Increased vulnerability to psychological distress and suicidal ideation among transgender women with self-reported disabilities in San Francisco, California by Abtin Shafie, Alexis Salvatore, Riley Shea, Eileen Yu, Oyku Ozyucel, Ansharan Akbar, Bow Suprasert, Erin C. Wilson, Willi McFarland, Kelly D. Taylor, Sean Arayasirikul

“…OBJECTIVE: Research among transgender women has found health, but especially mental health, to be shaped by social inequities and multiple, intersectional, structural vulnerabilities. While some studies have shown that transgender adults are also more likely to have a disability than cisgender adults, few studies have explored this intersection. …”
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Clinical profiles and health-related quality of life changes after treatment in advanced colorectal cancer patients: a nationwide study in China by Hongwei Liu, Ziyao Jia, Huifang Xu, Xiaoyang Wang, Hong Wang, Ruihua Kang, Qiong Chen, Xiaoli Guo, Ranran Qie, Mengfei Zhao, Cheng Cheng, Liyang Zheng, Shuzheng Liu, Yin Liu, Shaokai Zhang, China Working Group on Colorectal Cancer Survey

“…The multivariable regressions and structural equation model (SEM) were used to assess the association between characteristics and HRQOL. …”
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Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in <i>Trypanosoma cruzi</i>: Virtual Screening and In Vitro Studies by Eyra Ortiz-Pérez, Adriana Moreno-Rodríguez, Timoteo Delgado-Maldonado, Jessica L. Ortega-Balleza, Alonzo González-González, Alma D. Paz-González, Karina Vázquez, Guadalupe Avalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera

“…Future studies should focus on structural modifications to improve selectivity. Integrating docking, parasitological, and enzymatic data is crucial for optimizing drug candidates for Chagas disease.…”
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Predicting leakage of the VERCORS mock-up and concrete containment buildings - a digital twin approach by Laurent Charpin, Jessica Haelewyn, Anass Cherki El Idrissi, Julien Niepceron, Benoît Masson, Charles Toulemonde, Guillaume Boulant, Jean-Philippe Mathieu, François Hamon, Sylvie Michel-Ponnelle, Jean-Marie Hénault, Frédéric Taillade, Jean-Luc Adia, Florian Escoffier

“…An important numerical effort has also been made to implement structural computations of the mock-up and to capitalize these computations as well as their post-processing (so as to compare automatically with the monitoring data) in what can be called a digital twin of the mock-up. …”
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Pheochromocytoma metastasis to the central nervous system: a case report and systematic review by Justyna Małgorzata Fercho, Justyna Małgorzata Fercho, Justyna Małgorzata Fercho, Justyna Małgorzata Fercho, Oskar G. Chasles, Jakub Chamier-Gliszczyński, Dominik Ryszard Płaza, Bogdan Jabłoński, Klaudia Kokot, Maciej Mielczarek, Małgorzata Małłek-Grabowska, Małgorzata Małłek-Grabowska, Jacek Szypenbejl, Jacek Szypenbejl, Adrian Szkudlarek, Tomasz Szmuda, Tomasz Szmuda, Mariusz Siemiński, Mariusz Siemiński, Jacek Furtak, Jacek Furtak

“…MRI and PET improved the diagnostic accuracy over historical non-contrast CT use (41.7% spinal cases).InterpretationCNS mPCC metastases are exceedingly rare with distinct neurological (cranial) and structural (spinal) presentations. Advanced imaging, particularly magnetic resonance imaging (MRI) and positron emission tomography (PET), is critical for accurate diagnosis and surgical planning. …”
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Systemic inflammation is an important risk factor and predictor of graft loss and mortality one year after kidney transplantation by Torbjørn F. Heldal, Torbjørn F. Heldal, Torbjørn F. Heldal, Anders Åsberg, Anders Åsberg, Anders Åsberg, Thor Ueland, Thor Ueland, Thor Ueland, Anna V. Reisæter, Anna V. Reisæter, Søren E. Pischke, Søren E. Pischke, Tom E. Mollnes, Tom E. Mollnes, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Finn P. Reinholt, Anders Hartmann, Anders Hartmann, Kristian Heldal, Kristian Heldal, Kristian Heldal, Trond G. Jenssen, Trond G. Jenssen

