Targeting the IL-17A pathway for therapy in early-stage tendinopathy by Iain B McInnes, Richard M Siegel, Neal L Millar, Moeed Akbar, Michaela Kneissel, Frank Kolbinger, Friedrich Raulf, Yufei Li, Nicolau Beckmann, Nathalie Accart, Olivier Leupin, Claudio Calonder, Matthias Schieker, Christian Bruns, Eckhard Weber

“…In the rat ex vivo and in vivo models, IL-17A blockade alleviated inflammatory immune effector release, tendon structural degeneration, tendon inflammation and impaired tendon function.Conclusion Our data provide evidence that IL-17A is a key contributor to the pathogenesis of tendinopathy by promoting tendon inflammation and degeneration and that IL-17A blockade may represent a potential therapy in early-stage tendinopathy.…”
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Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging by Frank Li, Frank Li, Xuan Zhang, Xuan Zhang, Alejandro P. Comellas, Eric A. Hoffman, Eric A. Hoffman, Michael M. Graham, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin

“…This approach seeks to enhance our understanding of how structural and functional changes influence ventilation heterogeneity in COPD.MethodsEight COPD subjects completed a longitudinal study with three visits, spaced about a year apart. …”
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Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder by Bin Lu, Xue Li, Xue-Ping Gao, Jing Chen, Yi Liu, Jian-Ping Lu, Siu-Ching Kat, Zeng-Hui Ma, Li-Yang Zhao, Ting-Ni Yin, Xing Su, Fan-Chao Meng, Ya-Ru Zhang, Shu-Xian Wu, Wen-Jie Yan, Ya-Song Du, Xue-Rong Luo, Jing Liu, Chao-Gan Yan

“…Conclusion: The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics; however, EOS exhibits greater structural variation, while ASD presents with more subtle connectomic abnormalities. …”
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Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children by Kavari Hercules, Zhiyuan Liu, Eleni Christofilea, Jia Wei, Gladys Venegas, Olivia Ciocca, Alice Dyer, Goeun Lee, Sasha Santini-Bishop, Heather Shappell, Dylan G. Gee, Denis G. Sukhodolsky, Karim Ibrahim

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Stigma measurement in health: a systematic reviewResearch in context by Sara Malone, Lara Counts, Luke Zabotka, Anneliese Williams, Nele Loecher, Kayla Wynja, Gemma Bryan, Robin Tanner, Ana Cáceres-Serrano, Gia Ferrara, Lucia Fuentes, Tharwa Bilbeisi, Marissa Maheu, Benjamin K. Oelkers, Muna Ogwo, Lauren Yaeger, Asya Agulnik, Dylan Graetz, Shayla Lawrence, Jocelyn Rivera, Farris Abutineh, Doris Maldonado

“…Key gaps included lack of consensus on definitions, limited pediatric-focused research, and insufficient attention to structural drivers of stigma. Interpretation: This review calls for standardized, context-sensitive stigma measurement and interventions applicable across conditions and settings. …”
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Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation by Anna Solta, Büsra Ernhofer, Kristiina Boettiger, Christian Lang, Zsolt Megyesfalvi, Theresa Mendrina, Dominik Kirchhofer, Gerald Timelthaler, Beata Szeitz, Melinda Rezeli, Clemens Aigner, Arvand Haschemi, Lukas W. Unger, Balazs Dome, Karin Schelch

“…Methods Metabolic alterations were analyzed using proteomic data. Structural and functional differences of mitochondria were investigated using qPCR, flow cytometry, confocal imaging, and transmission electron microscopy and seahorse assays. …”
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The Mediator Role of Depression in the Successful Aging and Death Anxiety in Middle-Aged and Older People With Hypertension by Xiaoping Li, Lu Sun, Liu Yang, Congzhi Wang, Ting Yuan, Huanhuan Wei, Yunxiao Lei, Jing Li, Mingming Liu, Dongmei Zhang, Ying Hua, Haiyang Liu, Lin Zhang

“…Regression analysis reported that SA and depression significantly positively predicted DA ( F  = 4.013, R 2  = .111, p  < .01). the structural equation model showed that depression mediated the effect of SA on DA (χ 2 / df  = 3.055, p  < .01, RMSEA = 0.083, CFI = 0.960, IFI = 0.961, GFI = 0.952, PGFI = 0.508, PNFI = 0.628, PCFI = 0.640). …”
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Technological Assessment and Predictive Modeling of Probiotic Lactose-Free Fermented Milk with <i>Lacticaseibacillus paracasei</i> GV17 by Taynan Jonatha Neves Costa, Isabella Maciel Costa, Larissa Mirelle Mendes Magalhães, Marcelo Resende de Souza, Gabriel Augusto Marques Rossi, Bruna Maria Salotti-Souza, Camila Argenta Fante

“…Regarding technological characteristics, syneresis decreased by 8.90% after 28 days, indicating greater structural stability, while water retention capacity remained constant. …”
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Decoding Schizophrenia: How AI-Enhanced fMRI Unlocks New Pathways for Precision Psychiatry by Valeria Di Stefano, Martina D’Angelo, Francesco Monaco, Annarita Vignapiano, Vassilis Martiadis, Eugenia Barone, Michele Fornaro, Luca Steardo, Marco Solmi, Mirko Manchia, Luca Steardo

“…This manuscript explores how the integration of these technologies has unveiled key insights into schizophrenia’s structural and functional neural anomalies. fMRI research highlights disruptions in crucial brain regions like the prefrontal cortex and hippocampus, alongside impaired connectivity within networks such as the default mode network (DMN). …”
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Optimization of Protein Extraction from Rapeseed Oil Cake by Dephenolization Process for Scale-Up Application Using Artificial Neural Networks by Branislava Đermanovć, Jelena Vujetić, Tea Sedlar, Danka Dragojlović, Ljiljana Popović, Predrag Kojić, Pavle Jovanov, Bojana Šarić

