Clinical relevance of loss-of-function mutations of NEMO/IKBKG by Jin Wang, Kexin Shen, Hongxia Lou, Lina Zhou, Yunfei An, Xiaodong Zhao, Yuan Ding

“…Almost all cases of hyper-IgM occurred in patients with EDA-ID. Different structural domains correspond to symptoms with varying degrees of severity. …”
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Advances in diffuse glial tumors diagnosis by Luis Filipe de Souza Godoy, Vitor Ribeiro Paes, Aline Sgnolf Ayres, Gabriela Alencar Bandeira, Raquel Andrade Moreno, Fabiana de Campos Cordeiro Hirata, Frederico Adolfo Benevides Silva, Felipe Nascimento, Guilherme de Carvalho Campos Neto, Andre Felix Gentil, Leandro Tavares Lucato, Edson Amaro Junior, Robert J. Young, Suzana Maria Fleury Malheiros

“…This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. …”
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Predictors and health impacts of Ramadan intermittent fasting among patients with sickle cell disease by Mortadah Hadi Alsalman, Zaenb Alsalman, Maryam Mohammed Alshams, Jinan Mohammed Aljasem, Zahra Saleh Alsindi, Amani Abdullah Almutairi, Khadija Abdulrahman Alsunaikh, Hadeel Hesham Buali, Kefah Baqir Algadeeb, Nawal Eltayeb Omer Mohammed, Abdulaziz Abdullah Bushehab, Marwa Mahmoud Shafey

“…This study seeks to identify predictors of fasting capability and investigate the effects of fasting among this patient population.Participants and methodsThis cross-sectional study enrolled adult Muslim patients with SCD from Saudi Arabia. Data were collected through direct interviews using a structured questionnaire with four sections.ResultsA total of 320 patients with SCD were evaluated, with a mean age of 32.6 years (SD ± 11.01) and the majority were females (63.1%). …”
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The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications by Alaa A. A. Aljabali, Kenneth Lundstrom, Altijana Hromić-Jahjefendić, Nawal Abd El-Baky, Debaleena Nawn, Sk. Sarif Hassan, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

“…To achieve this, we conducted a structured search of the literature of peer-reviewed articles, preprints, and official surveillance data from 2023 to early 2025, prioritizing virological, clinical, and immunological reports related to XEC and its parent lineages. …”
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Patient and clinician experiences with the implementation of telemedicine and related adaptations in office-based buprenorphine treatment during the COVID-19 pandemic: a qualitativ... by Melissa Davoust, Angela R. Bazzi, Samantha Blakemore, Juliana Blodgett, Anna Cheng, Sarah Fielman, Kara M. Magane, Jacqueline Theisen, Richard Saitz, Alicia S. Ventura, Zoe M. Weinstein

“…From this clinic, we conducted semi-structured interviews with 25 patients and 16 clinicians (including prescribers and non-prescribers). …”
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Assessing the quality of care in primary health care facilities in all municipalities in Kosovo 2016–2023 by Astrid M. Knoblauch, Astrid M. Knoblauch, Sarah Rajkumar, Sarah Rajkumar, Robert Canavan, Robert Canavan, Qamile Ramadani, Ariana Bytyçi Katanolli, Shegë Bahtiri, Debra Stevenson, Debra Stevenson, Debra Stevenson, Merita Stavileci Mustafa, Nicu Fota, Nicu Fota, Nicu Fota, Jana Gerold, Jana Gerold

“…However, substantial challenges remain, particularly among managing non-communicable diseases (NCD) like diabetes and hypertension, due to gaps in structural and procedural aspects. The Accessible Quality Healthcare project (2016–2027) aimed at improving the health of the Kosovar population by strengthening the quality of PHC services with a specific focus on NCDs. …”
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A qualitative exploration of active ingredients and mechanisms of action of an online singing programme with mothers experiencing postnatal depression during the COVID-19 pandemic:... by Alexandra Burton, Rebecca H. Bind, Rachel Davis, Lorna Greenwood, Ching Yin Lee, Carolina Estevao, Katie Hazelgrove, Celeste Miller, Kristi Priestley, Lavinia Rebecchini, Tim Osborn, Hannah Dye, Paola Dazzan, Anthony Woods, Nikki Crane, Carmine M. Pariante, Daisy Fancourt

