Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study by Ruiyi Qian, Xue Zhao, Dongbin Lyu, Qingqing Xu, Kai Yuan, Xin Luo, Wanying Wang, Yang Wang, Yutong Liu, Yu Cheng, Yingting Tan, Fan Mou, Chengmei Yuan, Shunying Yu

“…Molecular docking was used to visualize the binding structure and fine affinity for <i>MAN1A2</i> and the drugs predicted by DSigDB. …”
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Genome-Wide Identification Analysis of the 4-Coumarate: Coa Ligase (4CL) Gene Family in <i>Brassica</i> U’s Triangle Species and Its Potential Role in the Accumulation of Flavonoid... by Mengzhen Zhang, Mengjiao Tian, Ziwuyun Weng, Yaping Yang, Nian Pan, Shulin Shen, Huiyan Zhao, Hai Du, Cunmin Qu, Nengwen Yin

“…Based on phylogenetics, gene structure, conserved motifs, chromosome localization and collinearity analysis, <i>4CLs</i> were relatively conserved in the evolution of <i>Brassica</i> U’s triangle species. …”
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Forest birds maintain body condition in Alder-leaf Birch (Betula alnoides) plantations in subtropical Asia by Wenyi Zhou, Alexandra A. Grossi, Daniel R. Gustafsson, Zhengzhen Wang, Zhuyang Zhang, Yuqing Han, Xinyi Wang, Anru Zuo, Miguel A. Acevedo, Yang Liu, Scott K. Robinson

“…Plantation forestry alters avian community assembly by creating homogeneous habitats with simplified vegetation structure. However, its effects on avian body condition remain poorly understood, despite the influence body condition has on survival and reproduction. …”
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Polar lights optimizer: A novel algorithm for accurate parameter estimation in proton exchange membrane fuel cells by Mohammad Aljaidi, Pradeep Jangir, Arpita, Sunilkumar P. Agrawal, Sundaram B. Pandya, Anil Parmar, G. Gulothungan, Ali Fayez Alkoradees, Mohammad Khishe, Reena Jangid

“…The complex multivariate structure together with nonlinear behavior of these systems makes it parameter estimation a challenging task, which negatively affects operational reliability and system lifespan. …”
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Pain, Function, and Elastosonographic Assessment After Shockwave Therapy in Non-Calcific Supraspinatus Tendinopathy: A Retrospective Observational Study by Gabriele Santilli, Antonello Ciccarelli, Milvia Martino, Patrizia Pacini, Francesco Agostini, Andrea Bernetti, Luca Giuliani, Giovanni Del Gaudio, Massimiliano Mangone, Vincenzo Colonna, Mario Vetrano, Maria Chiara Vulpiani, Giulia Stella, Samanta Taurone, Federico Vigevano, Vito Cantisani, Marco Paoloni, Pietro Fiore, Francesca Gimigliano

“…SWE proved to be a reliable method for monitoring structural and clinical changes in SNCCT. Further research, including randomized controlled trials, is recommended to confirm these findings and explore longer-term outcomes.…”
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Novel UAV-based 3D reconstruction using dense LiDAR point cloud and imagery: A geometry-aware 3D gaussian splatting approach by Kai Qin, Jing Li, Sisi Zlatanova, Haitao Wu, Yin Gao, Yuchen Li, Sizhe Shen, Xiangjun Qu, Zhiyuan Yang, Zhenxin Zhang, Banghui Yang, Shaoyi Wang

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Non-typhoidal Salmonella among slaughterhouse workers and in the pork value chain in selected districts of Uganda by Velma Kivali, Velma Kivali, Velma Kivali, Kristina Roesel, Kristina Roesel, Ian Dohoo, Lordrick Alinaitwe, Lordrick Alinaitwe, Lordrick Alinaitwe, Lordrick Alinaitwe, James Katamba Bugeza, James Katamba Bugeza, Jolly Justine Hoona, Denis Rwabiita Mugizi, Denis Rwabiita Mugizi, Clovice Kankya, Sinh Dang-Xuan, Sinh Dang-Xuan, Istvan Szabo, Uwe Rösler, Anika Friese, Elizabeth A. J. Cook, Elizabeth A. J. Cook

