Identification of multiple genomic alterations and prediction of neoantigens from circulating tumor cells at the single-cell level by Xiaochen Gao, Xinyu Li, Weize Xu, Ming Jiao, Yu Guo, Jiajia Wang, Weihao Wang, Jiling Feng, Qianqian Guo, Chengchao Wu, Taiyu Zhang, Yuqin Yang, Da Lin

“…In the PDX model, integrating data from seven CTCs captures 88.7% of SNPs and INDELs, and 75.0% of structural variants present in tumor tissue. …”
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Tackling Paradoxes and Double Binds for a Healthier Workplace: Insights from the Early COVID-19 Responses in Quebec and Ontario by Daniel Côté, Amelia León, Ai-Thuy Huynh, Jessica Dubé, Ellen MacEachen, Pamela Hopwood, Marie Laberge, Samantha Meyer, Shannon Majowicz, Meghan K. Crouch, Joyceline Amoako

“…We argue that PDBs represent a significant occupational health hazard for precarious workers. Addressing these structural contradictions through proactive management strategies could help mitigate workplace tensions, reduce stress, and enhance resilience in both crisis situations and regular organisational contexts. …”
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Prevalence and environmental abundance of the TSET complex in cosmopolitan algal groups by Mathias Penot-Raquin, Mandeep Sivia, Kelly M. Fafoumi, Raegan Larson, Richard G. Dorrell, Joel B. Dacks

“…Finally, diatom TSET genes are detectable in meta-transcriptomic data from Tara Oceans, suggesting functional roles in the wild. …”
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Multimodal gradients unify local and global cortical organization by Yezhou Wang, Nicole Eichert, Casey Paquola, Raul Rodriguez-Cruces, Jordan DeKraker, Jessica Royer, Donna Gift Cabalo, Hans Auer, Alexander Ngo, Ilana R. Leppert, Christine L. Tardif, David A. Rudko, Robert Leech, Katrin Amunts, Sofie L. Valk, Jonathan Smallwood, Alan C. Evans, Boris C. Bernhardt

“…Here, we present an approach to integrate inter- and intra-areal similarities of microstructure, structural connectivity, and functional interactions. …”
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Driving Forces and Future Scenarios for Territorial Business Development in Iran: A Future-Oriented Study with a Spatial Planning Emphasis by Ali Hosseini, Mostafa Aryankia

“…A range of factors and variables were considered in this study. To analyze the data and assess the structural impact of each variable, we employed MicMac and scenario analysis techniques. …”
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Electron microscopic changes in the nasal membrane of patients with COVID-19 depending on the clinical form and the period of the disease by E. V. Kryukov, K. V. Zhdanov, K. V. Kozlov, V. Yu. Kravtsov, O. V. Mal’tsev, V. S. Sukachev, P. I. Miklush, M. O. Sokolova, V. V. Sharabkhanov, R. I. Glushakov, V. V. Dvoryanchikov, R. R. Achba, D. V. Trishkin, I. I. Azarov

“…Understanding the ultra-structural cell changes of SARS-CoV-2 targets may help clarify the pathogenic aspects of infection in the lower respiratory tract. …”
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Magnetic Resonance Imaging Lesions Associated With Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury by Jamie E. Podell, Eric W. Moffet, Uttam K. Bodanapally, Mehrnaz Pajoumand, Luisa M. Silva, Peter Hu, Lujie K. Chen, Nicholas A. Morris, Gunjan Parikh, Gary T. Schwartzbauer, Bizhan Aarabi, Neeraj Badjatia

“…This exploratory study supports the hypothesis that structural damage to CAN regions is associated with the clinical syndrome of PSH after TBI, and provides foundational evidence for future data-driven studies.…”
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Targeting the IL-17A pathway for therapy in early-stage tendinopathy by Iain B McInnes, Richard M Siegel, Neal L Millar, Moeed Akbar, Michaela Kneissel, Frank Kolbinger, Friedrich Raulf, Yufei Li, Nicolau Beckmann, Nathalie Accart, Olivier Leupin, Claudio Calonder, Matthias Schieker, Christian Bruns, Eckhard Weber

“…In the rat ex vivo and in vivo models, IL-17A blockade alleviated inflammatory immune effector release, tendon structural degeneration, tendon inflammation and impaired tendon function.Conclusion Our data provide evidence that IL-17A is a key contributor to the pathogenesis of tendinopathy by promoting tendon inflammation and degeneration and that IL-17A blockade may represent a potential therapy in early-stage tendinopathy.…”
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Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging by Frank Li, Frank Li, Xuan Zhang, Xuan Zhang, Alejandro P. Comellas, Eric A. Hoffman, Eric A. Hoffman, Michael M. Graham, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin

“…This approach seeks to enhance our understanding of how structural and functional changes influence ventilation heterogeneity in COPD.MethodsEight COPD subjects completed a longitudinal study with three visits, spaced about a year apart. …”
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Resolution of the consensus of the Russian Federation experts on the diagnosis and treatment of osteoarthritis, 2022 by A. M. Lila, V. I. Mazurov, A. I. Martynov, N. V. Zagorodny, L. I. Alekseeva, N. V. Chichasova, A. E. Karateev, A. V. Naumov, E. V. Zonova, A. P. Rachin, E. A. Taskina