“…Data were analysed inductively using reflexive thematic analysis. …”
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Environmental risk factors associated with community diarrheal disease in Ethiopia by Devin LaPolt, Sage Smith, Lina Gazu, Silvia Alonso, Amete Mihret Teshale, Binyam Moges Azmeraye, Galana Mamo Ayana, Dessie Abebaw Angaw, Desalegne Degefaw, Ariel V. Garsow, Aaron Beczkiewicz, Getnet Yimer, Michala J. Krakowski, Robert Scharff, Eyasu T. Seyoum, Barbara Kowalcyk

“…REDCAP mobile app was used to collect data during face-to-face interviews using a structured, pretested questionnaire. …”
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Prevalence of vaping, vaping-associated short-term symptoms of respiratory and cardiovascular morbidities, and factors associated with the initiation of vaping among young adults i... by Aisha Altanaib, Arwa Alkhannah, Dhuha Alfouderi, Mariam Almutairi, Rawan Abdullah, Maryam Almuhaileej, Fajer Alqadeeri, Reema Alajmi, Loulwah Alenizi, Ahmad Alsultan, Saeed Akhtar

“…Methods In October 2024, a cross-sectional study enrolled students, aged ≥18 years, from various colleges of Kuwait University. Data were collected using a structured e-questionnaire administered through in-person invitations and online platforms. …”
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The COMBAT Project: study protocol for the development of a core outcome set for morbidity following surgery in paediatric brain tumour patients by Sandhya Trichinopoly Krishna, Nicola Harman, Conor Mallucci, Barry Pizer, Michael D. Jenkinson, Kristian Aquilina, Kim Bull, Jon Foss-Skiftesvik, Helen Hartley, James Hayden, Colin Kennedy, Ulrich W. Thomale, Sophie Wilne, Jeffrey H. Wisoff, Faris Bouaouiche, Liz Hull, John Robinson, Hannah L. Vickers, Carrol Gamble

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Stakeholder perspectives on the effects of environmental and socio-economic factors on children's health and learning: a qualitative study in Greater Manchester, England by Sarah Daniels, Hua Wei, Anne Clayson, Martie van Tongeren, Thomas Bannan, Melanie Carder, Luke Munford, Nicola Gartland

“…This study aimed to explore stakeholders' views on the impact of environmental and socio-economic factors on children's health and learning, and the effectiveness of local air quality initiatives.MethodsBetween April and June 2024, we conducted 15 semi-structured interviews with primary school teachers, local government and transport representatives from Greater Manchester (GM), a city region with high levels of deprivation in the Northwest of England. …”
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Confirmatory study on the retention rate of ketogenic diet therapy and related factors in children with drug‐resistant epilepsy: A single‐center cohort study by Jie Zhang, Qiang Gu, Yuan Wu, Han Xie, Cuijie Wei, Yao Zhang, Taoyun Ji, Xinhua Bao, Xingzhi Chang, Yuehua Zhang, Yuwu Jiang, Ye Wu

“…Methods This was a single‐center cohort study. Baseline data were collected, and regular follow‐up was conducted after KDT treatment. …”
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Patient and public involvement in the SPRUCE methodology study investigating electronic patient reported outcomes in oncology clinical trials by Morgaine Stiles, Monisha Dewan, Georgina Manning, Jessica Maudsley, Diana King, Jacqui Gath, Andy Deutsch, Esme Radin, Kim Watson, Franko Kowalczuk, Stephanie Foster, Alexa Gillman, Joanne Haviland, Elizabeth Hill, Lisa Lloyd, Robert Huddart, Emma Hall, Lara Philipps, Rebecca Lewis

“…The first committee meeting saw PPI members testing the electronic PRO (ePRO) system and giving feedback on this and the patient-facing documents, for which we provided structured feedback forms. Members also provided feedback on the meeting itself. …”
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Explanatory models and coping with alcohol misuse among conflict-affected men in Ukraine by Sergiy Bogdanov, Kateryna Koss, Kimberly Hook, Quincy Moore, Catharina Van der Boor, Alessandro Masazza, Daniela C. Fuhr, Bayard Roberts, Carl May, Olha Fedorets, Oxana Bayer, Andrii Karachevskyy, Abhijit Nadkarni