“…In this study, the effects of dephenolization on the structural, physicochemical, and functional properties of rapeseed protein isolate obtained from defatted rapeseed cake were investigated through four different protocols. …”
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Impact-induced energy release of typical HCP metal/PTFE/W reactive materials: Experimental study and predictive modeling via machine learning by Zhenwei Zhang, Weixi Tian, Tianyi Wang, Zhiyuan Liu, Yansong Yang, Chao Ge, Lei Guo, Yuan He, Chuanting Wang, Yong He

“…Zirconium, titanium, and other hexagonally close-packed (HCP) metals and their alloys are representative high specific strength, high reaction enthalpy, and high thermal conductivity structural materials. In this study, two typical HCP metals, zirconium, and titanium, were applied to reactive materials (RMs) to prepare Zr/PTFE/W RMs and Ti/PTFE/W RMs, validating the feasibility of HCP metal/PTFE/W RMs. …”
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Study on residual strength of oil and gas pipeline with corrosion defects under bending load by Song Chenxi, Shu Jie, Chen Han, Shi Tong, Wu Xiatong, Liu Xiaoben

“…These challenges include structural defects, geological disasters such as earthquakes, landslides, debris flows, and land subsidence, as well as external forces such as dynamic impact forces, shear forces, extrusion forces, and uneven settlement forces. …”
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Synergistic Enhancement of Rhodamine B Adsorption by Coffee Shell Biochar Through High-Temperature Pyrolysis and Water Washing by Xurundong Kan, Yao Suo, Bingfei Shi, Yan Zheng, Zaiqiong Liu, Wenhui Ma, Xianghong Li, Jianqiang Zhang

“…In this study, coffee shell-derived biochars were synthesized via pyrolysis at 500 and 700 °C, with and without water washing, and comprehensively characterized to evaluate their potential for removing Rhodamine B (RhB) from aqueous solution. Structural and surface analyses indicated that a higher pyrolysis temperature enhanced pore development and aromaticity, whereas water washing effectively removed inorganic ash, thereby exposing additional active sites. …”
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Valorization of Food Waste: Extracting Bioactive Compounds for Sustainable Health and Environmental Solutions by Nikša Bekavac, Korina Krog, Ana Stanić, Dunja Šamec, Anita Šalić, Maja Benković, Tamara Jurina, Jasenka Gajdoš Kljusurić, Davor Valinger, Ana Jurinjak Tušek

“…Various extraction techniques, including enzymatic hydrolysis and ultrasound-assisted methods, enhance the recovery of these bioactives while preserving their structural integrity and efficacy. By integrating technological advances and sustainable practices, the food industry can significantly reduce waste while developing high-value products that contribute to human health and environmental protection. …”
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Hospital Context Determinants of Variability in Healthcare-Associated Infection Prevalence: Multi-Level Analysis by Rui Malheiro, André Amaral Gomes, Carlos Fernandes, Ana Fareleira, Ana Lebre, Dulce Pascoalinho, João Gonçalves-Pereira, José-Artur Paiva, Rita Sá-Machado

“…The study variables included patient, structural, and process variables, tested as risk factors, with patients clustered in hospitals. …”
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Functional neuroplasticity in chronic post-stroke aphasia following a singing intervention in a cross-over randomised trial by Noelia Martínez-Molina, Anni Pitkäniemi, Sini-Tuuli Siponkoski, Nella Moisseinen, Linda Kuusela, Sari Laitinen, Essi-Reetta Särkämö, Johanna Pekkola, Susanna Melkas, Gottfried Schlaug, Boris Kleber, Aleksi J. Sihvonen, Teppo Särkämö

“…Abstract Group-based singing has been shown to improve language outcomes and induce structural neuroplasticity in chronic post-stroke aphasia (PSA). …”
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Surface patterning for multi-scale strain analysis of in-situ SEM mechanical experiments by Bin Zhang, Xianjue Ye, Jin Wang, Yuefei Zhang, Ze Zhang

“…Such experimental analyses offer an opportunity to further explore multi-scale strain heterogeneity in some advanced structural materials and provide reliable experimental verification for material mechanics simulations.…”
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Crafting the Organic Mindset Through Attitude: A PLS-SEM Approach by Kalisri L. Aravindan, Aysa Siddika, T. Ramayah, Farheen S. Wani, Sanmugam Annamalah, N. Ilhavenil, Lylia Hamdan Sunita

“…The study utilized purposive sampling, and data analysis was conducted by Partial Least Square, Structural Equation Modeling (PLS-SEM). …”
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Environmental behavior of microplastic - heavy metal synergistic contamination in a typical urban-rural river network by Kaihang Zhang, Jian Huang, Jiamei Zhang, Hua Zhang, Shanshan Xi

“…Based on the correlation analysis and structural equation model, the polymer type of MPs (path coefficient = 0.3798) and the content of HMs in water (path coefficient = 0.3391) were the significant influence drivers on the adsorption of HMs by MPs. …”
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GO-GREEN GASTRONOMY DELIVERY: THE ROLE OF GREEN-PACKAGE DESIGN ENHANCING QUALITY AND VALUE CREATION ON BANG SAEN’S TOURIST DESTINATION by Parinya NAKPATHOM, Kannapat KANKAEW, Charlton BRUTON, Ali Mohsin Salim Ba AWAIN, Ali Said JABOOB, Hyewon JANG, Chee Keng LEE

“…The questionnaire was administered for data collection both onsite and online. The direct and indirect effects were examined by Partial Least SquareStructural Equation Modelling (PLS-SEM). …”
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