Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…Limitations Study heterogeneity; the lack of a universal reference standard; simplifying assumptions relating to economic model structure; and estimation of some parameters are documented and justified. …”
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Effect of low-moderate intensity traditional Chinese exercises combined with acupuncture on patients with stable chronic obstructive pulmonary disease: study protocol for a randomi... by Hongxia Duan, Yidie Bao, Linhong Jiang, Peijun Li, Yingqi Wang, Yuchen He, Xinliao Deng, Weibing Wu, Wei Zhang, Xiaodan Liu, Xiaodan Liu

“…Secondary outcomes will include lung function, degree of dyspnea, diaphragmatic function, respiratory muscle strength, skeletal muscle structure, skeletal muscle function, psychological states, and quality of life. …”
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CORRECTION OF HYPODINAMY AS A FACTOR OF THE RISK OF OBESITY DEVELOPMENT IN FIRE-RESCUERS by E. V. BURDYUKOVA, A. N. ARKHANGELSKAYA, S. N. ALEKSEENKO, I. A. YAKIREVICH, E. A. DMITRIEVA, O. P. KARAZHELYASKOV, M. V. IVKINA, K. G. GUREVICH

“…A questionnaire was conducted to identify hypodynamia (according to the IPAQ questionnaire) and the nutrition structure (according to the questionnaire on the food label literacy questionnaire, past). …”
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Development and preliminary validation of a Chinese Physical Activity Parenting Practices Scale (3–6 years) by Ren Na, Ying Liang, Haiyue Zhang, Zhe Yang, Nan Li, Wei Zhang, Han Tang, Weiliang Ye, Linyuan Zhang, Xun Jiang, Lei Shang

“…We ultimately developed a formal version of the Chinese Physical Activity Parenting Practices Scale (CPAPPS) using the remaining 30 items. We examined the structure of the scale using factor analysis and evaluated its reliability, validity, and discriminant ability using data from 899 parents of children aged 3–6 years.ResultsThe CPAPPS includes 30 items in 6 dimensions scored on a 5-point Likert scale. …”
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Theory and engineering practice of coal-water coordinated mining based on constraints of formation bearing capacity by Zhenzhong PANG, Yifan ZENG, Keyao HAN, Qiang WU, Shouqiang LIU, Zhaolai HUA, Gangyi ZHAO, Shuai ZHANG, Huxiong YANG, Xuejun WANG, Feifan LI

“…Dominant factors controlling the formation structure damage were identified using the theory of simply supported beams and hydrogeological theories. …”
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Comparative genomics and phylogenetic analysis of mitochondrial genomes of Neocinnamomum by Wen Zhu, Di Zhang, Wenbin Xu, Yi Gan, Jiepeng Huang, Yanyu Liu, Yunhong Tan, Yu Song, Peiyao Xin

“…We successfully assembled the mitogenome of N. delavayi, which is 778,066 bp in size and exhibits a single circular structure. The analysis identified 659 dispersed repeats, 211 simple sequence repeats (SSRs), and 30 tandem repeats within the mitogenome. …”
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Generation of 1 km high resolution Standardized precipitation evapotranspiration Index for drought monitoring over China using Google Earth Engine by Yile He, Youping Xie, Junchen Liu, Zengyun Hu, Jun Liu, Yuhua Cheng, Lei Zhang, Zhihui Wang, Man Li

“…However, limited by its spatial resolution of 0.5 degrees, it is difficult to describe the local spatio-temporal structure of drought. How to improve its spatial resolution while maintaining spatio-temporal consistency is one of the current research hotspots. …”
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Characteristics of the gut virome in patients with premalignant colorectal adenoma by Pan Zhang, Xiaofeng Tuo, Jiong Jiang, Yue Zhang, Juhui Zhao, Chengzhao Deng, Gang Zhao, Yan Cheng, Lingqin Song, Yan Yang, Ruochun Guo, Huan Zhang, Hongli Zhao, Shiyang Ma, Lu Li, Haitao Shi

