Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia by Haeun Yang, Vladimir Li, Su Jung Park, Sang Won Cheon, Anne Lorant, Aloran Mazumder, Jin Young Lee, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Gilbert Kirsch, Dag Erlend Olberg, Guy Bormans, Hyoung Jin Kang, Byung Woo Han, Michael Schnekenburger, Marc Diederich

“…Methods and results Structural and biochemical analyses confirmed the efficient and selective binding of martinostat to HDAC isoenzyme ligand-binding pockets, resulting in histone and tubulin hyperacetylation in both imatinib-sensitive and resistant CML cells, outperforming vorinostat, a clinically used HDAC inhibitor (HDACi). …”
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PiezoSight: Coupling vision based tactile sensor neural network processing and piezoresistive stimulation for enhanced piezo-vision hybrid sensing by Abdullah Solayman, Hussain Sajwani, Oussama Abdul Hay, Rui Chang, Laith AbuAssi, Abdulla Ayyad, Yahya Zweiri, Yarjan Abdul Samad

“…A machine learning LSTM model was used to train the data for different designs for using such sensors in unsupervised environments.…”
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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals by Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang, Christoph Schramm, Johannes Fuss

“…Abstract Background Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. …”
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Edible microcapsules containing canola oil for cultivated meat production by Juliano Douglas Silva Albergaria, Ana Elisa Antunes dos Santos, Jorge Luís Melo Guadalupe, Isabella Paula de Araújo, Aline Gonçalves Lio Copola, João Paulo Ferreira Santos, Erika Cristina Jorge, Luciana de Oliveira Andrade, Aline Bruna da Silva

“…Fourier Transform Infrared Spectroscopy (FTIR) further validated the chemical structure of the materials. Microsphere stability in aqueous media was also evaluated. …”
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Transfer Learning Empowered Multiple‐Indicator Optimization Design for Terahertz Quasi‐Bound State in the Continuum Biosensors by Shengfeng Wang, Bingwei Liu, Xu Wu, Zuanming Jin, Yiming Zhu, Linjie Zhang, Yan Peng

“…However, prior approaches primarily establish one‐to‐one mappings between structure and optical response, neglecting the trade‐offs among key performance indicators. …”
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Workload, job, and family satisfaction in dual-earning parents with adolescents: the mediating role of work-to-family conflict by Berta Schnettler, Berta Schnettler, Berta Schnettler, Berta Schnettler, Andrés Concha-Salgado, Ligia Orellana, Ligia Orellana, Mahia Saracostti, Katherine Beroiza, Héctor Poblete, Germán Lobos, Cristian Adasme-Berríos, María Lapo, Leonor Riquelme-Segura, José A. Sepúlveda, José A. Sepúlveda, Karol Reutter, Enid Thomas

“…Mothers and fathers completed assessments about workload, WtoFC, and the Overall Job Satisfaction Scale, while all three family members responded to the Satisfaction with Family Life Scale.ResultsThe data were analyzed using the mediation Actor-Partner Interdependence Model and structural equation modeling. …”
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The genome landscape of the Xinglong buffalo by Yuan Chai, Shiyuan Li, Hui Wu, Yong Meng, Yujing Fu, Hong Li, Guansheng Wu, Junming Jiang, Taoyu Chen, Yuqing Jiao, Qiaoling Chen, Li Du, Lianbin Li, Churiga Man, Si Chen, Hongyan Gao, Wenguang Zhang, Fengyang Wang

“…The population genetic structure analysis indicates that at K = 3, the Xinglong buffalo for the first time showed a distinct ancestral origin from other water buffalo. …”
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The clinical spectrum associated with ERCC5 mutations: Is there a relationship between phenotype and genotype? by Jinpeng Zhang, Jiannan Ma, Yuanyuan Luo, Siqi Hong, Li Jiang, Tianyi Li

“…The gene mutation has not been reported and was predicted to seriously affect the protein structure. According to a review of 59 cases of ERCC5 mutations, cerebrooculofacioskeletal syndrome (COFS) occurred in 16 cases, XP in 19 cases, and XP/CS in 24 cases. …”
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Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation by Chelsy Chesterman, Thomas Desautels, Luz-Jeannette Sierra, Kathryn T. Arrildt, Adam Zemla, Edmond Y. Lau, Shivshankar Sundaram, Jason Laliberte, Lynn Chen, Aaron Ruby, Mark Mednikov, Sylvie Bertholet, Dong Yu, Kate Luisi, Enrico Malito, Corey P. Mallett, Matthew J. Bottomley, Robert A. van den Berg, Daniel Faissol

“…The top mutant identified underwent biophysical and x-ray crystallographic characterization to confirm that the overall structure of fHbp was maintained throughout this epitope engineering experiment. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. …”
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Title: race and ethnicity and the risk of community-acquired third-generation cephalosporin-resistant uropathogens: a systematic review and meta-analysis by Sweta Balaji, Sarah Blackmon, Esther E. Avendano, Samson Alemu Argaw, Rebecca A. Morin, Nanguneri Nirmala, Shira Doron, Maya L. Nadimpalli

