Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing by Jianxia Niu, Wenxi Wang, Zihao Wang, Zhe Chen, Xiaoyu Zhang, Zhen Qin, Lingfeng Miao, Zhengzhao Yang, Chaojie Xie, Mingming Xin, Huiru Peng, Yingyin Yao, Jie Liu, Zhongfu Ni, Qixin Sun, Weilong Guo

“…Abstract Background The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while the huge and complex genome of polyploid wheat hinders efficient genotyping of abundant varieties towards accurate identification, management, and exploitation of germplasm resources. …”
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Molecular characteristic, evolution, and pathogenicity analysis of avian infectious bronchitis virus isolates associated with QX type in China by Yuanlu Lu, Yiran Zeng, Haowei Luo, Bingchen Qiao, Qi Meng, Zijian Dai, Na Chen, Lingcai Zhao, Xianchen Meng, Haitao Zhang, Jun Xia, Jihui Ping

“…Our data indicate antigenicity variances between QX isolates and QXL87 vaccine strains, potentially resulting in immune evasion occurrences. …”
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Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…Studies have shown that APOE ɛ4 mediates the modulation of intrinsic functional brain networks in cognitively normal individuals and significantly disrupts the whole-brain topological structure in AD patients. However, how APOE ɛ4 regulates brain functional connectivity (FC) and consequently affects the levels of cognitive impairment in AD patients remains unknown. …”
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Understanding the Broad-line Region of Active Galactic Nuclei with Photoionization. I. The Moderate-accretion Regime by Qiaoya Wu, Yue Shen, Hengxiao Guo, Scott F. Anderson, W. N. Brandt, Catherine J. Grier, Patrick B. Hall, Luis C. Ho, Yasaman Homayouni, Keith Horne, Jennifer I-Hsiu Li, Donald P. Schneider

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Prognostic impact of small size sutureless prostheses: results for 241 patients from an international registry by Giuseppe Santarpino, Roberto Lorusso, Giovanni Concistrè, Josè Cuenca Castillo, Vincenzo Argano, Alistair Royse, Angelo Lucas Nobre, Patrick Parrino, Gianluigi Bisleri, Max Baghai, Theodor Fischlein, Giovanni Troise, Generoso Mastrogiovanni, Raphael Fontaine, Davide Pacini, Giuseppe Minniti, Aniello Pappalardo, George Chad Hughes, Philippe Noirhomme, Jean-Philippe Grimaud, Maximilian Scherner, Ignacio Muñoz, George Asimakopoulos, Antony Walker, Daniela Zakova, Michele Torella, Giorgio Vigano, Mark Connolly, Christian Dinges, Pierre Corbi, Loris Salvador, Mauro Rinaldi, Luis Maroto, David Heimansohn, Basel Ramlawi, Mattia Glauber, Jlenia D’Agnano, Valeria Cosco, Veronica D’Anna, Marco Solinas

“…At a maximum follow-up of 8.1 years, 10 cardiovascular deaths, 4 valve related reinterventions (3 structural valve deterioration (SVD) requiring TAVI Valve-in-Valve, 1 endocarditis) occurred. …”
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Cation disordering in ankerite as a function of Fe content by A. Zucchini, M. Masotta, M. Nazzari, M. Fastelli, P. Comodi

“…Crystal structure refinements, using single-crystal X-ray diffraction data, indicate that the temperature of the order–disorder phase transition in ankerite, when the space group changes from <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M7" display="inline" overflow="scroll" dspmath="mathml"><mrow><mi>R</mi><mover accent="true"><mn mathvariant="normal">3</mn><mo mathvariant="normal">¯</mo></mover></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="17pt" height="12pt" class="svg-formula" dspmath="mathimg" md5hash="f75e6c667c3f64f21a65bfc83826b4ad"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="ejm-37-577-2025-ie00003.svg" width="17pt" height="12pt" src="ejm-37-577-2025-ie00003.png"/></svg:svg></span></span> to <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M8" display="inline" overflow="scroll" dspmath="mathml"><mrow><mi>R</mi><mover accent="true"><mn mathvariant="normal">3</mn><mo mathvariant="normal">¯</mo></mover><mi>c</mi></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="23pt" height="12pt" class="svg-formula" dspmath="mathimg" md5hash="fe064a2c9801a78cad20978a78c22cc9"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="ejm-37-577-2025-ie00004.svg" width="23pt" height="12pt" src="ejm-37-577-2025-ie00004.png"/></svg:svg></span></span>, is significantly influenced by the amount of Fe in the mineral's crystal structure, being full disordering conditions attained at 1000 and 800 °C in ankerites with <span class="inline-formula"><i>x</i>=0.3</span> and <span class="inline-formula"><i>x</i>=0.7</span>, respectively. …”
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Fertility intentions among Chinese adults: a cross-sectional study using a national survey by Mingyan Hao, Chenxiao Zhang, Haofeng Fu, Jingting Zhang, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Chen Chen, Yajing Zhou, Jianzhong Zheng, Wei Liu, Lizheng Wang

“…Methods In our research, we performed a cross-sectional analysis using data gathered in 2022 from the Psychology and Behavior Investigation of Chinese Residents (PBICR), which encompassed 21,916 participants aged 18 to 49 years. …”
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Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model. by Ernesto Luna, Pankaj Agrawal, Riyaz Mehta, Maria E Boone, Charlotte Vernhes, Colombe Denys, Robert Small, Bhaswati Mukherjee, Norbert Tennagels, Stefan Maerten, Donald R Drake