“…BackgroundAn inflammatory environment following kidney transplantation is associated with increased risk of graft loss and mortality, however, evaluation of systemic inflammation is not implemented in structured risk assessment in kidney transplant recipients. …”
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Postnatal care could be the key to improving the continuum of care in maternal and child health in Ratanakiri, Cambodia. by Kimiyo Kikuchi, Junko Yasuoka, Keiko Nanishi, Ashir Ahmed, Yasunobu Nohara, Mariko Nishikitani, Fumihiko Yokota, Tetsuya Mizutani, Naoki Nakashima

“…Overall, 377 women were included, and data were collected via face-to-face interviews using a semi-structured questionnaire. …”
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Sources of uncertainty in DNA metabarcoding of whole communities: Implications for its use in biomonitoring by J. Iwan Jones, Amanda Arnold, Dominik Buchner, John F. Murphy, Jasmine N. Childress, Pedro Beja, Florian Altermatt, Kristian Meissner, Ian Adams, Meri Anderson, Yaisel J. Borrell, Andrew G. Briscoe, Kat Bruce, Cátia Chaves, Chris Conyers, Kristy Deiner, Vasco Elbrecht, Álvaro Fueyo, Tim Goodall, Javier Granero‐Castro, Cristina Hartmann‐Fatu, Eleanor Jones, Elvira Mächler, Filipa M. S. Martins, Sam McGreig, Lyndall Pereira‐da‐Conceicoa, James L. Pretty, Daniel S. Read, Ben Price, Florian Leese, Rosetta C. Blackman

“…However, the routine application of DNA‐based methods to monitor whole communities using a metabarcoding approach and derive ecosystem status continues to be limited. We undertook a structured experiment to assess factors influencing the precision and accuracy of molecular methods for freshwater macroinvertebrate community assessment. …”
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Experiencing family care for premature newborns during the COVID-19 pandemic by Giordanna Nayara Chagas-e Silva, Paula Andrea Pino-Rivera, Victoria Beatriz Trevisan Nobrega Martins- Ruthes, Verônica de Azevedo-Mazza, Gisele Weissheimer-Kaufmann, Ana Carolina Bueno-Guisso, Mayra Eduarda Borges-Moreno

