Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design by Xuanming Hong, Hui Cao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Ruqin Gao, Min Yu, Jinyi Zhou, Xianping Wu, Yu Liu, Shengli Yin, Wenjing Gao, Liming Li

“…Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in these associations are limited. Results Using data from 1,074 twins in the Chinese National Twin Registry and bivariate structural equation models (SEMs), we investigated the phenotypic (Rph), genetic (Ra), and environmental (Re) correlations between genome-wide DNAm and three obesity indices: BMI, waist circumference (WC), and waist-to-hip ratio (WHR). …”
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An inner membrane complex protein IMC1g in Plasmodium berghei is involved in asexual stage schizogony and parasite transmission by Yinjie Liu, Shitong Cheng, Gang He, Dawei He, Duo Wang, Sicong Wang, Lumeng Chen, Liying Zhu, Yonghui Feng, Liwang Cui, Yaming Cao, Xiaotong Zhu

“…Together, this work reveals an essential role of IMC1g in the parasite life cycle and suggests that IMC1 family members likely contribute to parasite gliding and invasion.IMPORTANCEThe malaria parasite’s inner membrane complex is critical to maintain its structural integrity and motility. Here, we identified the function of the IMC1g protein, a member of the IMC1 family, in invasive and proliferative stages of P. berghei. …”
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Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma by Qiwei Zhao, Qiwei Zhao, Yu Wang, Yu Wang, Long Ding, Long Ding, Zhuang Li, Zhuang Li, Mengyang Wang, Yueqing Huang, Qiushi Cao, Qiushi Cao, Yaqin Sun, Yaqin Sun, Xiaohong Guo, Xiaohong Guo

“…In this study, we aimed to validate whether CAP induces ferroptosis in TSCC and to elucidate the underlying mechanisms.MethodsCell viability in HN6 and CAL27 cells was assessed using CCK-8 assays. Mitochondrial structural changes were observed via transmission electron microscopy (TEM). …”
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Relative vacuum reduction innovative processes applied in primary magnesium production—Comprehensive analysis of thermodynamics, resource, energy flow, and carbon emission by Xiaolong Li, Tingan Zhang, Yan Liu, Junhua Guo, Jingzhong Xu, Yuanyuan Liang

“…Magnesium and magnesium alloys, serving as crucial lightweight structural materials and hydrogen storage elements, find extensive applications in space technology, aviation, automotive, and magnesium-based hydrogen industries. …”
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The alternative prey hypothesis revisited: Still valid for willow ptarmigan population dynamics. by Jo Inge Breisjøberget, Morten Odden, Per Wegge, Barbara Zimmermann, Harry Andreassen

“…In order to better understand the role of these potential changes in community structure on an alternative prey species, willow ptarmigan Lagopus lagopus, we analyzed nine years of population census data from SE Norway to investigate how community interactions affected their population dynamics. …”
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Raising Awareness of Canine, Feline and Human Dirofilariosis in Aveiro, Portugal: A One Health Perspective by Joana Esteves-Guimarães, José Alberto Montoya-Alonso, Jorge Isidoro Matos, Elmano Ramalheira, Elena Carretón, Ivan Rodríguez-Escolar, Alfonso Balmori-de la Puente, Manuel Collado-Cuadrado, Rodrigo Morchón, Ana Patrícia Fontes-Sousa

“…The coastal district of Aveiro, Portugal, marked by its unique hydrographic structure, Ria de Aveiro, and a concerning rise in heartworm disease, was the focus of our study. …”
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PiezoSight: Coupling vision based tactile sensor neural network processing and piezoresistive stimulation for enhanced piezo-vision hybrid sensing by Abdullah Solayman, Hussain Sajwani, Oussama Abdul Hay, Rui Chang, Laith AbuAssi, Abdulla Ayyad, Yahya Zweiri, Yarjan Abdul Samad