“…Results Our results revealed a notable shift in the gut virome structure of patients compared to healthy controls, characterized by a significant increase in viral families such as Microviridae, Podoviridae_crAss-like, and Quimbyviridae. …”
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Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia by Alison Hayes, Rebecca Wyse, Anna Lene Seidler, Kylie E Hunter, Rebecca K Golley, Louise A Baur, Anthony D Okely, Kenny Lawson, Jo-An Occhipinti, Louise Freebairn, Simon Keith Chiu, Joseph Carrello, L Kurt Kreuger

“…This research presents insights from a system dynamics model of childhood and adolescent obesity aimed at supporting evidence-based decision-making.Methods A system dynamics model was developed using the best available evidence and data, with input from research and industry experts to map the hypothetical causal structure of the factors contributing to childhood and adolescent obesity in Australia. …”
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Anatomical and histological characterization of the filum terminale in dogs by Christoforos Posporis, Javier Espinosa, Martí Pumarola, Ester Blasco Ortega, Jaume Alomar, Koen Santifort, Koen Santifort, Steven De Decker, Karol Lam, Juan José Mínguez, Patricia Álvarez, Vicente Aige-Gil

“…This study presents the first comprehensive anatomical and histological characterization of the normal canine FT, establishing baseline reference data to facilitate the identification of pathomorphological alterations associated with disorders involving this structure, such as tethered cord syndrome.…”
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Virtual Health Research Capacity Strengthening in Low- and Middle-Income Countries: A Systematic Integrative Review by Chelsea M. McGuire, Nikolina Boskovic, Bolatito Betty Fatusin, Pius Ameh, Taylor Reed, Priyanka Jethwani, David Flynn, Jo Cooke, Robert Saper

“…These include selecting well‑fitted program participants, intentionally designing program structure and content, conducting needs assessments or pilots, incorporating equity as a programmatic target, ensuring longitudinal program evaluation and monitoring, and utilizing a comprehensive conceptualization of program sustainability.…”
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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

“…Findings provide insight into how the PICU platform trial should be designed and operationalised, including having a broad and inclusive population eligible for inclusion onto the platform trial, with different inclusion and exclusion criteria for each domain; starting the trial with no more than three domains and prioritising the outcomes of Child quality of life and Survival (all participants). Optimal governance structure and suggestions about how any challenges to the success of the full trial can be overcome are also presented.Conclusions Young people, parents/carers and PICU staff viewed the proposed PICU platform trial to be acceptable. …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Baseline mental health data (Structured Clinical Interview for DSM-5, SCID-5RV), and secondary biomedical outcomes (HbA1c; glucose time in range; TIR) and person-reported outcome measures (PROM: Diabetes Eating Problems Survey-Revised, DEPS-R; Eating Disorder Examination Questionnaire Short, EDE-QS; Type 1 Diabetes Distress Scale, T1DDS; Generalised Anxiety Disorder Assessment, GAD-7; Patient Health Questionnaire, PHQ-9; Impact of Diabetes Profile, DIDP) were collected. …”
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Models of care and associated targeted implementation strategies for cancer survivorship support in Europe: a scoping review protocol by Josephine Hegarty, Gillian Prue, Gabriella Pravettoni, Michael Jefford, Angelos P Kassianos, Johanna Czamanski-Cohen, Volker Arndt, Sophie Pilleron, Angela G E M de Boer, Cristina Roldan-Jimenez, Maria Karekla, Aristea Ladas, Aysun Akcakaya Can, Csaba Laszlo Degi, Gökçe Işcan, Sevban Arslan, Aleksandar Celebic, Ascensión Doñate-Martínez, Tamara Alhambra-Borrás, Boce Mitrevski, Chiara Marzorati, Roberto Grasso, Evsen Nazik, Ewa Pawlowska, Iva Mucalo, John Patrick Browne, Katica Tripkovic, Katarina Vojvodic, Maria Moschofidou, Sule Biyik Bayram, Tânia Brandão, Poonam Jaswal, Remziye Semerci, Gamze Bozkul, Eda Sahin, Ismail Toygar, Maximos Frountzas, Rui Miguel Martins, Danielle Keane

