Overcoming challenges of developing a live-attenuated dengue vaccine and the path forward by Dr Walid Kandeil, Dr Mayuri Sharma

“…Additional immunogenicity analysis across phase I/II/III trials revealed engagement of long-lasting tetravalent, functional antibody, and cell-mediated immune responses directed against the structural and nonstructural components of the vaccine, irrespective of baseline serostatus. …”
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Path analysis of the influence of digital health literacy on self-management behaviour among elderly patients with chronic diseases in rural China by Xuefang Liu, Xiaomin Gan, Guangqin Ren, Zhongrui Mao, Jiuying Hu, Chengcheng Sha, Juan Wu

“…Common method bias tests, descriptive statistics and correlation analyses were performed via SPSS 29.0. The structural equation model was constructed and tested via AMOS 27.0. …”
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ProstaNet: A Novel Geometric Vector Perceptrons–Graph Neural Network Algorithm for Protein Stability Prediction in Single- and Multiple-Point Mutations with Experimental Validation... by Tianjian Liang, Ze-Yu Sun, Rieko Ishima, Xiang-Qun Xie, Ying Xue, Wei Li, Zhiwei Feng

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ROLE OF THE CELLULAR IMMUNITY IN THE PATHOGENESIS OF BRAIN CONTUSION by A. O. Norka, S. V. Vorobyev, R. N. Kuznetsova, M. K. Serebriakova, I. V. Kudryavtsev, S. N. Kovalenko

“…Traumatic brain injury (TBI) is one of the most common pathologies of the central nervous system in the world, and the use of structural neuroimaging methods – computed tomography (CT) and magnetic resonance imaging (MRI) – often doesn’t allow assessment of the severity of the brain injury that has occurred. …”
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Childhood maltreatment and depression: mediating role of lifestyle factors, personality traits, adult traumas, and social connections among middle-aged and elderly participants by Xuemei Wang, Zhi Cao, Shaohua Yin, Tingshan Duan, Tao Sun, Chenjie Xu

“…A path analysis using structural equation modeling (SEM) was then performed to assess the mediating effects of lifestyle factors, personality traits, adult traumas, and social connections. …”
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Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds by Lakshmi Mounika Kelam, Manjinder Singh Gill, M. Elizabeth Sobhia

“…MD revealed stable protein-ligand complexes, evidenced by low RMSD values (0.2–0.4 nm) and minimal residue fluctuations (RMSF), confirming their structural integrity. The generative AI approach using LigDream also generated 100 novel 4HILe derivatives, with top candidates exhibiting strong docking scores and key molecular interactions against α-glucosidase, α-amylase, and aldose reductase. …”
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Brain and brain blood vessels histological description in autopsies of fetuses/neonates born to mothers with hypertension during pregnancy. A case–control studyResearch in context... by Johana González, Jorge Anxdrés Franco, Carlos Escudero, Mercedes Olaya

“…Summary: Background: Children born to women with hypertension during pregnancy have a two to threefold increased risk of developing cognitive disorders compared to children born to women without hypertension. However, structural changes in the central nervous system of these children remain poorly understood. …”
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Investigating Clinicians’ Intentions and Influencing Factors for Using an Intelligence-Enabled Diagnostic Clinical Decision Support System in Health Care Systems: Cross-Sectional S... by Rui Zheng, Xiao Jiang, Li Shen, Tianrui He, Mengting Ji, Xingyi Li, Guangjun Yu

“… BackgroundAn intelligence-enabled clinical decision support system (CDSS) is a computerized system that integrates medical knowledge, patient data, and clinical guidelines to assist health care providers make clinical decisions. …”
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Ecosystem health evaluation and driving Force analysis of high groundwater Table Coal-Grain complex area based on remote sensing information by Anya Zhong, Zhenqi Hu, Tiantian Yang, Zhen Wang

“…Utilizing partial least squares structural equation modeling (PLS-SEM), this study examines the spatiotemporal evolution trends of ecological quality in HGT CGCA from 1985 to 2020 and explores the underlying driving mechanisms. …”
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Association between depressive symptoms and physical exercise in college students: longitudinal mediating effects of social support and psychological resilience by Yuanyuan Hou, Xinyi Liu, Zhendong Li, Shouzhen Huang, Wenjuan Chen, Yuhao Jiang, Panpan He, Jingquan Sun, Haijun Han

“…Amos 28.0 was used to construct the cross-lag model and structural equation model for analysis.Results(1) Depressive symptoms at T1 negatively predicted physical activity at T2 (β = −0.07, p < 0.05). …”
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Aneuploidy screening in women of advanced age in the public healthcare setting of a low- to middle- income country – an observational cohort study by L Geerts, N Du Toit, M Schoeman

“…As uptake of testing and/or TOP was higher with abnormal ultrasound findings, a prenatal screening programme addressing structural anomalies and aneuploidies simultaneously (i.e. ultrasound) is preferred over other DS screening tools that target DS specifically. …”
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Factors of coxitis progression in patients with axial spondyloarthritis. Results of a two-year dynamic observation by E. M. Agafonova, Sh. Erdes, T. V. Dubinina, A. B. Demina, A. V. Smirnov

“…It is also worth noting that the relationship between laboratory parameters of inflammation and disease activity indices is relatively weak, as well as with structural damage in axSpA.Conclusion. Factors influencing the development and progression of coxitis in axSpA are a combination of such signs as high clinical activity of the disease, the presence of peripheral arthritis and male gender.…”
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Immobilization of Oat Bran Polyphenols in Complex Coacervates of Whey Protein and Malthodextrin by Zyaitdinov Damir R., Ewteew Alexandr V., Bannikova Anna V.

