Quantifying of spatio-temporal variations in the regional gravity field and the effectiveness of earthquake prediction: A case study of MS ≥ 5.0 earthquakes in the Sichuan-Yunnan r... by Weimin Xu, Shi Chen, Yongbo Li, Jiangpei Huang, Bing Zheng, Yufei Han, Zhaohui Chen, Qiuyue Zheng, Hongyan Lu, Linhai Wang, Honglei Li, Dong Liu

“…Reportedly, crustal mass transfer, which is affected by stress state and structural environment, alters the characteristics of the regional gravity field, thus serving as an indicator for locations of moderate to strong earthquakes and a seismology-independent predictor for regions at risk for strong earthquakes. …”
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Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia by Karima Schwab, Lianne Robinson, Anne Annschuetz, Eline Dreesen, Mandy Magbagbeolu, Valeria Melis, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel

“…We measured the abundance of tau and synaptic proteins (VAMP-2, SNAP-25, SNTX-1, SYNPY-1, SYN-1, A-SYN) immunohistochemically to reveal structural synaptic alterations in these mice. Tau and synaptic markers were also examined in L66 mice treated with hydromethylthionine mesylate (HMTM) (15 mg/kg) and rivastigmine (0.5 mg/kg) administered singly and in combination. …”
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Transition from child to adult health services for young people with cerebral palsy in Ireland; implications from a mixed-methods study [version 2; peer review: 2 approved] by Owen Hensey, Amanda Breen, Aisling Walsh, Mary Owens, Claire Kerr, Sebastian Koppe, Grace Lavelle, Meriel Norris, Michael Walsh, Jennifer M. Ryan, Thilo Kroll, Jennifer Fortune

“…Methods A convergent parallel mixed-methods study was conducted. Data were collected from people with cerebral palsy aged 16–22 years, parents, and health professionals using surveys and semi-structured interviews, which were both informed by a framework of nine key transition practices. …”
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Investigation of an extensive outbreak of HIV infection among children in Sindh, Pakistan: protocol for a matched case–control study by Victoria Simms, Rashida Ferrand, Baseer Achakzai, Iqbal Azam, Amna R Siddiqui, Apsara Ali Nathwani, Syed H Abidi, Syed Faisal Mahmood, Sobiya Sawani, Abdul M Kazi, Aneeta Hotwani, Sikander Ali Memon, Jamila Soomro, Saqib Ali Shaikh, Quaid Saeed, Palwasha Khan, Fatima Mir

“…Following written informed consent from the guardian, a structured questionnaire will be administered to collect data on sociodemographic indices and exposure to risk factors for parenteral, vertical and sexual (only among those aged above 10 years) HIV transmission. …”
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Optimising Paediatric Transition to Intensive Care for Adults (OPTICAL): study protocol for a mixed method study by Padmanabhan Ramnarayan, Louise Rose, Julie Taylor, Christina Pagel, Jo Wray, Sarah E Seaton, Kate Oulton, Sonya Crowe, Rum Thomas, Qi Huang, Paul R Mouncey, Katherine Malbon, Anjalika Mallick, Charmaine Kohn, Sue Ben Abraham, Clare Windsor

“…To do this, we will: (1) link and analyse UK national data (years 2017–2024) on paediatric and adult ICU admissions, hospital inpatient, outpatient and emergency care visits and survival status, to determine the clinical characteristics and healthcare resource utilisation from teenage years to early adulthood of people admitted to an ICU as a young person (admission aged 14 and 15), and how these relate to ICU admissions after age 16; (2) conduct semistructured interviews, online forums and surveys with TYA patients, carers and health professionals to understand their experience of transition in ICU services; and (3) synthesise these strands of evidence and use a structured process of stakeholder engagement to propose potential targeted improvements as appropriate.Ethics and dissemination This study was approved by the East of England - Cambridge South Research Ethics Committee on 1 August 2024 (research ethics committee number 24/EE/0108), and the Health Research Authority Confidentiality Advisory Group (CAG) on 7 October 2024 (CAG number 24/CAG/0068). …”
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Comparative analysis of corpus callosum lipidome and transcriptome in schizophrenia and healthy brain by Maria S. Osetrova, Olga I. Efimova, Marina D. Zavolskova, Elena A. Stekolschikova, Gleb N. Vladimirov, Dmitry A. Senko, Tatiana A. Zhuravleva, Anna Y. Morozova, Yana A. Zorkina, Denis S. Andreyuk, George P. Kostyuk, Evgeniy N. Nikolaev, Philipp E. Khaitovich

