A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response by Xiao‐Ming Lyu, Xiao‐Wei Zhu, Manli Zhao, Xian‐Bo Zuo, Zhong‐Xi Huang, Xiao Liu, Tao Jiang, Xue‐Xi Yang, Xin Li, Xiao‐Bing Long, Jian‐Guo Wang, Jin‐Bang Li, Ming‐Yu Han, Shuang Wang, Teng‐Fei Liu, Bo Zhang, Tao Sun, Zhi Cheng, Mo‐Chang Qiu, Lei Dong, Lu Zheng, Long‐Cheng Zhang, Jia‐Hong Wang, Gan‐Guan Wei, Kaitai Yao, Qian Wang, Hou‐Feng Zheng, Xin Li

“…Abstract The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes. …”
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Mapping the Filamentary Nebula of NGC 1275 with Multiwavelength SITELLE Observations by Carter Lee Rhea, Julie Hlavacek-Larrondo, Marie-Lou Gendron-Marsolais, Benjamin Vigneron, Megan Donahue, Auriane Thilloy, Laurie Rousseau-Nepton, Mar Mezcua, Norbert Werner, Jorge Barrera-Ballesteros, Hyunseop Choi, Alastair Edge, Andrew Fabian, G. Mark Voit

“…The filamentary nebula encompassing the central galaxy of the Perseus Cluster, NGC 1275, is a complex structure extending dozens of kiloparsecs from NGC 1275. …”
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Association of cancer and outcomes of patients hospitalized for COVID-19 between 2020 and 2023 [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Robert F Terry, Rugiatu Z Kamara, Robert J Samuels, Donald S Grant, Sulaiman Lakoh, Mustapha Kabba, Innocent Nuwagira, Yusuf Sheku Tejan, Sia Morenike Tengbe, Ibrahim Franklyn Kamara, Shermarke Hassan, Abdulai Tejan Jalloh, Divya Nair, Laura Merson

“…Methods We conducted an analysis on data collected in a large prospective cohort study set-up by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC). …”
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Insights from a Pseudo-Polygyny Cohort unmasking high sperm concentration and low forward motility as potential risk factors for recurrent failure of sperm donation IVF (RFDI), a s... by Tiancheng Zhang, Fan Dong, Xu Zhang, Ping Ping, Jin Qiu, Zhen Lu, Huachun Zou, Qian Xiao, Jianhui Li, Gaoyue Zhang, Huijuan Shi, Xiangfeng Chen

“…We investigated potential risk factors for UMI leveraging data from a sperm bank with a “one male to multiple females” structure to reduce confounding arising from female factors. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

“…Intensive study of the T6SS structure has led to an understanding of certain issues related to its functional activity, but the exact regulatory mechanisms of E-I protein pair activity remain unclear. …”
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The MaNGA Dwarf Galaxy Sample (MaNDala): Stellar Profiles and Gradients Characterization by M. Cano-Díaz, A. Rodríguez-Puebla, A. C. Robleto-Orús, V. Ávila-Reese, H. M. Hernández-Toledo, J. A. Vázquez-Mata, O. Valenzuela, J. J. González, H. J. Ibarra-Medel, J. C. Clemente-González, L. Pavón-Alvarez

“…We derived robust radial profiles and inner/outer gradients of various stellar population (SP) properties for a sample of 124 bright dwarf galaxies, 10 ^7.53 ≤ M _* / M _⊙ ≤ 10 ^9.06 , from the MaNDala sample, using integral field spectroscopy observations. Given the complex structure of dwarf galaxies, we explored four different methods to derive SP radial profiles: two based on concentric elliptical rings, and the other two exploiting the spatially resolved nature of the data. …”
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A Rare Case of Exophiala Dermatitidis Isolation in a Patient with Non-Cystic Fibrosis Bronchiectasis: Colonization or True Infection? by Francesco Rocco Bertuccio, Nicola Baio, Simone Montini, Valentina Ferroni, Vittorio Chino, Lucrezia Pisanu, Marianna Russo, Ilaria Giana, Elisabetta Gallo, Lorenzo Arlando, Klodjana Mucaj, Mitela Tafa, Maria Arminio, Emanuela De Stefano, Alessandro Cascina, Angelo Guido Corsico, Giulia Maria Stella, Valentina Conio

