Faster efficacy and reduced nodule occurrence with PLLA (poly-l-lactic acid) porous microspheres by Qihua Cao, Qihua Cao, Qihua Cao, Jiayu Chen, Jiayu Chen, Jiayu Chen, Jiayu Chen, Zijun Zhang, Yufei Xiong, Jinxia Ma, Wei Sun, Xin Chen, Qilei Lou, Kaijia Tang, Kaijia Tang, Kaijia Tang, Kaijia Tang, Feng Lin, Feng Lin, Feng Lin, Yueliang Zhu, Yueliang Zhu, Yueliang Zhu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu, Xiaohua Yu

“…Post-euthanasia, tissue sections underwent histological examination through hematoxylin and eosin (H&E) staining and Masson’s trichrome technique, with subsequent statistical analysis of the observational data.ResultsThe PLLA porous microsphere group demonstrated significantly faster onset of action compared to the control, with observable collagen deposition as early as week 2, enhanced inflammatory cell infiltration, more homogeneous tissue distribution, and substantially fewer microaggregates upon histological examination.DiscussionStructural modification of PLLA microspheres has successfully accelerated their onset of action while reducing nodule formation, thereby providing novel insights for clinical applications.…”
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An open-source simulation platform to support and foster research collaboration in natural hazards engineering by Adam Zsarnóczay, Gregory G. Deierlein, Frank McKenna, Matthew Schoettler, Sang-Ri Yi, Barbaros Cetiner, Aakash Bangalore Satish, Jinyan Zhao, Justin Bonus, Abiy F. Melaku, Sina Naeimi, Pedro Arduino, Rachel Davidson, Rachel Davidson, Catherine Gorle, Sanjay Govindjee, Ahsan Kareem, Tracy L. Kijewski-Correa, Tracy L. Kijewski-Correa, Laura N. Lowes, Michael Motley, Seymour M. J. Spence, Ertugrul Taciroglu, Alexandros A. Taflanidis, Matthew DeJong

“…This paper presents the conceptual foundation and current capabilities of the SimCenter platform, covering hazard characterization, structural response analysis, damage and loss estimation, and recovery modeling. …”
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Signatures of omicron-like adaptation in early SARS-CoV-2 variants and chronic infection by Mark Tsz Kin Cheng, Mazharul Altaf, Jesu Castin, Ann-Kathrin Reuschl, Benjamin L. Sievers, Kimia Kamelian, Dejan Mesner, Rebecca B. Morse, Adam Abdullahi, Bo Meng, Kata Csiba, Steven A. Kemp, Darren P. Martin, Clare Jolly, Christopher Ruis, Lipi Thukral, Ravindra K. Gupta

“…These data shed light on the balance between SARS-CoV-2 upper airway adaptation/immune evasion, syncytium formation, and pathogenic potential.…”
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Increased vulnerability to psychological distress and suicidal ideation among transgender women with self-reported disabilities in San Francisco, California by Abtin Shafie, Alexis Salvatore, Riley Shea, Eileen Yu, Oyku Ozyucel, Ansharan Akbar, Bow Suprasert, Erin C. Wilson, Willi McFarland, Kelly D. Taylor, Sean Arayasirikul

“…OBJECTIVE: Research among transgender women has found health, but especially mental health, to be shaped by social inequities and multiple, intersectional, structural vulnerabilities. While some studies have shown that transgender adults are also more likely to have a disability than cisgender adults, few studies have explored this intersection. …”
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Clinical profiles and health-related quality of life changes after treatment in advanced colorectal cancer patients: a nationwide study in China by Hongwei Liu, Ziyao Jia, Huifang Xu, Xiaoyang Wang, Hong Wang, Ruihua Kang, Qiong Chen, Xiaoli Guo, Ranran Qie, Mengfei Zhao, Cheng Cheng, Liyang Zheng, Shuzheng Liu, Yin Liu, Shaokai Zhang, China Working Group on Colorectal Cancer Survey

“…The multivariable regressions and structural equation model (SEM) were used to assess the association between characteristics and HRQOL. …”
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Overview of antimicrobial resistance mitigation efforts in Benin 2024 by Alain K. Aissi, Tokpanou E.C. Koudjo, Filémon T. Tokponnon, Al Fattah Onifade, Akpeedje A.C. Wadagni, Géraud S.R. Padonou, Hervé A. Gbegnide, Léopold A. Azakpa, Adrien M. Hodonou, Roch C. Johnson, Francis M. Dossou