“…Qualitative data received from each subgroup were analysed separately. …”
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PSYCHOSOCIAL FACTORS AND LIFE QUALITY IN CORONARY HEART DISEASE PATIENTS: RESULTS OF THE RUSSIAN PART OF INTERNATIONAL MULTICENTER STUDY EUROASPIRE IV by N. V. Pogosova, R. G. Oganov, S. A. Boytsov, A. K. Ausheva, O. Yu. Sokolova, A. A. Kursakov, Yu. M. Pozdnyakov, A. O. Salbieva, I. N. Lelchuk, T. A. Gusarova, N. V. Gomyranova, A. V. Karpova, N. A. Eliseeva, E. B. Akhmedova, K. K. Bedeynikova, M. N. Korneeva

“…To the study protocol, the analysis of medical charts was included, with following visit and structured interview. During the study, long-term results were evaluated, presence and level of the risk factors, including psychosocial, life quality parameters, adequacy of the acquired by patients recommendations and the grade of adherence. …”
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Farmers’ Perception of Ecosystem Services Provided by Historical Rubber Plantations in Sankuru Province, DR Congo by Joël Mobunda Tiko, Serge Shakanye Ndjadi, Jémima Lydie OBANDZA - AYESSA, Daniel Botshumo Banga, Julien Bwazani Balandi, Charles Mumbere Musavandalo, Jean Pierre Mate Mweru, Baudouin Michel, Olivia Lovanirina Rakotondrasoa, Jean Pierre Meniko To Hulu

“…This study used a mixed methodological approach, integrating semi-structured interviews, focus groups, and statistical analyses including chi-square testing and multiple correspondence factorial analysis (MCAFA) to obtain and analyze the data comprehensively. …”
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‘I Don't Think There Is a One‐Size‐Fits‐All’: A Qualitative Study Exploring Healthcare Professional and Service Provider Perspectives of Using Innovative Models of Cervical Screeni... by Claire Bavor, Tessa Saunders, Mikayla Wolfe, Megan A. Smith, Nicola Creagh, Deborah Bateson, Angela Kelly‐Hanku, Paula Jops, Marion Saville, Natalie Taylor, Kate Broun, Julia M. L. Brotherton, Claire Nightingale

“…Data were analyzed using template analysis, a form of thematic analysis. …”
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HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines by Agnieszka Gogler, Agata Małgorzata Wilk, Damian Robert Sojka, Małgorzata Adamiec-Organiściok, Natalia Matysiak, Daria Kania, Klaudia Wiecha, Ewa Małusecka, Alexander Jorge Cortez, Dawid Zamojski, Michał Marczyk, Agnieszka Maria Mazurek, Sylwia Oziębło, Dorota Scieglinska

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Exploring indigenous knowledge and practices of the Gurage community on the biosystematics and utilization of Enset landraces for bone fracture and regeneration: the case of Gurage... by Temesgen Negassa, Asfaw Meressa, Negera Abdissa, Sileshi Degu, Getachew Addis, Eyob Debebe, Negessa Abdisa, Samuel W/kidan, Dereilo Bekere Belitibo, Sintayehu Ashenef, Werku Shanko, Zeynu Zuber, Lemessa Kumsa, Mewded Kassahun, Frehiwot Teka Assamo, Milkyas Endale

“…Descriptive statistics were employed for data presentation.ResultsA total of 37 Enset landraces were identified across the study Woredas. …”
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The effects of parent-child relationship, study stress, and mobile phone use on depressive symptoms among Chinese elementary school students: a moderated mediation model by Yiting Kong, Yiting Kong, Zhewei Su, Zhewei Su, Rui Wang, Rui Wang, Jianyu Tan, Jianyu Tan, Yuancen Zhong, Yuancen Zhong, Ming Ai, Ming Ai, Wo Wang, Wo Wang, Su Hong, Su Hong, Qi Zhang, Qi Zhang, Li Kuang, Li Kuang

“…This study investigated the association between parent-child relationship and depressive symptoms among Chinese elementary school students while testing a moderated mediation model to examine the mediating role of significant study stress and the moderating effect of frequent mobile phone use on this relationship.MethodsWe recruited elementary school students from grades 3 to 6 in S district of Chongqing, China, totaling 33,285 participants (51.72% girls; mean age = 10.36 years, SD = 1.24). Data was analyzed using structural equation modeling to assess the mediating and moderating effects of study stress and mobile phone use, respectively, on the relationship between parent-child relationship and depressive symptoms.ResultsDepressive symptoms prevalence in our study population was 16.3%. …”
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