A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA) by Mansour S. Alturki, Mohamed S. Gomaa, Nada Tawfeeq, Abdulaziz H. Al Khzem, Mohsina B. Shaik, Murtadha Alshaikh Jafar, Mohammad Alsamen, Hasan Al Nahab, Mohammad Al-Eid, Alhassan Almutawah, Thankhoe A. Rants’o, Khaled A. G. Ayil, Mohammed Almaghrabi

“…Methods: We utilized Maestro Schrödinger as a computational tool for preparing and docking simulations on the PAD 4 enzyme crystal structure that is retrieved from RCSB Protein Data Bank (PDB ID: 4X8G) while the docked FDA-approved medications are obtained from the Zinc 15 database. …”
Get full text

Bidirectional associations among positive affect, anhedonia and meaning in life during major depressive episode: ecological momentary assessment study in unipolar and bipolar indiv... by Heidi Ka Ying Lo, Roger S. McIntyre, Iris Wai Tung Tsui, Fiona Yan Yee Ho, Ting Kin Ng, Corine Sau Man Wong, Suet Ying Yuen, Chit Tat Lee, Chun Yin Poon, Inez Myin-Germeys, Ka Fai Chung

“…Multilevel modelling analysis was conducted, with estimation of first-order autoregressive model structure and time-lagged relationship between pleasure and positive affect. …”
Get full text

Application of HRCT-based radiomics to predict interstitial lung disease for juvenile dermatomyositis by Lingke Liu, Minfei Hu, Yun Zhou, Fei Zheng, Xiaohui Ma, Li Yang, Yiping Xu, Liping Teng, Bin Hu, Meiping Lu, Xuefeng Xu

“…The lung intelligence kit (LK) software was used to outline the bilateral lung tissue structure automatically. The radiomics score combining with clinical variables was used to establish a prediction model for JDM-ILD. …”
Get full text

The effects of formula milk on development, nutrient absorption, and immune characteristics of piglets by Chuang Tang, Zhengjiang Liu, Lu Lu, Bo Zeng, Zhi Li, Ruohan Yang, Duoduo Zhang, Xiaolan Fan, Jiaxue Cao, Haohuan Li, Jing Sun, Jinwei Zhang, Xiaoyuan Wei, Wei Sun, Liangpeng Ge, Mingzhou Li, Fanli Kong

“…Given the ethical constraints in conducting experimental studies on human breastfeeding, we employed pig, which have similar physiological structure with humans, to examine the impacts of different feeding practices. …”
Get full text

The impact of nuchal ligament ossification resection on cervical stability after modified laminoplasty: a long-term follow-up study by Chong Chen, Wenlin Ye, Tao Yu, Xing Cheng, Lutong Wang, Xingchen Zhao, Xiang Long, Jun Ouyang, Yunbing Chang, Xiaoqing Zheng

“…For DCM patients with long segmental ONL, more attention should be paid to protecting the MLC structure during posterior cervical surgery. Clinical trial number Not applicable.…”
Get full text

Beneficial effects of Lactobacillus plantarum on growth performance, immune status, antioxidant function and intestinal microbiota in broilers by Xiao Xiao, Tiantian Cui, Songke Qin, Tao Wang, Jinsong Liu, Lihan Sa, Yanping Wu, Yifan Zhong, Caimei Yang

Get full text

Exploring perceptions and preferences for PrEP choice and of an mHealth intervention: insights from the ImPrEP CAB‐Brasil study by Cristina Pimenta, Claudio G. Mann, Brenda Hoagland, Eduardo Carvalheira, Cristina Jalil, Marcos Benedetti, Nilo Fernandes, Carolina Coutinho, Emilia M. Jalil, Mayara Secco Torres Silva, Roberta Trefiglio, Alessandro Farias, Maria Paula G. Mourão, José Valdez Madruga, Josué N. deLima, Ronaldo Zonta, Gabrielle O'Malley, Valdilea G. Veloso, Beatriz Grinsztejn, Thiago S. Torres, for the ImPrEP CAB‐Brasil Study

“…A subset of participants from each site were invited to participate in the qualitative study (October 2023−July 2024). Semi‐structured interviews were conducted, recorded and transcribed. …”
Get full text

Correlates of duration between initial drug use and first drug injection among people who inject drugs in Iran, 2020 by Zahra Abdolahinia, Zahra Jaafari, Ali Karamoozian, Soheil Mehmandoost, Nima Ghalekhani, Mehrdad Khezri, Ghazal Mousavian, Mostafa Shokoohi, Ali Mirzazadeh, Ali Akbar Haghdoost, Mohammad Karamouzian, Mohammad Mehdi Gooya, Samaneh Akbarpour, Hamid Sharifi, Fatemeh Tavakoli

“…Policymakers should prioritize evidence-based, multi-faceted approaches that target both individual and structural factors to delay or prevent the transition to injection drug use and reduce associated health risks.…”
Get full text

H I Absorption Line and Anomalous Dispersion in the Radio Pulses of PSR B1937+21 by Jinchen Jiang, Shunshun Cao, Kejia Lee, Bojun Wang, Heng Xu, Siyuan Chen, Yanjun Guo, Peng Jiang, Weicong Jing, Jiguang Lu, Jiangwei Xu, Renxin Xu, Zihan Xue

“…By comparing this with the archival absorption spectra observed decades ago, we notice possible variations in the absorption spectra toward this pulsar, which correspond to a possible tiny-scale atomic structure of a few astronomical units in size. We also verify the apparent faster-than-light anomalous dispersion at the H I absorption line of this pulsar previously reported.…”
Get full text

