Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

“…This process leads to the loss of tissue structure and function. Nutmeg has been found to consist of a number of chemical components that have been linked to antioxidant, health promoting, and disease-prevention activity. …”
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Occurrence characteristics and utilization potential of scarce coking coal resources in Huaibei coalfield by Run ZHAN, Wenyong ZHANG, Feng HAN, Fengtang SUI, Jiayi GU, Guijian LIU, Tian ZHAO

“…The Huaibei Coalfield in Anhui Province, as one of the first key mining areas of scarce coking coal set up by the state, has rich resources and excellent coal quality, and is the most promising coking coal resource source in East China.In order to systematically understand the occurrence characteristics and exploitation and utilization potential of scarce coking coal in the study area, this paper reveals the spatio-temporal difference characteristics, formation control factors and resource potential of scarce coking coal in the study area through coal rock analysis, industrial coal quality index test, comprehensive mapping and resource evaluation, using previous drilling data and underground supplementary sampling tests.The results show that the scarce coking coal in Huaibei coalfield is well developed, and the floating coal after washing shows the characteristics of ultra−low water, ultra−low ash, ultra−low sulfur, ultra−low fixed carbon, medium and high volatile, and has the process properties of medium−strong bonding and coking, low potassium and sodium content, and good mechanical strength and thermal strength.The scarce coking coal is controlled by the regional structure and the sedimentary distribution of coal seams, and the coal seams of Xiashihezi Formation 7 and 8 are the most developed. …”
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Improvement of Gasless Laparoscopic Single-Site Lifting and Use in Surgery for Endometrial Carcinoma by Bingbing Zhao, Xinqiu Lu, Xuli Gan, Zhijun Yang, Li Li, Jieqing Zhang

“…This method of suspending the umbilical ligament through abdominal silk thread can increase exposure of the anatomical structure of the obturator position. The application of GLESS as the procedure for endometrial cancer is safe and feasible.…”
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FEATURES OF DENTAL STATUS AND SOME MICROBIOLOGICAL PARAMETERS OF THE ORAL CAVITY OF YOUNG MEN. by Y.Y. Vodoriz, N.M. Ilenko, N.V. Ilenko, T.O. Petrushanko

“…This habitat is subdivided into several subbiotops considering the anatomical structure and other characteristics of parts of the oral cavity such as gingival sulcus, gingival and periodontal pockets. …”
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Deep learning-based carotid plaque vulnerability classification with multicentre contrast-enhanced ultrasound video: a comparative diagnostic study by Yanli Guo, Hongxia Zhang, Yang Guang, Wen He, Bin Ning, Chen Yin, Mingchang Zhao, Fang Nie, Pintong Huang, Rui-Fang Zhang, Qiang Yong, Jianjun Yuan, Yicheng Wang, Lijun Yuan, Litao Ruan, Tengfei Yu, Haiman Song, Yukang Zhang

“…Moreover, with a more powerful network structure and better utilisation of video information, DL-DCCP provided greater diagnostic accuracy than a state-of-the-art static CNN model.Trial registration number ChiCTR1900021846,…”
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A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA) by Mansour S. Alturki, Mohamed S. Gomaa, Nada Tawfeeq, Abdulaziz H. Al Khzem, Mohsina B. Shaik, Murtadha Alshaikh Jafar, Mohammad Alsamen, Hasan Al Nahab, Mohammad Al-Eid, Alhassan Almutawah, Thankhoe A. Rants’o, Khaled A. G. Ayil, Mohammed Almaghrabi

“…Methods: We utilized Maestro Schrödinger as a computational tool for preparing and docking simulations on the PAD 4 enzyme crystal structure that is retrieved from RCSB Protein Data Bank (PDB ID: 4X8G) while the docked FDA-approved medications are obtained from the Zinc 15 database. …”
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Bidirectional associations among positive affect, anhedonia and meaning in life during major depressive episode: ecological momentary assessment study in unipolar and bipolar indiv... by Heidi Ka Ying Lo, Roger S. McIntyre, Iris Wai Tung Tsui, Fiona Yan Yee Ho, Ting Kin Ng, Corine Sau Man Wong, Suet Ying Yuen, Chit Tat Lee, Chun Yin Poon, Inez Myin-Germeys, Ka Fai Chung