“…This study presents PiezoSight, an encapsulated graphene-soaked textile in a stretchable elastomeric structure integrated with a VBTS. Piezosight overcomes VBTS weaknesses so that from the piezoresistive graphene textile, PiezoSight can detect a wide range of forces for robotic perception applications, varying from tiny forces for a soft touch and slip detection starting at 0.01 N up to an elevated force of 8 N. …”
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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals by Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang, Christoph Schramm, Johannes Fuss

“…Abstract Background Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. …”
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Edible microcapsules containing canola oil for cultivated meat production by Juliano Douglas Silva Albergaria, Ana Elisa Antunes dos Santos, Jorge Luís Melo Guadalupe, Isabella Paula de Araújo, Aline Gonçalves Lio Copola, João Paulo Ferreira Santos, Erika Cristina Jorge, Luciana de Oliveira Andrade, Aline Bruna da Silva

“…Fourier Transform Infrared Spectroscopy (FTIR) further validated the chemical structure of the materials. Microsphere stability in aqueous media was also evaluated. …”
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Transfer Learning Empowered Multiple‐Indicator Optimization Design for Terahertz Quasi‐Bound State in the Continuum Biosensors by Shengfeng Wang, Bingwei Liu, Xu Wu, Zuanming Jin, Yiming Zhu, Linjie Zhang, Yan Peng

“…However, prior approaches primarily establish one‐to‐one mappings between structure and optical response, neglecting the trade‐offs among key performance indicators. …”
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The genome landscape of the Xinglong buffalo by Yuan Chai, Shiyuan Li, Hui Wu, Yong Meng, Yujing Fu, Hong Li, Guansheng Wu, Junming Jiang, Taoyu Chen, Yuqing Jiao, Qiaoling Chen, Li Du, Lianbin Li, Churiga Man, Si Chen, Hongyan Gao, Wenguang Zhang, Fengyang Wang

“…The population genetic structure analysis indicates that at K = 3, the Xinglong buffalo for the first time showed a distinct ancestral origin from other water buffalo. …”
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Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits by Dennis Witt, Marc Sturm, Antje Stäbler, Benita Menden, Lisa Ruisinger, Kristin Bosse, Ines Gruber, Andreas Hartkopf, Silja Gauß, German Demidov, Nicolas Casadei, Elena Buena Atienza, Kira Mehnert, Janna Witt, Caspar Gross, Leon Schütz, Christopher Schroeder, Stephan Ossowski, Andreas Dufke, Tobias B. Haack, Olaf Riess, Ulrike Faust

“…GS offers a wealth of information, including the improved detection of structural variants, copy number variants, and parallel detection of complex genetic markers. …”
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Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy by Jiahui Mai, Jing Duan, Xiaoyu Chen, Liqin Liu, Dachao Liang, Tao Fu, Gang Lu, Wai Yee Chan, Xufeng Luo, Feiqiu Wen, Jianxiang Liao, Zhuo Li, Xinguo Lu

“…We used the optical genome mapping (OGM) technology to detect and analyze uncommon mutations or structural variations (SVs) within the DMD gene, thus contributing to more precise clinical diagnoses. …”
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CTV-MIND: A cortical thickness-volume integrated individualized morphological network model to explore disease progression in temporal lobe epilepsy by Xinyan Liu, Jiaqi Han, Xiating Zhang, Boxuan Wei, Lu Xu, Qilin Zhou, Yuping Wang, Yicong Lin, Jicong Zhang

“…This study aimed to investigate progressive changes in TLE by constructing a novel individualized morphological brain network based on T1-weighted structural magnetic resonance imaging (MRI). MRI data were collected from 34 postoperative seizure-free TLE patients and 28 age- and sex-matched healthy controls (HC), with patients divided into LONG-TERM and SHORT-TERM groups. …”
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Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study by Ken-ei Sada, Shuhei Yoshida, Kenji Saito, Yuya Fujita, Eisuke Inoue, Kiyoshi Migita, Naoki Matsuoka, Hiroshi Kajiyama, Ryusuke Yoshimi, Kunihiro Ichinose, Yoshia Miyawaki, Shigeru Ohno, Nobuyuki Yajima, Yasuhiro Shimojima, Shuzo Sato, Michio Fujiwara, Keisuke Nishimura, Takashi Kida, Yuya Sumichika, Haruki Matsumoto, Jumpei Temmoku, Tomoyuki Asano, Shotaro Ogawa, Jumpei Fukita, Yusuke Matsuo, Takahisa Onishi

