Benzbromarone Analog SAR: Potent hURAT1 (SLC22A12) Inhibitors and Drug Transporter Interaction Studies by Jutabha P, Kumar V, Anzai N, Rice PJ, Lightner JW, Endou H, Wempe MF

“…One, to report two benzbromarone analogs and test their in vitro activity in the URAT1 inhibition assay; and two, to probe the structure–activity relationship (SAR) of various benzbromarone analogs regarding other drug transporters that may play a role in the uric acid uptake/elimination interplay.Methods: In brief, chemical synthesis of two benzbromarone analogs was prepared using methods analogous to those reported. …”
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A család ereje: A házasságban élés és a nagycsaládos lét kapcsolata a jóllét különböző mutatóival by Andrea FERENCZI, Zsuzsanna KÖVI, Veronika MÉSZÁROS

“… The Strength of the Family: Links between Marital Status, Large Family Structure, and Indicators of Well-Being. THEORETICAL BACKGROUND – Based on previous empirical findings, the relationship between family formation, the number of children, and subjective well-being cannot be considered unambiguous. …”
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Negotiating Islamic Law through Custom: Resistance in Family Law Practices among the Anak Dalam Community in Jambi by Illy Yanti, Yuliatin Yuliatin, Siti Mahmudah, Mahluddin Mahluddin, Yuniar Galuh Larasati

“…Challenging prevailing scholarly emphasis on integrative frameworks between Islamic law and local custom, this study demonstrates that, in the SAD context, resistance emerges when elements of Islamic jurisprudence (fiqh) clash with the community’s socio-cultural structure and shared values. Using a socio-legal approach and qualitative methods, the research draws on in-depth interviews with seven key informants, including a religious leader, the tumenggung (tribal chief), customary elder, community facilitator, subdistrict head, and SAD community members. …”
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Explanation of Good Governance Factors in Shiraz by Ehsan Heidarzadeh, Mojtaba Arasteh, Elnaz Rafiee

“…But one of the differences that can be seen in this research with similar researches is the emphasis of this research on an important factor under the title of " institutional capacity of organization" in order to apply the concepts and criteria of good urban governance in the structure of local, regional and national governments. …”
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Postpartum maternal bonding scale: Development and validation in a low- and middle- income country setting. by Bushra Khan, Seyi Soremekun, Waqas Hameed, Bilal Iqbal Avan

“…After multiple rounds of expert review and cognitive pretesting, a 30-item tool was selected for field testing. Using data from 310 postpartum women, we examined the tool's structure through exploratory (EFA) and confirmatory factor analysis (CFA), leading to a refined 12-item tool. …”
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Study on the Impact of Exclosures on the Physicochemical Properties of Rangeland Soil (Case Study: Northern Golestan Province, Sufikam Rangelands) by Rasool Khatibi, Mohsen Farahi

“…Among the remedial methods for degraded soils, increasing rangeland fertility and striving to improve soil structure stability, reducing livestock trampling through grazing restrictions, are highlighted. …”
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Improvement and Validation of System Code for Thermal-hydraulic Analysis of In-pool Passive Residual Heat Removal System by LIAN Qiang1, 2, 3, ZHU Longxiang1, 2, 3, TANG Simiao1, 2, 3, HUANG Tao4, ZHANG Yong4, PAN Liangming1, 2

“…This study can provide the basic technology support for the structure design of PRHRS and safety analysis of the reactor system. …”
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Interrelations of physical state parameters and biological age of students in the process of physical education by Oleksandr Pryimakov, Marek Sawczuk, Stanislav Prysiazhniuk, Nataliya Mazurok, Oleksandr Petrachkov

“…It was found that the key indicators of students' physical state (PS) structure, which exerted the most significant influence on BMI, differ between young men and women. …”
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Psychological adaptation and quality of life of patients who underwent lower limb amputation due to cancer by O Yu Shchelkova, M V Iakovleva, E B Usmanova, E A Sushentsov, D I Sofronov