“…Methods: A retrospective cross-sectional evaluation was performed from 05 August 2024 to 30 September 2024. Data were collected through a documentary review, standardised questionnaires, semi-structured interviews and group discussions. …”
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Assessing the performance of a new gum Arabic harvesting tool through the insight of gum producers in the gum belt of Sudan by Muneer Elyas Siddig Eltahir, Suhad Ismail Eltahir, Moayad Balal Zaid, Hatim Mohamed Ahmed Elamin, Zeinab Mohammed Hamad, Osman Elsaid Adlan Abdelkareem, Faisal Ismail Musa, Ahmed Ismail Ahmed Safi, Awadelkareem Suliman Osman Khalifa, Abdalaziz Elsaid Hamad, Mohammed Osman Hassan, Heba Abdalla Noureldeen, Mohammed Eltom Elhaja, Uttam Kumar Sahoo

“…We conducted a study in North and West Kordofan of Sudan to assess the performance, use, and efficiency of the newly designed harvesting tool, and to understand the level of its adoption by the gum Arabic producers. Data were collected through a structured questionnaire, and by group discussion involving 44 trained gum producers by a purposive selection method. …”
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The High Burden of Depression, Anxiety, and Stress among University Students in Southern Iraq: A Cross-Sectional Study by Hassan Al-Karagoly, Zahraa Al-attar, Hjar Al-asadi, Sajad Al-Lahibi, Sajad Al-Lahibi, Russul Al-Fartousi, Teeba Al-Jadry, Menatallah Bali, Menatallah Bali, Baneen Al-Hasnawi, Qassim Al-rubaie, Hanan Al-aboudi, Ali Al-mosawi, Mohsin Al-samawi, Abdulsalam Halboup

“…A cross-sectional study was conducted among Iraqi university students using a structured questionnaire, including the DASS-21, Insomnia Severity Index, and Internet Addiction Test. …”
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Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in <i>Trypanosoma cruzi</i>: Virtual Screening and In Vitro Studies by Eyra Ortiz-Pérez, Adriana Moreno-Rodríguez, Timoteo Delgado-Maldonado, Jessica L. Ortega-Balleza, Alonzo González-González, Alma D. Paz-González, Karina Vázquez, Guadalupe Avalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera

“…Future studies should focus on structural modifications to improve selectivity. Integrating docking, parasitological, and enzymatic data is crucial for optimizing drug candidates for Chagas disease.…”
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Predicting leakage of the VERCORS mock-up and concrete containment buildings - a digital twin approach by Laurent Charpin, Jessica Haelewyn, Anass Cherki El Idrissi, Julien Niepceron, Benoît Masson, Charles Toulemonde, Guillaume Boulant, Jean-Philippe Mathieu, François Hamon, Sylvie Michel-Ponnelle, Jean-Marie Hénault, Frédéric Taillade, Jean-Luc Adia, Florian Escoffier

“…An important numerical effort has also been made to implement structural computations of the mock-up and to capitalize these computations as well as their post-processing (so as to compare automatically with the monitoring data) in what can be called a digital twin of the mock-up. …”
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Quality of Care of Adult Patients With Allergic Diseases in Urban, Rural, and Remote Primary Care Sites in the Philippines by Carol Stephanie C. Tan-Lim, Robbi Miguel G. Falcon, Jeremiah F. Feliciano, Michael B. Fong MD, Mark Anthony U. Javelosa, Leonila F. Dans, Iris Thiele C. Isip-Tan, Josephine T. Sanchez, Mia P. Rey, Antonio Miguel L. Dans

“…Methods: This was a retrospective review of electronic health records of all adult patients who consulted in the 3 sites from May 2019 to April 2022. Data of adult patients with allergic diseases was extracted from the 3 EHR systems operating across the participating sites using standardized Structured Query Language queries across the 3 systems. …”
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Contextual factors in value-based decision support to enhance health technologies adoption: the case of biosimilars by Maximilian Otte, Maximilian Otte, Maximilian Otte, Zoltán Kaló, Zoltán Kaló, Zoltán Kaló, Hussain Abdulrahman Al-Omar, Meindert Boysen, Yingyao Chen, Ana Paula Beck Da Silva Etges, Ana Paula Beck Da Silva Etges, Guvenc Kockaya, Iñaki Gutierrez-Ibarluzea, Ahmed Mohammed Seyam, Deirdre Mullen, Deirdre Mullen, Hans-Peter Dauben, Hans-Peter Dauben, Hans-Peter Dauben

“…The MCDA framework offers a structured approach to operationalize these principles. …”
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Orthopaedic Consultation is Associated With Fewer Patient-Perceived Barriers to Total Joint Arthroplasty by Insa Mannstadt, BS, BA, J. Alex B. Gibbons, BA, Troy B. Amen, MD, MBA, Mangala Rajan, PhD, Sarah R. Young, PhD, Henry Tischler, MD, Michael L. Parks, MD, Mark Figgie, MD, Anne Bass, MD, Linda Russell, MD, Bella Mehta, MD, MS, Iris Navarro-Millán, MD, Susan M. Goodman, MD

