Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. …”
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Study on the incremental carbon sink of tea plantations under spatio-temporal variation characteristics by Yaxiang Pan, Yaxiang Pan, Jingling Bao, Jingling Bao, Yuxuan Ji, Yuxuan Ji, Wen Li, Wen Li, Weiyu Lin, Shuisheng Fan, Shuisheng Fan, Shuisheng Fan, Liyu Mao, Liyu Mao

“…The results show that: (1) During the period of 2010–2022, the total carbon sink of tea plantations in Fujian Province increased by 133.12 × 105Mg, showing a continuous growth trend; in terms of spatial distribution, the intensity of tea plantation carbon sinks in the study area showed a gradual and present trend of migration and concentration from the southwest to the northeast. (2) Construct the evaluation index system of carbon sinks in tea plantations, divided into social, living, industrial and population factors and other four categories of eight indicators. (3)The single-factor driver of tea plantation carbon sinks shows that it is mainly affected by industrial scale, population density and industrial structure, with q-values exceeding 0.5. (4)The interaction of the drivers shows that the urban-rural disparity and industrial scale have the highest interaction effect, with q-values reaching 0.9698. …”
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Atmospheric Boundary Layer Stability in Urban Beijing: Insights from Meteorological Tower and Doppler Wind Lidar by Linlin Wang, Bingcheng Wan, Yuanjian Yang, Sihui Fan, Yi Jing, Xueling Cheng, Zhiqiu Gao, Shiguang Miao, Han Zou

“…The limited understanding of the structure of the urban surface atmospheric boundary layer can be attributed to its inherent complexity, as well as a deficiency in comprehensive measurements. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…In this sense, the current study explored the influence of normotensive and hypertensive postnatal environments on the intestinal microbiota structure, composition, and functional capacity of SHR and Wistar rats. …”
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Clinical and epidemiological characteristics of imported intestinal infections in children by E. Yu. Pylaeva, N. N. Zverevа, А. А. Erovichenkov, S. K. Pylaeva, E. A. Artamonova, N. Yu. Pshenichnaya, A. M. Demkina, O. N. Solodovnikova, Yu. N. Khlypovka, A. Yu. Dyagileva, A. Kh. Nurpeysova, A. U. Berestovskaia, O. V. Shamsheva, D. N. Protsenko

“…Imported intestinal infections most often occurred with symptoms of gastroenteritis, were assessed by CDS at 5 points, and rotavirus predominated in the etiological structure.…”
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Comparative analysis of mitochondrial genomes in lycoperdaceae fungi reveals intron dynamics and phylogenetic relationships by Xianyi Wang, Guoyu Wang, Jiawei Tao, Zhongyao Guo, Guangyin Xu, Jiayu Li, Jichuan Kang, Qin Zuo, Hongmei Liu, Qirui Li

“…However, mitochondrial genome data for the Lycoperdaceae family is insufficient, and investigating its structure offers valuable insights into the evolutionary relationships between puffball fungi and other Agaricales taxa. …”
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Unveiling host-genetic drivers of caecal microbial communities in chickens through genome-wide association studies by Ankit Hinsu, Xiaoxia Dai, Christos Dadousis, Christos Dadousis, Melanie Hay, Bruno Fosso, Matteo Crotta, Ramesh Pandit, Javier Guitian, Fiona Tomley, Prakash Koringa, Chaitanya Joshi, Chaitanya Joshi, Damer Blake, Androniki Psifidi

“…Whole-genome sequencing data were then used to further investigate candidate regions around significantly associated variants from the high-density DNA array. …”
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A novel gene linked to Imipenem resistance in E. coli isolate lacking known Imipenem-resistance genes by Trang Thu Hoang, Huyen Thanh Thi Le, Sang Ngoc Nguyen, Ung Dinh Nguyen, Tuan Ngoc Tran, Cuong Hung Nguyen, Thang Quang Truong, Nam S. Vo, Duc Quang Le, Son Hoang Nguyen, Minh Duc Cao, Thi Minh Ngoc Dao, Thi Huyen Bui, Thu An Nguyen, Thi Lan Anh Pham, Thi Bich Thao Le, Tho Huu Ho

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Trait-mediated responses and co-occurrence patterns of breeding steppe birds under human footprint in Inner Mongolia by Wenyu Xu, Chunlu Wang, Yanqi Wang, Xi Yang, Lishi Zhang, Piotr Tryjanowski, Frédéric Jiguet, Zheng Han, Haitao Wang

“…This study investigates how human impacts affect the distribution and community structure of breeding steppe birds in Inner Mongolia, a biodiversity hotspot in Asia. …”
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Longitudinal Immunoprofiling of the CD8⁺ T-Cell Response in SARS-CoV-2 mRNA Vaccinees and COVID-19 Patients by Jesús Emanuel Brunetti, Beatriz Escudero-Pérez, Fátima Lasala, Gonzalo Rivas, Mikel Mancheño-Losa, David Rial-Crestelo, Jaime Lora-Tamayo, Dániel Cadar, Miles Carroll, Rafael Delgado, César Muñoz-Fontela, Estefanía Rodríguez

“…Of note, we have observed variations in the memory subset structure at every stage of disease and vaccination. …”
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Deciphering genetic characteristics of South China and North China indigenous pigs through selection signatures by Yahui Gao, Xueyan Feng, Shuqi Diao, Yuqiang Liu, Zhanming Zhong, Xiaotian Cai, Guangzhen Li, Jinyan Teng, Xiaohong Liu, Jiaqi Li, Zhe Zhang

