Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…Currently, the identification of effective therapies for KRAS-mutant NSCLC is difficult for reasons of the structural and biochemical characteristics of the KRAS protein. …”
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Talking about an emergency in an urgent situation: prosody and information by Charlotte Danino

“…These analyses lead us to reconsider the role of prosody in information structuring and to consider that it might have more to do with information processing.…”
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Sustainability Analysis of Urban Settlement Distribution in Kanigoro by Trisno Widodo, Antariksa, Fadillah Putra, Septiana Hariyani, Punjung Aziz Satria

“…After being established as the capital of Blitar Regency based on Government Regulation No. 3/2010 dated January 5, 2010, Kanigoro experienced a shift from rural to urban land use followed by an increase in population, causing the quality of the environment to decline, requiring the structuring of sustainable urban development from social, economic, and environmental aspects. …”
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An Assessment of the Traumatic Experiences of Women Victims of Boko Haram Insurgency in Michika by Roseline Luka Vandi, Ikenye Ndung'u, Julius Kithinji

“…Michika, the local government of Adamawa State, is one such place that has been destabilised economically, socially, spiritually, and structurally. Women have been traumatised because they are a significant target. …”
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The Image of Russia in South Africa Media Discourse: Frames and Metaphors by Olga A. Solopova, Natalia N. Koshkarova

“…The diagnostic frame “partnership” and two prognostic subframes “progress” and “degradation” are dominant in structuring Russia’s image construal. The frame “partnership” is actualized by lexemes with the semantics of cooperation, jointness, and metaphors of “relationship”. …”
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Le choléra en milieu rural : la pandémie de 1866 dans les provinces de Namur et Luxembourg by Mélanie Bourguignon, Yoann Doignon, Thierry Eggerickx, Jean-Paul Sanderson

“…Concerning the determinants of cholera mortality, the analyses confirm the structuring effect of age, with a high risk of death among the most vulnerable, i.e. the youngest and the oldest. …”
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Cost Management for Scientific research by an industrial Enterprise by I. E. Mizikovskii

“…The paper describes the issues of improving the existing methods and ways of structuring the information and instrumental space for making managerial decisions in scientific research (R&D) by industrial enterprises on their own. …”
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Vibrotactile Feedback Strategies for Trunk-Stabilizing Exercises in a Home-Based Scenario: Qualitative Interview Study Among Physiotherapists by Kaya Holzmeyer, Lisa-Marie Lüneburg, Luca Oppici, Philipp Flößel, Doris Lachmann, Jens Krzywinski, Susanne Narciss

“…Interview statements referring to the use of vibrotactile feedback were categorized by modality, task requirements, localization, time, content, frequency, function, and individualization. Quantitative data from observations were evaluated using frequency distributions, and qualitative interview data were analyzed using content structuring content analysis. …”
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User Experience With a Personalized mHealth Service for Physical Activity Promotion in University Students: Mixed Methods Study by Silke Wittmar, Tom Frankenstein, Vincent Timm, Peter Frei, Nicolas Kurpiers, Stefan Wölwer, Axel Georg Meender Schäfer

“…Qualitative insights were gathered from transcribed focus group discussions and analyzed using content-structuring, qualitative content analysis. Quantitative findings were cross-validated with qualitative data. …”
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Ontological Representation of Business Processes in an Educational Institution by E. A. Bushchyk

“…This model displays classes, instances, and relations between them, which allows structuring and unifying the knowledge base of the subject area under consideration.…”
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Experiences of support to return to work after stroke: longitudinal case studies from RETAKE trial by Diane Trusson, Katie Powers, Kathryn Radford, Audrey Bowen, Kristelle Craven, Jain Holmes, Rebecca Lindley, Christopher McKevitt, Julie Phillips, Ellen Thompson, Caroline Watkins, David J Clarke

“…Objectives This article aims to understand participants’ experiences of being supported to return to work and explores the social and structural factors which support, or act as barriers to, implementation of the Early Stroke Specialist Vocational Rehabilitation intervention. …”
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Research On Calculation of Longitudinal Deformation of The Underlying Shield Tunnel Caused By Excavation of The Foundation Pit Considering Consolidation Effects by LYU Linhai, DONG Cheng, ZHAO Zhe, JIANG Mingjie, JI Yongkai, QIU Shizheng, ZHANG Zhendong, MEI Guoxiong

“…A reference case is analyzed with the following parameters: 1)Foundation pit: 24 m (length)×16 m (width) × 8 m (depth), excavated continuously at 0.4 m/day (total duration: 20 days). 2)Tunnel: Structural properties: 6 m OD, 5.4 m ID .Aligned parallel to the pit's long side, centered beneath it; axis depth z₀ = 8 m; bending stiffness <italic>EI</italic>= 7.8×10⁴ MN·m². 3)Soil: Homogeneous saturated clay (<italic>H</italic>= 20 m), unit weight = 18 kN/m³, rebound modulus <italic>E</italic>ᵣ = 24 MPa, Poisson's ratio = 0.3, permeability <italic>k</italic>ᵥ =<italic>k</italic>ₕ = 10⁻³ m/day. …”
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Petrology and Geochemistry of the Aroud Granitoid Pluton, North of Alam Kuh, Central Western Alborz by Shadi Noori KHeymehsari, Nematollah Rashidnejad Omran, Mohammadreza Ghorbani, Huai-jen yang