“…Methods: We performed a post-hoc analysis of questionnaire responses based on data from a previous study that used semi-structured interviews with patients with advanced osteoarthritis. …”
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Inaccuracies of venous thromboembolism risk assessment and prevention practices among medically ill patients by Brandyn D. Lau, Aditya Bhave, Jennifer C. Yui, Rakhi Naik, Kathryn E. Dane, John Lindsley, Dauryne L. Shaffer, Peggy S. Kraus, Erik H. Hoyer, Elliott R. Haut, Michael B. Streiff

“…Leveraging existing structured data to autopopulate VTE risk assessments can assist providers in improving accuracy. …”
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Research on the charging periods of the ultra-shallow play in front of the Hashan area, northwestern margin of the Junggar Basin by WANG Qianjun, ZHOU Jian, ZHANG Faqiang, YU Hongzhou, WU Qianqian, LU Hongli, LIU Qingxin, ZHOU Yu, CHENG Ming, YAN Jianzhao, LYU Yanfang

“…The second phase took place during the Late Cretaceous (73 Ma), marked by structural adjustment and hydrocarbon redistribution. …”
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Open Innovation the Impact of Social Capital on Tourism Growth Through the Mediating Role of Open Innovation (Case study: The municipality of Khomam County) by Seyed Hamed Hashemi, Hossein Poorghasem

“…This research is applied in terms of purpose and is survey-based for data collection. Moreover, from a methodological perspective, it employs a correlational design; the data collection tool used in this study was a questionnaire, rated using a Likert scale, and its reliability was assessed using Cronbach's alpha. …”
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Distinct subnetworks of the mouse anterior thalamic nuclei by Houri Hintiryan, Mitchell Rudd, Sumit Nanda, Adriana E. Gutierrez, Darrick Lo, Tyler Boesen, Luis Garcia, Jiandong Sun, Christian Estrada, Hyun-Seung Mun, Seita Yamashita, Yeji E. Han, Ian Bowman, Lin Gou, Chunru Cao, Jennifer Gonzalez, Keivan Moradi, Qiuying Zhao, Inga Yenokian, Aishwarya Dev, Brian Zingg, Hanpeng Xu, Qing Xue, Muye Zhu, Lijuan Liu, Xin Chen, Zhixi Yun, Hanchuan Peng, Nicholas N. Foster, Hong-Wei Dong

“…Therefore, the ATN provide a promising avenue to investigate the relationship between structural and functional complexity with neuron type diversity. …”
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Association between the use of herbal medicines during pregnancy and adverse fetal outcomes among mothers in eastern Ethiopia, 2023 by Tamirat Getachew, Abera Kenay Tura, Merga Dheresa, Shamble Niguse, Bikila Balis, Lemma Demissie Regassa, Addis Eyeberu

“…Methods: A community-based cross-sectional study was conducted among 882 randomly selected mothers from February 1, 2023 to November 1, 2023. Data were collected through face-to-face interviews using structured questionnaires adapted from previous literature. …”
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Evaluation of Screening Tool of Older People’s Prescriptions (STOPP) Criteria in an Urban Cohort of Older People with HIV by Lauren F. O’Connor, Jenna B. Resnik, Sam Simmens, Vinay Bhandaru, Debra Benator, La’Marcus Wingate, Amanda D. Castel, Anne K. Monroe

“…Negative binomial models were used to evaluate factors associated with PIP and structural equation modeling was used to evaluate whether symptom burden mediates the relationship between PIP and quality of life. …”
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Redefining respite for family caregivers: lessons learned from the COVID-19 pandemic by Rebecca L. Utz, Hannah L. Mundinger, Amber Thompson, Gail L. Towsley, Gail L. Towsley, Kara B. Dassel, Kara B. Dassel, Alex Terrill, Alycia A. Bristol

“…This study aimed to understand how caregivers accessed and achieved respite when respite services were not readily available, and how their experiences during and following the unprecedented global public health crisis have influenced and informed the way that caregivers achieve the needed and desired respite.MethodsThis study integrates several sources of qualitative and descriptive data collected via electronic surveys and semi-structured interviews with family caregivers and respite providers over the past several years (from 2019 to 2024).ResultsThe following themes were identified: (a) disruption and loss of formal respite services resulted in caregiver isolation, as well as acute and protracted stress, (b) personal networks and shared caregiving arrangements provide opportunities for informal respite, (c) respite is associated improved caregiver wellbeing, but caregivers often are hesitant to use respite (d) daily activities and routines can provide a form of respite for caregivers, (e) family caregivers showed resilience and adaptability in the face of COVID-19 challenges, revealing the potential benefit of taking “short breaks” throughout the day to achieve a feeling of respite.Discussion and conclusionsThese qualitative, descriptive insights provide a blueprint for a reimagined definition of caregiver respite, where respite is conceptualized as an outcome or benefit that caregivers seek and can create on their own, rather than only defining respite as a formal service provided to caregivers by outside organizations. …”
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