“…In vitro enzymatic hydrolysis protocol simulating digestion in the gastrointestinal tract was used to study the effect of capsule structural characteristics on the kinetics of polyphenol release. …”
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Probabilistic Modelling of Fatigue Behaviour of 51CrV4 Steel for Railway Parabolic Leaf Springs by Vítor M. G. Gomes, Felipe K. Fiorentin, Rita Dantas, Filipe G. A. Silva, José A. F. O. Correia, Abílio M. P. de Jesus

“…The longevity of railway vehicles is an important factor in their mechanical and structural design. Fatigue is a major issue that affects the durability of railway components, and therefore, knowledge of the fatigue resistance characteristics of critical components, such as the leaf springs, must be extensively investigated. …”
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Spontaneous Intracranial Hypotension and Dural Ectasia in Marfan Syndrome: An Illustrative Case Successfully Treated with Steroid Therapy and Literature Review by Francesco Signorelli, Omar Ktari, Ludovico Agostini, Giorgio Ducoli, Fabio Zeoli, Massimiliano Visocchi

“…Patients with Marfan Syndrome (MS) and other connective tissue disorders are at an increased risk for dural ectasia, which may predispose them to spontaneous CSF leaks due to the structural weakness of their dural membranes. The management of SIH in MS patients is debated. …”
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Genome-Wide Analysis of Caffeoyl-CoA-O-methyltransferase (CCoAOMT) Family Genes and the Roles of <i>GhCCoAOMT7</i> in Lignin Synthesis in Cotton by Lina Ma, Jin Wang, Kaikai Qiao, Yuewei Quan, Shuli Fan, Liqiang Wu

“…Motif analysis revealed that all CCoAOMT proteins possess conserved Methyltransf_3 domains, and conserved structural features were identified based on the genes’ exon-intron organization. …”
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Drying kinetics and quality characteristics of ultrasound-assisted germination of quinoa grains: A study on functional properties, mineral content and bioactive compounds by Jabir Khan, Yang Li, Palwasha Gul, Qingyun Li, Kunlun Liu

“…This study evaluated functional properties, minerals, bioactive compounds and structural properties of Pre-treatments assisted germination of quinoa grains JQ-778 including, Only germinated seeds (OGS), soaked germinated seeds (SGS), ultrasound at 28 &amp; 40 frequencies (US 28 kHz &amp; US 40 kHz) for 30 min in a Biochemical-Incubator of 96-hour period at 25 °C, 12/12 h dark and light circle, followed by drying at temperatures 50 °C, 60 °C, 70 °C &amp; combined (70, 60, 50 °C). …”
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The mediating effect of the budget process on the performance of small- and medium-sized enterprises in Ho Chi Minh City, Vietnam by Vuong Khanh Tuan, Premkumar Rajagopal

“…Structural equation modelling (SEM) was used to test both the conceptual framework and the hypothesis of the real study. …”
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Construction of Clinical Predictive Models for Heart Failure Detection Using Six Different Machine Learning Algorithms: Identification of Key Clinical Prognostic Features by Qu FZ, Ding J, An XF, Peng R, He N, Liu S, Jiang X

“…Fang Zhou Qu,1 Jiang Ding,2 Xi Feng An,3 Rui Peng,4 Ni He,5 Sheng Liu,1 Xin Jiang5 1Medical School, Xizang Minzu University, Xianyang, People’s Republic of China; 2Institute of Electrical Power Systems, Graz University of Technology, Graz, Austria; 3The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 4Affiliated Nanhua Hospital, University of South China, Hengyang, People’s Republic of China; 5Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an, People’s Republic of ChinaCorrespondence: Xin Jiang, Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an, Shanxi Province, People’s Republic of China, Email 18560453060@163.comPurpose: Heart failure (HF) is a clinical syndrome in which structural or functional abnormalities of the heart result in impaired ventricular filling or ejection capacity. …”
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Strengthening health system's capacity for pre-exposure prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS'Cap-PrEP): Protocol... by Edward Nicol, Trisha Ramraj, Mbuzeleni Hlongwa, Wisdom Basera, Ngcwalisa Jama, Carl Lombard, Tracy McClinton-Appollis, Darshini Govindasamy, Desiree Pass, Noluntu Funani, Sarah Aheron, Ariana Paredes-Vincent, Jennifer Drummond, Mireille Cheyip, Sibongile Dladla, Jason Bedford, Cathy Mathews

“…In South Africa, various approaches of delivering PrEP have been adopted at different service delivery points (facility-based only, school-based only, community-based only and hybrid school-facility and community-facility models) to overcome challenges associated with individual, structural, and health systems related barriers that may hinder access to and uptake of PrEP among these populations. …”
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