Damage before destruction? X-ray-induced changes in single-pulse serial femtosecond crystallography by Lewis J. Williams, Amy J. Thompson, Philipp Dijkstal, Martin Appleby, Greta Assmann, Florian S. N. Dworkowski, Nicole Hiller, Chia-Ying Huang, Tom Mason, Samuel Perrett, Eduard Prat, Didier Voulot, Bill Pedrini, John H. Beale, Michael A. Hough, Jonathan A. R. Worrall, Robin L. Owen

“…Serial femtosecond crystallography (SFX) exploits extremely brief X-ray free-electron laser pulses to obtain diffraction data before destruction of the crystal. However, during the pulse X-ray-induced site-specific radiation damage can occur, leading to electronic state and/or structural changes. …”
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Energy Efficiency in Network Slicing: Survey and Taxonomy by Adnei Willian Donatti, Marcia Cristina Machado, Marvin Alexander Lopez Martinez, Sabino S. Rogerio Antunes, Eli Carlos Figueiredo Souza, Sand L. Correa, Tiago C. Ferreto, Jose Augusto Suruagy, Joberto S. B. Martins, Tereza Cristina Carvalho

“…By consolidating insights from recent developments, our work bridges existing gaps in the literature, offering a structured foundation for researchers and practitioners to design, evaluate, and improve energy-efficient network slicing systems.…”
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Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity by Samantha Corrà, Alessandro Zuppardo, Sebastian Valenzuela, Louise Jenninger, Raffaele Cerutti, Sirelin Sillamaa, Emily Hoberg, Katarina A. S. Johansson, Urska Rovsnik, Sara Volta, Pedro Silva-Pinheiro, Hannah Davis, Aleksandra Trifunovic, Michal Minczuk, Claes M. Gustafsson, Anu Suomalainen, Massimo Zeviani, Bertil Macao, Xuefeng Zhu, Maria Falkenberg, Carlo Viscomi

“…Cryogenic electron microscopy highlighted structural differences between human and mouse POLγ, particularly in the POLγB subunit, which may explain the higher activity of mouse POLγ and the reduced severity of mutations in mice. …”
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Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study by Miaomiao Shao, Ying Li, Jing Qin, Yuchen Zhou, Yixin Sun, Peiyi Yang, Xisi Wang, Cheng Huang, Yan Su, Wen Zhao

“…Methods Children aged 1–18 years with solid tumors treated with HEC were enrolled. A structured diary was used to record CINV data, and the pediatric nausea assessment tool (PeNAT) was employed to assess the degree of nausea. …”
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Determining the Teachers' Attitude towards "Mistake" and "Making Mistakes" in the Learning Process and Improving the Culture facing it (case study: elementary school students) by Mazhar Babaee, Hedyeh Azagh

“…The research tool was a semi-structured interview conducted by the researcher and the data format was audio. …”
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Instance-based generalization for human judgments about uncertainty. by Philipp Schustek, Rubén Moreno-Bote

“…As probability distributions are high dimensional objects, only constrained families of distributions with a low number of parameters can be specified from finite data. However, it is unknown what the structural assumptions are that the brain uses to estimate them. …”
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Fine mapping and identification of CaTTG1, a candidate gene that regulates the hypocotyl anthocyanin accumulation in Capsicum annuum by Jin Wang, Yao Dai, Luzhao Pan, Ying Chen, Li Dai, Yanqing Ma, Xiaoxun Zhou, Wu Miao, Muhammad Rizwan Hamid, Xuexiao Zou, Feng Liu, Cheng Xiong