“…Our study is a qualitative, multiple-case study, conducted between September 2021 and March 2022, with family members of premature newborns who underwent outpatient childcare at a university hospital in southern Brazil that implemented the Kangaroo Method. We collected data through online interviews with a semi-structured instrument and thematic categorical analysis of the data. …”
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Patterns of antibiotic use, pathogens, and prediction of mortality in hospitalized neonates and young infants with sepsis: A global neonatal sepsis observational cohort study (NeoO... by Neal J Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook, James A Berkley, Bethou Adhisivam, Ramesh Agarwal, Nawshad Uddin Ahmed, Manica Balasegaram, Daynia Ballot, Adrie Bekker, Eitan Naaman Berezin, Davide Bilardi, Suppawat Boonkasidecha, Cristina G Carvalheiro, Neema Chami, Suman Chaurasia, Sara Chiurchiu, Viviane Rinaldi Favarin Colas, Simon Cousens, Tim R Cressey, Ana Carolina Dantas de Assis, Tran Minh Dien, Yijun Ding, Nguyen Trong Dung, Han Dong, Angela Dramowski, Madhusudhan Ds, Ajay Dudeja, Jinxing Feng, Youri Glupczynski, Srishti Goel, Herman Goossens, Doan Thi Huong Hao, Mahmudul Islam Khan, Tatiana Munera Huertas, Mohammad Shahidul Islam, Daniel Jarovsky, Nathalie Khavessian, Meera Khorana, Angeliki Kontou, Tomislav Kostyanev, Premsak Laoyookhon, Sorasak Lochindarat, Mattias Larsson, Maia De Luca, Surbhi Malhotra-Kumar, Nivedita Mondal, Nitu Mundhra, Philippa Musoke, Marisa M Mussi-Pinhata, Ruchi Nanavati, Firdose Nakwa, Sushma Nangia, Jolly Nankunda, Alessandra Nardone, Borna Nyaoke, Christina W Obiero, Maxensia Owor, Wang Ping, Kanchana Preedisripipat, Shamim Qazi, Lifeng Qi, Tanusha Ramdin, Amy Riddell, Lorenza Romani, Praewpan Roysuwan, Robin Saggers, Emmanuel Roilides, Samir K Saha, Kosmas Sarafidis, Valerie Tusubira, Reenu Thomas, Sithembiso Velaphi, Tuba Vilken, Xiaojiao Wang, Yajuan Wang, Yonghong Yang, Liu Zunjie, Sally Ellis, Julia A Bielicki, A Sarah Walker, Paul T Heath, Mike Sharland

“…<h4>Background</h4>There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). …”
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Credit Risk Management Practices and Loan Performance of Commercial Banks in Uganda. A Case Study of Commercial Banks in Mbarara City by Francis, Agaba

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Credit Risk Management Practices and Loan Performance of Commercial Banks in Uganda. A Case Study of Commercial Banks in Mbarara City by Agaba, Francis

“…Hence, the study used a quantitative approach to collect numeric and categorical data using structured questionnaires to generate inferential statistics (correlations and regressions).xiii Quantitative method have been used because it produces results that are easy to summarize, compare, generalize and confirm whether the hypotheses hold true or false. …”
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Physiologically based pharmacokinetic model of sodium-glucose cotransporter 2 inhibitors predicted pharmacokinetics and pharmacodynamics to explore dosage regimen for patients with... by Guimu Guo, Guimu Guo, Meng Ke, Meng Ke, Jianwen Xu, Jianwen Xu, Wanhong Wu, Wanhong Wu, Jiarui Chen, Jiarui Chen, Chengjie Ke, Chengjie Ke, Pinfang Huang, Pinfang Huang, Cuihong Lin, Cuihong Lin

“…ObjectiveThis study aimed to compare the hypoglycemic effects of four SGLT2 inhibitors (dapagliflozin, canagliflozin, empagliflozin, and ipragliflozin), simulate the 24-h urinary glucose excretion (UGE) of these inhibitors in T2DM patients with renal insufficiency, and investigate optimal dosage regimen for the SGLT2 inhibitor in these patients.MethodWe established a physiologically based pharmacokinetic (PBPK) model of SGLT2 inhibitors using the PK-Sim software, and the renal physiological tissue structure was expanded to include renal tubules using the MoBi software. …”
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Evaluating analytic strategies to obtain high-resolution, vertex-level measures of cortical neuroanatomy in children in low- and middle-income countries by Charlotte M. Pretzsch, František Váša, Michael Brammer, Lucy Brink, Mandy Potter, Wendy Mackay, Petrusa Smit, Carolina Du Plessis, Marcelle Wagner, Deborah Jonker, Kirsten A. Donald, Freda Scheffler, Cindy Pham, Viola Hollestein, Eva Loth, Declan GM Murphy, Hein J. Odendaal, Elizabeth R. Sowell, Priscilla E. Springer, Dan J. Stein, Christine Ecker

