Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites by Wisam A. Dawood, Gillian M. Fisher, Josefa Kremeyer, Fabian Fischer, Jessica L. Home, Christopher D. Goodman, Kwong Sum Lam, Alexander G. Maier, Thomas Kurz, Katherine T. Andrews

“…Furthermore, 4o was found to stabilise PfHDAC1 in P. falciparum protein lysates using solvent-induced protein stability Western blot assays with anti-PfHDAC1 antibody. Together, these data provide new structure-activity relationship and mechanistic insights on pentyloxyamide-based HDAC inhibitors as potential therapeutic starting points for malaria.…”
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Deep learning-based computational approach for predicting ncRNAs-disease associations in metaplastic breast cancer diagnosis by Saleem Ahmad, Imran Zafar, Shaista Shafiq, Laila Sehar, Hafsa Khalil, Nida Matloob, Mehvish Hina, Sidra Tul Muntaha, Hamid Khan, Najeeb Ullah Khan, Samreen Rana, Ahsanullah Unar, Muhammad Azmat, Muhammad Shafiq, Yousef A. Bin Jardan, Musaab Dauelbait, Mohammed Bourhia

“…SHAP analysis identified key sequence motifs (e.g., "UUG") and structural free energy (ΔG = − 12.3 kcal/mol) as critical predictors, validated by PCA (82% variance) and t-SNE clustering. …”
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Accounting for temporal and spatial autocorrelation to examine the effects of climate change on vegetation greenness trend in China by Lingwei Chen, Likai Zhu, Cuiyutong Yang, Zizhen Dong, Rui Huang, Jijun Meng, Min Liu

“…This method considers temporal and spatial autocorrelation structure, and aggregates pixel information to rigorously test the hypotheses about regional patterns. …”
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Molecular epidemiology of Neisseria gonorrhoeae isolates in Russia, 2015–2023: current trends and forecasting by Ilya Kandinov, Boris Shaskolskiy, Dmitry Kravtsov, Anatoliy Larkin, Alexei Kubanov, Marina Shpilevaya, Julia Shagabieva, Nikita Nosov, Dmitry Gryadunov

“…Two clusters of isolates pose a particular threat to Russia: NG-MAST G2212, linked to MLST 1901/1902, carries a mosaic structure in the penA gene; G12302, linked to MLST 9363, contains mosaic alleles in the mtrR and mtrD genes. …”
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A life cycle thinking-based environmental risk framework for screening sustainable feedstocks in early-stage bioeconomy projects by George Bishop, Carmen Girón-Domínguez, James Gaffey, Maeve Henchion, Réamonn Fealy, Jesko Zimmermann, Wriju Kargupta, David Styles

“…Criteria are proposed to structure evaluation of (i) probability and (ii) severity of environmental impact, in relation to four categories of feedstock: primary (determining product), high-value by-product, low-value by-product, and waste. …”
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Decentralized fintech platforms adoption intention in cyber risk environment among GenZ: A dual-method approach using PLS-SEM and necessary condition analysis by Md Sharif Hassan, Nguyen Hong Mai, Nor Shaipah Abdul Wahab, Mohammad Bin Amin, Md Maruf Hassan, Judit Oláh

“…A total of 391 valid responses were received. The data were analyzed through partial least squares structural equation modeling (PLS-SEM) and necessary condition analysis (NCA). …”
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Charting the path to the implementation of universal health coverage policy in Nigeria through the lens of Delphi methodology by Jibril M. Bashar, Sulaiman Hadiza, Ozoilo J. Ugochi, Lawal S. Muhammad, Adeoye Olufemi, Ukoh Eberechi, Yakubu Agada-Amade, Alhassan Yusuf, Abdulhamid H. Abdullahi, Hassan S. Musa, Ahmad A. Ibrahim, Kalu-Umeh Nnennaya, Jennifer Anyanti, Dayyabu Yusuf, Kenneth Okoineme, Jennifer Adebambo, Samuel O. Ikani, Dennis Aizobu, Musa Abubakar, Babandi S. Zaharaddeen, Lawal Aminu, Yusuf H. Wada

“…These seven priority areas that have been identified include enrolment, equity, organizational health and structure, data and technology, quality, market efficiency, and citizen engagement. …”
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Comparison of Molnupiravir Exposure‐Response Relationships for Virology Response and Mechanism of Action Biomarkers With Clinical Outcomes in Treatment of COVID‐19 by Akshita Chawla, Ruthie Birger, Brian M. Maas, Youfang Cao, Hong Wan, Julie Strizki, Arthur Fridman, Amanda Paschke, Carisa deAnda, Wei Gao, Matthew L. Rizk, Wendy Painter, Wayne Holman, Susanne Sardella, George Painter, Julie A. Stone

“…Exposure‐response (E‐R) analyses for viral RNA mutation rate and virologic outcomes were conducted using data from three phase 2/3 studies of molnupiravir (P006, MOVe‐IN, and MOVe‐OUT). …”
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Genomic investigation of NDM-1 producing Enterobacterales transmission in a South Korean hospital by Jeong-Ih Shin, Sun Hee Park, Chulmin Park, Seung-Hyun Jung, Dong-Gun Lee

“…These plasmids contained conserved mobile genetic elements, including the IS26-dsbD-trpF-ble-blaNDM-1 structure. Conclusions: This study highlights the dual roles of clonal spread and plasmid-mediated horizontal gene transfer in the dissemination of blaNDM-1 in hospital settings. …”
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Mapping rapeseed (Brassica napus L.) aboveground biomass in different periods using optical and phenotypic metrics derived from UAV hyperspectral and RGB imagery by Chuanliang Sun, Chuanliang Sun, Weixin Zhang, Genping Zhao, Qian Wu, Wanjie Liang, Ni Ren, Hongxin Cao, Lidong Zou, Lidong Zou

