Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation by Chiara Sassoli, Federica Pierucci, Alessia Tani, Alessia Frati, Flaminia Chellini, Francesca Matteini, Ambra Vestri, Giulia Anderloni, Daniele Nosi, Sandra Zecchi-Orlandini, Elisabetta Meacci

“…Notably, active S1PR1/MMP-2 signalling is required for F-actin structure assembly (lamellipodia, microspikes, and stress fibers) and, in turn, cell proliferation. …”
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Rare ginsenosides: A unique perspective of ginseng research by Wenxiang Fan, Linhong Fan, Ziying Wang, Yuqi Mei, Longchan Liu, Linnan Li, Li Yang, Zhengtao Wang

“…Aim of review: In this review, recent advances of Rare ginsenosides (RGs) were summarized dealing with the structurally diverse characteristics, traditional usage, drug discovery situation, clinical application, pharmacological effects and the underlying mechanisms, structure–activity relationship, toxicity, the stereochemistry properties, and production strategies. …”
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Spectral characteristics of seismic ambient vibrations reveal changes in the subglacial environment of Glacier de la Plaine Morte, Switzerland by J. van Ginkel, J. van Ginkel, F. Walter, F. Walter, F. Lindner, M. Hallo, M. Hallo, M. Huss, M. Huss, D. Fäh

“…Our results highlight the value of long time series of HVSR measurements which show variations in the peak and trough structure that reflect hydrological changes in the subglacial environment.…”
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Effects of plant growth regulator (2,4-D) treatments on fruit development and chemical content in the kiwifruit plant (Actinidia chinensis) by Linhui Wu, Jiaqi Dong, Hao Zheng, Yule Wang, Dongliang Qiu, Arif Atak, Qiong Zhang, Caihong Zhong

“…The fruit set rate of parthenocarpic fruits reached 16.95% with 2,4-D treatment at 140 days after flowering; female flowers treated with 2,4-D showed differences in pollen structure compared to those treated with water. Also, no viability was detected in female flower pollen treated with 2,4-D. …”
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Orthopedic surgical treatment of osteomalacia induced by culprit soft tissue tumor in the hip region: a single-center retrospective study by Shuzhong Liu, Xi Zhou, Jinyi Xing, Annan Liang, Yong Liu, Weibo Xia

“…Abstract Background Due to its occult position, complex anatomical structure, and spatial relationships, the causative tumor of Tumor-Induced Osteomalacia (TIO) in the hip region is quite difficult to detect and qualitatively diagnose in clinical practice. …”
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Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation by Linhao Xu, Yanli Bi, Yizhou Xu, Yihao Wu, Xiaoxue Du, Yixuan Mou, Jian Chen

“…GSK2606414, a specific chemical inhibitor of the PERK pathway, reduced the expression of p-PERK, ATF-4, p-elf2α, and CHOP and rescued ER structure. In addition, Bax and Bak accumulated in the mitochondria after IH treatment, which induced cytochrome c release and initiated apoptosis. …”
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Potential to use of viral reverse transcriptase inhibitors in oncology by O. A. Vlasova, I. A. Antonova, Kh. M. Magomedova, M. A. Usolkina, K. I. Kirsanov, G. A. Belitsky, T. T. Valiev, M. G. Yakubovskaya

“…To date, reverse transcriptase inhibitors of viruses of nucleoside and non-nucleoside structure have been developed and are successfully used in the clinic. …”
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Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer by Anna Dieper, Stephan Scheidegger, Rudolf M. Füchslin, Paraskevi D. Veltsista, Ulrike Stein, Mathias Weyland, Dominik Gerster, Marcus Beck, Olof Bengtsson, Daniel Zips, Pirus Ghadjar

“…Among those, by reviewing the included publications, we identified RF-EMF-induced ion channel activation, altered gene expression, altered membrane potentials, membrane oscillations, and blebbing, as well as changes in cytoskeletal structure and cell morphology.Conclusion The existent literature points toward a yet untapped therapeutic potential of RF-EMF treatment, which might aid in damaging cancer cells through bio-electrical and electro-mechanical molecular mechanisms while minimizing adverse effects on healthy tissue cells. …”
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Ultra-processed food intake and brain health in middle-aged and older adults by Jiawei Gu, Linli Chen, Yujia Bao, Xueer Yang, Xuhua Chen, Zheshen Han, Yibin Zhou, Xiaobei Deng, Yuhua Li, Jinjun Ran

“…Given the increasing prevalence of ultra-processed foods (UPFs) in modern diets and their links to various chronic diseases, this study investigates their associations with neurodegeneration and alterations in brain structure. Design: A prospective cohort study. Setting and participants: 58,423 participants aged 40–70 years from the UK Biobank cohort (enrolled from 2006 to 2010) were included to examine the associations between UPF intake and neurodegenerative diseases, with a subsample of 5,462 participants with neuroimaging data used to investigate associations with regional gray matter morphology, including volume, thickness, and surface area. …”
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Effects of Different Levels of Green Tea Powder on Performance, Antioxidant Activity, Egg Mass, Quality, and Cecal Microflora of Chickens by Wei Luo, Qisong Tan, Hui Li, Tao Ye, Tao Xiao, Xingzhou Tian, Weiwei Wang

