Sex differences in the association of Alzheimer’s disease biomarkers and cognition in a multicenter memory clinic study by Cecilia Boccalini, Debora Elisa Peretti, Max Scheffler, Linjing Mu, Alessandra Griffa, Nathalie Testart, Gilles Allali, John O. Prior, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Giovanni B. Frisoni, Valentina Garibotto

“…Methods 249 participants (females/males:123/126), who underwent tau-PET, amyloid-PET, structural MRI, and plasma glial fibrillary acidic protein (GFAP) measurement were included from Geneva and Lausanne Memory Clinics. …”
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Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells by Verena Schlösser, Helen Louise Lightfoot, Christine Leemann, Seyedeh Elnaz Banijamali, Aathma Merin Bejoy, Shashank Tiwari, Jeffrey L. Schloßhauer, Valentina Vongrad, Andreas Brunschweiger, Jonathan Hall, Karin J. Metzner, Jochen Imig

“…Results: We established that Enoxacin, but not the structurally similar compound nalidixic acid, exhibits strong anti-HIV-1 effects in the T-cell line CEM-SS, but not MT-4. …”
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Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury by Ana Luiza Zaninotto, Fabiola Macruz, Fabricio S. Feltrin, Celi S. Andrade, Claudia C. Leite, Vinicius Monteiro de Paula Guirado, Wellingson S. Paiva, Sylvain Bouix

“…Twenty-one adults with moderate and severe DAI were analyzed. Structural and diffusion data were acquired on a 3T system 3 and 6 months after the injury. …”
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Climate, soil and management factors drive the quantitative relationships between soil fertility and spring maize water productivity in northern China by Jiao Shi, Minggang Xu, Xinhua He, Huaiping Zhou, Jianhua Li

“…The random forest, partial least squares structural equation modeling and variance partitioning analysis were then applied to address the quantitative relationships (QRs) and relevant differences. …”
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Flares on TRAPPIST-1 Reveal the Spectrum of Magnetic Features on Its Surface by Valeriy Vasilyev, Nadiia Kostogryz, Alexander I. Shapiro, Astrid M. Veronig, Benjamin V. Rackham, Christoph Schirninger, Julien de Wit, Ward Howard, Jeff Valenti, Adina D. Feinstein, Olivia Lim, Sara Seager, Laurent Gizon, Sami K. Solanki

“…Our analysis rules out lingering flare decay as the cause of the flux enhancement and thus, points to structural changes on the stellar surface induced by flares. …”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
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Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice by Tao Lu, Huan Liu, Xiaoqing Yuan, Desheng Li, Guanqing Zhang, Yue Wang, Qiqiang Xie, Xinhao Wang, Jingjian Chi, Zhenzhen Wang, Shaoping Wang, Yanling Gao, Ling Zhou, Maolei Xu

“…The results confirmed, for the first time, that PET MPs can induce oxidative stress, lipid accumulation, and apoptosis in liver cells, resulting in structural damage and functional abnormalities in the liver. …”
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Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus by Ling Wang, Yu Zhang, Rui Zhao, Yan Huang, Xinghao Wang, Yuyou Huang, Jiancheng Zhang, Han Lv, Pengfei Zhao, Zhenghan Yang, Qian Chen, Zhenchang Wang

“…Objective: To examine structural and functional changes in auditory cortex(AC) subregions of patients with tinnitus and identify potential predictive indicators for sound therapy. …”
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Influencing Factors and Paths of the Coupling Relationship Between Ecosystem Services Supply–Demand and Human Well-Being in the Hexi Regions, Northwest China by Yongge Li, Wei Liu, Meng Zhu, Qi Feng, Linshan Yang, Jutao Zhang, Zhenliang Yin, Xinwei Yin

“…Here, we assessed dynamic changes in ecosystem services supply–demand, human well-being, their coupling relationships and influencing factors in the Hexi Regions by integrating remote sensing data, ecological model, ecosystem services supply–demand ratio (ESDR), coupling coordination degree (CCD) model, and the partial least squares structural equation modeling (PLS-SEM). …”
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Ecotype-specific responses of Typha domingensis to microplastics: Antioxidant defense and biochemical adaptations in wetland ecosystems by Muhammad Aqeel, Ali Noman, Saher Nawaz, Noreen Khalid, Muhammad Kashif Irshad, Muhammad Faisal Iqbal, Modhi O. Alotaibi, Motirh Al-Mutairi, Mohamed O. Alshahrani, Nahaa M. Alotaibi, Fahad Mohammed Alzuaibr