“…BACKGROUND: Functional and structural studies of the brain highlight the importance of white matter alterations in schizophrenia. …”
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Vulvovaginal candidiasis: knowledge, practices and occurrence among pregnant women receiving antenatal care in a teaching hospital, Ghana by Florence Shine Edziah, Florence Shine Edziah, Princess Ruhama Acheampong, Philip Apraku Tawiah, Cedric Dzidzor Amengor, Godsway Edem Kpene, Grace Otobea Amponsah, Priscilla Appiah Baffoe, Georgina Korankye, John Gameli Deku

“…This study assessed the knowledge, practices and occurrence of Vulvovaginal candidiasis among pregnant women accessing antenatal care at a teaching hospital in Ghana.MethodsA cross-sectional study was conducted among 336 pregnant women receiving antenatal care at the Ho Teaching Hospital. A structured questionnaire was used to assess their knowledge of the infection and practices on vaginal hygiene. …”
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The experience of immersive virtual reality in patients with heart failure during cardiac rehabilitation: a qualitative study by Valentina Micheluzzi, Valentina Micheluzzi, Gavino Casu, Gavino Casu, Francesco Burrai, Antonella Canu, Antonio Sircana, Pierluigi Merella, Pierluigi Merella, Angelo Laconi, Angelo Laconi, Andrea Chelo, Andrea Chelo, Piero Cozzula, Michela Piredda, Ercole Vellone, Ercole Vellone

“…The intervention group experienced iVR in natural settings, while the control group received standard care. Semi-structured individual interviews were conducted in person after the intervention group’s eighth rehabilitation session. …”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…The secondary outcome assessed the association between demographic factors (age, gender, income, education, smoking status) and KAP scores using structural equation modelling (SEM).Results The mean KAP scores were 1.26±2.85 for knowledge, 30.46±3.63 for attitudes and 34.58±5.55 for practices. …”
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Innovative strategies for bone organoid: Synergistic application and exploration of advanced technologies by Xu Lou, Qirong Zhou, Zhenglin Dong, Long Bai, Jiacan Su, Hua Yue

“…While 3D bioprinting enhances spatial precision and structural complexity, artificial intelligence accelerates organoid optimization through data-driven approaches. …”
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Strengthening neonatal care through ward assistants: a Kenyan case study in enhancing infection prevention and control practices by Michuki Maina, Nancy Odinga, Vincent Kagonya, Gloria Ngaiza, Sebastian Fuller, Onesmus Onyango, Caroline Waithira, Dorothy Oluoch, David Gathara, Peter Mwangi, Loise Mwangi, Penina Musyoka, Lucy Kinyua, Lydia Thuranira, Virginia Njoroge, Ngina Mwangi, Zainab Kioni, Mike English, Edna Mutua

“…Methods This study employed a mixed methods approach in four public neonatal units in Kenya to assess the impact of deploying ward assistants on IPC practices. Data collection included structured and unstructured observations, in-depth interviews, and focus group discussions with healthcare workers and caregivers. …”
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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…The interviews were conducted by two researchers who have extensive experience interviewing KOA patients, and data were gathered through face-to-face, semi-structured interviews to ensure a high level of information power. …”
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Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surf... by Feng Ni, Cunle Wu, Ping Xu, Ping Wang, Yves Fortin, Melanie Arbour, Luke Masson, Denis L’Abbé, Andrea Acel, Mylene Gosselin, Anne E.G. Lenferink

