National Health Policy and factors predicting its implementation at the local level in Nepal: an exploratory cross-sectional study by Dipendra Khadka, Dipendra Khadka, Dipendra Khadka, Zhang Xinyi, Zhang Xinyi, Zhang Mengjie, Zhang Mengjie, Rajan Bhusal, Chichen Zhang, Chichen Zhang

“…This study evaluated the implementation status, challenges, and opportunities of the NHP at the local level in Nepal.Materials and methodsA descriptive cross-sectional study was conducted in the Lumbini province among 166 health workers selected through simple random sampling. Data were collected from October 10 to November 15, 2024, using a structured questionnaire developed in Nepali through literature review and expert consultations. …”
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The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation by Belayneh Mengist, Mojtaba Lotfaliany, Julie A. Pasco, Bruno Agustini, Michael Berk, Malcolm Forbes, Melissa M. Lane, Suzanne G. Orchard, Joanne Ryan, Alice J. Owen, Robyn L. Woods, John J. McNeil, Mohammadreza Mohebbi

“…We applied inverse probability treatment weighting to balance confounders. Marginal structural models were employed to estimate the population-level average effect of intervention using generalised estimated equations. …”
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Exploring key factors related to child well-being: a community-based participatory research together with children with migration background residing in socio-economically disadvan... by Louise Burenby Yxne, Louise Burenby Yxne, Rathi Ramji, Rathi Ramji, Elisabeth Mangrio, Elisabeth Mangrio, Elisabeth Mangrio, Katarina Sjögren Forss, Katarina Sjögren Forss, Therese Sterner, Therese Sterner, Margareta Rämgård, Margareta Rämgård

“…The themes covered structural aspects, such as school, healthcare and human rights, but also more personal dimensions, like close relations and the near environment, related to Bronfenbrenner’s ecological theory of human development.ConclusionThe dialogs with the children provided a deeper understanding and a holistic view of the perceptions of children with migration backgrounds residing in socio-economically disadvantaged areas regarding essential factors for their well-being. …”
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Understanding Associations Between Patient‐Level Factors and Participation in a Breast Cancer Clinical Trial by Nicole E. Caston, Luqin Deng, Courtney P. Williams, Emily B. Levitan, Andres Azuero, Russell Griffin, Karen L. Smith, Antonio C. Wolff, Michelle E. Melisko, Eileen H. Shinn, Kathleen Gallagher, Rebekah Angove, Stephanie B. Wheeler, Gabrielle B. Rocque

“…Standardized total effects (bTot) were estimated using a prespecified Structural Equation Model with 0.1, 0.3, and 0.5 indicating weak, medium, and large magnitude, respectively. …”
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Diarrhea Prevalence and Sociodemographic Factors among Under-Five Children in Rural Areas of North Gondar Zone, Northwest Ethiopia by Atalay Getachew, Tadesse Guadu, Alebachew Tadie, Zemichael Gizaw, Mulat Gebrehiwot, Daniel Haile Cherkos, Martha Alemayehu Menberu, Teklay Gebrecherkos

“…A community-based cross-sectional study was conducted from April to June 2016 among 736 randomly selected households with one child under five years old. A structured questionnaire was used for collecting information on sociodemographic characteristics and diarrheal occurrence. …”
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Co-producing a transition model of care for eating disorders: lessons learned from a multi-perspective qualitative study with young people, carers and mental health professionals by Maria Livanou, Anya Heneghan, Grace Hill, Alanta McKenzie, Marta Marlais, Francesca Marshall, Zara Smalley, Eleni Xanthopoulou, Nora Kornai, Jessica Wilks, Ailsa McKay, Jun Teh, Isabel Taylor, Charlotte Burton, Julian Baudinet

“…Methods Fifteen semi-structured interviews were conducted with young people (n = 6) and carers (n = 9), alongside two focus groups involving 12 mental health professionals. …”
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Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus by Ling Wang, Yu Zhang, Rui Zhao, Yan Huang, Xinghao Wang, Yuyou Huang, Jiancheng Zhang, Han Lv, Pengfei Zhao, Zhenghan Yang, Qian Chen, Zhenchang Wang

“…Objective: To examine structural and functional changes in auditory cortex(AC) subregions of patients with tinnitus and identify potential predictive indicators for sound therapy. …”
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Influencing Factors and Paths of the Coupling Relationship Between Ecosystem Services Supply–Demand and Human Well-Being in the Hexi Regions, Northwest China by Yongge Li, Wei Liu, Meng Zhu, Qi Feng, Linshan Yang, Jutao Zhang, Zhenliang Yin, Xinwei Yin

“…Here, we assessed dynamic changes in ecosystem services supply–demand, human well-being, their coupling relationships and influencing factors in the Hexi Regions by integrating remote sensing data, ecological model, ecosystem services supply–demand ratio (ESDR), coupling coordination degree (CCD) model, and the partial least squares structural equation modeling (PLS-SEM). …”
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Diagnosis, evaluation and management of osteoporosis in chronic kidney disease: navigating treatment approaches – Indian consensus statement by Vijay Kher, Rajkumar Sharma, Georgi Abraham, Bharat Shah, Sishir Gang, Sanjeev Gulati, Manisha Sahay, Jatin Kothari, Anil Kumar BT, Raja Ramachandran, Sanjay Kalra, Rakesh Kumar Sahay, Om Lakhani, Jay Kumar Sharma, Deepak Bunger, Thomas L. Nickolas

