Cognitive gains and cortical thickness changes after 12 weeks of resistance training in older adults with low and high risk of mild cognitive impairment: Findings from a randomized... by Simona Kušleikienė, Gal Ziv, Wouter A.J. Vints, Erika Krasinskė, Milda Šarkinaite, Orgesa Qipo, Ivan Bautmans, Uwe Himmelreich, Nerijus Masiulis, Vida J. Česnaitienė, Oron Levin

“…Background: In this randomized controlled trial, we assessed the neuroprotective effect of a 12-week resistance training (RT) program on executive control and cortical thickness of the prefrontal, temporal, parietal, and central cortex, regions prone to structural decline in individuals with mild cognitive impairment (MCI). …”
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Clinical relevance of loss-of-function mutations of NEMO/IKBKG by Jin Wang, Kexin Shen, Hongxia Lou, Lina Zhou, Yunfei An, Xiaodong Zhao, Yuan Ding

“…Almost all cases of hyper-IgM occurred in patients with EDA-ID. Different structural domains correspond to symptoms with varying degrees of severity. …”
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Advances in diffuse glial tumors diagnosis by Luis Filipe de Souza Godoy, Vitor Ribeiro Paes, Aline Sgnolf Ayres, Gabriela Alencar Bandeira, Raquel Andrade Moreno, Fabiana de Campos Cordeiro Hirata, Frederico Adolfo Benevides Silva, Felipe Nascimento, Guilherme de Carvalho Campos Neto, Andre Felix Gentil, Leandro Tavares Lucato, Edson Amaro Junior, Robert J. Young, Suzana Maria Fleury Malheiros

“…This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. …”
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Assessing the quality of care in primary health care facilities in all municipalities in Kosovo 2016–2023 by Astrid M. Knoblauch, Astrid M. Knoblauch, Sarah Rajkumar, Sarah Rajkumar, Robert Canavan, Robert Canavan, Qamile Ramadani, Ariana Bytyçi Katanolli, Shegë Bahtiri, Debra Stevenson, Debra Stevenson, Debra Stevenson, Merita Stavileci Mustafa, Nicu Fota, Nicu Fota, Nicu Fota, Jana Gerold, Jana Gerold

“…However, substantial challenges remain, particularly among managing non-communicable diseases (NCD) like diabetes and hypertension, due to gaps in structural and procedural aspects. The Accessible Quality Healthcare project (2016–2027) aimed at improving the health of the Kosovar population by strengthening the quality of PHC services with a specific focus on NCDs. …”
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Confirmatory study on the retention rate of ketogenic diet therapy and related factors in children with drug‐resistant epilepsy: A single‐center cohort study by Jie Zhang, Qiang Gu, Yuan Wu, Han Xie, Cuijie Wei, Yao Zhang, Taoyun Ji, Xinhua Bao, Xingzhi Chang, Yuehua Zhang, Yuwu Jiang, Ye Wu

“…Methods This was a single‐center cohort study. Baseline data were collected, and regular follow‐up was conducted after KDT treatment. …”
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HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines by Agnieszka Gogler, Agata Małgorzata Wilk, Damian Robert Sojka, Małgorzata Adamiec-Organiściok, Natalia Matysiak, Daria Kania, Klaudia Wiecha, Ewa Małusecka, Alexander Jorge Cortez, Dawid Zamojski, Michał Marczyk, Agnieszka Maria Mazurek, Sylwia Oziębło, Dorota Scieglinska

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The effects of parent-child relationship, study stress, and mobile phone use on depressive symptoms among Chinese elementary school students: a moderated mediation model by Yiting Kong, Yiting Kong, Zhewei Su, Zhewei Su, Rui Wang, Rui Wang, Jianyu Tan, Jianyu Tan, Yuancen Zhong, Yuancen Zhong, Ming Ai, Ming Ai, Wo Wang, Wo Wang, Su Hong, Su Hong, Qi Zhang, Qi Zhang, Li Kuang, Li Kuang

