Therapeutic potential of miR-204-5p in intervertebral disc degeneration: targeting the SSRP1/NF-κB pathway to inhibit apoptosis by Chenhao Zhao, Qiuwei Li, Cailiang Shen

“…This study investigated the protective role of miR-204-5p in IVDD by targeting the Structure-specific recognition protein-1(SSRP1)/nuclear factor-kappa B (NF-κB) signaling pathway. …”
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Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study by Mohammad K. Parvez, Md. Tabish Rehman, Perwez Alam, Mohammed S. Al-Dosari, Saleh I. Alqasoumi, Mohammed F. Alajmi

“…Being the most important drug target, a 3-D structure of HBV polymerase (Pol/RT) was modeled and docked with the active compounds, including lamivudine as standard. …”
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Development of a Method for Obtaining Nanoscale Magnesium Carbonate Stabilized with Chitosan as the Basis of Scaffold Matrices for Regenerative Medicine by A. V. Blinov, Z. A. Rekhman, A. A. Gvozdenko, M. A. Yasnaya, M. A. Kolodkin, M. A. Taravanov

“…The creation of three-dimensional matrices based on scaffolds for the formation of systems that are as close as possible to bone tissue in structure has been studied. It is known that the active substances of the scaffold matrix can be hydroxyapatite, tricalcium phosphate, as well as silicates, carbonates of magnesium, calcium, copper, zinc, and manganese. …”
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Emergence and evolution of rare ST592 blaNDM-1-positive carbapenem-resistant hypervirulent Klebsiella pneumoniae in China by Huan Zhang, Su Dong, Caiping Mao, Yuejuan Fang, Junjie Ying

“…Conjugation-related elements were predicted using oriTfinder. The plasmid structure was visualized using Circos, and a possible evolutionary model was constructed using BioRender.ResultsIsolates KPZM6 and KPZM16 were identified as ST592 and KL57, respectively, and were collected from the same department. …”
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Evaluation of tissue computed tomography number changes and dosimetric shifts after conventional whole-breast irradiation in patients undergoing breast-conserving surgery by Joo Hwan Lee, Dong Soo Lee, So Hyun Park, Young Kyu Lee, Jeong Soo Kim, Yong Seok Kim

“…Dosimetric parameters (V 105% , V 103% , V 100% , V 98% , V 95% , V 90% : V x% indicates volumes which receive X% of prescribed doses) between initial and re-sim CT scans were compared. The CT number data (CT mean , CT max , CT min ) of the original and irradiated CT (re-sim CT) scans from each representative structure (lung, rib bone, soft tissue, muscle, etc.) were examined and recruited. …”
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SELECTION CRITERIA OF COMPOUNDS FOR DEVELOPMENT OF HIGH-POTENT ANALGESICS AND OTHER CNS DRUGS by A. V. Sosnov, F. M. Semchenko, V. N. Tohmahchi, A. A. Sosnova, M. I. Vlasov, A. S. Radilov, D. V. Krivorotov

“…In order to analyze best practices, develop a strategy for highly effective controlled medicinal and veterinary drugs (analgesics, anesthetics, antidotes and other vital therapies) and coordinate theirdevelopment and production it is necessary to create competent management structure combining the tasks of provision of civilian population and personnel of national defense agencies of effective and safe drugs.…”
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Genome-Wide Association Study for Belly Traits in Canadian Commercial Crossbred Pigs by Zohre Mozduri, Graham Plastow, Jack Dekkers, Kerry Houlahan, Robert Kemp, Manuel Juárez

“…To identify quantitative trait loci (QTLs) and genes linked to key carcass traits, we conducted a genome-wide association study (GWAS) using whole-genome sequencing data from 1118 commercial pigs (Duroc sires and Yorkshire/Landrace F1 dams). …”
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The Effect of Maternal Attitudes and Depression on Bonding During the Postpartum Period by Şenyaşar Meterelliyoz K, Çağlar Mengi K, Yazar MS, Akbay Kısa AS

“…The findings indicated that an individual with a psychiatric diagnosis was 2.653 times more likely to exhibit impaired bonding (OR: 2.653, 95% CI: [1.08– 6.517]; p = 0.033), and those with a higher AToM score were 1.044 times more likely to display impaired bonding (OR: 1.044, 95% CI: [1.013– 1.075]; p = 0.004).Conclusion: The cognitive structure of the mother is associated with impaired mother-baby bonding. …”
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Cluster advantages in the state management of the financial resources of the agricultural sector in the Sakha (Yakutia) Republic by T. S. Rotar

“…Table methods of qualitative data visualization and statistical methods of social and economic phenomena and processes were used as a range of statistical tools in the research. …”
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Novel Magnetically Recoverable Amino-Functionalized MIL-101(Fe) Composite with Enhanced Adsorption Capacity for Pb(II) and Cd(II) Ions by Claudia Maria Simonescu, Daniela C. Culita, Gabriela Marinescu, Irina Atkinson, Virgil Marinescu, Ovidiu Oprea, Nicolae Stanica

