Exploration of the relationship between partial pressure of brain tissue oxygen and intracranial pressure by Martin Shaw, Laura Moss, Ian Piper, Maya Kommer, Richard Boulton, Roddy O'Kane, Christopher Hawthorne

“…Material and methods: Patients with PbtO2 monitoring were identified from the BrainIT database, a multi-centre dataset, containing minute by minute PbtO2 and ICP readings. Missing data was imputed and a multi-level log-normal regression model with a compound symmetry correlation structure was built. …”
Get full text

COZMIC. I. Cosmological Zoom-in Simulations with Initial Conditions Beyond Cold Dark Matter by Ethan O. Nadler, Rui An, Vera Gluscevic, Andrew Benson, Xiaolong Du

“…Thus, future development of IDM SHMF models can improve IDM cross section bounds by up to a factor of ∼20 with current data. COZMIC presents an important step toward accurate small-scale structure modeling in beyond-CDM cosmologies, critical to upcoming observational searches for dark matter physics.…”
Get full text

Helping people with psychosis with a low-cost intervention DIALOG+: protocol for the economic evaluation in a randomised control trial in India and Pakistan by Victoria Jane Bird, Sara Evans-Lacko, Lakshmi Venkatraman, Padmavati Ramachandran, Ashar Muhammad Malik, Renata Peppl, Sana Zehra Zehra Sajun, Onaiza Qureshi, Krishna Priya, Hufsa Sarwar

“…Incremental cost, incremental effectiveness and incremental cost-effectiveness ratios will be calculated using linear regression models with a hierarchical data structure. A probabilistic sensitivity analysis will be carried out to test for the uncertainty surrounding the estimates of cost-effectiveness.Discussion This study will provide evidence of a patient-centred approach to improve the quality of community-based care for people with psychosis in India and Pakistan. …”
Get full text

Effects and mechanisms of supramaximal high-intensity interval training on extrapulmonary manifestations in people with and without chronic obstructive pulmonary disease (COPD-HIIT... by Johan Jakobsson, Chris Burtin, Mattias Hedlund, Carl-Johan Boraxbekk, Jonas Westman, Nina Karalija, Per Stål, Thomas Sandström, David Ruttens, Harry R. Gosker, Jana De Brandt, André Nyberg

“…Key secondary outcomes include change from baseline exercise tolerance, brain structure, and function measured by MRI, neuroinflammation measured by PET/CT, systemic inflammation, and intramuscular adaptations. …”
Get full text

Development and Characterization of Pyrolyzed Sodium Alginate–Montmorillonite Composite for Efficient Adsorption of Emerging Pharmaceuticals: Experimental and Theoretical Insights... by Ibrahim Allaoui, Rachid Et-Tanteny, Imane Barhdadi, Mohammad Elmourabit, Brahim Arfoy, Youssef Draoui, Mohamed Hadri, Khalid Draoui

“…Using Density Functional Theory (DFT) along with the 6-31G (d) basis set, the geometric structure of the molecule was determined, and the properties were estimated by analyzing its boundary molecular orbitals. …”
Get full text

Optimizing the Construction Supply Chain Network Considering the Flow of Materials, Equipment, Manpower, Drawings and Technical Documents by Seyed Saeid Helli, Hadi Mokhtari, Saeed Dehnavi

“…In the classic supply chain, the flow of materials and output at the end of the chain includes the manufactured product, while in the construction supply chain, the final output includes a building or a structure. Individuals, industries and even countries incur a lot of construction costs to meet their needs in the field of construction. …”
Get full text

Validation of a questionnaire to assess complexity of palliative care needs in primary care in Malaga, Spain: a study protocol by Jose Miguel Morales-Asencio, Rafael Gomez-Garcia, Pilar Barnestein-Fonseca, Francisca Leiva-Fernandez, Auxiliadora Fernández-López, Maria Luisa Martín-Roselló, Virginia Patricia Aguiar-Leiva

“…A specific diagnostic tool to assess complexity in PC (IDC-Pal: Instrumento Diagnóstico de la Complejidad en Cuidados Paliativos, in Spanish) was created in community and hospital settings with 36 items to diagnose PC complexity, but its application in primary care is difficult.Aims (1) To generate an adapted version to primary care of the IDC-Pal tool to identify and stratify PC complexity in the adult population. (2) To determine face, content, criterion and construct validity and reliability of the new instrument.Methods and analysis There are three phases of clinimetric cross-sectional observational validation study: Phase 0: Review of the original tool structure suitability for its use in primary care setting by a committee (researchers and the original developer team). …”
Get full text

Geospatial Innovation Breakthroughs: A Study on the Impact of Talent Birthplace Diversity and Multidimensional Proximity by Jin Wenwan, He Xinyi, Zhu Shengjun, Zhang Xudong

“…However, the global distribution of technological innovation remains uneven, with a sustained "core-periphery" structure. From the perspective of evolutionary economic geography, technological development paths are closely linked to the local knowledge base, making it generally difficult to overcome spatial constraints. …”
Get full text

