Synthesis of the serotonin derivative 5-PT and establishment of a research system for protein serotonylation by XIAO Shuyu, TULAMATI Aziguli, YANG Yan, ZHANG Zhigang, YANG Xiaomei, DU Chang, ZHANG Xueli

“…Objective·To establish a research framework for serotonylation of proteins and to provide a methodological basis for the identification of serotonylated proteins.Methods·The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases were used to analyze the expression of the transglutaminase 2 (TGM2) gene, which encodes the key enzyme for serotonylation, and the solute carrier family 6 (SLC6A4) gene, which encodes the serotonin transporter (SERT), in normal and pan-cancer tissues. 5-Propargyltryptamide (5-PT), a serotonin derivative, was synthesized stepwise from serotonin hydrochloride, and its structure was characterized by the Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR), and time-of-flight mass spectrometry (TOF-MS). …”
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The use of modern military technologies in the light of the law of weapons and the law of targeting by Behzad Seyfi

“…Therefore, the change in the nature of war can create major changes in different structures. However, technology by itself does not make war regular. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon by Everaldo B. de Souza, Douglas B. S. Ferreira, Luciano J. S. Anjos, Alan C. Cunha, João Athaydes Silva, Eliane C. Coutinho, Adriano M. L. Sousa, Paulo J. O. P. Souza, Waleria P. Monteiro Correa, Thaiane S. Silva Dias, Alexandre M. C. do Carmo, Carlos B. B. Gutierrez, Giordani R. C. Sodré, Aline M. M. Lima, Edson J. P. Rocha, Bergson C. Moraes, Luciano P. Pezzi, Tercio Ambrizzi

“…Furthermore, we conducted a comprehensive composite analysis on the tropical ocean–atmosphere dynamic structure that elucidated the various triggering mechanisms of disasters arising from Inundations, Droughts, and Forest fires (on seasonal scale), and Flash floods and Heavy rainfall (on sub-monthly scale) in Pará. …”
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A Multiwavelength Portrait of the 3C 220.3 Lensed System by Sóley Ó. Hyman, Belinda J. Wilkes, S. P. Willner, Joanna Kuraszkiewicz, Mojegan Azadi, D. M. Worrall, Adi Foord, Simona Vegetti, Matthew L. N. Ashby, Mark Birkinshaw, Christopher Fassnacht, Martin Haas, Daniel Stern

“…The new HST images also reveal extended emission around galaxy A, and the spectra show extended [O ii ] emission with irregular morphology and complex velocity structure. All indications are that the two lensing galaxies are a gravitationally interacting pair. …”
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Livestock rearing as a key component of mitigation efforts for non-CO2 greenhouse gas emissions in global crop-livestock system by Li Zheng, Qingwen Zhang, Ji Chen, Baojing Gu, Xiaoying Zhan, Bowei Yu, Yulong Shi, Hafiz Athar Hussain, Xuekai Jing

“…The Logarithmic Mean Divisia Index (LMDI) was used to decompose drivers and six scenarios (BAU (Baseline), RSA (Rearing Structure Adjustment), LMO (Livestock Management Optimization), BMPs-30% and BMPs-50% (best management practices with a manure substitution ratio of 30% or 50%), and NMA (No Manure Application)) were developed to assess mitigation potential. …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…Cardiovascular magnetic resonance were utilized to assess RV structure, function, and global myocardial strain [including peak strain (PS), peak systolic (PSSR) and diastolic strain rate (PDSR) in longitudinal, circumferential, and radial directions]. …”
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The potential spatiotemporal distribution patterns of Avena nuda and Avena sativa from global perspective provide new insights for the cultivation of commonly cultivated oats by Huanhuan Lu, Yuying Zheng, Ting Zhao, Liuban Tang, Fan Zhang, Wengang Xie

“…Abstract Background Commonly cultivated oats (Avena nuda and Avena sativa) play an important role in agricultural planting structure adjustment, ecological environment protection and grassland animal husbandry development, and their effective cultivation is conducive to food security and grassland degradation restoration. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Analogs of Precambrian microbial communities formed de novo in Caucasian mineral water aquifers by Daria G. Zavarzina, Alexey A. Maslov, Alexander Y. Merkel, Nataliya A. Kharitonova, Alexandra A. Klyukina, Ekaterina I. Baranovskaya, Elena A. Baydariko, Evgeniy G. Potapov, Kseniya S. Zayulina, Andrey Y. Bychkov, Nikolay A. Chernyh, Elizaveta A. Bonch-Osmolovskaya, Sergey N. Gavrilov