“…Antimicrobial resistance profiles were determined using tube microdilution and Sensititre® EUVSEC3® plates. Semi- structured questionnaires with 35 questions were used to collect data on demographics, work related risk factors and activities outside the slaughterhouse.Results and discussionOverall NTS prevalence was 19.2% (365/1899). …”
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Effectiveness of a multicomponent intervention to promote physical activity during the school day: rationale and methods of the MOVESCHOOL study by Francisco J. Bandera-Campos, Francisco J. Bandera-Campos, Alberto Grao-Cruces, Alberto Grao-Cruces, Daniel Camiletti-Moirón, Daniel Camiletti-Moirón, Fátima Martín-Acosta, Fátima Martín-Acosta, Raúl Muñoz-González, María González-Pérez, María González-Pérez, Abel Ruiz-Hermosa, Abel Ruiz-Hermosa, Miguel Vaquero-Solís, Miguel Vaquero-Solís, Carmen Padilla-Moledo, Carmen Padilla-Moledo, David Sánchez-Oliva, David Sánchez-Oliva, David Sánchez-Oliva

“…Additionally, qualitative data were gathered through semi-structured individual interviews and focus groups, and information will be evaluated with thematic analysis.DiscussionThe MOVESCHOOL study represents a pioneering effort in Spain, being the first of its kind to evaluate the effectiveness of a multicomponent programme in secondary schools. …”
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A rare haplotype of the GJD3 gene segregating in familial Meniere’s disease interferes with connexin assembly by Alba Escalera-Balsera, Paula Robles-Bolivar, Alberto M. Parra-Perez, Silvia Murillo-Cuesta, Han Chow Chua, Lourdes Rodríguez-de la Rosa, Julio Contreras, Ewa Domarecka, Juan Carlos Amor-Dorado, Andrés Soto-Varela, Isabel Varela-Nieto, Agnieszka J. Szczepek, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez

“…The connexin monomer and the homomeric connexon structural models were predicted using AlphaFold2 and HDOCK. …”
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“A cure might help, but it won't erase it all”: a qualitative study of policy challenges and priorities for long‐term survivors of HIV in the United States by Ali Ahmed, Jeff Taylor, Rachel Lau, Joyce Ching‐Jung Lai, Sithara Deshan Diunugala, Michael Louella, Thomas J. Villa, William Freshwater, Dawn Averitt, Maile Karris, Jeff Berry, Lynda Dee, Karine Dubé

“…Using inductive thematic analysis, we identified key policy concerns and recommendations based on participants’ lived experiences. Data collection continued until thematic saturation was reached. …”
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Rapid escalation and release of risks to forest ecosystems triggered by warming: Insights from tree growth synchrony in temperate forests by Liangjun Zhu, Danyang Yuan, J. Julio Camarero, David J. Cooper, Mai-He Li, Shuguang Liu, Xiaochun Wang, Paolo Cherubini

“…These results provide crucial insights for forest management practice to enhance structural diversity and resilience capacity against climate change-induced synchrony shifts.…”
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How national leaders keep ‘us’ safe: A longitudinal, four-nation study exploring the role of identity leadership as a predictor of adherence to COVID-19 non-pharmaceutical interven... by Niklas K Steffens, S Alexander Haslam, Svenja B Frenzel, Nina M Junker, Aidos Bolatov, Valerie A Erkens, Jan A Häusser, Ronit Kark, Ines Meyer, Andreas Mojzisch, Lucas Monzani, Stephen D Reicher, Adil Samekin, Sebastian C Schuh, Liliya Sultanova, Dina Van Dijk, Llewellyn E van Zyl, Rolf van Dick

“…Hypotheses testing was conducted with structural equation modelling.Setting Data collection during the COVID-19 pandemic in China, Germany, Israel and the USA in April/May 2020 and four weeks later.Participants Adults in China (n=548, 66.6% women), Germany (n=182, 78% women), Israel (n=198, 51.0% women) and the USA (n=108, 58.3% women).Measures Identity leadership (assessed by the four-item Identity Leadership Inventory Short-Form) at Time 1, perceived shared national identification (PSNI; assessed with four items) and adherence to health-protective NPIs (assessed with 10 items that describe different health-protective interventions; for example, wearing face masks) at Time 2.Results Identity leadership was positively associated with PSNI (95% CI 0.11 to 0.30, p&lt;0.001) in all countries. …”
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The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking by Jia-Qi Wang, Jia-Qi Wang, Yuan-Yu Liang, Yuan-Yu Liang, Zhong-Xue Zhao, Zhong-Xue Zhao, Wei Xie, Wan-Ning Sun, Wan-Ning Sun, Ji-Yu Zou, Ji-Yu Zou, Xiao-Dong Lv, Xiao-Dong Lv, Youfu He, Li-Jian Pang, Li-Jian Pang