Taxonomic composition, distribution and resources of macrobenthos in Peter the Great Bay in 2011 by Victor A. Nadtochy, Nikolai V. Kolpakov

“…Anyway, the dominant taxonomic groups of Peter the Great Bay macrobenthos were constantly bivalves and polychaetes (and barnacles in the Amur Bay) and all changes in taxonomic structure or even replacing each other concerned the subdominant and minor taxa. …”
Get full text

Synthesis and study of the anticancer activity of some new 7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazines by I. I. Myrko, T. I. Chaban, V. V. Ohurtsov, I. V. Drapak, V. S. Matiichuk

“…The reaction proceeds by heating the above reagents in alcohol with the closure of the thiadiazine ring and the formation of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine systems. The structure of all synthesized compounds was confirmed by 1H NMR spectroscopy and elemental analysis data. …”
Get full text

Device optimization of CsPbI2Br-based inorganic perovskite solar cells using different charge transport layers via SCAPS-1D by Muhammad Siddique, Muhammad Sultan, M.Shahid Iqbal Khan, Syed Hamza Safeer

“…We hope our findings will contribute to understanding the Perovskite solar cells (PSCs) structure with different hole transport layers, and ultimately lead to the development of more efficient, stable, and cost-effective perovskite solar cells for commercial applications.…”
Get full text

Asteroseismology of One of the Most Rapidly Rotating DBV Stars: EPIC 248705247 by Jiayi Zhang, Jianning Fu, Tianqi Cang, Jie Su, Yanhui Chen, Xiaoyu Ma, Gang Meng

Get full text

Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis by Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim

“…All three NEK1 variants exhibited abnormal primary ciliary structure, impaired sonic hedgehog signaling, and altered cell-cycle progression. …”
Get full text

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model. by Emily A Kendall, Sourya Shrestha, Ted Cohen, Eric Nuermberger, Kelly E Dooley, Lice Gonzalez-Angulo, Gavin J Churchyard, Payam Nahid, Michael L Rich, Cathy Bansbach, Thomas Forissier, Christian Lienhardt, David W Dowdy

“…Limitations include sparse data on key model parameters and necessary simplifications to model structure and outcomes.…”
Get full text

Left bundle branch block in coronary artery disease: toward novel electrocardiographic markers by Yuri N. Fedulaev, Irina V. Makarova, Alisa V. Grigorieva, Dzhamilya R. Kapitonova, Gulfiya A. Khairetdinova

“…There were no significant differences in the mortality structure between groups. CONCLUSION: The presence of fragmented QRS complexes on electrocardiogram in patients with complete left bundle branch block is associated with further QRS widening and QTc prolongation, a trend toward reduced left ventricular ejection fraction, increased frequency of cardiovascular-related hospitalizations, and progression of heart failure severity. …”
Get full text

Environmental Impact of Physical Visits and Telemedicine in Nursing Care at Home: Comparative Life Cycle Assessment by Egid M van Bree, Lynn E Snijder, Hans C Ossebaard, Evelyn A Brakema

“…Telemedicine visits were elementary in nature, such as supporting patients in taking their medication or structuring their daily agenda. We quantified average environmental impacts from cradle to grave, using the Environmental Footprint method, and verified the robustness of the comparison via uncertainty analysis. …”
Get full text

The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies by Bowen Wang, Desheng Xie, Jianming Huang, Zheyuan Huang, Weizong Weng, Danlei Huang, Ying Zhang, Xiaolin Chen

“…Conclusions: Exosome-loaded hydrogels show potential for improving the structure and function of intervertebral discs in IDD treatment, potentially slowing degeneration by inhibiting matrix degradation and cellular aging. …”
Get full text

Technical advances and research directions of borehole geophysical prospecting for coal mines by Jianyuan CHENG, Yu YAN, Yuteng LI, Pan WANG, Rui ZHAO, Bici JIANG

“…ProgressFor intra-borehole geophysical technology, high-frequency (HF) reflection radar within a near-horizontal borehole in coal mines allows for the coal-rock interface exploration and geological structure identification within a radial distance range of 0 to 10 m. …”
Get full text

In Vitro Effects of Vanadate Erbium/Silver Oxide (ErVO4/AgO) and Vanadate Iron/Silver Oxide (FeVO4/AgO) Nanoparticles on the Adult of Fasciola hepatica by Arbabi Mohsen, Esmaili Monireh, Hooshyar Hossein, Delavari Mahdi, Sobhani Nasab Ali, Nejati Majid

“…To ensure the reliability of the data, the tests on the sample were performed twice. …”
Get full text

Multi-branch horizontal well hole docking pressure control extraction technology for close distance coal seam group by Liang CHEN, Zhiheng CHENG, Xin LUO, Hongyang YU, Zherui ZHANG, Peng WANG, Xiangdong WANG

“…Taking Shaqu well field in Lyuliang city, Shanxi province as an example, through theoretical analysis and data statistics, the geological structure of coalbed methane accumulation in the well field, the influence of hydrodynamic conditions, coalbed methane reservoir characteristics and gas-bearing distribution are obtained. …”
Get full text