“…Multilevel modelling analysis was conducted, with estimation of first-order autoregressive model structure and time-lagged relationship between pleasure and positive affect. …”
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Deep dive into hydrologic simulations at global scale: harnessing the power of deep learning and physics-informed differentiable models (<i>δ</i>HBV-globe1.0-hydroDL) by D. Feng, D. Feng, D. Feng, H. Beck, J. de Bruijn, J. de Bruijn, R. K. Sahu, Y. Satoh, Y. Wada, J. Liu, M. Pan, K. Lawson, C. Shen

“…Nevertheless, relative to LSTM, the differentiable model was hampered by structural deficiencies for cold or polar regions, highly arid regions, and basins with significant human impacts. …”
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Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microg... by Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao

“…Through this approach, four new (<b>1</b>–<b>4</b>) and nine known (<b>5</b>–<b>13</b>) PUFA analogues were obtained from large-scale cultures of the marine dinoflagellate <i>Prorocentrum lima</i>, with lipidomic profiling identifying FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and FA22:6 methyl ester (<b>11</b>) as major constituents of the algal oil extract. Structural elucidation was achieved through integrated spectroscopic analyses of IR, 1D and 2D NMR, and HR-ESI-MS data. …”
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Application of HRCT-based radiomics to predict interstitial lung disease for juvenile dermatomyositis by Lingke Liu, Minfei Hu, Yun Zhou, Fei Zheng, Xiaohui Ma, Li Yang, Yiping Xu, Liping Teng, Bin Hu, Meiping Lu, Xuefeng Xu

“…Methods We retrospectively analyzed clinical data of 56 children with JDM, and all participants gave written informed consent. …”
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E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness by Alf Spitschak, Prabir Dhar, Krishna P. Singh, Rosaely Casalegno Garduño, Shailendra K. Gupta, Shailendra K. Gupta, Julio Vera, Luca Musella, Nico Murr, Anja Stoll, Brigitte M. Pützer, Brigitte M. Pützer

“…To explore E2F1’s role in immune regulation in presence of aggressive melanoma cells, we established a coculture system and utilized transcriptome and cytokine arrays combined with bioinformatics and structural modeling. We identified an E2F1-dependent gene regulatory network with IL6 as a central hub. …”
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The effects of formula milk on development, nutrient absorption, and immune characteristics of piglets by Chuang Tang, Zhengjiang Liu, Lu Lu, Bo Zeng, Zhi Li, Ruohan Yang, Duoduo Zhang, Xiaolan Fan, Jiaxue Cao, Haohuan Li, Jing Sun, Jinwei Zhang, Xiaoyuan Wei, Wei Sun, Liangpeng Ge, Mingzhou Li, Fanli Kong

“…Given the ethical constraints in conducting experimental studies on human breastfeeding, we employed pig, which have similar physiological structure with humans, to examine the impacts of different feeding practices. …”
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The impact of nuchal ligament ossification resection on cervical stability after modified laminoplasty: a long-term follow-up study by Chong Chen, Wenlin Ye, Tao Yu, Xing Cheng, Lutong Wang, Xingchen Zhao, Xiang Long, Jun Ouyang, Yunbing Chang, Xiaoqing Zheng

“…For DCM patients with long segmental ONL, more attention should be paid to protecting the MLC structure during posterior cervical surgery. Clinical trial number Not applicable.…”
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Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits by Dennis Witt, Marc Sturm, Antje Stäbler, Benita Menden, Lisa Ruisinger, Kristin Bosse, Ines Gruber, Andreas Hartkopf, Silja Gauß, German Demidov, Nicolas Casadei, Elena Buena Atienza, Kira Mehnert, Janna Witt, Caspar Gross, Leon Schütz, Christopher Schroeder, Stephan Ossowski, Andreas Dufke, Tobias B. Haack, Olaf Riess, Ulrike Faust