“…Gender-stratified analysis showed that the risk burden of smoking was higher in older men in Asia, whereas the high BMI-related burden was higher in women in more developed regions.ConclusionThis study demonstrates a structural shift in the composition of asthma risk factors among older adults, with high BMI emerging as a dominant contributor amid declining traditional behavioral risks such as smoking. …”
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Analysis of the Impact of Effectiveness of Media (Seda-va-Sima) Advertisement on the Extent of Consumers’ Urge to Consume National Commodities by Abolfazl Danaei

“…Descriptive statistics were used to investigate the respondents' demographic characteristics, and inferential statistics, structural equation, and path analysis were used to analyze data and test hypothesis. …”
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Health poverty reduction effect of medical insurance in China’s middle-aged and elderly populations: a cross-sectional study by Haijun Yang, Rui Chen, Ye Li, Qunhong Wu, Linghan Shan, Bing Wu, Fang Yin, Yiyun Zhang, Yongqiang Lai, Xinwei Liu, Wanxin Tian, Xiyu Zhang, Yujuan Xu, Wenqing Miao, Baoguo Shi, Feifei Leng

“…Objectives In the context of demographic structure and disease spectrum changes: to study the role of the medical insurance system in providing protection and risk resilience for middle-aged and elderly vulnerable groups who are prone to impoverishment by medical expenses (IME), identify the vulnerable points and propose recommendations for improving the medical insurance system.Setting The research used data from the 2018 China Health and Retirement Longitudinal Study.Participants 9184 households were included in the research ultimately.Primary and secondary outcome measures We use the WHO’s recommended composite measure of disease-related poverty and algorithm to determine the occurrence of IME in households. …”
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Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors by Sara Boi, Silvia Puxeddu, Ilenia Delogu, Domenica Farci, Dario Piano, Aldo Manzin, Matteo Ceccarelli, Fabrizio Angius, Mariano Andrea Scorciapino, Stefan Milenkovic

“…The automated protocol presented here could be used to inspect, in silico, many alternatives of a given molecular structure, with the output being the list of the best candidates to be then synthesized and tested. …”
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Interface characterization of Cu18150/Al1060/Cu18150 laminated composite produced by combined cast-roll and hot-roll technique by Mahmoud Ebrahimi, Yuchao Zhao, Huisheng Cai, Shokouh Attarilar, Zhengping Shang, Qudong Wang

“…Scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) analyses elucidate the formation of IMCs at the interfaces, with predicted formation sequences influenced by Gibbs free energy data. Electron backscatter diffraction (EBSD) analysis indicates that hot rolling promotes grain refinement in Cu18150, resulting in a homogeneous structure with elongated fine grains, while Al1060 shows nonuniform grain distribution. …”
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Identification and Analysis of <i>KAS II</i>, <i>FAT</i>, <i>SAD</i>, and <i>FAD</i> Gene Families in <i>Hippophae rhamnoides</i> by Alexander A. Arkhipov, Ekaterina M. Dvorianinova, Anastasia A. Turba, Roman O. Novakovskiy, Yury A. Zubarev, Pavel A. Predushchenko, Elizaveta A. Sigova, Daiana A. Zhernova, Elena V. Borkhert, Elena N. Pushkova, Chengjiang Ruan, Nataliya V. Melnikova, Alexey A. Dmitriev

“…As a result of structure and phylogenetic analyses, 4 <i>KAS II</i>, 8 <i>FAT</i>, 9 <i>SAD</i>, and 12 <i>FAD</i> genes were identified in the <i>H. rhamnoides</i> genome, which were classified into subfamilies: <i>KAS II, FATA</i>, <i>FATB</i>, <i>FAD2</i>, <i>FAD3</i>, <i>FAD6</i>, and <i>FAD7/8</i>. …”
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Differential effects of oral versus intravenous hydrocortisone and dexamethasone on capillary blood glucose levels in adult inpatients − a single centre study by Vaishali Limbachia, Ian Nunney, Daniel J. Page, Hannah A. Barton, Leena K. Patel, Georgia N. Thomason, Stephan L. Green, Kieran F.J. Lewis, Ketan Dhatariya

“…An auto-regressive covariance structure was employed to model correlations between repeated measurements. …”
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Whole-Genome Resequencing to Identify Selection Signatures Associated with High Fertility in Lüliang Black Goat by Xu Wang, Zhenqi Zhou, Xinrui Chai, Jie Li, Wannian Wang, Zhixu Pang, Lifen Cheng, Caihong Cheng, Liying Qiao, Yangyang Pan, Kaijie Yang, Wenzhong Liu, Jianhua Liu

“…Based on whole-genome resequencing data, this study comprehensively assessed the population structure and genetic diversity of LBG and explored the related genes that affect reproductive performance. …”
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