“…Functionalization of the silica surface with chloride groups enables strong electrostatic interactions between the magnetic component and metal organic framework (MOF), ensuring a homogeneous and stable hybrid structure. The new composite’s capacity to remove Pb(II) and Cd(II) ions from aqueous solutions was systematically investigated. …”
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Quantifying synthetic bacterial community composition with flow cytometry: efficacy in mock communities and challenges in co-cultures by Fabian Mermans, Ioanna Chatzigiannidou, Wim Teughels, Nico Boon

“…This research illustrates the feasibility and challenges of flow cytometry for the determination of community structure in synthetic mock communities and co-cultures.…”
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Comparative Evaluation of the Effect of Hepatoprotectors on Oxidative Homeostasis in the Blood of Patients with Alcoholic Hepatitis: A Randomized Experimental Study by I. M. Bykov, G. A. Ermakova, K. A. Popov, I. Yu. Tsymbalyuk, M. I. Bykov, Ya. E. Denisova, S. M. Tutarisheva

“…An analysis of published results on the chemical structure, pharmacodynamics and pharmacokinetics of hepatoprotective agents, as well as their practical application, shows that a holistic view on the pharmacology of hepatoprotective agents is yet to be developed. …”
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Does a growth mindset curb anxiety among Chinese medical students? Validation based on propensity score matching by Xiao-Jing Yang, Yu-Tian Gan, Zi-Jiao Wang, Jian-Ye Wang, Xiao-Jian Duan, Xing Ma, Tao Sun, De-Pin Cao, Shu-E Zhang

“…Educators should foster the cultivation of growth mindset in medical students through multidimensional interventions involving cognitive scaffolding, behavioral reinforcement, and environmental structuring, which consequently enhances their psychological well-being. …”
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Development of production and the influence of regional factors on technological parameters qualities of sunflower seeds and oil by M. I. Lukinykh, E. Yu. Minnikhanova, A. V. Vyatkin

“…A correlation and regression analysis of the relationship between the indicators of sunflower seed production in the Russian Federation and a number of related data for the period 1945-2020 was performed. The analysis of the structure of production and consumption of sunflower oil in the Russian Federation is given. …”
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Regional features of the incidence of mental disorders in the population (on the example of the Irkutsk region): a retrospective study by Igor N. Alekhin, Nadezhda S. Apkhanova, Ekaterina V. Dushina, Maria L. Prokopyeva

“…Growing psychoneurologic visits are observed along with the institutional redirection of fi rst diagnoses towards decreasing the numbers of dispensary care vs. medical counselling outpatients. Thus, the structure of fi rst mental diagnoses changed towards prevailed medical counselling. …”
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Living by the clock of the book: religious observance enhances circadian stability and reduces social jetlag in older adults, a cross-sectional study by Daria Zarina, Adi Berger, Pavel Fishbein, Vadim Tkachev, Maria Korman

“…Abstract Background Religious practices often structure daily behavior, yet their role in shaping sleep–wake patterns remains underexplored. …”
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Competition for labor resources: losses of the Amur region by A. V. Vasilyeva

“…Statistical methods of analyzing social and economic phenomena and processes were used as tools for carrying out the research: indexes of dynamics, structure, and tabular and graphic methods of visualization of quantitative data.As a result of the conducted statistical research, it was found out that the population of the Amur region decreases annually, at the same time the decline in the population of the region is long-term and steady in nature. …”
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Practical experience and clinical results of reconstructive surgical correction of primary and secondary mitral regurgitation by V. V. Osaulenko, V. O. Hubka, K. O. Chmul, S. Yu. Nakonechnyi, R. I. Budahov

“…Depending on clinical and etiological factors, the structure of patients with MR was defined as follows: primary MR – 47.66 % (n = 51), secondary MR – 52.34 % (n = 56) cases. …”
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Prognostic role of demographic indicators and Charlson comorbidity index in oxygen-dependent patients with coronavirus disease (COVID-19) by V. V. Cherkaskyi, O. V. Riabokon, Yu. Yu. Riabokon

“…We used the WHO age classification when analyzing the age structure of patients. The Charlson comorbidity index was calculated for each patient. …”
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Efficient removal of Sr²⁺, V⁵⁺, and Rb⁺ ions from groundwater using a hybrid Mg-MCM-41/Talc composite; Siwa Oasis in Egypt as case study by Hussein A. ELsayed, Mohamed Hamdy Eid, Umer Farooq, Ahmad Al-Qawasmeh, Abdehamid Albiad, Fahad Abdulaziz, Ahmed Mehaney, Péter Szűcs, Mostafa R. Abukhadra

“…The composite exhibited a mesoporous architecture (9.6 nm) and a specific surface area of 123.6 m²/g, combining the high reactivity of MCM-41 with the layered structure of talc. Batch adsorption experiments revealed exceptional saturation capacities (Qsat) of 229.9 mg/g (Sr²⁺), 188.8 mg/g (V⁵⁺), and 137.2 mg/g (Rb⁺). …”
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