“…Virus-induced gene silencing (VIGS) confirmed that CaTTG1 regulated anthocyanin accumulation. RNA-seq data showed that expression of structural genes CaDFR, CaANS, and CaUF3GT in the anthocyanin biosynthetic pathway was significantly decreased in Cha1 compared to the wild type. …”
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Optimisation of the deployment of automated external defibrillators in public places in England by Terry P Brown, Lazaros Andronis, Asmaa El-Banna, Benjamin KH Leung, Theodoros Arvanitis, Charles Deakin, Aloysius N Siriwardena, John Long, Gareth Clegg, Steven Brooks, Timothy CY Chan, Steve Irving, Louise Walker, Craig Mortimer, Sandra Igbodo, Gavin D Perkins

“…Methods This was a secondary analysis of data collected by the Out-of-Hospital Cardiac Arrest Outcomes registry on historical out-of-hospital cardiac arrests, data held on the location of automated external defibrillators registered with ambulance services, and locations of points of interest. …”
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HOTSED: A new integrated model for assessing potential hotspots of sediment sources and related sediment dynamics at watershed scale by Manuel La Licata, Alberto Bosino, Seyed Hamidreza Sadeghi, Mattia De Amicis, Andrea Mandarino, Andrea Terret, Michael Maerker

“…HOTSED integrates geomorphic spatial information with both structural and functional properties of connectivity. …”
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Electron microscopic changes in the nasal membrane of patients with COVID-19 depending on the clinical form and the period of the disease by E. V. Kryukov, K. V. Zhdanov, K. V. Kozlov, V. Yu. Kravtsov, O. V. Mal’tsev, V. S. Sukachev, P. I. Miklush, M. O. Sokolova, V. V. Sharabkhanov, R. I. Glushakov, V. V. Dvoryanchikov, R. R. Achba, D. V. Trishkin, I. I. Azarov

“…Understanding the ultra-structural cell changes of SARS-CoV-2 targets may help clarify the pathogenic aspects of infection in the lower respiratory tract. …”
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Magnetic Resonance Imaging Lesions Associated With Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury by Jamie E. Podell, Eric W. Moffet, Uttam K. Bodanapally, Mehrnaz Pajoumand, Luisa M. Silva, Peter Hu, Lujie K. Chen, Nicholas A. Morris, Gunjan Parikh, Gary T. Schwartzbauer, Bizhan Aarabi, Neeraj Badjatia

“…This exploratory study supports the hypothesis that structural damage to CAN regions is associated with the clinical syndrome of PSH after TBI, and provides foundational evidence for future data-driven studies.…”
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Targeting the IL-17A pathway for therapy in early-stage tendinopathy by Iain B McInnes, Richard M Siegel, Neal L Millar, Moeed Akbar, Michaela Kneissel, Frank Kolbinger, Friedrich Raulf, Yufei Li, Nicolau Beckmann, Nathalie Accart, Olivier Leupin, Claudio Calonder, Matthias Schieker, Christian Bruns, Eckhard Weber

“…In the rat ex vivo and in vivo models, IL-17A blockade alleviated inflammatory immune effector release, tendon structural degeneration, tendon inflammation and impaired tendon function.Conclusion Our data provide evidence that IL-17A is a key contributor to the pathogenesis of tendinopathy by promoting tendon inflammation and degeneration and that IL-17A blockade may represent a potential therapy in early-stage tendinopathy.…”
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Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging by Frank Li, Frank Li, Xuan Zhang, Xuan Zhang, Alejandro P. Comellas, Eric A. Hoffman, Eric A. Hoffman, Michael M. Graham, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin

“…This approach seeks to enhance our understanding of how structural and functional changes influence ventilation heterogeneity in COPD.MethodsEight COPD subjects completed a longitudinal study with three visits, spaced about a year apart. …”
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Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder by Bin Lu, Xue Li, Xue-Ping Gao, Jing Chen, Yi Liu, Jian-Ping Lu, Siu-Ching Kat, Zeng-Hui Ma, Li-Yang Zhao, Ting-Ni Yin, Xing Su, Fan-Chao Meng, Ya-Ru Zhang, Shu-Xian Wu, Wen-Jie Yan, Ya-Song Du, Xue-Rong Luo, Jing Liu, Chao-Gan Yan