“…It was found that functional capability (p<0.01), objective (p<0.001) and subjective (p<0.001) severity of pain syndrome, as well as employment (p=0.05) have the lowest indicators in group 1 compared with group 2; at the same time, the levels of QoL in both groups of patients do not differ and do not correspond the expert assessment, exceeding it; patients rate their cognitive and emotional activity most highly; the lowest, physical and role activity, and financial impact. In the structure of coping of group 1, the strategy “Seeking for social support” predominates; the values of the scales “Distancing” (p=0.05), “Escape–avoidance” (0.1<p<0.05), “Positive reappraisal” (p<0.05) are higher than in group 2, but lower than average normative values. …”
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The Effect of Selective and Mass Immunization Against Pneumococcal Infection on the Morbidity and Mortality due to Community-Acquired Pneumonia in Children Under 5 Years of Age by Vadislav V. Semerikov, Elena S. Zubova, Lyudmila V. Sofronova

“…It is also important to estimate the rate of hospital admissions in this patient group, long-term and annual cycles, morbidity age and etiology structure, and mortality due to community-acquired pneumonia as one of the most common form of pneumococcal disease. …”
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Changes in physical activity and sedentary behaviours of children living in Italy due to the COVID-19 pandemic: the EPaS-ISS study by Paola Nardone, Serena Broccoli, Angela Spinelli, Marta Buoncristiano, Silvia Andreozzi, Mauro Bucciarelli, Marco Giustini, Silvia Ciardullo, on behalf of the EPaS-ISS Group

“…The possible effects of gender, geographical area of residence, parents’ nationality and educational level, family structure, family-perceived wealth, availability of home outdoor spaces and house size were investigated. …”
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Urban Hierarchy Migration Model and Impact Mechanism of Graduates Admitted to the Guangdong Provincial Civil Service Examination by Wu Jinghao, Liu Ye, Tang Honglin

“…As China enters a critical transition period towards a knowledge-based economy, the optimization of the educational attainment structure and spatial distribution of the civil service, a crucial component of modernizing the national governance system and capacity, exerts a profound influence on enhancing government efficiency and fostering social progress. …”
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Hippocampus alterations in post-traumatic stress disorder among survivors of the consecutive Kahramanmaraş (Turkey) earthquakes in February 6, 2023: earthquake brain at the end of... by Olga Bayar-Kapıcı, Yaşar Kapıcı, Dilek Örüm, Mehmet Hamdi Örüm, Mehmet Şirik

“…Our study supports the information that stress exposure results in changes in hippocampus structure in PTSD. Longitudinal studies are needed to elucidate possible mechanisms.…”
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Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

“…This process leads to the loss of tissue structure and function. Nutmeg has been found to consist of a number of chemical components that have been linked to antioxidant, health promoting, and disease-prevention activity. …”
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Occurrence characteristics and utilization potential of scarce coking coal resources in Huaibei coalfield by Run ZHAN, Wenyong ZHANG, Feng HAN, Fengtang SUI, Jiayi GU, Guijian LIU, Tian ZHAO

“…The Huaibei Coalfield in Anhui Province, as one of the first key mining areas of scarce coking coal set up by the state, has rich resources and excellent coal quality, and is the most promising coking coal resource source in East China.In order to systematically understand the occurrence characteristics and exploitation and utilization potential of scarce coking coal in the study area, this paper reveals the spatio-temporal difference characteristics, formation control factors and resource potential of scarce coking coal in the study area through coal rock analysis, industrial coal quality index test, comprehensive mapping and resource evaluation, using previous drilling data and underground supplementary sampling tests.The results show that the scarce coking coal in Huaibei coalfield is well developed, and the floating coal after washing shows the characteristics of ultra−low water, ultra−low ash, ultra−low sulfur, ultra−low fixed carbon, medium and high volatile, and has the process properties of medium−strong bonding and coking, low potassium and sodium content, and good mechanical strength and thermal strength.The scarce coking coal is controlled by the regional structure and the sedimentary distribution of coal seams, and the coal seams of Xiashihezi Formation 7 and 8 are the most developed. …”
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Improvement of Gasless Laparoscopic Single-Site Lifting and Use in Surgery for Endometrial Carcinoma by Bingbing Zhao, Xinqiu Lu, Xuli Gan, Zhijun Yang, Li Li, Jieqing Zhang

