Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes by Tobias Brünger, Alina Ivaniuk, Eduardo Pérez-Palma, Ludovica Montanucci, Stacey Cohen, Lacey Smith, Shridhar Parthasarathy, Ingo Helbig, Michael Nothnagel, Patrick May, Dennis Lal

“…Across ten genes encoding voltage-gated sodium channels and 22 expert-curated disorders, we identify cross-paralog correlated phenotypes based on 3D structure spatial position. For example, multiple established loss-of-function related disorders across SCN1A, SCN2A, SCN5A, and SCN8A show overlapping spatial variant clusters. …”
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Functional Analysis of <i>Penicillium expansum</i> Glucose Oxidase-Encoding Gene, <i>GOX2</i>, and Its Expression Responses to Multiple Environmental Factors by Yongcheng Yuan, Yutong Ru, Xiaohe Yuan, Shuqi Huang, Dan Yuan, Maorun Fu, Wenxiao Jiao

“…It is either an integrated membrane protein (such as a receptor or channel) that is directly anchored to the membrane through a transmembrane structure or a non-classical secreted protein that is secreted extracellularly. …”
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Some issues of local drinking water supply of the population during martial law (using the example of Ukrainian cities with a population of over 100 thousand people). Part 2 by Yu. F. Rudenko, N. A. Yurkova, O. V. Gural, V. Yu. Saprykin

“…Considering the high potential risks of damage from massive weapons to urban agglomerations with a high population density and infrastructure facilities within residential areas, reliable supply of drinking water to the social structure is one of the most important factors in the life support of the population. …”
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Extending isolation by resistance to predict genetic connectivity by Robert J. Fletcher Jr, Jorge A. Sefair, Nicholas Kortessis, Roldolfo Jaffe, Robert D. Holt, Ellen P. Robertson, Sarah I. Duncan, Andrew J. Marx, James D. Austin

“…Our empirical example highlights that the SAMC better predicts population structure than circuit theory and least‐cost analysis by acknowledging asymmetric environmental gradients (i.e. slope) and migration mortality in this species. …”
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Whole genome insights into genetic diversity, introgression, and adaptation of Yunnan indigenous cattle of Southwestern China by Xiwen Guan, Weixuan Xiang, Kaixing Qu, Zulfiqar Ahmed, Jianyong Liu, Ming Cai, Jicai Zhang, Ningbo Chen, Chuzhao Lei, Bizhi Huang

“…Results Herein, we employed 140 whole-genome sequencing data from Yunnan indigenous cattle across eight breeds to elucidate their genetic diversity and population structure. …”
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A Systematic Analysis of Meteorological Parameters in Predicting Rainfall Events by Muhammad Salman Pathan, Pardhu Nadella, Yasin Ul Haq, Soumini Chaudhury, Jiantao Wu, Avishek Nag, Soumyabrata Dev

“…However, due to the complexity and dynamic structure of climate systems, rainfall prediction is a difficult task. …”
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Synthesis of <i>bis</i>-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines by Dorota Olender, Anna Pawełczyk, Anna Leśków, Katarzyna Sowa-Kasprzak, Lucjusz Zaprutko, Dorota Diakowska

“…In this study, we synthesized chalcone compounds with <i>bis</i>-chalcone’s chemical structure under microwave (MW) and microwave–ultrasound (MW-US) conditions and compared them to chalcones produced using the classical synthesis method. …”
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Exploring the feasibility of integrating ultra‐high field magnetic resonance imaging neuroimaging with multimodal artificial intelligence for clinical diagnostics by Yifan Yuan, Kaitao Chen, Youjia Zhu, Yang Yu, Mintao Hu, Ying‐Hua Chu, Yi‐Cheng Hsu, Jie Hu, Qi Yue, Mianxin Liu

“…The superior spatial resolution of 7TMRI provides detailed visualizations of brain structure, which are crucial forunderstanding complex central nervous system diseases and tumors. …”
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Quantitative risk assessment and eco-engineering mitigation strategies for debris flows utilizing dynamic process simulation in Shuzheng gully, Jiuzhaigou valley scenic and histori... by Dongxu Yang, Dongxu Yang, Xin Zong, Bin Wu, Yiming Wang, Binqi Liang, Fangkai Wan, Jiankang Liu, Jiansong Peng

“…The PPGD raises the erosion base level to dissipate impact energy and features a stepped gabion structure that promotes progressive solid-liquid separation, thereby reducing sediment concentration and enhancing ecological resilience. …”
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DSF2-NAS: Dual-Stage Feature Fusion via Network Architecture Search for Classification of Multimodal Remote Sensing Images by Shiyang Feng, Zhaowei Li, Bo Zhang, Tao Chen, Bin Wang

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Global trends in thermal burn burden, 1990–2021: a comprehensive analysis for the global burden of disease study 2021 by Yuke Zhang, Qingsong Chen, Ru Wang, Linfen Guo, Peiyu Li, Ke Deng, Haitao Xiao, Xuewen Xu