“…The inherent ability of plants to withstand microplastic (MP) stress is primarily governed by complex structural and physio-biochemical adaptations. In this study, the MP tolerance mechanisms of six naturally occurring ecotypes of Typha domingensis Pers. were assessed by examining plant pigments, ionic homeostasis, secondary metabolites, and antioxidant defense responses in MP-contaminated wetlands. …”
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Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). Subsequently, the structural, textural, and surface chemistry properties of these biochars were assessed. …”
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snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

“…Subsequently, we employed single-nucleus RNA sequencing (snRNA-seq) to comprehensively characterize iWAT cellular dynamics during cold stimulation and the subsequent two-week period after the return to thermoneutrality.ResultsOur findings revealed that while iWAT phenotypically reverts to a white state after 2 weeks of rewarming, as evidenced by structural, functional, and bulk transcriptomic characteristics, significant cold-induced molecular and cellular signatures persist. …”
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Mediation of nutritional status between the number of teeth and depressive symptoms in multi-ethnic older adults from Western China by Xin Tian, Xin Xia, Huixian Li, Yuexia Hu, Yuqing Xie, Xiuying Hu, Jirong Yue, Birong Dong, Bei Wu, Yanyan Wang

“…This study aimed to investigate the role of nutritional status in mediating the number of teeth and depressive symptoms.MethodA prospective multi-ethnic baseline data of 6,632 adults aged 50 years and older was derived from the 2018 West China Health and Aging Trend study. …”
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The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens by Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu

“…By analysing the polymorphism of this residue in various subtype viruses, we found that PA-X 100 was highly variable in H7N9 viruses. Structural analysis revealed that 100 V was generally close to the PA-X endonuclease active site, which may account for its host shutoff activity. …”
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Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

“…Background: Outdoor air pollution exposure is associated with structural and functional brain differences and an increased risk for psychopathology. …”
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Engagement of Indigenous peoples in commercial tobacco reform strategies: a scoping review protocol by Andrew Waa, Raglan Maddox, El-Shadan Tautolo, Michelle Kennedy, Patricia Nez Henderson, Hershel Clark, Priscilla Nez, Penney Upton, Andrew Daniel Perusco, Sydney A. Martinez, Sierra Wilcox, Jeyasakthi Venugopal

“…This review supports the global goal of eradicating commercial tobacco-related harms – reframing commercial tobacco use as a structurally imposed harm sustained by colonial and commercial forces rather than personal choice. …”
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Social Determinants of Health Associated With SARS-CoV-2 Testing and Vaccine Attitudes in a Cross-Sectional Study of Latinx Individuals in Oregon by Elizabeth L. Budd, PhD, MPH, Stephanie De Anda, PhD, Sven Halvorson, MS, Leslie D. Leve, PhD, Anne Marie Mauricio, PhD, Ellen H. McWhirter, PhD, Jorge I. Ramírez García, PhD, David S. DeGarmo, PhD

“…Multilevel structural equation path modeling addressed the nonindependence of respondents nested within 52 SARS-CoV-2 testing sites across Oregon, U.S. …”
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Case Report: Phenotypic heterogeneity within an NF1 family: assessment of the pathogenicity of a de novo c.6640dupA shift mutation and a splice variant with an epilepsy phenotype by Sijing Ren, Sijing Ren, Sijing Ren, Yanling Wang, Xinhua Tong, Xiaoyu Wu, Xiaoyu Wu, Huan Yan, Huan Yan, Qing-Xia Kong, Qing-Xia Kong, Qing-Xia Kong

“…The identified genes were validated using Sanger sequencing, and alterations in the tertiary structural physicochemical properties of the mutant proteins were analyzed using AlphaFold2 bioinformatics software.ResultsWe identified two mutation sites in the NF1 gene of the patient. …”
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The relationship between educational and scientific regulatory interventions and socio-economic development in military conflict-affected countries: A Sustainable Development Goals... by Dariusz Krawczyk, Nadiia Artyukhova, Dmytro Svynarenko, Anna Vorontsova, Artem Artyukhov, Robert Rehak, Tetiana Vasylieva

“…Type of the article: Research Article AbstractThis study investigates the structural relationships between educational and scientific regulatory interventions and socio-economic development in countries affected by armed conflict and political instability, using the framework of Sustainable Development Goals (SDGs), specifically SDG 4 (Quality Education), SDG 8 (Decent Work and Economic Growth), and SDG 9 (Industry, Innovation and Infrastructure). …”
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