“…Population structure analysis using PCA revealed distinct genetic clustering among these populations. …”
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Assessing the quality of care in primary health care facilities in all municipalities in Kosovo 2016–2023 by Astrid M. Knoblauch, Astrid M. Knoblauch, Sarah Rajkumar, Sarah Rajkumar, Robert Canavan, Robert Canavan, Qamile Ramadani, Ariana Bytyçi Katanolli, Shegë Bahtiri, Debra Stevenson, Debra Stevenson, Debra Stevenson, Merita Stavileci Mustafa, Nicu Fota, Nicu Fota, Nicu Fota, Jana Gerold, Jana Gerold

“…However, substantial challenges remain, particularly among managing non-communicable diseases (NCD) like diabetes and hypertension, due to gaps in structural and procedural aspects. The Accessible Quality Healthcare project (2016–2027) aimed at improving the health of the Kosovar population by strengthening the quality of PHC services with a specific focus on NCDs. …”
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Confirmatory study on the retention rate of ketogenic diet therapy and related factors in children with drug‐resistant epilepsy: A single‐center cohort study by Jie Zhang, Qiang Gu, Yuan Wu, Han Xie, Cuijie Wei, Yao Zhang, Taoyun Ji, Xinhua Bao, Xingzhi Chang, Yuehua Zhang, Yuwu Jiang, Ye Wu

“…Results A total of 337 patients were included. 43.3% (146/337) of the patients had only spasms, 16.9% (57/337) had a genetic etiology, and 14.0% (47/337) had a structural etiology. Overall, 51.9% (175/337) of the patients were classified as having infantile epileptic spasm syndrome. …”
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Element Nucleosynthetic Origins from Abundance Spatial Distributions beyond the Milky Way by Zefeng Li, Mark R. Krumholz, Anna F. McLeod, A. Mark Swinbank, Emily Wisnioski, J. Trevor Mendel, Francesco Belfiore, Giovanni Cresci, Giacomo Venturi, Jia-Lai Kang

“…These findings both open a new avenue to test nucleosynthetic models and make predictions for the structure of stellar chemical abundance distributions.…”
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A 14-bp motif in the KIT active promoter region is critical for melanin accumulation in yaks, mice, and humans by Xinfeng Liu, Tongcheng Wang, Zeyu Zheng, Congcong Dong, Wenyu Liu, Zhimin Niu, Yingbo Yang, Xiaoyun Wu, Qiang Qiu, Yongzhi Yang, Kexin Li, Johannes A. Lenstra, Ping Yan, Minghui Kang, Bowen Li, Lingzhao Fang, Jianquan Liu

“…Results Using whole-genome sequencing data from 387 yaks, we analyzed the population genetic structure of all-white yaks and discovered that they clustered into two distinct genetic groups. …”
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Echoes of 1816: microbial footprints in heritage artifacts from Argentina’s museum of independence by Daniel Gonzalo Alonso-Reyes, Daniel Gonzalo Alonso-Reyes, Fátima Silvina Galván, Fátima Silvina Galván, Natalia Noelia Alvarado, Natalia Noelia Alvarado, María Cecilia D’Arpino, María Cecilia D’Arpino, Luciano José Martinez, Luciano José Martinez, Hernán José Esquivel, Cecilia Aymara Gallardo, María Julia Silva Manco, María Julia Silva Manco, Virginia Helena Albarracín, Virginia Helena Albarracín, Virginia Helena Albarracín, Virginia Helena Albarracín

“…Selected isolates were further subjected to genomic analysis.ResultsSEM imaging revealed diverse and well-structured biofilms with intricate three-dimensional architectures embedded in extracellular polymeric substances. …”
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MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway by Cong Liu, Jinjin Xiang, Yueqin Chen, Chang He, Jun Tong, Yinglin Liao, Huangyi Lei, Lingyun Sun, Genhong Yao, Zhenggao Xie

“…MSC-sEVs decreased the accumulation of ROS and improved the structure and function of mitochondria of Müller cells with AGEs treatment. …”
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Symbiotic microalgae and microbes: a new frontier in saline agriculture by Cheng-Gang Ren, Cun-Cui Kong, Si-Ming Li, Xiao-Jing Wang, Xiao Yu, Yin-Chu Wang, Yin-Chu Wang, Song Qin, Song Qin, Hong-Li Cui

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Development and Evaluation of Hydrogel-Based Sulfasalazine-Loaded Nanosponges for Enhanced Topical Psoriasis Therapy by Sunil Kumar, Anroop B. Nair, Varsha Kadian, Pooja Dalal, Babu Lal Jangir, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Nouf Alwadei, Rekha Rao

“…<b>Results:</b> Physiochemical data confirms nanoscale architecture, drug inclusion in nanosponges, crystalline structure, and formulation stability. …”
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AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis by M. Niiranen, M. Niiranen, P. Bendel, P. Bendel, J. Koikkalainen, J. Lötjönen, T. Selander, E. Solje, E. Solje, P. Hartikainen, S. Simula, R. Vanninen, R. Vanninen, A. M. Portaankorva

“…Based on this study, the corpus callosum is a crucial structure in monitoring disease progression in BRRMS.…”
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