“…The prospects of the combined use of pharmacological and non-drug methods of treatment are noted; emphasis was placed on the importance of rehabilitation measures at the first level of medical care, provided to patients with OA, long before the development of structural changes.The proposed algorithms for managing patients can be considered as the basis for future recommendations for managing patients with this pathology.…”
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Assessing the impact of Amazon’s marketing strategies on consumer behavior in the food sector by Sherouk Hassan, Aijun Liu, Aijun Liu, Rohullah Niazi, Mohamed A. Ahmed, Esraa. A. Aali, Ochieng Stella Anyango, Ahmed Ayoub, Mohamed Ahmed Moustafa, Mohamed Ahmed Moustafa, Abdelrahman Ali, Abdelrahman Ali, Moataz Eliw

“…The research examined variables such as convenience motivation, price-saving orientation, app quality, service quality, perceived risk, subjective norms, perceived control, and consumer attitude toward online food purchase intention. Data were gathered through online surveys of 400 participants from Cairo and analyzed using structural equation modeling (SEM). …”
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DSM-Based Precise Pointing Angle Deviation Measurement Method for Beaconless Free Space Optical Communication by Xueyuan Ao, Yansheng Zou, Yang Zou, Qirun Fan, Xiaoxiao Dai, Chen Liu, Qi Yang, Deming Liu

“…However, the separated beacon laser beam commonly used in ATP will increase the structural complexity of the terminal such as the size, weight, and power. …”
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Damage before destruction? X-ray-induced changes in single-pulse serial femtosecond crystallography by Lewis J. Williams, Amy J. Thompson, Philipp Dijkstal, Martin Appleby, Greta Assmann, Florian S. N. Dworkowski, Nicole Hiller, Chia-Ying Huang, Tom Mason, Samuel Perrett, Eduard Prat, Didier Voulot, Bill Pedrini, John H. Beale, Michael A. Hough, Jonathan A. R. Worrall, Robin L. Owen

“…Serial femtosecond crystallography (SFX) exploits extremely brief X-ray free-electron laser pulses to obtain diffraction data before destruction of the crystal. However, during the pulse X-ray-induced site-specific radiation damage can occur, leading to electronic state and/or structural changes. …”
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Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity by Samantha Corrà, Alessandro Zuppardo, Sebastian Valenzuela, Louise Jenninger, Raffaele Cerutti, Sirelin Sillamaa, Emily Hoberg, Katarina A. S. Johansson, Urska Rovsnik, Sara Volta, Pedro Silva-Pinheiro, Hannah Davis, Aleksandra Trifunovic, Michal Minczuk, Claes M. Gustafsson, Anu Suomalainen, Massimo Zeviani, Bertil Macao, Xuefeng Zhu, Maria Falkenberg, Carlo Viscomi

“…Cryogenic electron microscopy highlighted structural differences between human and mouse POLγ, particularly in the POLγB subunit, which may explain the higher activity of mouse POLγ and the reduced severity of mutations in mice. …”
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Syn-to post-orogenic mineralization in the Shuangkoushan Au–Ag–Pb deposit, North Qaidam: insights from H–O–S isotopes and U–Pb geochronology by Junzhen Yu, Junzhen Yu, Dexian Li, Dexian Li, Youye Zheng, Youye Zheng, Bo Ma, Bo Ma, Jian Wang, Jian Wang, Guomei Shi, Guomei Shi, Rongke Xu, Junaid Khan, Asma Tahir

“…The syn-orogenic meta-basaltic rocks, intruded by gabbros, host numerous orogenic Au deposits and are structurally controlled by a NW–SE-trending ductile shear zone. …”
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Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow by Alejandro Gomez Toledo, Sounak Chowdhury, Elisabeth Hjortswang, James T. Sorrentino, Nathan E. Lewis, Anna Bläckberg, Simon Ekström, Sven Kjellström, Arman Izadi, Berit Olofsson, Pontus Nordenfelt, Lars Malmström, Magnus Rasmussen, Johan Malmström

“…A selected subset of the identified antigens is then expressed recombinantly to isolate antigen-specific IgG, followed by characterization of the structural and functional properties of these antibodies. …”
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Simulation Analysis and Experimental Verification of the Transport Characteristics of a High-Volume CubeSat Storage Device by Yong Zhao, Yuhao Zhang, Zeming Zhao, Chenyuan Li, Lili Zhang, Xiaoze Yang, Honghao Yue, Caiting He, Jianlei Zhu, Ye erken Halishi, Youle Wu, Guicheng Xing, Milamujiang Kezierbieke

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Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics by Amy J. Petty, Adela Rambi Cardones, Yingai Jane Jin, Vaibhav Jain, Emily Hocke, Harsh B. Pathak, Amrita Mitra, Simon G. Gregory, M. Angelica Selim, Jennifer Y. Zhang

“…Very little is understood about the underlying pathogenesis underpinning injury at this location, especially the contribution of keratinocytes and other structural skin cells. We performed single-cell RNA sequencing to compare the transcriptome of epidermal and dermal chronic GVHD samples with that of healthy control samples. …”
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Food parenting stress among caregivers receiving government food assistance: a study from the United States by Faith Hardy, Alison Tovar, Emily G. Elenio, Yarisbel Melo Herrera, Michelle Perry, Katherine W. Bauer, Maya K. Vadiveloo

“…Nutrition education should be paired with supports that address structural barriers.…”
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ODEP-Based Robotic System for Micromanipulation and In-Flow Analysis of Primary Cells by Joanna Filippi, Paola Casti, Valentina Lacconi, Gianni Antonelli, Michele D’Orazio, Giorgia Curci, Carlo Ticconi, Rocco Rago, Massimiliano De Luca, Alessandro Pecora, Arianna Mencattini, Steven L. Neale, Luisa Campagnolo, Eugenio Martinelli

“…The induced responses obtained under time-variant ODEP stimulation reflect the cells’ chemical, morphological, and structural characteristics in an automated, flexible, and label-free manner. …”
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