“…Statistical analyses employed marginal structural models with stabilised inverse probability of treatment weighting to adjust for confounders.Results The analysis included 1004 patients; the incidence of severe infections was 6.5% in the MMF group and 7.5% in the non-MMF group, with no significant difference (OR 0.69, 95% CI 0.34 to 1.39). …”
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The mediating role of physical activity avoidance in the association between weight stigma and physical activity by Po-Ching Huang, Hung-Ching Wu, Ji-Kang Chen, Xavier C.C. Fung, Nadia Bevan, Daniel Kwasi Ahorsu, Mark D. Griffiths, Jung-Sheng Chen, Kuo-Hsin Lee, Amir H. Pakpour, Chung-Ying Lin

“…Results: Structural equation modeling showed that weight-related self-stigma was significantly associated with PA avoidance (standardized coefficient [β] = 0.67, p < 0.01), and negatively associated with PA (β = −0.14, p < 0.01). …”
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Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia by Melanie A. Matyi, Hamsanandini Radhakrishnan, Christopher A. Olm, Jeffrey S. Phillips, Philip A. Cook, Emma Rhodes, James C. Gee, David J. Irwin, Corey T. McMillan, Lauren Massimo

“…Given that behavioral variant frontotemporal degeneration (bvFTD) is a neurodegenerative disease associated with executive dysfunction and selective vulnerability of the salience network, we tested the hypotheses that bvFTD structural networks are de-differentiated compared to cognitively normal controls (CNC) and that network de-differentiation relates to worse executive function. …”
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Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains by Yue Xiang, Saixian Zhang, Yi Huang, Zhuqing Zheng, Jiahui Sun, Qiulin Zhao, Peng Zhou, Xiaolong Qi, Jingjin Li, Fuyang Xiong, Jing Xu, Shengquan Wang, Liangliang Fu, Xinyun Li

“…Abstract Background Pig brains serve as a valuable biomedical model for studying brain-related diseases due to their significant structural similarities to the human brain. Furthermore, the long-term domestication and artificial selection of domestic pigs have profoundly shaped their brains, making them an interesting subject for research. …”
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THE INFLUENCE OF HEART RATE VARIABILITY ON CLINICAL COURSE OF CHRONIC HEART FAILURE AND RENAL FUNCTION IN ATRIAL FIBRILLATION PATIENTS by E. A. Polyanskaya, S. V. Mironova, N. A. Koziolova

“…Aim. Evaluation of structural and functional condition of the left ventricle (LV) and kidneys in permanent atrial fibrillation patients (AF) with ischemic chronic heart failure (CHF) according to mean 24 hour heart rate and heart rate variability.Material and methods. …”
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Impact of job crafting and work engagement on the mental and physical health of palliative care nurses by Ateya Megahed Ibrahim, Donia Elsaid Fathi Zaghamir, Mohamed Gamal Elsehrawy, Hassanat Ramadan Abdel-Aziz, Samia Eaid Elgazzar, Fathia Gamal Elsaid Hassabelnaby, Heba Ahmed Osman Mohamed, Nahed Abd Elazeem Abd Elsalam

“…Results The study revealed a positive correlation between job crafting behaviours and physical health (r = 0.52, p < 0.001) and a negative correlation between job crafting behaviors and mental health distress (r = -0.56, p < 0.001). The structural equation modeling (SEM) results demonstrated significant paths from job crafting to both physical health (β = 0.40) and mental health distress (β = -0.45), indicating that job crafting positively affects physical health and negatively affects mental health distress. …”
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