“…Abstract High-field magnetic resonance imaging to explore brain structure and function remains limited to high-resource settings. …”
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Optical Coherence Tomography Angiography, Elastography, and Attenuation Imaging for Evaluation of Liver Regeneration by Svetlana Rodimova, Ekaterina Gubarkova, Nikolai Bobrov, Ilya Shchechkin, Vera Kozlova, Natalia Zolotova, Arseniy Potapov, Elena Kiseleva, Grigory Gelikonov, Natalia Gladkova, Vladimir Zagainov, Elena Zagaynova, Daria Kuznetsova

“…In this study, we used multimodal optical coherence tomography (MM OCT), a combination of three optical coherence tomography modalities—OCT–angiography (OCTA), attenuation coefficient mapping, and OCT–elastography (OCE) to provide real-time three-dimensional and label-free assessment of changes in microcirculation, and in the structure and stiffness of the liver during regeneration. …”
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MSCPUnet: A multi-task neural network for plot-level crop classification in complex agricultural areas by Kedi Fang, Shengwei Zhang, Yongting Han, Lin Yang, Meng Luo, Lu Liu, Qian Zhang, Bo Wang

“…Leveraging this capability, a crop classification framework is proposed, which first extracts crop attributes from Sentinel-2 (S2) time series data. The plot information obtained from the MSCPUnet model is then combined with the area dominance method to assign crop attributes to vector plots, facilitating crop structure identification at the plot scale. …”
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First Molecular Identification of <i>Cotylophoron cotylophorum</i> in Ecuador and Its Phylogenetic Relationship with <i>Fasciola hepatica</i> by Geanella Barragán-López, Fausto Bedoya-Páez, María Lugo-Almarza, Carolina Fonseca-Restrepo, Francisco Angulo-Cubillán, Edison J. Romero, Jacobus H. de Waard, Armando Reyna-Bello

“…Distinct single-nucleotide polymorphisms (SNPs) in the ITS2 chromatograms suggest a diploid genome structure in both trematode species. This is the first report of <i>C. cotylophorum</i> in Ecuador, and its presence may be linked to the late 19th-century introduction of Zebu cattle (<i>Bos taurus indicus</i>) from India.…”
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Conjunctival melanoma in children: a systematic review by Maria Partyka, Julia Plewniok, Maksymilian Janeczek, Karolina Kinga Kantor, Wiktoria Maria Szymańska, Julia Wójcik, Kacper Wojciech Pamuła, Marcin Cholewa, Maciej Kuca, Karolina Jaglarz

“…Clinically, it presents as a pigmented lesion with heterogeneous shape and structure. Its development may be associated with UV radiation and genetic mutations. …”
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Towards climate-resilient conservation: Integrating genetics and environmental factors in determining adaptive units of a xeric shrub by Yong-Zhi Yang, Pei-Wei Sun, Chong-Yi Ke, Min-Xin Luo, Jui-Tse Chang, Chien-Ti Chao, Run-Hong Gao, Pei-Chun Liao

“…ENM identified the central-east and west-north regions as optimal habitats, while GF analysis revealed seed and breeding zones based on 1637 climate-adaptive SNPs, indicating significant genetic differentiation linked to temperature and precipitation. Population structure analysis revealed both congruences and discrepancies between genetic and climatic clustering, particularly in peripheral regions, suggesting that adaptive genes may not follow isolation-by-distance rules like neutral genes. …”
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Whole exome sequencing identifies ABHD14A and MRNIP as novel candidate genes for developmental language disorder by Amal Bouzid, Malek Belcadhi, Amal Souissi, Meryam Chelly, Fakher Frikha, Hela Gargouri, Crystel Bonnet, Fida Jebali, Salma Loukil, Christine Petit, Saber Masmoudi, Rifat Hamoudi, Mariem Ben Said

“…Complementary analyses showed that these variants are predicted pathogenic and the missense variant Leu230Arg significantly affects the stability and structure modelling of the ABHD14A protein. Biological functions and interconnections analyses predicted the potential roles of ABHD14A and MRNIP in neuronal development pathways. …”
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