A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1 by Trina Saha, Dipanjan Karati

“…Conclusion The most frequent BIN1 variants are found in non-coding regions immediately upstream of the gene, and it is thus likely that their impact is regulatory and not structural. The variants can influence the levels of BIN1 or splicing between isoforms, especially the distribution of isoforms. …”
Get full text

Leaf Morpho-Anatomy of Twelve <i>Cymbidium</i> (Orchidaceae) Species from China and Their Taxonomic Significance by Xiangke Hu, Lei Tao, Jialin Huang, Kaifeng Tao, Dong Ma, Lu Li

“…<i>Cymbidium</i> are endangered and ornamental orchids, and the taxonomy and species identification of this genus have been debated due to some overlapping morphological features between taxa and limited data being available. The leaf morpho-anatomy of 12 <i>Cymbidium</i> species from China was investigated using light microscopy and paraffin sectioning. …”
Get full text

Molecular Determinants for the Binding of the Highly Infectious SARS-CoV-2 Omicron (BA.1) Variant to the Human ACE2 Receptor by Majed S. Aljohani, Pawan Bhatta, Xiche Hu

“…Additionally, allosteric effects improve the contributions of non-mutated residues (notably A475, Y453, and F486) via structural realignment and novel hydrogen bonding with ACE2 residues such as S19, leading to an overall increase in the electrostatic and π-system interaction energy. …”
Get full text

Scientific and pedagogical staff as a social community in the changing conditions of academic development by G. E. Zborovsky, P. A. Ambarova

“…The main results of the study presented in the article were quantitative, structure and substantive characteristics of the social community of the SPS. …”
Get full text

Diversity and equity in medical education over the past decade: applications, matriculations, and the growing gaps by Gang Lv, Xiangxiang Jiang, Jordan Franklin, Minghui Li, Jing Yuan, Z. Kevin Lu

“…Methods This study used data from the Association of American Medical Colleges from 2015 to 2024. …”
Get full text

Association of workplace support for health with occupational health literacy and illness avoidance: moderated mediation by functioning through a salutogenic lens by Nestor Asiamah, Isaac Aidoo, Etornam Doamekpor, Emelia Sarpong, Emelia Danquah, Cosmos Yarfi, Eric Eku, Usman Yaw Baidoo, Christiana Afriyie Manu, Rita Sarkodie Baffoe

“…., WSH, OHL, functioning, and illness avoidance) were measured with Likert-type scales adopted in whole from the literature. Data were analysed with Hayes’ Process Model through structural equation modelling. …”
Get full text

PSYCHOLOGICAL READINESS OF SECONDARY VOCATIONAL EDUCATION TEACHERS FOR MASTERING NEW ACTIVITIES IN THE CONTEXT OF PROFESSIONAL REORIENTATION by I. I. Khasanova, S. S. Kotova

“…The functionality of this technology, its tasks, structural components, possible methods and estimated effects of its implementation in practice of the SPE (Secondary Professional Education) system are noted.Practical significance. …”
Get full text

Update of the safety assessment of N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amines (FCM No 19) and N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amine hydrochlorides (FCM No 20) for their use in... by EFSA Panel on Food Contact Materials (FCM), Claude Lambré, Riccardo Crebelli, Maria daSilva, Konrad Grob, Evgenia Lampi, Maria Rosaria Milana, Marja Pronk, Mario Ščetar, Georgios Theodoridis, Els Van Hoeck, Nadia Waegeneers, Claudia Bolognesi, Ronan Cariou, Laurence Castle, Emma Di Consiglio, Roland Franz, Detlef Wölfle, Zainab Al Harraq, Eric Barthélémy, Daniele Comandella, Julia Fontán Vela, Blanka Halamoda, Gilles Rivière

“…This exception for infant foods and the restriction for maximum thickness do not apply to caps of bottles; (ii) the migration does not exceed 5 mg/kg food; (iii) the source of the alkyl group is either from hydrogenated vegetable oil or synthetic from ethylene oligomers with a high degree of linear structure and (iv) the impurities do not exceed 5% w/w. …”
Get full text

Enhancing Accessibility in Philippine Public Bus Systems: Addressing the Needs of Persons with Disabilities by Ma. Janice J. Gumasing, Timothy Ray P. Del Castillo, Antoine Gabriel L. Palermo, Janred Thien G. Tabino, Josiah T. Gatchalian

“…Structural equation modeling (SEM) was used to analyze the hypothesized relationships between these variables, passenger satisfaction, and intention to reuse public transport. …”
Get full text

Viral activity in lake analogs of anoxic early Earth oceans by Natascha S. Varona, Bailey A. Wallace, Alice Bosco-Santos, Julianna Mullinax, Alexandra K. Stiffler, Molly D. O’Beirne, Josh Ford, James M. Fulton, Josef P. Werne, William P. Gilhooly, Cynthia B. Silveira

“…This suggests that viral lysis may contribute less to bacterial community structuring in these high-density microbial plates. …”
Get full text

Therapeutic potential of miR-204-5p in intervertebral disc degeneration: targeting the SSRP1/NF-κB pathway to inhibit apoptosis by Chenhao Zhao, Qiuwei Li, Cailiang Shen

“…This study investigated the protective role of miR-204-5p in IVDD by targeting the Structure-specific recognition protein-1(SSRP1)/nuclear factor-kappa B (NF-κB) signaling pathway. …”
Get full text

Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study by Mohammad K. Parvez, Md. Tabish Rehman, Perwez Alam, Mohammed S. Al-Dosari, Saleh I. Alqasoumi, Mohammed F. Alajmi

“…Being the most important drug target, a 3-D structure of HBV polymerase (Pol/RT) was modeled and docked with the active compounds, including lamivudine as standard. …”
Get full text

A descriptive analysis of significant factors influencing the behavioral intention to adopt robot kiosks/service robots in service stores: Integrating the UTAUT and higher-order SE... by Dioseph Andre F. Anduyo, Ardvin Kester S. Ong, Maela Madel L. Cahigas, Ma. Janice J. Gumasing, Dhonn Q. Tomas

“…Utilizing the integrated Unified Theory of Acceptance and Use of Technology (UTAUT) model and SERVQUAL 5 dimensions higher-ordered structural equation modeling approach, the study found that tangibles (β: 0.807), empathy (β: 0.782), responsiveness (β: 0.765), assurance (β: 0.711), reliability (β: 0.646), and behavioral intention (β: 0.104) significantly affected customer satisfaction. …”
Get full text

Development of a Method for Obtaining Nanoscale Magnesium Carbonate Stabilized with Chitosan as the Basis of Scaffold Matrices for Regenerative Medicine by A. V. Blinov, Z. A. Rekhman, A. A. Gvozdenko, M. A. Yasnaya, M. A. Kolodkin, M. A. Taravanov

“…The creation of three-dimensional matrices based on scaffolds for the formation of systems that are as close as possible to bone tissue in structure has been studied. It is known that the active substances of the scaffold matrix can be hydroxyapatite, tricalcium phosphate, as well as silicates, carbonates of magnesium, calcium, copper, zinc, and manganese. …”
Get full text

Emergence and evolution of rare ST592 blaNDM-1-positive carbapenem-resistant hypervirulent Klebsiella pneumoniae in China by Huan Zhang, Su Dong, Caiping Mao, Yuejuan Fang, Junjie Ying

“…The antimicrobial susceptibility testing data revealed that KPZM16 possesses an extensively drug-resistant (XDR) profile, whereas KPZM6 is a susceptible K. pneumoniae. …”
Get full text

Evaluation of tissue computed tomography number changes and dosimetric shifts after conventional whole-breast irradiation in patients undergoing breast-conserving surgery by Joo Hwan Lee, Dong Soo Lee, So Hyun Park, Young Kyu Lee, Jeong Soo Kim, Yong Seok Kim

“…Dosimetric parameters (V 105% , V 103% , V 100% , V 98% , V 95% , V 90% : V x% indicates volumes which receive X% of prescribed doses) between initial and re-sim CT scans were compared. The CT number data (CT mean , CT max , CT min ) of the original and irradiated CT (re-sim CT) scans from each representative structure (lung, rib bone, soft tissue, muscle, etc.) were examined and recruited. …”
Get full text

The Chain Mediating Effect of Health Literacy and Self-Care Ability on the Relationship Between Dysmenorrhea Symptoms and Negative Emotions Among Chinese Female College Students by Luo Y, Liu D, Sun G, Lu Y, Fang M, Zhang Y, Xu C, Bai G, Chen C

“…Multiple linear regression analysis was conducted to analyze the effects of variables with statistically significant differences (P < 0.05) identified through one-way ANOVA, independent sample t-tests, and correlation analysis on psychological levels. Structural Equation Modeling (SEM) was used to explore mediating effects.Results: This study shows that dysmenorrhea symptoms, health literacy, self-care ability, and negative emotions are significantly correlated. …”
Get full text

Airway epithelial cell-specific deletion of EGFR modulates mucoinflammatory features of cystic fibrosis-like lung disease in mice by Ishita Choudhary, Kshitiz Paudel, Rahul Kumar, Amit Sharma, Sonika Patial, Yogesh Saini

“…The airway epithelial cell-specific EGFR-deficient wild-type (WT) mice did not exhibit any obvious structural and functional defects in the lungs. The deletion of EGFR in airway epithelial cells in Tg+ mice, however, resulted in increased recruitment of neutrophils and macrophages into the lung airspaces, which was accompanied by significantly increased bronchoalveolar lavage fluid (BALF) levels of inflammatory mediators, including KC, G-CSF, MIP-2, MIP-1α, TNF-α, and MIP-1β. …”
Get full text

SELECTION CRITERIA OF COMPOUNDS FOR DEVELOPMENT OF HIGH-POTENT ANALGESICS AND OTHER CNS DRUGS by A. V. Sosnov, F. M. Semchenko, V. N. Tohmahchi, A. A. Sosnova, M. I. Vlasov, A. S. Radilov, D. V. Krivorotov

“…In order to analyze best practices, develop a strategy for highly effective controlled medicinal and veterinary drugs (analgesics, anesthetics, antidotes and other vital therapies) and coordinate theirdevelopment and production it is necessary to create competent management structure combining the tasks of provision of civilian population and personnel of national defense agencies of effective and safe drugs.…”
Get full text

Formation of Adaptive and Integrative Potential of Children with Mental Retardation in Artistic and Creative Activities by O. A. Denisova, T. V. Gudina, I. A. Bukina, O. L. Lekhanova, A. V. Selina

“…Zuckermann), etc. The obtained data were processed through a mathematical method of assessing the significance of differences using the Spearman’s rank correlation coefficient.Results and scientific novelty. …”
Get full text