“…This study investigated the association between parent-child relationship and depressive symptoms among Chinese elementary school students while testing a moderated mediation model to examine the mediating role of significant study stress and the moderating effect of frequent mobile phone use on this relationship.MethodsWe recruited elementary school students from grades 3 to 6 in S district of Chongqing, China, totaling 33,285 participants (51.72% girls; mean age = 10.36 years, SD = 1.24). Data was analyzed using structural equation modeling to assess the mediating and moderating effects of study stress and mobile phone use, respectively, on the relationship between parent-child relationship and depressive symptoms.ResultsDepressive symptoms prevalence in our study population was 16.3%. …”
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Development and Assessment of a New Multichannel Electrocutaneous Device for Non-Invasive Somatosensory Stimulation for Magnetic Resonance Applications by Carolina Travassos, Alexandre Sayal, Paulo Fonte, Bruno Direito, Luis Lopes, Nuno Carolino, Sonia Afonso, Tania Lopes, Teresa Sousa, Miguel Castelo-Branco

“…Next, the device’s capacity to generate perceptible tactile sensations and user acceptability were assessed by testing the device on a single participant outside the MR environment. Finally, structural and functional data were acquired from three participants during a somatosensory stimulation experiment as a proof of concept to confirm the brain activity elicited by stimulation. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…Current propagation efforts face significant challenges, including low natural germination rates, and dependence on specific habitats and obligate mycorrhizal fungi, precluding the development of efficient large-scale cultivation and seedling production systems.ConclusionMarked progress has been made in characterizing small-molecule metabolites of G. conopsea, yet comprehensive structural elucidation of polysaccharides remains incomplete. …”
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OP-13 CHOLANGIOCARCINOMA IN LATIN AMERICA: A MULTICENTER OBSERVATIONAL STUDY ALERTS ON ETHNICAL DISPARITIES IN TUMOR PRESENTATION AND OUTCOME by Leonardo G Da Fonseca, Laura Izquierdo Sanchez, Pedro H Hashizume, Yanina Carlino, Estefanía Liza Baca, Cristina Zambrano, Santiago Sepulveda, Andrea Bolomo, Pedro M Rodrigues, Ioana Riaño, Andre Boonstra, Jose D Debes, Luis Bujanda, Flair J Carrilho, Marco Arrese, Juan C Roa, Enrique Carrera, Javier Díaz Ferrer, Domingo Balderramo, Claudia P Oliveira, Jesus M Banales

“…These findings highlight structural challenges in cancer screening and healthcare access among diverse ethnic backgrounds and lower socioeconomic statuses in the region. …”
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Mapping grey matter and cortical thickness alterations associated with subjective cognitive decline and mild cognitive impairment among rural-dwelling older adults in China: A popu... by Ziwei Chen, Qianqian Xie, Jiafeng Wang, Yan Wang, Huisi Zhang, Chunyan Li, Yongxiang Wang, Lin Cong, Shi Tang, Tingting Hou, Lin Song, Yifeng Du, Chengxuan Qiu

“…Background: The structural brain alterations for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are poorly defined. …”
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Human gut microbiota adaptation to high-altitude exposure: longitudinal analysis over acute and prolonged periods by Xianzong Ma, Changwei Duan, Xiaoying Wang, Yurong Tao, Lang Yang, Yongsheng Teng, Yuanming Pan, Mingjie Zhang, Junfeng Xu, Jianqiu Sheng, Xin Wang, Peng Jin

“…In summary, acute high-altitude exposure caused dramatic changes in gut microbiota, while prolonged exposure led to structural and functional reshaping. These findings enhance our understanding of how high-altitude environments reshape gut microbiota.IMPORTANCEThis study is the first to investigate the impact of high-altitude exposure on gut microbiota adaptation in a large-scale longitudinal cohort. …”
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Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep by Samantha J. Murray, Mustafa M. Almuqbel, Simon A. Felton, Nickolas J. Palmer, Ashley R. Deane, Daniel J. Myall, Reza Shoorangiz, Arsène Ella, Matthieu Keller, David N. Palmer, Tracy R. Melzer, Nadia L. Mitchell

“…Method Sheep treated at a pre‐symptomatic timepoint underwent five T1‐weighted structural MRI scans between 5 and 18 months of age. …”
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Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design by Xuanming Hong, Hui Cao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Ruqin Gao, Min Yu, Jinyi Zhou, Xianping Wu, Yu Liu, Shengli Yin, Wenjing Gao, Liming Li

