Trend analysis of precipitation and temperature in Lahaul-Spiti district, Himachal Pradesh, India by Pankaj Kumar, Dhanjit Deka, Md. Arif Husain, Manish Kumar, Pandurang Choudhari, Shipra Singh, Azka Kamil, Abhishek Banerjee

“…Changes in the pattern of precipitation and temperature affect the socioeconomic structure of the region, affecting sectors such as agriculture, livestock, forestry, tourism, and human health. …”
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Interfaz entre el plan de producción y el programa de producción en ambientes de ensamble Interface between the production plan and the master production schedule in assembly envir... by Marcos Moya Navarro, Magaly Sánchez Brenes

“…</p> <p>The aim of this paper is to show the interface between both the production process planning and the scheduling process in assembly environments by means of linear programming.The manufacturing process selected is capable of producing three products with a product structure arranged on three levels with a maximum of eight components each. …”
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On exploring cross-sectional stability and persistence of microbiome in a multiple body site colorectal cancer dataset by Hajra Ashraf, Hajra Ashraf, Sama Rezasoltani, Mohammad Mehdi Feizabadi, Seyedesomaye Jasemi, Hamid Asadzadeh Aghdaei, Zahra Bakudezfouli, Umer Zeeshan Ijaz, Umer Zeeshan Ijaz, Umer Zeeshan Ijaz, Leonardo A. Sechi, Leonardo A. Sechi

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Study on the spatial and temporal differences and influencing factors of out-of-pocket payments as a share of total health expenditure in China by Xiaoyu Dong, Huaizhi Cheng, Ruotong Tian, Lingxiao Gao, Wenpei Lyu, Jiaqi Zhang, Doudou Huang, Bin Guo

“…The government should further implement differentiated medical security policies, optimize the allocation structure of health resources, enhance the capacity of primary medical services, promote cross-provincial medical cooperation, and ensure that local residents can enjoy equal access to high-quality medical services and reduce their medical burden.…”
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Transcriptome analysis of gills reveal the key metabolism-related genes and pathways response to ammonia nitrogen stress in Scylla paramamosain by Chaoyue Wang, Xiao Liu, Jie Zhou, Sixiang Wang, Xia Zheng, Zehao Li, Yuanyuan Fu, Zhongwen Jin, Lei Liu

“…Ammonia nitrogen stress caused significant damage to the morphology and structure of the gills, with prolonged exposure leading to further damage, including cellular vacuolization and narrowing of the gill hemolymph chambers. …”
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Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulati... by Chunxiu Lin, Yugui Lin, Rui Xiao, Min Guo, Hao Zhang, Wei Chen, Gang Wang

“…Notably, both in vitro intestinal fermentation models and genomic analyses demonstrated that the three Bifidobacterium species cannot synthesize these unsaturated fatty acids due to the lack of related genes. However, data suggested that these species might promote the accumulation of arachidonic acid and docosahexaenoic acid by regulating the gut microbiota’s structure and function. …”
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Heterogeneous Integrated III-V-on-SOI Photodetector Using Micro-transfer Printing Method by WANG Zhaocong, QUAN Zhiheng, ZHENG ShiGuanqing, ZHU Yan, YE Nan, LU Liangjun, ZHOU Linjie, SONG Yingxiong

“…【Results】The response bandwidth of the heterogeneous integrated photodetector obtained by micro-transfer integration is about 4 GHz, and the dark current is about 13 nA (@-13 V), which is basically consistent with the performance test data before the integration of the sample. Affected by the coupling loss, the responsivity of the integrated structure is 7.3×10^-3 A/W (@-25 V). …”
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Evaluation of the Efficacy and Safety of Initial Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Middle-Aged People by T. V. Alexandrova, O. V. Muslimova, M. V. Zhuravleva, A. A. Alexandrov, G. I. Gorodetskaya, E. Yu. Demchenkova, O. A. Demidova, E. A. Sokova, I. A. Mazerkina, Yu. А. Smirnova

“…The study results indicate that the structure of comorbidity did not affect the effectiveness of initial empirical ABT. …”
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Whole genome resequencing reveals the evolutionary history and geographic isolation of the eastern Asian Hickory (Carya) by Da Zhang, Rui‐Feng Yang, Jia‐Hui Chen, Lang‐Bo Pan, Wei Duan, Guo‐Hua Xia, Qi‐Xiang Zhang, You‐Jun Huang

“…Based on the SNPs (single nucleotide polymorphisms) data generated by the whole genome deep resequencing of five EA (Eastern Asian) Carya species, we constructed the phylogenetic tree, genetic structure, and species distribution modeling to clarify the phylogenetic relationships and to predict the potential distribution area of EA Carya. …”
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Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration by Dan Wu, Chen Yan, Linhui Han, Fudong Li, Ximing Xu, Jingchuan Sun, Yong Cao, Kaiqiang Sun, Jiangang Shi, Yuan Wang

“…Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncovered that the aberrant accumulation of R-Loops—a type of triple-stranded nucleic acid structure—can result in the cytoplasmic accumulation of double-stranded DNA (dsDNA) and activate cGAS/STING signaling and induce cellular senescence in nucleus pulposus cells (NPCs) during IVDD. …”
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A new index for detection of submerged aquatic plants under variable quality water: an extension of the soil-line concept by Shruti Khanna, Erin L. Hestir, Joaquim Bellvert, Jennifer D. Boyer, Kristen D. Shapiro, Susan L. Ustin

