Clinical profiles and health-related quality of life changes after treatment in advanced colorectal cancer patients: a nationwide study in China by Hongwei Liu, Ziyao Jia, Huifang Xu, Xiaoyang Wang, Hong Wang, Ruihua Kang, Qiong Chen, Xiaoli Guo, Ranran Qie, Mengfei Zhao, Cheng Cheng, Liyang Zheng, Shuzheng Liu, Yin Liu, Shaokai Zhang, China Working Group on Colorectal Cancer Survey

“…The multivariable regressions and structural equation model (SEM) were used to assess the association between characteristics and HRQOL. …”
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Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in <i>Trypanosoma cruzi</i>: Virtual Screening and In Vitro Studies by Eyra Ortiz-Pérez, Adriana Moreno-Rodríguez, Timoteo Delgado-Maldonado, Jessica L. Ortega-Balleza, Alonzo González-González, Alma D. Paz-González, Karina Vázquez, Guadalupe Avalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera

“…Future studies should focus on structural modifications to improve selectivity. Integrating docking, parasitological, and enzymatic data is crucial for optimizing drug candidates for Chagas disease.…”
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Predicting leakage of the VERCORS mock-up and concrete containment buildings - a digital twin approach by Laurent Charpin, Jessica Haelewyn, Anass Cherki El Idrissi, Julien Niepceron, Benoît Masson, Charles Toulemonde, Guillaume Boulant, Jean-Philippe Mathieu, François Hamon, Sylvie Michel-Ponnelle, Jean-Marie Hénault, Frédéric Taillade, Jean-Luc Adia, Florian Escoffier

“…An important numerical effort has also been made to implement structural computations of the mock-up and to capitalize these computations as well as their post-processing (so as to compare automatically with the monitoring data) in what can be called a digital twin of the mock-up. …”
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Temperature and excipient mediated modulation of monoclonal antibody interactions revealed by kD, rheology, and Raman spectroscopy by Olivia Noelle Eskens, Sabitoj Singh Virk, Akashdeep Singh Virk, Deepika Venkataramani, Maureen Crames, Maria Calderon Vaca, Matthew Matusewicz, Connor Smith, Joshin George, Collin Taylor, Michael S. Marlow, Samiul Amin

“…Raman spectral analysis of Amide I/III regions confirmed structural invariance under thermal and shear stress, attributing viscosity modulation to colloidal rather than conformational perturbations. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Despite studies conducted, there are no unambiguous data showing how IMQ affects the condition of tumor blood vessels. …”
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EXPERIMENTAL EVALUATION OF LONG-TERM ADVERSE SIDE EFFECTS OF CYTOSTATIC DRUGS ON FEMALE REPRODUCTIVE FUNCTION AND PHARMACOLOGICAL WAYS TO REDUCE THEM by T. G. Borovskaya, V. E. Goldberg, M. E. Poluektova, A. V. Vychuzhanina, Yu. A. Shchemerovа, V. A. Grigoreva, A. A. Ligacheva, E. A. Bokhan

“…Ovarian reserve was evaluated using morphological analysis of the ovaries using quantitative assessments of structural damage. Concentration of anti-Muller hormone in the blood of adult rats-females receiving etoposide and rhG-CS F were evaluated by enzyme immunoassay (IFA, ELISA , Cloud clone, Corp. …”
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Development of the 10-question household foodwork interactional assessment questionnaire (FIA-Q10) by Leah E. Cahill, Sharon I. Kirkpatrick, Catherine L. Mah, Jennifer LP. Protudjer, Cynthia Kendell, Mary E. Jung, Helen Wong, Ellen T. Crumley, Meghan Day, Karen T. Y. Tang, Yan Huang, Jyoti Sihag, Laura Brady, Karthik K Tennankore, Navdeep Tangri, Rebecca C. Mollard, Dylan MacKay

“…An optional accompanying module was developed to collect self-identified demographic data to provide context for understanding how social-structural positionality factors may interact to influence foodwork. …”
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Preliminary observations of glucose metabolism dysregulation in pediatric Huntington’s disease by Federica Graziola, Federica Rachele Danti, Martina Penzo, Antonio Spagarino, Eleonora Minacapilli, Marco Moscatelli, Federica Zibordi, Caterina Mariotti, Giovanna Zorzi, Giovanna Zorzi

“…Clinical, neuroimaging, and neuropsychological data were collected alongside metabolic assessments, including cerebrospinal fluid (CSF) and plasma glucose and lactate levels, CSF-to-serum glucose ratio, and red blood cell GLUT1 expression using the METAglut1 test. 18F-FDG PET imaging and brain MRI were performed to assess cerebral metabolism and structural changes.ResultsBoth patients exhibited progressive motor and cognitive decline with dystonia-parkinsonian features, learning disabilities, and behavioral disturbances. …”
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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark

“…Furthermore, binding of one mAb, DCR‐2, to CD300f exposes a structural epitope recognized by a second CD300f mAb, UP‐D2. …”
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Genome-wide identification of the AcBAM family in kiwifruit (Actinidia chinensis cv. Hongyang) and the expression profiling analysis of AcBAMs reveal their role in starch metabolis... by Xuchen Gong, Mengfei Lin, Jie Song, Jipeng Mao, Dongliang Yao, Zhu Gao, Xiaoling Wang