“…This method of suspending the umbilical ligament through abdominal silk thread can increase exposure of the anatomical structure of the obturator position. The application of GLESS as the procedure for endometrial cancer is safe and feasible.…”
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FEATURES OF DENTAL STATUS AND SOME MICROBIOLOGICAL PARAMETERS OF THE ORAL CAVITY OF YOUNG MEN. by Y.Y. Vodoriz, N.M. Ilenko, N.V. Ilenko, T.O. Petrushanko

“…This habitat is subdivided into several subbiotops considering the anatomical structure and other characteristics of parts of the oral cavity such as gingival sulcus, gingival and periodontal pockets. …”
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A multi-omics reciprocal analysis for characterization of bacterial metabolism by Gabriel Santos Arini, Gabriel Santos Arini, Gabriel Santos Arini, Tiago Cabral Borelli, Tiago Cabral Borelli, Tiago Cabral Borelli, Elthon Góis Ferreira, Rafael de Felício, Paula Rezende-Teixeira, Matheus Pedrino, Matheus Pedrino, Franciene Rabiço, Franciene Rabiço, Guilherme Marcelino Viana de Siqueira, Guilherme Marcelino Viana de Siqueira, Luiz Gabriel Mencucini, Luiz Gabriel Mencucini, Henrique Tsuji, Henrique Tsuji, Lucas Sousa Neves Andrade, Leandro Maza Garrido, Gabriel Padilla, Alberto Gil-de-la-Fuente, Alberto Gil-de-la-Fuente, Mingxun Wang, Norberto Peporine Lopes, Daniela Barretto Barbosa Trivella, Letícia Veras Costa-Lotufo, María-Eugenia Guazzaroni, Ricardo Roberto da Silva, Ricardo Roberto da Silva, Ricardo Roberto da Silva

“…Further exacerbating the annotation challenge, databases and tools for annotation and omics integration are scattered, requiring complex computations to annotate and integrate omics datasets.MethodsHere we performed a two-way integrative analysis combining genomics and metabolomics data to describe a new approach to characterize the marine bacterial isolate BRA006 and to explore its biosynthetic gene cluster (BGC) content as well as the bioactive compounds detected by metabolomics.Results and DiscussionWe described BRA006 genomic content and structure by comparing Illumina and Oxford Nanopore MinION sequencing approaches. …”
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Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile by Yan Ma, Xingdong Chen, Jie Wei, Li Guo, Jian Huang, Li Xie, Lei Chen, Ping Lu, Wei Sun, Wei Shi, Feng Ding, Liping Zhang, Yue Zhang, Linlin Zhang, Rui Song, Yi Huang, Jun Shen, Hong Xu, Zhigang Chen, Qian Shen, Ying Ma, Yiwen Zhang, Hongxia Li, Yihui Zhai, Biao Xu, Xian Zhou, Jun Sun, Bing Wu, Rui Su, Xiaoyan Yu, Jianhong Zhu, Yihong Huang, Ling Gong, Nana Wu, Jingjing Sun, Tianyi Liu, He Yuan, Yiwen Shen, Jiaojiao Liu, Xia Han, Juanjuan Wu, Yinghua Sun, Suxiang Xu, Qinyi Zhang, Na Xie, Jianfeng Ji, Weizhi Mo, Yuanxin Liu, Xinghua Shi, Wanshan Qiu, Jiapeng Mi, Juhua Yan, Minghui Zhu, Pei Feng, Wenqian Sheng, Mingqin Tai, Chunqin Zhou, Qian Jin, Chengyu Gu, Xiujuan Huang, Qinfang Qian, Yixin Cao, Haochen Shen, Ziwen Xue, Yucui Ma, Juan Tian, Yingdan Zhang, Weiyuan Zhuang, Kaiqun Yang, Xiaohui Shen, Yanwei Gu, Beibei Shi, Chenhong Pan, Hongmei Zhou, Xiuchen Zhang, Meihua Tang, Kaixuan Gu, Hongping Liu, Yuanxian Li

“…Structured CKD questionnaires were administered, and biosamples (urine and dried blood spots) were obtained for the long-term storage and analysis using standard procedures. …”
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Distributed Knowledge Base System by Kulykovska N. A., Timenko A. V., Ilyashenko M. B., Kirichek G. G.

“…One of the main problems of any distributed system is the analysis of the properties of the ob-tained data and their further use for logical reasoning. …”
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