“…Submersed aquatic plant (SAP) communities are important determinants of estuarine and lacustrine food web structure, nutrient cycling, and water quality. Variation in water quality, SAP community composition and cover present challenges when mapping SAP robustly across estuarine ecosystems. …”
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Epigenetic modifications in the murine liver upon depletion of transcriptional coregulator host cell factor 1 by Shruti Kaushal, Debashruti Bhattacharya, Saran Kumar, Winship Herr, Jaspreet Kaur Dhanjal, Shilpi Minocha

“…RNA-seq analyses revealed significant downregulation of genes involved in cell cycle progression, metabolism, and mitochondrial structure and function including those regulating oxidative phosphorylation. …”
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Endoscopic retrograde cholangiopancreatography consultation after digestive tract reconstruction and risk factors for complications by Yan Cheng, Jiahui Feng, Xiaojia Chen, Jun Lin, Hongling Wang

“…Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of biliary and pancreatic diseases, and its success rate and therapeutic effect are considerable, and its use in patients with gastrointestinal tract reconstruction is also increasing. The anatomical structure of the digestive tract has been changed in these patients, which makes the use of endoscopic retrograde cholangiopancreatography technically more challenging. …”
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Spatio-temporal Evolution of Land Surface Temperature and Its Response to LULC in the Urban Agglomeration of Central Yunnan by LIN Zhiqiang, PENG Shuangyun, SHI Shuangfu, HUANG Bangmei, MA Dongling, ZHU Ziyi, MA Xiaoliang, GONG Luping

“…[Conclusion] LULC is an important factor affecting the LST, and reasonable configuration of LULC structure can improve the thermal environment of urban agglomeration. …”
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Color matching and translucency of single-shade resin composites: effects of restoration thickness, background shade, and aging by Hamideh Sadat Mohammadipour, Soroush Sarafraz Yazdi, Mohammad Javad Moghaddas Mashhad, Saber Babazadeh, Arsalan Shahri

“…Abstract Background Achieving a seamless color match in resin composite restorations remains a significant clinical challenge due to variations in tooth structure and background shades. The aim of this in vitro study was to assess the effect of background shade, thermal aging, and composite thickness on color matching and translucency of three single-shade resin composites. …”
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Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study. by Yuqi Hu, Le Gao, Lingyue Zhou, Wenlong Liu, Cuiling Wei, Boyan Liu, Qi Sun, Wenxin Tian, Rachel Yui Ki Chu, Song Song, Franco Wing Tak Cheng, Joe Kwun Nam Chan, Amy Pui Pui Ng, Heidi Ka Ying Lo, Krystal Chi Kei Lee, Wing Chung Chang, William Chi Wai Wong, Esther Wai Yin Chan, Ian Chi Kei Wong, Yi Chai, Francisco Tsz Tsun Lai

“…<h4>Methods and findings</h4>We extracted data from a territory-wide public healthcare database from January 2001 to August 2022 in Hong Kong to conduct a retrospective cohort study of anonymized patients aged 18+ years with a diagnosis of schizophrenia who used clozapine or olanzapine (drug comparator with highly similar chemical structure and pharmacological mechanisms) for 90+ days, with at least 2 prior other antipsychotic use records within both groups. …”
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The Effectiveness of Couple Therapy Based on Acceptance and Commitment ACT on Marital Violence and Desire for Separation in Couples Applying for Divorce by M Sadeghi, H Bagholi, R Azarmidakht, H Javidi

“…Methods: The present study applied a quasi-experimental, semi-experimental design with a pre-test and post-test structure, including a control group. The statistical sample consisted of 40 individuals selected from all couples seeking divorce in Yasuj, Iran, who were referred to family counseling centers in the first three months of 2023. …”
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Cloning and Analysis of the Expansin Gene BdEXP1 from Migration Plant parasitic Nematode (Bursaphelenchus doui) by Kaiyang GUO, Shifeng LIN, Rengang WANG, Li LI, Jie ZHANG, Shizhou YU, Zili WANG, Guoqin LIU

“…The BdEXP1 protein had the highest sequence similarity (64%) with the homologous protein of B. xylophilus, and contained a typical DPBB_SPI-like conservative domain and a signal peptide but no transmembrane structure, indicating that it was a secretory protein. …”
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Lipitension and cardiometabolic risk factors in young people by A. V. Sineglazova, A. Sh. Fakhrutdinova, T. Yu. Kim, S. D. Parve

“…In patients with lipitension, 43,8% were diagnosed with HTN, while the remaining 56,2% had BP ≥130/85 mm Hg. In the structure of dyslipidemia in lipitension, 79,2% had abnormalities in ≥2 lipid parameters, of which increased levels of low-density lipoprotein cholesterol (LDL-C) and hypercholesterolemia (78,3%) were most often detected. …”
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Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice by Ashish Kumar Tripathi, Sadaf Dabeer, Jun Song, Tatyana Vikulina, Susanne Roser-Page, Jessica A. Alvarez, David. R. Archer, M. Neale Weitzmann

“…To investigate HU action on SCD-related vertebral defects, we used HU-treated “Townes” mice, an SCD animal model and performed high-resolution micro-computed tomography (µCT) imaging to resolve bone volume and micro-architectural structure of cortical and trabecular bone, the two major compartments contributing to bone mass and strength. …”
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