“…Conclusion: The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics; however, EOS exhibits greater structural variation, while ASD presents with more subtle connectomic abnormalities. …”
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Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children by Kavari Hercules, Zhiyuan Liu, Eleni Christofilea, Jia Wei, Gladys Venegas, Olivia Ciocca, Alice Dyer, Goeun Lee, Sasha Santini-Bishop, Heather Shappell, Dylan G. Gee, Denis G. Sukhodolsky, Karim Ibrahim

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Stigma measurement in health: a systematic reviewResearch in context by Sara Malone, Lara Counts, Luke Zabotka, Anneliese Williams, Nele Loecher, Kayla Wynja, Gemma Bryan, Robin Tanner, Ana Cáceres-Serrano, Gia Ferrara, Lucia Fuentes, Tharwa Bilbeisi, Marissa Maheu, Benjamin K. Oelkers, Muna Ogwo, Lauren Yaeger, Asya Agulnik, Dylan Graetz, Shayla Lawrence, Jocelyn Rivera, Farris Abutineh, Doris Maldonado

“…Databases were searched for stigma measurement in health through July 2024. 8123 citations were screened. Data on definitions, measurement, psychometrics, and interventions were extracted. …”
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Determinants of Rotavirus Vaccine Acceptance in an Area of Southern Italy with Low Vaccination Coverage: A Case-Control Study by the Health Belief Model Questionnaire by Davide Anzà, Massimiliano Esposito, Giorgio Bertolazzi, Alessandra Fallucca, Carlo Genovese, Gabriele Maniscalco, Andrea D. Praticò, Tiziana Scarpaci, Ermanno Vitale, Vincenzo Restivo

“…Methods: This case-control study was conducted in Southern Italy to identify factors influencing parental acceptance of RVV. Data were collected from parents using a structured questionnaire that assessed socio-demographic factors, vaccine knowledge, and attitudes based on the Health Belief Model (HBM). …”
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Vendor density mapping and compliance assessment with tobacco control laws around schools in Bhubaneswar City—a geo-spatial mapping and observational study by Nancy Satpathy, Nancy Satpathy, Pratap Jena, Pratap Jena, Amit Yadav, Venkatarao Epari, Vikrant Mohanty, Muhammad Imran Ali, Rishika Khare, Yogesh Pratap Singh, Ashish Kumar Pandey

“…This study examines tobacco vendor density around schools in Bhubaneswar City, Odisha, utilizing advanced geo-spatial mapping techniques to provide evidence for regulatory enforcement.MethodsA geo-spatial mapping approach was employed using ArcMap 10.8 and Google Maps to identify tobacco vendors within a 100-yard radius of 15 selected high schools. Data collection was conducted through a structured questionnaire with 53 closed-ended questions via the Epicollect5 platform. …”
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Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation by Anna Solta, Büsra Ernhofer, Kristiina Boettiger, Christian Lang, Zsolt Megyesfalvi, Theresa Mendrina, Dominik Kirchhofer, Gerald Timelthaler, Beata Szeitz, Melinda Rezeli, Clemens Aigner, Arvand Haschemi, Lukas W. Unger, Balazs Dome, Karin Schelch

“…Methods Metabolic alterations were analyzed using proteomic data. Structural and functional differences of mitochondria were investigated using qPCR, flow cytometry, confocal imaging, and transmission electron microscopy and seahorse assays. …”
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Health workers’ perspectives regarding climate change and health in Kween District, Mount Elgon, Uganda – A qualitative study by Aggrey Siya, Akim Tafadzwa Lukwa, Chemutai Faith, Noah Mutai, Plaxcedes Chiwire

“…Health facilities were selected through purposive sampling and 69 health service providers participated. Data collection involved semi-structured interviews that explored health workers' knowledge of climate change and its impacts on health, including malaria. …”
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