“…Conclusions: As antibiotic resistance rises in community settings, our findings support the need to understand the structural issues that underpin differential risk of 3GC-R uropathogens across race and ethnicity. …”
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Tertiary cancer center results of sterilized auto-graft prosthetic osteo-articular complex reconstruction following bone tumor resection by Himanshu Rohela, Anupam Lahiri, Irfan Ahmed, Kundan Singh Chufal, Kripa Mishra, Rajan Arora

“…Background: Bone tumor resections necessitate complex reconstruction methods to maintain limb function and structural integrity. Various approaches, including tumor prostheses and biological reconstructions, offer distinct advantages and disadvantages. …”
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Study on the incremental carbon sink of tea plantations under spatio-temporal variation characteristics by Yaxiang Pan, Yaxiang Pan, Jingling Bao, Jingling Bao, Yuxuan Ji, Yuxuan Ji, Wen Li, Wen Li, Weiyu Lin, Shuisheng Fan, Shuisheng Fan, Shuisheng Fan, Liyu Mao, Liyu Mao

“…In this study, we selected the data of nine prefecture-level cities in Fujian Province, a major province of tea industry, from 2010 to 2022, and borrowed the standard deviation ellipse and trend surface analysis methods to clarify the spatial and temporal evolution of the carbon sinks in tea plantations, and combined with the geodetic detector model to explore the driving factors of spatial differentiation. …”
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Atmospheric Boundary Layer Stability in Urban Beijing: Insights from Meteorological Tower and Doppler Wind Lidar by Linlin Wang, Bingcheng Wan, Yuanjian Yang, Sihui Fan, Yi Jing, Xueling Cheng, Zhiqiu Gao, Shiguang Miao, Han Zou

“…The limited understanding of the structure of the urban surface atmospheric boundary layer can be attributed to its inherent complexity, as well as a deficiency in comprehensive measurements. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…In this sense, the current study explored the influence of normotensive and hypertensive postnatal environments on the intestinal microbiota structure, composition, and functional capacity of SHR and Wistar rats. …”
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Clinical and epidemiological characteristics of imported intestinal infections in children by E. Yu. Pylaeva, N. N. Zverevа, А. А. Erovichenkov, S. K. Pylaeva, E. A. Artamonova, N. Yu. Pshenichnaya, A. M. Demkina, O. N. Solodovnikova, Yu. N. Khlypovka, A. Yu. Dyagileva, A. Kh. Nurpeysova, A. U. Berestovskaia, O. V. Shamsheva, D. N. Protsenko

“…Imported intestinal infections most often occurred with symptoms of gastroenteritis, were assessed by CDS at 5 points, and rotavirus predominated in the etiological structure.…”
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Comparative analysis of mitochondrial genomes in lycoperdaceae fungi reveals intron dynamics and phylogenetic relationships by Xianyi Wang, Guoyu Wang, Jiawei Tao, Zhongyao Guo, Guangyin Xu, Jiayu Li, Jichuan Kang, Qin Zuo, Hongmei Liu, Qirui Li

“…However, mitochondrial genome data for the Lycoperdaceae family is insufficient, and investigating its structure offers valuable insights into the evolutionary relationships between puffball fungi and other Agaricales taxa. …”
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Unveiling host-genetic drivers of caecal microbial communities in chickens through genome-wide association studies by Ankit Hinsu, Xiaoxia Dai, Christos Dadousis, Christos Dadousis, Melanie Hay, Bruno Fosso, Matteo Crotta, Ramesh Pandit, Javier Guitian, Fiona Tomley, Prakash Koringa, Chaitanya Joshi, Chaitanya Joshi, Damer Blake, Androniki Psifidi

“…Whole-genome sequencing data were then used to further investigate candidate regions around significantly associated variants from the high-density DNA array. …”
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A novel gene linked to Imipenem resistance in E. coli isolate lacking known Imipenem-resistance genes by Trang Thu Hoang, Huyen Thanh Thi Le, Sang Ngoc Nguyen, Ung Dinh Nguyen, Tuan Ngoc Tran, Cuong Hung Nguyen, Thang Quang Truong, Nam S. Vo, Duc Quang Le, Son Hoang Nguyen, Minh Duc Cao, Thi Minh Ngoc Dao, Thi Huyen Bui, Thu An Nguyen, Thi Lan Anh Pham, Thi Bich Thao Le, Tho Huu Ho

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Trait-mediated responses and co-occurrence patterns of breeding steppe birds under human footprint in Inner Mongolia by Wenyu Xu, Chunlu Wang, Yanqi Wang, Xi Yang, Lishi Zhang, Piotr Tryjanowski, Frédéric Jiguet, Zheng Han, Haitao Wang

“…This study investigates how human impacts affect the distribution and community structure of breeding steppe birds in Inner Mongolia, a biodiversity hotspot in Asia. …”
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