“…<b>Discussion:</b> This case underscores the diagnostic challenges in distinguishing fungal colonization from true infection in structurally abnormal lungs. In NCFB, disrupted mucociliary clearance and microbial dysbiosis may facilitate fungal persistence, even in the absence of overt immunosuppression. …”
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Using Natural Language Processing to Explore Patient Perspectives on AI Avatars in Support Materials for Patients With Breast Cancer: Survey Study by Eleanor Cheese, Raouef Ahmed Bichoo, Kartikae Grover, Dorin Dumitru, Alexandros Zenonos, Joanne Groark, Douglas Gibson, Rebecca Pope

“…We applied and evaluated different NLP machine learning techniques to draw insights from these unstructured data, namely sentiment analysis, topic modeling, summarization, and term frequency–inverse document frequency word clouds. …”
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Clinical analysis of vitrectomy combined with dexamethasone intraveal implant in the treatment of epiretinal membrane by WU Kunfang, GUO Meimei, LI Xiang, WANG Dingding

“…Both surgical methods can improve the structure, function, and microcirculation disorders in the macular area. …”
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User-Driven Development of a Digital Behavioral Intervention for Chronic Pain: Multimethod Multiphase Study by Afra Selma Taygar, Sara Laureen Bartels, Rocío de la Vega, Ida Flink, Linnéa Engman, Suzanne Petersson, Sophie I Johnsson, Katja Boersma, Lance M McCracken, Rikard K Wicksell

“…The Consolidated Framework for Implementation Research was used to structure analyses of end-user feedback. …”
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Nanoscale Organic Contaminant Detection at the Surface Using Nonlinear Bond Model by Hendradi Hardhienata, Muhammad Ahyad, Fasya Nabilah, Husin Alatas, Faridah Handayasari, Agus Kartono, Tony Sumaryada, Muhammad D. Birowosuto

“…Our simulations show good agreement with rotational anisotropy (RA) SHG intensity experimental data across all polarization angles, with a total error estimate of 3%. …”
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Vaccine Hesitancy and Immunization Patterns in Central and Eastern Europe: Sociocultural, Economic, Political, and Digital Influences Across Seven Countries by Kurpas D, Stefanicka–Wojtas D, Soll–Morka A, Lomper K, Uchmanowicz B, Blahova B, Bredelytė A, Dumitra GG, Hudáčková V, Javorska K, Juhász Z, Manulik S, Mohos A, Skarbalius E, Tkachenko VI, Uchmanowicz I

“…Differences were influenced by healthcare system structure, public trust, exposure to misinformation, and digital communication strategies.Conclusion: Addressing vaccine hesitancy requires targeted, context-sensitive communication and digital literacy programs. …”
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Comparative analysis of efficacy and safety of transurethral and vesicoscopic surgery of primary vesicoureteral reflux in children by A. V. Pirogov, V. V. Sizonov, M. I. Kogan

“…When comparing the gender structure of the groups, differences were not detected (p &gt;0.05). …”
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Depressive disorders in women of climacteric age (review of foreign literature for 2012–2016) by N. A. Bokhan, E. V. Lukiyanova, G. G. Simutkin

“…Low timely diagnostics of depressions, high incidence rate of somaticized CD are noted. In the structure of climacteric syndrome the psychoemotional disturbances predominate above neurovegetative and metabolic-endocrine or are combined with vegetative dysfunction. …”
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Fecal microbiota transplants (FMT) of three distinct human communities to germ-free mice exacerbated inflammation and decreased lung function in their offspring by Ivon A. Moya Uribe, Hinako Terauchi, Julia A. Bell, Alexander Zanetti, Sanket Jantre, Marianne Huebner, S. Hasan Arshad, Susan L. Ewart, Linda S. Mansfield