Integrated assessment of antimicrobial stewardship in carbapenem resistant Klebsiella pneumoniae prevalent hospitals in China: a multidisciplinary surveillance network-based survey by Haishaerjiang Wushouer, Weibin Li, Junxuan Yu, Lin Hu, Xiaodong Guan, Xiaolin Liu, Anhua Wu, Xiaoqiang Yang, Minggui Wang, Yingchun Xu, Yanping Luo, Xun Huang, Luwen Shi

“…Five key areas were identified for improving multidisciplinary AMS: organizational structure, staffing and training, drug formulary and prescription management, laboratory testing and quality control, and clinical sampling and data reporting. …”
Get full text

Multifractal Analysis and Experimental Evaluation of MCM-48 Mesoporous Silica as a Drug Delivery System for Metformin Hydrochloride by Mousa Sha’at, Maria Ignat, Liviu Sacarescu, Adrian Florin Spac, Alexandra Barsan (Bujor), Vlad Ghizdovat, Emanuel Nazaretian, Catalin Dumitras, Maricel Agop, Cristina Marcela Rusu, Lacramioara Ochiuz

“…<b>Results</b>: SEM-EDX confirmed the uniform distribution of silicon and oxygen, while TEM images revealed a highly ordered cubic mesoporous structure. Nitrogen adsorption analyses showed a high specific surface area of 1325.96 m²/g for unloaded MCM-48, which decreased with drug loading, confirming efficient incorporation of metformin hydrochloride. …”
Get full text

Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future by Emmama Jamil, Emmama Jamil, Zikria Saleem, Brian Godman, Brian Godman, Brian Godman, Matti Ullah, Afreenish Amir, Abdul Haseeb, Johanna C. Meyer, Johanna C. Meyer, Muhammad Usman Qamar, Safa S. Almarzoky Abuhussain

“…The findings highlighted significant disparities in the development, adaptation, and implementation of guidelines across different WHO regions, confirming the previously noted lack of standardization and comprehensiveness in LMICs.ConclusionSignificant disparities exist in the availability, structure, and methodological rigor of antibiotic prescribing guidelines across countries with different income levels. …”
Get full text

New Epitopes for the Serodiagnosis of Human Borreliosis by Mônica E. T. Alcón-Chino, Virgínia L. N. Bonoldi, Rosa M. R. Pereira, Gilberto S. Gazeta, João P. R. S. Carvalho, Paloma Napoleão-Pêgo, Andressa M. Durans, André L. A. Souza, Salvatore G. De-Simone

“…Cross-reactivity was assessed through data bank access and in vitro analysis. Among the 19 epitopes identified, four were selected for further investigation based on their signal intensity, secondary structure, and peptide matching. …”
Get full text

Dalbavancin to facilitate early discharge in the treatment of complex musculoskeletal infections: a multi-centre real-life application by T. Azamgarhi, S. Warren, A. Scobie, N. Karunaharan, C. Perez-Sanchez, R. Houghton, S. Hassan, J. Lourtet-Hascoët, J. Lourtet-Hascoët, H. Kershaw, P. Sendi, K. Saeed, K. Saeed

“…Although dalbavancin is approved for acute bacterial skin and skin structure infections, its off-label use in complex musculoskeletal infection (MSKI) is increasing. …”
Get full text

Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis by Xiaojuan Huang, Manman Sun, Xiaoyu Du, Lin Quan, Jinquan Chao, Xiaomin Deng, Hongze Liao

“…Conserved motifs, gene structure, and motif analysis further bolster the validity of phylogenetic classification. …”
Get full text

Efficacy of psychosocial interventions on social functioning in individuals with childhood maltreatment experiences: a protocol for a systematic review and network meta-analysis by Natalia E. Fares-Otero, Silvia Amoretti, Brisa Solé, Sarah L. Halligan, Eduard Vieta, Stefan Leucht, Soraya Seedat, Mathias Harrer

“…Other candidate moderators/mediators (personality, post-traumatic symptoms, brain structure/function, cognitive reserve) will also be explored and narratively summarised. …”
Get full text

Mapping, Modeling and Designing a Marble Quarry Using Integrated Electric Resistivity Tomography and Unmanned Aerial Vehicles: A Study of Adaptive Decision-Making by Zahid Hussain, Hanan ud Din Haider, Jiajie Li, Zhengxing Yu, Jianxin Fu, Siqi Zhang, Sitao Zhu, Wen Ni, Michael Hitch

“…Images were taken with 75% frontal and 70% side overlaps. The Structure from Motion (SfM) processing chain generated high-resolution outputs, including point clouds, Digital Elevation Models (DEMs), Digital Surface Models (DSMs), and orthophotos. …”
Get full text

Ethical issues in implementation science: perspectives from a National Heart, Lung, and Blood Institute workshop by Neal W. Dickert, Donna Spiegelman, Jennifer S. Blumenthal-Barby, Garth Graham, Steven Joffe, Jeremy M. Kahn, Nancy E. Kass, Scott Y. H. Kim, Meeta P. Kerlin, Aisha T. Langford, James V. Lavery, Daniel D. Matlock, Kathleen N. Fenton, George A. Mensah

“…Fifth, there is significant overlap between implementation science and quality improvement, and the ideal regulatory oversight structure for implementation science remains unclear. …”
Get full text

Usefulness of differential somatic cell count for udder health monitoring: Effect of intramammary infections, days in milk, quarter location, and parity on quarter-level differenti... by Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Simon Dufour

“…Given the hierarchical structure of the data, a 4-level, linear mixed model with herd, cow, and quarter as random intercepts was built with either SCS or DSCC as the outcome. …”
Get full text

Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…Characterization techniques such as FTIR, XRD, SEM, and EDS reveal a highly porous morphology due to NiO nanoparticle integration within the OP matrix, a structure that provides numerous active sites for adsorption. …”
Get full text