of a Pathogenic Strain of <i>Streptococcus suis</i> Serotype 3 by Longbai Wang, Jingli Qiu, Bing He, Xuemin Wu, Qiuyong Chen, Quanxi Wang, Renjie Wu, Bohan Zheng, Lunjiang Zhou, Xiaohong Huang

“…Different <i>S. suis</i> serotypes exhibit diverse characteristics in population structure and pathogenicity. Epidemiology data underscore the importance of <i>S. suis</i> serotype 3 (SS3). …”
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