“…The statistical software SPSS was used to perform a one-way analysis of variance (ANOVA) on the experimental data, and Duncan’s method was used to perform multiple comparisons among groups. …”
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Psychometric properties of the Persian version of the training needs assessment for critical care nurses by Amir Jalali, Mostafa Bafandeh Zendeh, Azam Sharifi, Amirhossein Naghibzadeh, Leila Moradi, Jalal Karimi, Nazanin Mardani Taghvostani, Khalil Moradi

“…Results The results of the EFA and CFA confirmed the thirteen-factor structure with 66 items, explaining 62.337% of the total variance. …”
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Lipopolysaccharide and ARDS caused by new coronavirus infection: hypotheses and facts by I. A. Yatskov, V. A. Beloglazov, E. I. Ryapova

“…ARDS is a syndrome of severe respiratory failure, an acutely occurring diffuse inflammatory lesion of lung tissue that develops as a nonspecific reaction to various direct (aspiration, inhalation of toxic gases), and systemic (sepsis, polytrauma) damaging factors and leading to development of acute respiratory failure (ARF), due to impaired structure of the lung parenchyma, disturbances in vascular permeability, decreased area of ventilated lung tissue. …”
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Optimizing XGBoost Hyperparameters for Credit Scoring Classification Using Weighted Cognitive Avoidance Particle Swarm by Atul Vikas Lakra, Sudarson Jena, Kaushik Mishra

“…Weighted cognitive avoidance particle swarm optimization for the XGBoost (WCAPSO-XGB) model has been proposed for credit score classification. The structure of the XGBoost (XGB) model is determined by the hyperparameters, which must be initialized prior to model evaluation. …”
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TWO STAGES OF THE CENOZOIC ALKALINE-BASALT VOLCANISM IN THE DARKHAD DEPRESSION (NORTHERN MONGOLIA) – GEOCHRONOLOGY, GEOCHEMISTRY, AND GEODYNAMIC CONSEQUENCES by S. S. Tsypukova, A. B. Perepelov, E. I. Demonterova, A. V. Ivanov, S. I. Dril, M. I. Kuzmin, A. V. Travin, Yu. D. Shcherbakov, M. Yu. Puzankov, S. V. Kanakin

“…The origin of trachybasalt magmas of the final stage is associated with the processes of decompression melting of peridotites in a weakly metasomatized lithospheric mantle at the rift stage of the Darkhad structure development.…”
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Thermal, Optical, and Emission Traits of SM³⁺-Ion-Doped Fluoride/Chloride/Oxide Glass for Red/Orange Laser Fiber Applications by Bozena Burtan-Gwizdala, Jan Cisowski, Radoslaw Lisiecki, Kinga J. Kowalska, Bozena Jarzabek, Natalia Nosidlak, Manuela Reben, Ali M. Alshehri, Khalid I. Hussein, El Sayed Yousef

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Assessment of synthetic post-therapeutic OCT images using the generative adversarial network in patients with macular edema secondary to retinal vein occlusion by Shi Feng, Jingyuan Yang, Xinyu Zhao, Jianchun Zhao, Yunfeng Du, Weihong Yu, Dayong Ding, Xirong Li, Youxin Chen

“…Segmentation of macular location, retinal structure, and typical lesions were added to the input information. …”
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Study of Morphological Features of Sea Buckthorn Leaves by Luminescent and Stereomicroscopy Methods by N. A. Kovaleva, O. V. Trineeva, A. A. Gudkova, A. I. Slivkin

“…When removing the layer of hairs, the spongy structure of the epidermis of the leaf is visible. …”
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Energy efficiency assessment of the 3ES5K electric locomotives when using interval regulation technology in the form of "virtual coupling" by S. V. Vlas'yevskiy, O. A. Malysheva, N. G. Shabalin, V. V. Semchenko

“…This technology removes the problem of extending the receiving and departure tracks, reduces peak loads on the traction power supply system and the formation time of the virtual coupling structure, and increases the train speed to the yellow traffic signal with safety guaranteed. …”
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Separation of Hydrogen Isotopes by Metal-Organic Framework Quantum Sieving Effect by Peng LIU, Jia-xian CHENG, Fu-qiu MA

“…Among them, the metal-organic framework has the advantages of designable structure, adjustable pore size, diverse functional groups, large specific surface area, and good stability. …”
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Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway by Ai Z, Yuan D, Li Y, Cai J, Zhou D, Liu W

“…Transcriptomic sequencing of anorectal tissues was integrated with experimental validation using ELISA, immunohistochemistry (IHC), and Western blotting to delineate molecular mechanism. Data were analyzed by one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparison post hoc test (significance at p< 0.05).Results: MHG significantly reduced ARC, macroscopic severity score, and Evans blue extravasation, restored intestinal villus structure and goblet cell numbers, and alleviated inflammation. …”
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