“…Vegetation indices (VI), texture features (TF), and structural features (SF) were extracted from UAV hyperspectral and ultra-high-resolution RGB images to assess their correlation with rapeseed biomass at different growth stages. …”
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Isolation, Identification, and Molecular Genetic Characteristics of a Pathogenic Strain of <i>Streptococcus suis</i> Serotype 3 by Longbai Wang, Jingli Qiu, Bing He, Xuemin Wu, Qiuyong Chen, Quanxi Wang, Renjie Wu, Bohan Zheng, Lunjiang Zhou, Xiaohong Huang

“…Different <i>S. suis</i> serotypes exhibit diverse characteristics in population structure and pathogenicity. Epidemiology data underscore the importance of <i>S. suis</i> serotype 3 (SS3). …”
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Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicryResearch in context by Xin Ma, Jian Zhang, Qianling Jiang, Yong-Xin Li, Guan Yang

“…Of note, half of these analogs could bind to MHC II and interact with TCR through structural modeling of the interaction using fine-tuned AlphaFold. …”
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Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure by Zhenglong Guo, Yunfei Liu, Zhiming Zhou, Jianchao Chen, Lin Guo, Keke Liang, Yibin Hao, Bingtao Hao, Bin Yang, Shixiu Liao

“…Conclusions These findings suggest that the epigenetic dysregulation of cardiac stress-response and structural genes contributes to the pathogenesis of DCM-HF. …”
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School nutrition programs in Dubai: a landscape analysis by Reem AlGurg, Reem AlGurg, Nour Abu Mahfouz, Farah Otaki, Farah Otaki, Agnes Paulus, Agnes Paulus, Amar Hassan Khamis, Mohamad Alameddine

“…The stakeholders involved in developing and maintaining the respective SNPs and the intended outcomes of those programs also differed across the schools.ConclusionThis study highlights, in alignment with Sustainable Development Goals 3, 4, 9 and 17, the importance of the proposed reformation around SNPs in Dubai to take into account the governance structure on the local and national levels, quality assurance measures, stakeholder engagement, and programs’ intended outcomes and compositions. …”
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Gut microbiota characteristics in neonatal respiratory distress syndrome and the therapeutic potential of probiotics in recovery by Yongcheng Fu, Xiujuan Wang, Lintao Nie, Zhaorui Wang, Xiao Ma, Lijia Wu, Liping Han, Wenjun Fu, Ruoming Wang, Hongyan Ren, Da Zhang, Juan Ding

“…Probiotic intervention notably restored the gut microbiota structure in the NRDS group, particularly by enhancing the abundance of beneficial genera such as Streptococcus, Bifidobacterium, and Clostridium. …”
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A systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein by Juan José Valenzuela-Fuenzalida, Benjamín Rodríguez-Osorio, Cristian Salgado-Torres, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandro Bruna-Mejías, Roberto Avila-Sepulveda, Álvaro Becerra-Farfán, Macarena Rodríguez-Luengo, Juan Sanchis-Gimeno, Guinevere Granite, Héctor Gutiérrez-Espinoza

“…Tree authors independently performed the search, study selection and data extraction. Methodological quality was evaluated with an assurance tool for anatomical studies. …”
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Effects of perinatal variables on echocardiographic assessments of left ventricular dimensions in infants born large for gestational age: a prospective cohort analysis by Ahmed Amarah, Ibrahim Elmakaty, Iram Nadroo, Manoj Chhabra, Danthanh Hoang, Debbie Suk, Ali M. Nadroo, Nitin Ron, Beata Dygulska, Madhu B. Gudavalli, Pramod Narula, Ashraf Gad

“…Certain perinatal variables were identified as key determinants affecting various aspects of LV structure. These insights highlight the importance of considering these perinatal factors in neonatal cardiac assessments for early detection and intervention.…”
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Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project by Linda Sharp, Sarah Bailey, Colin Rees, Willie Hamilton, Dawn Craig, Joe West, David Humes, Gary Abel, James Turvill, Brian Nicholson, Chloe Thomas, Jim Chilcott, Colin Crooks, Olena Mandrik, John Whelpton

“…Cost-effectiveness improves as risk thresholds rise. High structural uncertainty around cancer progression during diagnostic delay and diagnosis of other serious bowel diseases considerably affects cost-effectiveness.Conclusions COLOFIT is likely to be more cost-effective than FIT alone and could help alleviate pressure on diagnostic services. …”
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A systematic review on environmental DNA (eDNA) Science: An eco-friendly survey method for conservation and restoration of fragile ecosystems by Ashish Sahu, Mahender Singh, Adnan Amin, Monisa Mehboob Malik, Shariq Nazir Qadri, Adnan Abubakr, S.Surya Teja, Shabir Ahmad Dar, Ishtiyaq Ahmad

“…The conservation and restoration of fragile ecosystems and their genetic resources depends on precisely assessing species diversity and richness, understanding spatiotemporal dynamics, and stock structure analysis. Traditional monitoring methods like visual surveys, physical captures, individual counting, sibling or cryptic species identification, and immature life stages (juveniles) of animals are often intrusive, time-consuming, and provide rough estimates. …”
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Impact of residential density on heavy metal mobilization in urban soils: Human activity patterns and eco-health risks in the Beijing-Tianjin-Hebei region by Siyu Wang, Lingqing Wang, Xiaoyong Liao, Guangjin Zhou, Yizhong Huan, Shun Li, Tao Liang

“…Co-occurrence network and Partial Least Squares Structural Equation Modeling (PLS-SEM) suggested that human activities may indirectly influence metal dispersion by altering soil organic carbon (TOC) and nitrogen dynamics, rather than directly increasing bulk metal content. …”
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