“…<h4>Background</h4>The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. …”
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Validation of Quantitative Ultrasound and Texture Derivative Analyses-Based Model for Upfront Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer by Adrian Wai Chan, Lakshmanan Sannachi, Daniel Moore-Palhares, Archya Dasgupta, Sonal Gandhi, Rossanna Pezo, Andrea Eisen, Ellen Warner, Frances C. Wright, Nicole Look Hong, Ali Sadeghi-Naini, Mia Skarpathiotakis, Belinda Curpen, Carrie Betel, Michael C. Kolios, Maureen Trudeau, Gregory J. Czarnota

“…Explanations for the misclassified cases included unplanned modifications made to the type of chemotherapy during treatment, inherent limitations of the predictive model, presence of DCIS in tumour structure, and an ill-defined tumour border in a minority of cases. …”
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Genome-Wide Identification of <i>G3BP</i> Family in U’s Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i> by Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue

“…We then analyzed their gene structure, protein motifs, gene duplication type, phylogeny, subcellular localization, SSR loci, and upstream miRNAs. …”
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Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease by Da-Ya Zhang, Da Li, Shi-Ju Chen, Li-Jun Zhang, Xu-Li Zhu, Fa-Di Chen, Chen Chen, Qi Wang, Yiping Du, Jian-Xin Xiong, Shi-Mei Huang, Xiao-Dong Zhang, Yan-Ting Lv, Fan Zeng, Run-Xiang Chen, Xianfeng Huang, Fengjiao Mao, Shuo Zhou, Qicen Yao, Yuliang Huang, Runyu Chen, Ying Mo, Yunqian Xie, Yue-Hong Jiang, Zhai Chen, Cui-Yi Mo, Jia-Jia Chen, Fei-Hu Bai

“…Distinct differences were identified in both the microbial community structure and metabolomic profiles between MAFLD patients and healthy controls. …”
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Correlates of duration between initial drug use and first drug injection among people who inject drugs in Iran, 2020 by Zahra Abdolahinia, Zahra Jaafari, Ali Karamoozian, Soheil Mehmandoost, Nima Ghalekhani, Mehrdad Khezri, Ghazal Mousavian, Mostafa Shokoohi, Ali Mirzazadeh, Ali Akbar Haghdoost, Mohammad Karamouzian, Mohammad Mehdi Gooya, Samaneh Akbarpour, Hamid Sharifi, Fatemeh Tavakoli

“…Policymakers should prioritize evidence-based, multi-faceted approaches that target both individual and structural factors to delay or prevent the transition to injection drug use and reduce associated health risks.…”
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Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

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Clinical analysis of vitrectomy combined with dexamethasone intraveal implant in the treatment of epiretinal membrane by WU Kunfang, GUO Meimei, LI Xiang, WANG Dingding

“…Both surgical methods can improve the structure, function, and microcirculation disorders in the macular area. …”
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The mediating role of professional values and self-efficacy in the relationship between organizational justice and quality of working life among nurses in southwestern Iran by Sahar Ansari, Zinat Mohebbi, Camellia Torabizadeh, Alimohammad Keshtavarz Hesam Abadi

“…To perform structural equation modeling (SEM) considering the sample size, we used Smart PLS version 4, and to determine the role and strength of the mediating effects of professional values and self-efficacy, we utilized Sobel tests and the Variance Accounted For (VAF) statistic. …”
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User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…The Consolidated Framework for Implementation Research was used to structure analyses of end-user feedback. …”
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Non-targeted metabolomics and network pharmacology of Taohong Siwu Decoction in hepatic fibrosis mouse model using high resolution mass spectrometry by Shengsheng Li, Shengsheng Li, Shenglan Qi, Rongsheng Li, Fangming Yang, Zhenyi Niu, Wei Liu, Suping Ma, Zhun Xiao

“…Network pharmacology and metabolomic data were integrated to elucidate the therapeutic targets, differential metabolites, and signaling pathways of THSW Decoction. …”
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Nanoscale Organic Contaminant Detection at the Surface Using Nonlinear Bond Model by Hendradi Hardhienata, Muhammad Ahyad, Fasya Nabilah, Husin Alatas, Faridah Handayasari, Agus Kartono, Tony Sumaryada, Muhammad D. Birowosuto

“…Our simulations show good agreement with rotational anisotropy (RA) SHG intensity experimental data across all polarization angles, with a total error estimate of 3%. …”
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Vaccine Hesitancy and Immunization Patterns in Central and Eastern Europe: Sociocultural, Economic, Political, and Digital Influences Across Seven Countries by Kurpas D, Stefanicka–Wojtas D, Soll–Morka A, Lomper K, Uchmanowicz B, Blahova B, Bredelytė A, Dumitra GG, Hudáčková V, Javorska K, Juhász Z, Manulik S, Mohos A, Skarbalius E, Tkachenko VI, Uchmanowicz I

“…Differences were influenced by healthcare system structure, public trust, exposure to misinformation, and digital communication strategies.Conclusion: Addressing vaccine hesitancy requires targeted, context-sensitive communication and digital literacy programs. …”
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Epidemiological, clinical, and molecular analysis of human adenovirus infections in hospitalized children with acute respiratory infections in Tianjin, China by Yulian Fang, Yulian Fang, Min Lei, Min Lei, Lu Zhang, Mengzhu Hou, Mengzhu Hou, Ning Wang, Ning Wang, Chunquan Cai, Chunquan Cai

“…Molecular characterization revealed structural conservation in the Penton protein of HAdV-C and identified Hexon as the most polymorphic region with 85 variable sites, indicating divergent evolutionary pressures across viral domains.ConclusionHAdV-3, HAdV-7, HAdV-2, and HAdV-1 were the predominant HAdV types in children hospitalized with ARIs in Tianjin. …”
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