“…GS offers a wealth of information, including the improved detection of structural variants, copy number variants, and parallel detection of complex genetic markers. …”
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The antioxidant property of CAPE depends on TRPV1 channel activation in microvascular endothelial cells by Miltha Hidalgo, Bárbara Railef, Vania Rodríguez, Carolina Navarro, Vanessa Rubio, Jorge Meneses-Pacheco, Sandra Soto-Alarcón, Christine Kreindl, Carolina Añazco, Leandro Zuñiga, Omar Porras

“…Herein, we hypothesized that a subfamily of TRP ion channels works as the molecular entity that recognizes CAPE at the plasma membrane and allows a fast shift in the antioxidant capacity of intact endothelial cells (EC).By monitoring cytoplasmic Ca2+ in a microvascular EC model, we compared the calcium responses evoked by three structurally related compounds: caffeic acid phenethyl ester, neochlorogenic acid and caffeic acid. …”
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Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy by Jiahui Mai, Jing Duan, Xiaoyu Chen, Liqin Liu, Dachao Liang, Tao Fu, Gang Lu, Wai Yee Chan, Xufeng Luo, Feiqiu Wen, Jianxiang Liao, Zhuo Li, Xinguo Lu

“…We used the optical genome mapping (OGM) technology to detect and analyze uncommon mutations or structural variations (SVs) within the DMD gene, thus contributing to more precise clinical diagnoses. …”
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CTV-MIND: A cortical thickness-volume integrated individualized morphological network model to explore disease progression in temporal lobe epilepsy by Xinyan Liu, Jiaqi Han, Xiating Zhang, Boxuan Wei, Lu Xu, Qilin Zhou, Yuping Wang, Yicong Lin, Jicong Zhang

“…This study aimed to investigate progressive changes in TLE by constructing a novel individualized morphological brain network based on T1-weighted structural magnetic resonance imaging (MRI). MRI data were collected from 34 postoperative seizure-free TLE patients and 28 age- and sex-matched healthy controls (HC), with patients divided into LONG-TERM and SHORT-TERM groups. …”
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Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study by Ken-ei Sada, Shuhei Yoshida, Kenji Saito, Yuya Fujita, Eisuke Inoue, Kiyoshi Migita, Naoki Matsuoka, Hiroshi Kajiyama, Ryusuke Yoshimi, Kunihiro Ichinose, Yoshia Miyawaki, Shigeru Ohno, Nobuyuki Yajima, Yasuhiro Shimojima, Shuzo Sato, Michio Fujiwara, Keisuke Nishimura, Takashi Kida, Yuya Sumichika, Haruki Matsumoto, Jumpei Temmoku, Tomoyuki Asano, Shotaro Ogawa, Jumpei Fukita, Yusuke Matsuo, Takahisa Onishi

“…Statistical analyses employed marginal structural models with stabilised inverse probability of treatment weighting to adjust for confounders.Results The analysis included 1004 patients; the incidence of severe infections was 6.5% in the MMF group and 7.5% in the non-MMF group, with no significant difference (OR 0.69, 95% CI 0.34 to 1.39). …”
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The mediating role of physical activity avoidance in the association between weight stigma and physical activity by Po-Ching Huang, Hung-Ching Wu, Ji-Kang Chen, Xavier C.C. Fung, Nadia Bevan, Daniel Kwasi Ahorsu, Mark D. Griffiths, Jung-Sheng Chen, Kuo-Hsin Lee, Amir H. Pakpour, Chung-Ying Lin

“…Results: Structural equation modeling showed that weight-related self-stigma was significantly associated with PA avoidance (standardized coefficient [β] = 0.67, p < 0.01), and negatively associated with PA (β = −0.14, p < 0.01). …”
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Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia by Melanie A. Matyi, Hamsanandini Radhakrishnan, Christopher A. Olm, Jeffrey S. Phillips, Philip A. Cook, Emma Rhodes, James C. Gee, David J. Irwin, Corey T. McMillan, Lauren Massimo

“…Given that behavioral variant frontotemporal degeneration (bvFTD) is a neurodegenerative disease associated with executive dysfunction and selective vulnerability of the salience network, we tested the hypotheses that bvFTD structural networks are de-differentiated compared to cognitively normal controls (CNC) and that network de-differentiation relates to worse executive function. …”
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