“…The geochemical evidence points towards a post-collisional extensional environment primarily associated with a back-arc setting (Fig. 8).Discussion and ConclusionThe Aroud granitoid pluton, located north of Alam Kuh within the central Alborz structural zone, is interpreted to represent a post-collisional, extensional magmatic arc environment. …”
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Geochemistry and emplacement environment of intrusive bodies of Shele Boran Mo-Cu deposit (Northeast of Ahar, East Azarbaijan) by Seyed Ghafour Alavi, Mansour Kazemi rad, Mohsen Moayyed, Mohammad Reza Hosseinzadeh

“…The change process of these samples is compatible with the characteristics of the geo-structural environment related to subduction.Discussion and Conclusion The parent magma of the intrusion bodies has shoshonite and high-K calc-alkaline affinity.  …”
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Effect of grinding wheel type and cooling method on grinding quality of SiCf/SiC ceramic matrix composites by Ben WANG, Jiajie TANG, Hongdi CHU, Qi ZHANG

“…ObjectivesSiCf/SiC fiber-reinforced ceramic matrix composites have been widely used in aerospace, nuclear energy, and high temperature structural parts due to their excellent high-temperature resistance, high specific strength, and oxidation resistance. …”
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Complex Variation in Afrotropical Mammal Communities With Human Impact by Deogratias Tuyisingize, Lars Kulik, Delagnon Assou, Diorne Zausa, Solange Kamga, Onella Mundi, Stefanie Heinicke, Inza Kone, Samedi Jean Pierre Mucyo, Tenekwetche Sop, Christophe Boesch, Colleen Stephens, Anthony Agbor, Samuel Angedakin, Emma Bailey, Mattia Bessone, Charlotte Coupland, Josephine Head, Tobias Deschner, Paula Dieguez, Villard Ebot Egbe, Anne‐Céline Granjon, Thurston Cleveland Hicks, Sorrel Jones, Ammie K. Kalan, Kevin E. Langergraber, Juan Lapuente, Kevin C. Lee, Laura K. Lynn, Nuria Maldonado, Maureen S. McCarthy, Amelia Meier, Lucy Jayne Ormsby, Alex K. Piel, Lilah Sciaky, Volker Sommer, Fiona A. Stewart, Erin G. Wessling, Jane Widness, Roman M. Wittig, Pauline Strohbach, Mimi Arandjelovic, Yntze van derHoek, Hjalmar S. Kühl

“…We assessed variation in the structure and composition of Afrotropical medium and large mammal communities within and outside protected areas, and under varying human impact. …”
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Splicing defect of StDRO2 intron 1 promotes potato root growth by disturbing auxin transport to adapt to drought stress by Jianping Zhao, Baolin Yao, Ziai Peng, Xinyue Yang, Kuixiu Li, Xiaoyan Zhang, Haiyan Zhu, Xuan Zhou, Meixian Wang, Lihui Jiang, Xie He, Yan Liang, Xiaoping Zhan, Xiaoran Wang, Yuliang Dai, Yanfen Yang, Ao Yang, Man Dong, Suni Shi, Man Lu, Yi Zhao, Mingyun Shen, Liwei Guo, Changning Liu, Hongji Zhang, Decai Yu, Yunlong Du

“…Furthermore, the secondary structure of StDRO2 mRNA analyzed with RNAfold WebServer was altered in the dro2 mutant. …”
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Genotype-Phenotype Correlations in Denys-Drash Syndrome in Children by Mathilde Glénisson, Mathilde Grapin, Thomas Blanc, Evgenia Preka, Julien Hogan, Manon Aurelle, Gwenaëlle Roussey, Antoine Mouche, Caroline Rousset-Rouviere, Robert Novo, Camille Faudeux, Marc Fila, Isabelle Vrillon, Sylvie Cloarec, Thomas Simon, Jérôme Harambat, Edouard Martinez Casado, Julien Rod, Morgane Carre Lecoindre, Laurence Heidet, Olivia Boyer, Nicolas Garcelon, Jessica Kachmar, Guillaume Dorval, Sabine Sarnacki

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Impact of Y chromosome loss on the risk of Parkinson's disease and progressionResearch in context by Junhao Wang, Xinyi Chen, Wenxuan Du, Cha Lin, Yu Liao, Jean-Christophe Corvol, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Michael A. Schwarzschild, Pille Taba, Sulev Kõks, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Baijayanta Maiti, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Clemens R. Scherzer, Ganqiang Liu, Ganqiang Liu, Rebecca R. Valentino, Zhixiang Liao, Joseph J. Locascio, Jean-Christophe Corvol, Xianjun Dong, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H. Growdon, Albert Y. Hung, Michael A. Schwarzchild, Michael T. Hayes, Anne-Marie Wills, Todd M. Herrington, Bernard Ravian, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G. Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Peter Heutink, Jacobus J. van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A. Barker, Caroline H. Williams-Gray, Johan Marinus, Clemens R. Scherzer

“…In the Parkinson's Progression Markers Initiative (PPMI) cohort, we further compared brain structure using T1-weighted magnetic resonance imaging (MRI) scans, and carried out brain network functional connectivity analysis based on resting-state functional MRI (rs-fMRI) datasets. …”
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Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

“…Autophagy, a cytosolic structure degradation pathway is involved in the maintenance of cellular homeostasis, degradation of intracellular pathogens and generation of energy for immune responses. …”
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