“…Structure of HUmicrobiotas played a key role in determining varied allergic responses and resulting lung impairment, yet, strikingly, all mice with HUmicrobiotas had impaired lung function even in the absence of allergens. …”
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Advancing Heart Valve Replacement: Risk Mitigation of Decellularized Pulmonary Valve Preparation for Its Implementation in Public Tissue Banks by Rodríguez Martínez JI, Castells-Sala C, Piteira AR, Montagner G, Trojan D, Martinez-Legazpi P, Acosta Ocampo A, Fernández-Santos ME, Bermejo J, Jashari R, Pérez ML, Agustí E, Tabera J, Vilarrodona A

“…The present study aims to document the work performed for the safe implementation in public tissue banks of a new decellularization method for human pulmonary heart valves, based on previous risk evaluation.Methods: After assessing new preparation method associated risks, using EuroGTP-II methodologies, an extensive array of in vitro studies were defined to validate the new technique, mitigate the risks and provide quality and safety data.Results: Initial evaluation of risks using EuroGTP II tool, showed Final Risk Score of 23 (high risk), and four studies were devised to mitigate identified risks: (i) tissue structure integrity; (ii) cell content; (iii) microbiological safety; and (iv) cytotoxicity evaluation in final tissue preparation. …”
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Trends in the epidemiology of diabetic retinopathy in Russian Federation according to the Federal Diabetes Register (2013–2016) by Dmitry V. Lipatov, Olga K. Vikulova, Anna V. Zheleznyakova, Mikhail А. Isakov, Elena G. Bessmertnaya, Anna A. Tolkacheva, Timofey A. Chistyakov, Marina V. Shestakova, Ivan I. Dedov

“…Trend of new DR cases/per year increased: T1 153,2&rarr;187,8; T2 99,7&rarr;114,9. The structure of new cases of DR in 2016: non-proliferative stage (T1 71,4%, T2 80,3%), pre-proliferative stage 16,4%, 13,8%, proliferative 12,1%, 5,8%, terminal 0,2%, 0,1%, respectively, these data indicated the earlier detection of DR. …”
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PROPERTIES OF NEW SALTS OF 2-(5-(ADAMANTANE-1-YL)-4-R-1,2,4-TRIAZOLE-3-YLTIO)ACETIC ACIDS IN THE GLUCOSE TOLERANCE TEST by V. M. Odyntsova, Ye. S. Pruhlo, O. I. Panasenko, Ye. H. Knysh

“…The dependence of pharmacological activity on chemical structure has been determined. Conclusion In conditions of glucose tolerance test all studied salts increased blood glucose level. …”
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Construction of a preoperative emotional state and postoperative intra-abdominal pressure based prediction model for early enteral feeding intolerance in postoperative patients wit... by Yingying Xu, Qiongyuan Hu, Dandan Pei, Yin Zhang, Huanhuan Zhu, Yan Hui, Wenxian Guan, Meiling Xu, Li Chen

“…BackgroundThe incidence of enteral feeding intolerance (ENFI) in the early postoperative period is high in patients after gastric cancer resection due to the characteristics of surgical traumatic stress and changes in the physiological structure of the digestive tract, and the current evaluation of ENFI after gastric cancer resection mostly depends on the symptoms and complaints of patients after gastric cancer resection, which is lagging and subjective. …”
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Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors by Marta La Vecchia, Michela Giulia Clavenna, Marika Sculco, Gloria Sala, Denise Marradi, Elettra Barberis, Soni Joseph, Marta Mellai, Nico Pagano, Renzo Boldorini, Barbara Azzimonti, Elisa Bona, Edoardo Pasolli, Flavia Prodam, Carlotta Sacerdote, Daniela Ferrante, Emilia Ghelardi, Marcello Manfredi, Anna Aspesi, Irma Dianzani

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