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51721
Evaluation of dengue virus seroprevalence in four boroughs of Mexico City among persons aged 5-35 years in 2022
Published 2025-02-01“…However, it is important to note that the structural conditions of the dwellings in these boroughs, which offer minimal barriers to vector infestation, could facilitate the establishment of local transmission under favorable conditions. …”
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51722
Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies
Published 2025-06-01“…Nevertheless, challenges persist regarding hepatic safety, pharmacodynamic variability, and limited long-term outcome data. This review integrates current structural, pharmacological, and clinical evidence, highlights key mechanistic innovations—including biased agonism, covalent binding strategies, and allosteric modulation—and discusses future directions for this rapidly evolving therapeutic class in metabolic disease management.…”
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51723
Comprehensive Dissolution Study on Two Double Ce(IV) Phosphates with Evidence of Secondary CeO<sub>2</sub> Nanoparticle Formation
Published 2025-05-01“…In contrast, the nanophase NaCe<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> exhibits exceptional structural and chemical stability, showing no signs of recrystallisation, phase transformation, or CeO<sub>2</sub> formation, even after extended ageing. …”
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51724
USP7 V517F mutation as a mechanism of inhibitor resistance
Published 2025-03-01“…We discovered a key treatment-emergent heterozygous mutation (V517F) in USP7 in the binding pocket of compounds as the primary cause of resistance to the USP7 inhibitor USP7-797. Our structural analysis, supported by AlphaFold2 predictions, indicates that the V517F mutation altered the conformation of the compound binding pocket, causing steric hindrance and reducing the affinity between USP7 and its inhibitors. …”
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51725
Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors
Published 2025-01-01“…We conducted a global survey involving healthcare professionals (n =204) to understand the role of various determinants in adopting ICTs and their implications for organizational performance. Data was analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) and multiple regression for micro-level constructs. …”
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51726
The Expression and Molecular Roles of MAMDC2 in MSS Colorectal Cancer with a High Tumor Stromal Ratio
Published 2025-05-01“…The meprin/A5/PTPmu (MAM) domain, a conserved structural motif in transmembrane proteins, remains undercharacterized in CRC pathogenesis. …”
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51727
Anthropogenic and natural influence on vegetation ecosystems from 1982 to 2023
Published 2025-01-01“…In addition, frequent land cover changes promoted the growth of greening trends (∼23%), which is linked to enhanced structural plasticity of vegetation. This effect has become more pronounced since 2000, with 92% of such changes occurring during this period. …”
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51728
TET dioxygenases localize at splicing speckles and promote RNA splicing
Published 2025-12-01“…This study explores the relationship between RNA splicing and the TET dioxygenase activity, shedding light on the role of hm5C (RNA 5-hydroxymethylcytosine), and TET proteins in RNA metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, and different functional assays, including in vitro splicing, TET proteins were found to regulate splicing. …”
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51729
Person-centred care of people living with dementia and its regulation in German-speaking nursing homes: A qualitative focus group study
Published 2025-12-01“…Leadership is inextricably linked to other elements, such as setting priorities, mindset, structural requirements, internal regulations and outcomes. …”
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51730
Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment
Published 2025-05-01“…IntroductionWhile the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral ventricle (LV) inter-individual variability may reveal more atrophic patterns that might be overlooked in analyses without this adjustment,—and such LV-adjusted atrophic patterns may reduce discrepancies observed in earlier studies and better elucidate complex conditions associated with HIV, such as HAND.MethodsTo test this hypothesis, we employed a number of adjustment strategies on MRI T1-image-derived data extracted using deep learning models and compared their ability to identify the presence and extent of HIV-specific atrophic patterns based on statistical measures and strength.ResultsOur results show that both ICV adjustments may be effective to identify atrophic patterns associated with either aging or HIV in areas of the thalamus, basal ganglia, ventral DC and lateral ventricle, some of which may be overlooked without these adjustments. …”
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51731
The impact of online social capital on innovative job performance: mediated by work engagement
Published 2025-05-01“…Employing a quantitative, cross-sectional survey, data from 313 Malaysian public sector employees were analyzed using Partial Least Squares-Structural Equation Modeling (PLS-SEM). …”
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51732
Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis
Published 2025-03-01“…Conclusion The findings underscore the active involvement of various immune and structural cells in the aortic tissues of TAK patients and reveal the presence of the complement signaling pathway in peripheral blood T cells. …”
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51733
Transcriptomic and metabolomic analyses for the mechanism underlying anthocyanin synthesis during the growth and development of purple eggplant (Solanum melongena L)
Published 2025-05-01“…Transcriptomics revealed 8 structural genes and 11 MYB TFs enriched in the anthocyanin pathway. …”
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51734
Sleep quality and renal function among Chinese incoming college freshmen: the mediating role of lifestyle behaviors
Published 2025-06-01“…Multiple logistic regression (MLR) was applied to explore the related biochemical indicators associated with sleep quality. Structural equation modeling (SEM) was subsequently used to evaluate the mediating effects of lifestyle factors in this relationship.ResultsHigher creatinine levels (OR = 1.01, p = 0.002) increased the risk of poor sleep quality, while higher urea levels (OR = 0.87, p < 0.001) decreased it. …”
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51735
Knowledge, attitude, and practice related to dementia and cognitive impairment among medical specialists with expertise unrelated to dementia
Published 2025-04-01“…A self-designed questionnaire was used for data collection and KAP assessment. A total of 1288 valid questionnaires were collected, 62.58% from female participants. …”
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51736
Integrated 3D Geological Modeling, Stress Field Modeling, and Production Simulation for CBM Development Optimization in Zhengzhuang Block, Southern Qinshui Basin
Published 2025-05-01“…Structural architecture and reservoir heterogeneity were characterized through Petrel-based modeling, while finite-element analysis identified stress anisotropy with favorable stimulation zones concentrated in southwestern sectors. …”
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51737
Early Paleozoic Extension-Compression Transition and Formation of a Paleo-Oil Reservoir System in the NW Sichuan Basin: Implications for Deeply Buried Hydrocarbon Accumulation
Published 2021-01-01“…With abundant oil and gas play in the NSWSCD, the study of paleo-oil reservoir systems and early hydrocarbon accumulation in this area is of great significance for deep marine hydrocarbon distribution prediction in complex structural settings. Analysis on the northern section of the Mianyang-Changning Intracratonic Sag (MY-CN IS) and the Tianjingshan Paleouplift (TJS PU), the two Early Paleozoic tectonic units are laterally superimposed. …”
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51738
A microgripper based on electrothermal Al–SiO2 bimorphs
Published 2024-12-01“…In this study, we develop an electrothermal actuated microgripper with Al-SiO2 bimorphs as the primary structural element. The fabricated microgripper naturally adopts a closed state due to process-induced residual stresses. …”
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51739
Exploring predictors of AI chatbot usage intensity among students: Within- and between-person relationships based on the technology acceptance model
Published 2025-03-01“…A daily diary study over five days was conducted among university students, distinguishing between inter-individual (between-person) and intra-individual (within-person) variations. Multilevel structural equation modeling (SEM) was used to analyze the data. …”
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51740
Human-Robot Interaction: The Hospitality Experience of Young People in Hotels that Use Robots
Published 2024-11-01“…., robots) and describe the human-robot interaction. The data was collected through an online survey and analysed through structural equation modelling (SEM). …”
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