“…Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in these associations are limited. Results Using data from 1,074 twins in the Chinese National Twin Registry and bivariate structural equation models (SEMs), we investigated the phenotypic (Rph), genetic (Ra), and environmental (Re) correlations between genome-wide DNAm and three obesity indices: BMI, waist circumference (WC), and waist-to-hip ratio (WHR). …”
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An inner membrane complex protein IMC1g in Plasmodium berghei is involved in asexual stage schizogony and parasite transmission by Yinjie Liu, Shitong Cheng, Gang He, Dawei He, Duo Wang, Sicong Wang, Lumeng Chen, Liying Zhu, Yonghui Feng, Liwang Cui, Yaming Cao, Xiaotong Zhu

“…Together, this work reveals an essential role of IMC1g in the parasite life cycle and suggests that IMC1 family members likely contribute to parasite gliding and invasion.IMPORTANCEThe malaria parasite’s inner membrane complex is critical to maintain its structural integrity and motility. Here, we identified the function of the IMC1g protein, a member of the IMC1 family, in invasive and proliferative stages of P. berghei. …”
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Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma by Qiwei Zhao, Qiwei Zhao, Yu Wang, Yu Wang, Long Ding, Long Ding, Zhuang Li, Zhuang Li, Mengyang Wang, Yueqing Huang, Qiushi Cao, Qiushi Cao, Yaqin Sun, Yaqin Sun, Xiaohong Guo, Xiaohong Guo

“…In this study, we aimed to validate whether CAP induces ferroptosis in TSCC and to elucidate the underlying mechanisms.MethodsCell viability in HN6 and CAL27 cells was assessed using CCK-8 assays. Mitochondrial structural changes were observed via transmission electron microscopy (TEM). …”
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Relative vacuum reduction innovative processes applied in primary magnesium production—Comprehensive analysis of thermodynamics, resource, energy flow, and carbon emission by Xiaolong Li, Tingan Zhang, Yan Liu, Junhua Guo, Jingzhong Xu, Yuanyuan Liang

“…Magnesium and magnesium alloys, serving as crucial lightweight structural materials and hydrogen storage elements, find extensive applications in space technology, aviation, automotive, and magnesium-based hydrogen industries. …”
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THE INFLUENCE OF HEART RATE VARIABILITY ON CLINICAL COURSE OF CHRONIC HEART FAILURE AND RENAL FUNCTION IN ATRIAL FIBRILLATION PATIENTS by E. A. Polyanskaya, S. V. Mironova, N. A. Koziolova

“…Aim. Evaluation of structural and functional condition of the left ventricle (LV) and kidneys in permanent atrial fibrillation patients (AF) with ischemic chronic heart failure (CHF) according to mean 24 hour heart rate and heart rate variability.Material and methods. …”
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Impact of job crafting and work engagement on the mental and physical health of palliative care nurses by Ateya Megahed Ibrahim, Donia Elsaid Fathi Zaghamir, Mohamed Gamal Elsehrawy, Hassanat Ramadan Abdel-Aziz, Samia Eaid Elgazzar, Fathia Gamal Elsaid Hassabelnaby, Heba Ahmed Osman Mohamed, Nahed Abd Elazeem Abd Elsalam

“…Results The study revealed a positive correlation between job crafting behaviours and physical health (r = 0.52, p < 0.001) and a negative correlation between job crafting behaviors and mental health distress (r = -0.56, p < 0.001). The structural equation modeling (SEM) results demonstrated significant paths from job crafting to both physical health (β = 0.40) and mental health distress (β = -0.45), indicating that job crafting positively affects physical health and negatively affects mental health distress. …”
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Safety and Tolerability of Implanted Subcutaneous Cardioverter-Defibrillator Systems by A. V. Vereshchagina, T. M. Uskach, O. V. Sapelnikov, V. A. Amanatova, I. R. Grishin, A. A. Kulikov, V. S. Kostin, R. S. Akchurin

“…The use of S-ICD, even in patients with structural myocardial disease who do not require antibradycardia pacing, is effective in preventing SCD. …”
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