“…Their structure and the metabolic traits of their prokaryotic populations were similar to those presumed to have dominated the Earth’s biosphere during several critical periods of its evolutionary history, that is, the Early Archean, the period of banded iron formations accumulation, and the Great Oxidation Event. …”
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Intra-host genomic variation of serologically nontypeable Haemophilus influenzae isolates from otitis media by Randall J. Olsen, S. Wesley Long, Yuvanesh Vedaraju, Sandra Tomasdottir, Helga Erlendsdottir, Karl G. Kristinsson, James M. Musser, Gunnsteinn Haraldsson

“…While research has begun advancing our understanding of the population genomic structure of H. influenza strains infecting humans, little is known about intra-host genomic variation. …”
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Feasibility and preliminary findings of a bacterial diversity study in periodontitis: a pilot investigation from the Western Cape by Salma Kabbashi, Yvonne Prince, Ndonwi Elvis Ngwa, Haly Holmes, Glenda Mary Davison, Saarah F. G. Davids, Manogari Chetty

“…Several alpha and beta-diversity metrics assessed biodiversity within-sample and population structure between different microbiota datasets, respectively. …”
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Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial by Jean-Yves Reginster, J Badurski, N Bellamy, W Bensen, R Chapurlat, X Chevalier, C Christiansen, H Genant, F Navarro, E Nasonov, P N Sambrook, T D Spector, C Cooper

“…Treatment with strontium ranelate 1 and 2 g/day is associated with a significant effect on structure in patients with knee osteoarthritis, and a beneficial effect on symptoms for strontium ranelate 2 g/day.Additional supplementary data are published online only. …”
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Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
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QTL mapping associated with Verticillium wilt resistance in cotton based on MAGIC population by Muhammad Ayyaz, Zewei Chang, Shugen Ding, Peng Han, Lin Xu, Abudurezike Abudukeyoumu, Irfan Ali Siddho, Zhibo Li, Hairong Lin, Jianwei Xu, Yuanlong Wu, Xinhui Nie

“…Families with higher ARDI values, indicating stronger resistance, were more common, likely due to genetic diversity and environmental factors. Population structure analysis divided the MAGIC population into three subgroups, with Group I showing higher genetic variation and Groups II and III displaying more uniform resistance performance. …”
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Analysis of the changes and correlation of soft and hard tissues in the lower facial third before and after BSSRO with genioplasty in patients with unilateral mandibular asymmetry by HU Shuangyu, HE Shixi, MA Cheng, LIU Liyuan, HUANG Xuanping

“…Objective To investigate the effects and alterations in soft and hard tissues in the lower third of the facial structure in patients exhibiting facial asymmetry following bilateral sagittal split ramus osteotomy (BSSRO) with genioplasty, and to examine the correlation between the changes observed in soft and hard tissues. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
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Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study by Lu Liu, Qianyi Zhou, Tianbao Xu, Qiufeng Deng, Yuhao Sun, Jingxiang Fu, Muxuan Chen, Xiaojiao Chen, Zhenchao Ma, Quanbin Dong, Beining Ma, Yuwen Jiao, Yan Zhou, Tingting Wu, Huayiyang Zou, Jing Shi, Yifeng Wang, Yanhui Sheng, Liming Tang, Chao Zheng, Wei Wu, Wenjun Ma, Wei Sun, Shixian Hu, Hongwei Zhou, Yan He, Xiangqing Kong, Lianmin Chen

“…Abstract Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. …”
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全基因组关联分析标准化流程的构建与扩展应用(Development and Extended Applications of Standardized Processes for Genome-Wide Association Studies) by 许喆1，2，石延枫1，2，张杰1，2，姜明慧1，2，刘阳1，2，李昊1，2，3，廖晓凌4，程丝1，2，3(XU Zhe1,2, SHI Yanfeng1,2, ZHANG Jie1,2, JIANG Minghui1,2, LIU Yang1,2, LI Hao1,2,3, LIAO Xiaoling4, CHENG Si1,2,3)

“…Methods A modular analysis system was constructed based on international GWAS quality control standards and multi-omics integration strategies. Pre-GWAS data quality control module: this module performed stringent quality control on sample and variant call rates, population genetic structure and stratification, and kinship. …”
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Petrology and mineral chemistry of the Hamaneh granitoid, West of Yazd (Central Iran zone) by Javad Ghanei Ardakani, Maryam Ahankoub

“…The parent magma of the rocks under study belongs to the subduction structural ground position related to the active continental margin.…”
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