“…Transverse relaxation optimized NMR spectroscopy of 11H9-F(Ab) in complex with the CA-IX IDR outlines structural rigidification of a linear epitope, while the rest of the IDR remains largely unstructured upon complex formation. …”
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A Multidata Approach to Open Clusters: Roslund 3 and Ruprecht 174 in CCD UBV and Gaia DR3 Context by Hülya Karagöz, Talar Yontan, Selçuk Bilir, Olcay Plevne, Tansel Ak, Serap Ak, Remziye Canbay, Timothy Banks

“…A detailed analysis of the structural, astrophysical, kinematic, and dynamical properties of the open clusters Roslund 3 and Ruprecht 174 is carried out using CCD UBV photometry in conjunction with astrometric and photometric data from Gaia DR3. …”
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Fostering achievement of sustainable development goals through green culture and digital transformation: Empirical evidence from an Indonesian education human resources university by Indah Prabawati, Wiwik Sri Utami, Harmanto, Meirinawati, Suci Megawati, Artanti Indrasetianingsih, Sud Sudirman

“…Utilizing a quantitative approach, a survey was conducted with 435 students from State University of Surabaya, a leading IEHRU. Data were analyzed using partial least squares structural equation modeling (PLS-SEM) with SmartPLS 4. …”
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Quantitative Characterization and Determination of the Main Factors That Control Fracture Development in the Lower Paleozoic Shale in Southeastern Chongqing, China by Zhiping Zhang, Xiangye Kong, Qing Chen, Ye Zhang, Zhi Deng, Chuan Yu, Zhian Lei, Haijie Zhang, Xiaofeng Wang, Guanghua Yao, Licheng Yang, Xianfeng Tan

“…The results obtained showed that there are three types of fractures in the lower Paleozoic shale in southeastern Chongqing, which are structural, diagenetic, and abnormal high-pressure fractures. …”
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Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy by Zhibo Hu, Yu Zhou, Cailing Gao, Junfen Liu, Congqing Pan, Jun Guo

“…Conclusions The anti-pyroptosis effect of AS-IV via the TXNIP-NLRP3-GSDMD axis improves the renal function and podocyte damage of db/db mice and delays the onset of DKD, according to in vivo and in vitro experimental data.…”
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Effects of timely case conferencing between general practitioners and specialist palliative care services on symptom burden in patients with advanced chronic disease: results of th... by Tina Mallon, Josefine Schulze, Nadine Pohontsch, Thomas Asendorf, Jan Weber, Silke Böttcher, Uta Sekanina, Franziska Schade, Nils Schneider, Judith Dams, Michael Freitag, Christiane Müller, Friedemann Nauck, Tim Friede, Martin Scherer, Gabriella Marx

“…Methods The cluster-randomised controlled trial compared a structured palliative care nurse visit followed by an interprofessional case conference to usual care. …”
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The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial by R.D. Singh, J.T.J.M. van Dijck, T.A. van Essen, H.P. Nix, R.J.G. Vreeburg, H.F. den Boogert, G.C.W. de Ruiter, B. Depreitere, W.C. Peul

“…Furthermore, non-structured interviews with involved clinical research personnel were conducted. …”
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Retention of medical officers in the district health services of the Western Cape, South Africa: An exploratory descriptive qualitative study by Robert J. Mash, Werner Viljoen, Steve Swartz, Mumtaz Abbas, Leigh Wagner, Herma Steyn, Gavin Hendricks, Dusica Stapar, Andrew Williams, Adeloye Adeniji, Johan Schoevers, Paul Kapp

“…Medical officers were purposefully selected in terms of districts, facility types, gender, seniority and perceived likelihood of leaving in the next four years. Semi-structured interviews were performed by family physicians, and the qualitative data were analysed using the framework method. …”
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