“…Decomposition analysis was performed to quantify the relative contributions of epidemiological changes, age structure shifts, and population growth to the thermal burn burden. …”
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Proteomic study of the inhibitory effects of tannic acid on MRSA biofilm by Yang Miao, Wang Shuang, Qu Qianwei, Liu Xin, Peng Wei, Yang Hai, Zhou Yonghui, Yu Xinbo

“…Differentially expressed proteins (DEPs) were screened using proteomic and biological information analyses, and their transcriptional levels were verified using real-time quantitative polymerase chain reaction.ResultsThe MIC of TA was 0.625 mg/mL, whereas 1/2 MIC (0.3125 mg/mL) of TA significantly inhibited biofilm formation without affecting the bacterial growth (p &lt; 0.01) and prevented the formation of a complete three-dimensional biofilm structure. Using 1/2 MIC of TA, 208 DEPs were identified, of which 127 were upregulated and 81 were downregulated. …”
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Implications of Fermionic Dark Matter Interactions on Anisotropic Neutron Stars by Premachand Mahapatra, Chiranjeeb Singha, Ayush Hazarika, Prasanta Kumar Das

“…Furthermore, increasing the coupling ( g ) between DM and its mediator leads to the formation of a core–halo structure, with a DM halo surrounding the baryonic matter. …”
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Applicability of Adults 2015 American Thyroid Association Differentiated Thyroid Cancer Guidelines for Postoperative Risk Stratification and Postradioiodine Treatment Dynamic Risk... by Shashank Shekhar Singh, Bhagwant Rai Mittal, Ashwani Sood, Anish Bhattacharya, Ganesh Kumar, Amit Singh Shekhawat, Harpreet Singh

“…Forty-seven patients were classified as responders (excellent and indeterminate responses) and incomplete responders (biochemical and structurally incomplete responses) by assessing the RTT at 1.5 years follow-up similar to recommendation of 2015 adult DTC ATA guidelines. …”
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Correlation between mitral annular plane systolic excursion (MAPSE) at different degrees of ejection fraction in patients with diabetes mellitus by Muhammad Rido, Khalid Saleh, A. Makbul Aman, Syakib Bakri, Haerani Rasyid, Andi Alfian Zainuddin

“…Diabetic cardiomyopathy is characterized by myocardial structure and function abnormality in the absence of other cardiovascular risk factors. …”
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Outer membrane protein OMP76 of Riemerella anatipestifer contributes to complement evasion and virulence by binding to duck complement factor vitronectin by Sen Li, Yanhua Wang, Rongkun Yang, Xiaotong Zhu, Hongying Bai, Xiaojian Deng, Jiao Bai, Yang Zhang, Yuncai Xiao, Zili Li, Zhengfei Liu, Zutao Zhou

“…Combining tertiary structure analysis and homology modelling, truncated and knocked-out fragments of OMP76 showed that a cluster of critical amino acids in an extracellular loop of OMP76 mediate the interaction with dVn. …”
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Monitoring <i>Moringa oleifera</i> Lam. in the Mediterranean Area Using Unmanned Aerial Vehicles (UAVs) and Leaf Powder Production for Food Fortification by Carlo Greco, Raimondo Gaglio, Luca Settanni, Antonio Alfonzo, Santo Orlando, Salvatore Ciulla, Michele Massimo Mammano

“…This study presents an integrated approach using Unmanned Aerial Vehicles (UAVs) equipped with multispectral and thermal cameras to monitor the vegetative performance and determine the optimal harvest period of four <i>M. oleifera</i> genotypes in a Mediterranean environment. High-resolution data were collected and processed to generate the NDVI, canopy temperature, and height maps, enabling the assessment of plant vigor, stress conditions, and spatial canopy structure. …”
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The Role of RNA Polymerase II Contiguity and Long-Range Interactions in the Regulation of Gene Expression in Human Pluripotent Stem Cells by Livia Eiselleova, Viktor Lukjanov, Simon Farkas, David Svoboda, Karel Stepka, Irena Koutna

“…The eukaryotic nucleus is a highly complex structure that carries out multiple functions primarily needed for gene expression, and among them, transcription seems to be the most fundamental. …”
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Domain Knowledge Decomposition for Cross-Domain Few-Shot Scene Classification From Remote Sensing Imagery by Can Li, He Chen, Yin Zhuang, Liang Chen, Lianlin Li

“…First, a cross-domain pseudo-label decomposed learning structure is proposed for DKD to facilitate domain-common knowledge transfer and correct interference with domain-specific knowledge. …”
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Effects of the Gully Land Consolidation Project on soil properties and carbon stocks of farmland in the Chinese Loess Plateau by Zeqiong Qiu, Tingjun Gong, Xiaocao Chen, Xia Yu, Qixin Wu, Yanling An, Jie Zeng

“…These results indicate that although the GLC project can improve soil structure and water retention capacity, it may also lead to the loss of surface SOC, thereby reducing soil fertility. …”
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