From Clinical Presentation to Genetic Confirmation: A Case of L2HGDH-Related Leukodystrophy in an 11-Year-Old by Negareh Poursalehi, Mojtaba Movahedinia, Mohammad Hossein Mohammadi, Mohamammad Ebrahim Ghanei, Mohammad Yahya Vahidi Mehrjerdi, Seyed Mehdi Kalantar

“…In silico studies, including protein structural modeling and docking analyses, were conducted using Phyre-2 tools to further investigate the molecular consequences of the mutation in L2HGDH.Result: After the filtration the data obtained from Whole exome sequencing of the patient identified a homozygous missense mutation (c.751C>T; p. …”
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Development of Hybrid District Heating Systems by A. V. Sednin, K. M. Dyussenov

“…The technical aspects of the creation of hybrid control systems are analyzed, generalized structural technological schemes of hybrid district heating systems and the main measures, the implementation of which is necessary during their transition to the state of a new generation of district heating systems, are introduced. …”
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Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulati... by Chunxiu Lin, Yugui Lin, Rui Xiao, Min Guo, Hao Zhang, Wei Chen, Gang Wang

“…Notably, both in vitro intestinal fermentation models and genomic analyses demonstrated that the three Bifidobacterium species cannot synthesize these unsaturated fatty acids due to the lack of related genes. However, data suggested that these species might promote the accumulation of arachidonic acid and docosahexaenoic acid by regulating the gut microbiota’s structure and function. …”
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Heterogeneous Integrated III-V-on-SOI Photodetector Using Micro-transfer Printing Method by WANG Zhaocong, QUAN Zhiheng, ZHENG ShiGuanqing, ZHU Yan, YE Nan, LU Liangjun, ZHOU Linjie, SONG Yingxiong

“…【Results】The response bandwidth of the heterogeneous integrated photodetector obtained by micro-transfer integration is about 4 GHz, and the dark current is about 13 nA (@-13 V), which is basically consistent with the performance test data before the integration of the sample. Affected by the coupling loss, the responsivity of the integrated structure is 7.3×10^-3 A/W (@-25 V). …”
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The effects of elastic band resistance training on serum levels of growth differentiation factor 11, myostatin, and insulin resistance in overweight elderly women by Akbar Azamian Jazi, Elias Abdellah

“…Even though these two factors have similar structural and signaling pathways, they can have different functions, and the available information about their effects on the regeneration of degenerated muscles during old age is contradictory. …”
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Evaluation of the Efficacy and Safety of Initial Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Middle-Aged People by T. V. Alexandrova, O. V. Muslimova, M. V. Zhuravleva, A. A. Alexandrov, G. I. Gorodetskaya, E. Yu. Demchenkova, O. A. Demidova, E. A. Sokova, I. A. Mazerkina, Yu. А. Smirnova

“…The study results indicate that the structure of comorbidity did not affect the effectiveness of initial empirical ABT. …”
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Whole genome resequencing reveals the evolutionary history and geographic isolation of the eastern Asian Hickory (Carya) by Da Zhang, Rui‐Feng Yang, Jia‐Hui Chen, Lang‐Bo Pan, Wei Duan, Guo‐Hua Xia, Qi‐Xiang Zhang, You‐Jun Huang

“…Based on the SNPs (single nucleotide polymorphisms) data generated by the whole genome deep resequencing of five EA (Eastern Asian) Carya species, we constructed the phylogenetic tree, genetic structure, and species distribution modeling to clarify the phylogenetic relationships and to predict the potential distribution area of EA Carya. …”
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Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration by Dan Wu, Chen Yan, Linhui Han, Fudong Li, Ximing Xu, Jingchuan Sun, Yong Cao, Kaiqiang Sun, Jiangang Shi, Yuan Wang

“…Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncovered that the aberrant accumulation of R-Loops—a type of triple-stranded nucleic acid structure—can result in the cytoplasmic accumulation of double-stranded DNA (dsDNA) and activate cGAS/STING signaling and induce cellular senescence in nucleus pulposus cells (NPCs) during IVDD. …”
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A new index for detection of submerged aquatic plants under variable quality water: an extension of the soil-line concept by Shruti Khanna, Erin L. Hestir, Joaquim Bellvert, Jennifer D. Boyer, Kristen D. Shapiro, Susan L. Ustin

“…Submersed aquatic plant (SAP) communities are important determinants of estuarine and lacustrine food web structure, nutrient cycling, and water quality. Variation in water quality, SAP community composition and cover present challenges when mapping SAP robustly across estuarine ecosystems. …”
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Epigenetic modifications in the murine liver upon depletion of transcriptional coregulator host cell factor 1 by Shruti Kaushal, Debashruti Bhattacharya, Saran Kumar, Winship Herr, Jaspreet Kaur Dhanjal, Shilpi Minocha

“…ChIP-seq data showed altered H3K4me3 patterns at promoter and enhancer regions of key hepatic genes. …”
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Endoscopic retrograde cholangiopancreatography consultation after digestive tract reconstruction and risk factors for complications by Yan Cheng, Jiahui Feng, Xiaojia Chen, Jun Lin, Hongling Wang