“…A search strategy has been developed according to the Population, Concept and Context structure and will be applied to seven databases. A targeted search of grey literature will be completed. …”
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The mediating role of professional values and self-efficacy in the relationship between organizational justice and quality of working life among nurses in southwestern Iran by Sahar Ansari, Zinat Mohebbi, Camellia Torabizadeh, Alimohammad Keshtavarz Hesam Abadi

“…To perform structural equation modeling (SEM) considering the sample size, we used Smart PLS version 4, and to determine the role and strength of the mediating effects of professional values and self-efficacy, we utilized Sobel tests and the Variance Accounted For (VAF) statistic. …”
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Non-targeted metabolomics and network pharmacology of Taohong Siwu Decoction in hepatic fibrosis mouse model using high resolution mass spectrometry by Shengsheng Li, Shengsheng Li, Shenglan Qi, Rongsheng Li, Fangming Yang, Zhenyi Niu, Wei Liu, Suping Ma, Zhun Xiao

“…Furthermore, molecular dynamics simulations were conducted to evaluate the structural stability and binding interactions. Finally, core targets were validated in vivo.ResultsTHSW Decoction effectively reduced CCl4-induced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, alleviating liver inflammation and collagen deposition. …”
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Epidemiological, clinical, and molecular analysis of human adenovirus infections in hospitalized children with acute respiratory infections in Tianjin, China by Yulian Fang, Yulian Fang, Min Lei, Min Lei, Lu Zhang, Mengzhu Hou, Mengzhu Hou, Ning Wang, Ning Wang, Chunquan Cai, Chunquan Cai

“…Molecular characterization revealed structural conservation in the Penton protein of HAdV-C and identified Hexon as the most polymorphic region with 85 variable sites, indicating divergent evolutionary pressures across viral domains.ConclusionHAdV-3, HAdV-7, HAdV-2, and HAdV-1 were the predominant HAdV types in children hospitalized with ARIs in Tianjin. …”
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An integrated microbiome- and metabolome-genome-wide association study reveals the role of heritable ruminal microbial carbohydrate metabolism in lactation performance in Holstein... by Chenguang Zhang, Huifeng Liu, Xingwei Jiang, Zhihong Zhang, Xinfeng Hou, Yue Wang, Dangdang Wang, Zongjun Li, Yangchun Cao, Shengru Wu, Sharon A. Huws, Junhu Yao

“…Moreover, the highly heritable microbes can increase energy-corrected milk (ECM) production by reducing the rumen acetate/propionate ratio, according to the structural equation model (SEM) analysis (CFI = 0.898). …”
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Studying the Digital Intervention Engagement–Mediated Relationship Between Intrapersonal Measures and Pre-Exposure Prophylaxis Adherence in Sexual and Gender Minority Youth: Second... by Michael P Williams, Justin Manjourides, Louisa H Smith, Crissi B Rainer, Lisa B Hightow-Weidman, Danielle F Haley

“…Conversely, the direct effects observed in this study may reflect existing structural disparity (eg, race and ethnicity) or behavioral dispositions toward technology (eg, tracking health via phone apps). …”
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Genomic characterization of three marine fungi, including Emericellopsis atlantica sp. nov. with signatures of a generalist lifestyle and marine biomass degradation by Ole Christian Hagestad, Lingwei Hou, Jeanette H. Andersen, Espen H. Hansen, Bjørn Altermark, Chun Li, Eric Kuhnert, Russell J. Cox, Pedro W. Crous, Joseph W. Spatafora, Kathleen Lail, Mojgan Amirebrahimi, Anna Lipzen, Jasmyn Pangilinan, William Andreopoulos, Richard D. Hayes, Vivian Ng, Igor V. Grigoriev, Stephen A. Jackson, Thomas D. S. Sutton, Alan D. W. Dobson, Teppo Rämä

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