“…Given the lack of robust clinical trial data and a notable knowledge gap exists among nephrologists regarding an optimal management in this population, an expert consensus is crucial for developing tailored management strategies. …”
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High prevalence of fecal carriage of extended-spectrum beta-lactamase producing Enterobacterales among patients with urinary tract infections in rural Tanzania by Magreth Erick Macha, Magreth Erick Macha, Magreth Erick Macha, Weihong Qi, Salome N. Seiffert, Anja Bösch, Philipp Kohler, Honorathy Msami Urassa, Sabine Haller, Erin West, Maja Weisser Rohacek, Maja Weisser Rohacek, Maja Weisser Rohacek, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury

“…Francis Regional Referral Hospital, Ifakara, Tanzania, from October 2021 to August 2023, involving 326 UTI patients. Demographic data and resistance risk factors were collected via structured questionnaires. …”
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Ecotype-specific responses of Typha domingensis to microplastics: Antioxidant defense and biochemical adaptations in wetland ecosystems by Muhammad Aqeel, Ali Noman, Saher Nawaz, Noreen Khalid, Muhammad Kashif Irshad, Muhammad Faisal Iqbal, Modhi O. Alotaibi, Motirh Al-Mutairi, Mohamed O. Alshahrani, Nahaa M. Alotaibi, Fahad Mohammed Alzuaibr

“…Data were analyzed using one-way ANOVA and PCA (n = 6), with significance at P ≤ 0.05. …”
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Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). Subsequently, the structural, textural, and surface chemistry properties of these biochars were assessed. …”
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snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

“…Subsequently, we employed single-nucleus RNA sequencing (snRNA-seq) to comprehensively characterize iWAT cellular dynamics during cold stimulation and the subsequent two-week period after the return to thermoneutrality.ResultsOur findings revealed that while iWAT phenotypically reverts to a white state after 2 weeks of rewarming, as evidenced by structural, functional, and bulk transcriptomic characteristics, significant cold-induced molecular and cellular signatures persist. …”
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Mediation of nutritional status between the number of teeth and depressive symptoms in multi-ethnic older adults from Western China by Xin Tian, Xin Xia, Huixian Li, Yuexia Hu, Yuqing Xie, Xiuying Hu, Jirong Yue, Birong Dong, Bei Wu, Yanyan Wang

“…This study aimed to investigate the role of nutritional status in mediating the number of teeth and depressive symptoms.MethodA prospective multi-ethnic baseline data of 6,632 adults aged 50 years and older was derived from the 2018 West China Health and Aging Trend study. …”
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Serological evaluation of Crimean-Congo Hemorrhagic fever in humans with High-Risk professional exposure and in residual sera collected in 2022-2023 across Corsica (France) by Paloma Kiwan, Morena Gasparine, Dorine Decarreaux, Lisandru Capai, Shirley Masse, Miša Korva, Tatjana Avšič-Županc, Jean Canarelli, Marie-Helene Simeoni, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi

“…Sociodemographic and epidemiological data were collected using a structured questionnaire in the high-risk group. …”
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The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens by Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu

“…By analysing the polymorphism of this residue in various subtype viruses, we found that PA-X 100 was highly variable in H7N9 viruses. Structural analysis revealed that 100 V was generally close to the PA-X endonuclease active site, which may account for its host shutoff activity. …”
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Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

“…Background: Outdoor air pollution exposure is associated with structural and functional brain differences and an increased risk for psychopathology. …”
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Perceived effectiveness and recommendations from a childbirth quality assurance and improvement programme in India’s private sector: a qualitative evaluation using the RE-AIM frame... by Katherine Semrau, Meghna Desai, Lauren Spigel, Somesh Kumar, Megan Marx Delaney, Lauren Bobanski, Suranjeen Pallipamula, Natalie Henrich, Tapas Sadasivan Nair, Hema Divakar, Rajat Chabba, Shweta Jindal, Gulnoza Usmanova, Sukanya Dutta, Aarushi Gupta, Sucheta Kinjawadekar, Priti Kumar, Priyanka Kumari, Prerna Mukharya, Hrishikesh Pai, Ameya Purandare, Pompy Sridhar

“…We aimed to understand participants’ motivations for joining or not joining, the perceived value of Manyata and recommendations for sustainment and scale.Methods We aimed to sample 238 Manyata participants for semi-structured, in-depth interviews between February and July 2021. …”
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COVID-19 vaccine uptake, barriers and associated factors among healthcare workers in Malawi by Clara Sambani, Tonny Muwonge, Liness Chinyamunyamu, Amon Dembo, Mosoka P. Fallah, Victor Chikwapulo, Mavuto Thomas, Charity Gondwe, Regina Mankhamba, Leah Mbabazi, Suzan Nakasendwa, Rodgers R. Ayebare, Collins Mitambo, Matthew Kagoli, Dzinkambani Kambalame, Clement Seven, Tadala Mwale, Edna Mandala, Abigail Kazembe, McWilliam Kalua, Senga Sembuche, Elizabeth Gonese, Tamrat Shaweno, Nebiyu Dereje, Evelyn C. Banda, Tajudeen Raji, Mitch Matoga

“…Data were managed in REDCap and analysed using STATA version 14. …”
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Clinical effectiveness of mindfulness-based music therapy on improving emotional regulation in blind older women: A randomized controlled trial by Sunny H.W. Chan, Meryl Y.C. Cheung, Armstrong T.S. Chiu, Mimi H.T. Leung, Michael C.C. Kuo, Donald Y.C. Yip, Carole C.Y. Hui, Sally W.I. Kam, King Yeung, Doreen S.P. Mui, Shu-Mei Wang, Calvin C.K. Yip

“…Background: This study aimed to investigate clinical effectiveness of a structured eight-week mindfulness-based music therapy (MBMT) program on improving mood regulation in older women with blindness. …”
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