“…., Glu186 and Glu380) and exhibited similar structural properties. Phylogenetic and collinearity analyses grouped the genes into three main clusters, with segmental and tandem duplications contributing to their expansion. …”
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The Relationship between Personality Disorders and Parent\'s Social Capital with the Social Health of Children and Adolescents in Yazd by Nastaran Ahmadi, Parvane Rashidpour, Mohammadreza Mohammadi, Mohammadhadi Farahzadi, Javad Ardeshirpay, Hosein Abouzari, Malihe Mobini, Masoud Mirzaei, Amirhoushang Mehrparvar, Fatemeh Rismanian Yazdi

“…Millon's test of fathers demonstrates a significant correlation with the average scores of structural social capital, cognitive social capital, communicative social capital, and total social capital (P-value < 0.001). …”
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Promoting active behaviours in schoolchildren using the socio-ecological model in the physical education class: study protocol of the ACTIBESE project by Fernando Rodríguez-Rodríguez, Carlos Cristi-Montero, Natalia Zurita-Corvalán, Caroline Brand, Jorge Mota, Palma Chillón, Anelise Reis Gaya, Javier Brazo-Sayavera, Nicolás Aguilar-Farias

“…The research will use mixed models, ANCOVA, and logistic regressions for data analysis, network analysis, exploratory factors analysis, and structural equation modelling. …”
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The role of neotectonics and climate variability in the Pleistocene-to-Holocene hydrological evolution of the Fuente de Piedra playa lake (southern Iberian Peninsula) by A. Jiménez-Bonilla, L. Martegani, L. Martegani, M. Rodríguez-Rodríguez, F. Gázquez, F. Gázquez, M. Díaz-Azpíroz, S. Martos, K. Reicherter, I. Expósito

“…We conducted an interdisciplinary study combining structural, geomorphic, sedimentological, mineralogical and hydrological analyses to better understand the evolution of the Fuente de Piedra (FdP) playa lake in southern Spain. …”
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Assessing the foreign economic security of Ukraine by Yuliia Yehorova, Svitlana Chorna, Yuriy Petrushenko, Fedir Zhuravka, Khrystyna Potapenko, Iryna D’yakonova, Oksana Zamora

“…At the same time, the growth of foreign economic security is recorded in the period of stabilization during the implementation of structural reforms: 2005–2008 – the period after the Orange Revolution, 2014–2016 – the period of growth after the Revolution of Dignity, 2021 – post-pandemic recovery. …”
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Bioactive Chalcones from <i>Aizoon africanum</i>: Isolation and Cytotoxicity Against Liver and Neural Cancer Cells by Ali O. E. Eltahir, Naeem Sheik Abdul, Taskeen F. Docrat, Paolo Bristow, Elias Chipofya, Robert C. Luckay, Monde A. Nyila, Jeanine L. Marnewick, Kadidiatou O. Ndjoubi, Ahmed A. Hussein

“…The methanolic extract of <i>A. africanum</i> was re-investigated and subjected to various chromatographic techniques, including preparative HPLC, resulting in the isolation of eight compounds (<b>1</b>–<b>8</b>). Structural elucidation was primarily based on NMR data. …”
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Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning by Xinyuan Zheng, Patrick Worhunsky, Qiong Liu, Xueqi Guo, Xiongchao Chen, Heng Sun, Jiazhen Zhang, Takuya Toyonaga, Adam P. Mecca, Ryan S. O’Dell, Christopher H. van Dyck, Gustavo A. Angarita, Kelly Cosgrove, Deepak D’Souza, David Matuskey, Irina Esterlis, Richard E. Carson, Rajiv Radhakrishnan, Chi Liu

“…The image translation accuracy was evaluated based on the mean squared error, structural similarity index, percentage bias and Pearson’s correlation coefficient between the ground truth and the predicted images. …”
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A detailed investigation of induced residual stresses in the laser powder bed fusion process using the modified inherent strain approach and experimental measurements by Marjan Molavi-Zarandi, Ali Bonakdar, Hossein Mohammadtaheri, Mehran Bagheri, Ramin Sedaghati

“…By offering a comprehensive depth-resolved analysis, this work provides new insights into subsurface stress evolution, critical for ensuring the structural integrity of LPBF parts. The study provides a critical assessment of the MIS method's capabilities and offers essential guidance for future research opportunities to improve residual stress predictions in LPBF-produced parts.…”
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Deep learning radiomics of left atrial appendage features for predicting atrial fibrillation recurrence by Yanping Yin, Sixiang Jia, Jing Zheng, Wei Wang, Ziwen Wang, Jiangbo Lin, Wenting Lin, Chao Feng, Shudong Xia, Weili Ge

“…Abstract Background Structural remodeling of the left atrial appendage (LAA) is characteristic of atrial fibrillation (AF), and LAA morphology impacts radiofrequency catheter ablation (RFCA) outcomes. …”
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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…The association of serum bicarbonate concentration (HCO3−) < 22 mmol/l (metabolic acidosis) and HCO3− < 18 mmol/l (severe metabolic acidosis) with allograft outcome was investigated using stratified Cox models and marginal structural models. Secondary analyses included the identification of risk factors for metabolic acidosis and the relationship between alkali supplementation and allograft outcome. …”
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Characterization of the pork sector in the productive core of Argentina: a look at small producers by Carlos Figueroa, Diana Acosta, Matias Mac Allister, Gabriela Fernández, Mariano Merino

“…These findings show the need for professional intervention in smaller-scale pig farms to overcome structural barriers and access to the production chain. …”
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