“…Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of biliary and pancreatic diseases, and its success rate and therapeutic effect are considerable, and its use in patients with gastrointestinal tract reconstruction is also increasing. The anatomical structure of the digestive tract has been changed in these patients, which makes the use of endoscopic retrograde cholangiopancreatography technically more challenging. …”
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Spatio-temporal Evolution of Land Surface Temperature and Its Response to LULC in the Urban Agglomeration of Central Yunnan by LIN Zhiqiang, PENG Shuangyun, SHI Shuangfu, HUANG Bangmei, MA Dongling, ZHU Ziyi, MA Xiaoliang, GONG Luping

“…[Conclusion] LULC is an important factor affecting the LST, and reasonable configuration of LULC structure can improve the thermal environment of urban agglomeration. …”
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Color matching and translucency of single-shade resin composites: effects of restoration thickness, background shade, and aging by Hamideh Sadat Mohammadipour, Soroush Sarafraz Yazdi, Mohammad Javad Moghaddas Mashhad, Saber Babazadeh, Arsalan Shahri

“…Abstract Background Achieving a seamless color match in resin composite restorations remains a significant clinical challenge due to variations in tooth structure and background shades. The aim of this in vitro study was to assess the effect of background shade, thermal aging, and composite thickness on color matching and translucency of three single-shade resin composites. …”
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Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study. by Yuqi Hu, Le Gao, Lingyue Zhou, Wenlong Liu, Cuiling Wei, Boyan Liu, Qi Sun, Wenxin Tian, Rachel Yui Ki Chu, Song Song, Franco Wing Tak Cheng, Joe Kwun Nam Chan, Amy Pui Pui Ng, Heidi Ka Ying Lo, Krystal Chi Kei Lee, Wing Chung Chang, William Chi Wai Wong, Esther Wai Yin Chan, Ian Chi Kei Wong, Yi Chai, Francisco Tsz Tsun Lai

“…<h4>Methods and findings</h4>We extracted data from a territory-wide public healthcare database from January 2001 to August 2022 in Hong Kong to conduct a retrospective cohort study of anonymized patients aged 18+ years with a diagnosis of schizophrenia who used clozapine or olanzapine (drug comparator with highly similar chemical structure and pharmacological mechanisms) for 90+ days, with at least 2 prior other antipsychotic use records within both groups. …”
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Comparison of strategies based on DTI visualisation for stereotactic minimally invasive surgery in the treatment of moderate-volume thalamo-basal ganglia cerebral haemorrhage: a pr... by Shiqiang Yang, Yanwei Liu, Shiqiang Wang, Hua Peng, Xin Qi, Zhonghai Cai, Xuhui Hui, Anqiang Yang

“…Methods and analysis Diffusion Tensor Imaging (DTI) is a method used to assess the structural and physiological characteristics of biological tissue by examining the diffusion behavior of water molecules.In the central nervous system, limb paralysis will be inevitable if the corticospinal tract is damaged. …”
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The Effectiveness of Couple Therapy Based on Acceptance and Commitment ACT on Marital Violence and Desire for Separation in Couples Applying for Divorce by M Sadeghi, H Bagholi, R Azarmidakht, H Javidi

“…Methods: The present study applied a quasi-experimental, semi-experimental design with a pre-test and post-test structure, including a control group. The statistical sample consisted of 40 individuals selected from all couples seeking divorce in Yasuj, Iran, who were referred to family counseling centers in the first three months of 2023. …”
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Cloning and Analysis of the Expansin Gene BdEXP1 from Migration Plant parasitic Nematode (Bursaphelenchus doui) by Kaiyang GUO, Shifeng LIN, Rengang WANG, Li LI, Jie ZHANG, Shizhou YU, Zili WANG, Guoqin LIU

“…The BdEXP1 protein had the highest sequence similarity (64%) with the homologous protein of B. xylophilus, and contained a typical DPBB_SPI-like conservative domain and a signal peptide but no transmembrane structure, indicating that it was a secretory protein. …”
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Grain size effect of landscape in Jiangxi Guanshan subtropical evergreen broad-leaved forest by RAN Huan1, LAN Yong2, DAI Yufeng2, XIONG Yong2, WEN Renquan1, SONG Qingni1, YANG Qingpei1, LIU Jun1*

“…Patch density(PD), number of patches(NP), edge density(ED), landscape shape index(LSI), mean fractal dimension index(FRAC_MN), contagion index(CONTAG)exhibited significant negative correlations with increasing grain size, while mean patch area(AREA_MN), Shannon's diversity index(SHDI), Shannon's evenness index(SHEI)exhibited significant positive correlations with increasing grain size.(3)The coefficients of variation for landscape indices PD, NP, ED, LSI, and AREA_MN were the highest, combining landscape structural stability and diversity, the changes in different landscape indices were primarily concentrated around the inflection point at 5 meters. …”
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AIGC Using Behavior Analysis from the Perspective of Artificial Intelligence Literacy by Yuhong CUI, Jintao ZHAO

“…[Method/Process] This study adopts a mixed-method approach that primarily integrates Structural Equation Modeling (SEM) and mediation analysis to explore the relationships between the factors that influence AIGC tool usage. …”
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Lipitension and cardiometabolic risk factors in young people by A. V. Sineglazova, A. Sh. Fakhrutdinova, T. Yu. Kim, S. D. Parve

“…In patients with lipitension, 43,8% were diagnosed with HTN, while the remaining 56,2% had BP ≥130/85 mm Hg. In the structure of dyslipidemia in lipitension, 79,2% had abnormalities in ≥2 lipid parameters, of which increased levels of low-density lipoprotein cholesterol (LDL-C) and hypercholesterolemia (78,3%) were most often detected. …”
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