Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulati... by Chunxiu Lin, Yugui Lin, Rui Xiao, Min Guo, Hao Zhang, Wei Chen, Gang Wang

“…Notably, both in vitro intestinal fermentation models and genomic analyses demonstrated that the three Bifidobacterium species cannot synthesize these unsaturated fatty acids due to the lack of related genes. However, data suggested that these species might promote the accumulation of arachidonic acid and docosahexaenoic acid by regulating the gut microbiota’s structure and function. …”
Get full text

Heterogeneous Integrated III-V-on-SOI Photodetector Using Micro-transfer Printing Method by WANG Zhaocong, QUAN Zhiheng, ZHENG ShiGuanqing, ZHU Yan, YE Nan, LU Liangjun, ZHOU Linjie, SONG Yingxiong

“…【Results】The response bandwidth of the heterogeneous integrated photodetector obtained by micro-transfer integration is about 4 GHz, and the dark current is about 13 nA (@-13 V), which is basically consistent with the performance test data before the integration of the sample. Affected by the coupling loss, the responsivity of the integrated structure is 7.3×10^-3 A/W (@-25 V). …”
Get full text

Evaluation of the Efficacy and Safety of Initial Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Middle-Aged People by T. V. Alexandrova, O. V. Muslimova, M. V. Zhuravleva, A. A. Alexandrov, G. I. Gorodetskaya, E. Yu. Demchenkova, O. A. Demidova, E. A. Sokova, I. A. Mazerkina, Yu. А. Smirnova

“…The study results indicate that the structure of comorbidity did not affect the effectiveness of initial empirical ABT. …”
Get full text

Whole genome resequencing reveals the evolutionary history and geographic isolation of the eastern Asian Hickory (Carya) by Da Zhang, Rui‐Feng Yang, Jia‐Hui Chen, Lang‐Bo Pan, Wei Duan, Guo‐Hua Xia, Qi‐Xiang Zhang, You‐Jun Huang

“…Based on the SNPs (single nucleotide polymorphisms) data generated by the whole genome deep resequencing of five EA (Eastern Asian) Carya species, we constructed the phylogenetic tree, genetic structure, and species distribution modeling to clarify the phylogenetic relationships and to predict the potential distribution area of EA Carya. …”
Get full text

Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration by Dan Wu, Chen Yan, Linhui Han, Fudong Li, Ximing Xu, Jingchuan Sun, Yong Cao, Kaiqiang Sun, Jiangang Shi, Yuan Wang

“…Through integrative analysis of single-cell RNA-seq data from intervertebral discs (IVDs), we have firstly uncovered that the aberrant accumulation of R-Loops—a type of triple-stranded nucleic acid structure—can result in the cytoplasmic accumulation of double-stranded DNA (dsDNA) and activate cGAS/STING signaling and induce cellular senescence in nucleus pulposus cells (NPCs) during IVDD. …”
Get full text

A new index for detection of submerged aquatic plants under variable quality water: an extension of the soil-line concept by Shruti Khanna, Erin L. Hestir, Joaquim Bellvert, Jennifer D. Boyer, Kristen D. Shapiro, Susan L. Ustin

“…Submersed aquatic plant (SAP) communities are important determinants of estuarine and lacustrine food web structure, nutrient cycling, and water quality. Variation in water quality, SAP community composition and cover present challenges when mapping SAP robustly across estuarine ecosystems. …”
Get full text

Epigenetic modifications in the murine liver upon depletion of transcriptional coregulator host cell factor 1 by Shruti Kaushal, Debashruti Bhattacharya, Saran Kumar, Winship Herr, Jaspreet Kaur Dhanjal, Shilpi Minocha

“…RNA-seq analyses revealed significant downregulation of genes involved in cell cycle progression, metabolism, and mitochondrial structure and function including those regulating oxidative phosphorylation. …”
Get full text

Endoscopic retrograde cholangiopancreatography consultation after digestive tract reconstruction and risk factors for complications by Yan Cheng, Jiahui Feng, Xiaojia Chen, Jun Lin, Hongling Wang

“…Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) has been widely used in the diagnosis and treatment of biliary and pancreatic diseases, and its success rate and therapeutic effect are considerable, and its use in patients with gastrointestinal tract reconstruction is also increasing. The anatomical structure of the digestive tract has been changed in these patients, which makes the use of endoscopic retrograde cholangiopancreatography technically more challenging. …”
Get full text

Spatio-temporal Evolution of Land Surface Temperature and Its Response to LULC in the Urban Agglomeration of Central Yunnan by LIN Zhiqiang, PENG Shuangyun, SHI Shuangfu, HUANG Bangmei, MA Dongling, ZHU Ziyi, MA Xiaoliang, GONG Luping

“…[Conclusion] LULC is an important factor affecting the LST, and reasonable configuration of LULC structure can improve the thermal environment of urban agglomeration. …”
Get full text

Color matching and translucency of single-shade resin composites: effects of restoration thickness, background shade, and aging by Hamideh Sadat Mohammadipour, Soroush Sarafraz Yazdi, Mohammad Javad Moghaddas Mashhad, Saber Babazadeh, Arsalan Shahri

“…Abstract Background Achieving a seamless color match in resin composite restorations remains a significant clinical challenge due to variations in tooth structure and background shades. The aim of this in vitro study was to assess the effect of background shade, thermal aging, and composite thickness on color matching and translucency of three single-shade resin composites. …”
Get full text

Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study. by Yuqi Hu, Le Gao, Lingyue Zhou, Wenlong Liu, Cuiling Wei, Boyan Liu, Qi Sun, Wenxin Tian, Rachel Yui Ki Chu, Song Song, Franco Wing Tak Cheng, Joe Kwun Nam Chan, Amy Pui Pui Ng, Heidi Ka Ying Lo, Krystal Chi Kei Lee, Wing Chung Chang, William Chi Wai Wong, Esther Wai Yin Chan, Ian Chi Kei Wong, Yi Chai, Francisco Tsz Tsun Lai

“…<h4>Methods and findings</h4>We extracted data from a territory-wide public healthcare database from January 2001 to August 2022 in Hong Kong to conduct a retrospective cohort study of anonymized patients aged 18+ years with a diagnosis of schizophrenia who used clozapine or olanzapine (drug comparator with highly similar chemical structure and pharmacological mechanisms) for 90+ days, with at least 2 prior other antipsychotic use records within both groups. …”
Get full text

The Effectiveness of Couple Therapy Based on Acceptance and Commitment ACT on Marital Violence and Desire for Separation in Couples Applying for Divorce by M Sadeghi, H Bagholi, R Azarmidakht, H Javidi

“…Methods: The present study applied a quasi-experimental, semi-experimental design with a pre-test and post-test structure, including a control group. The statistical sample consisted of 40 individuals selected from all couples seeking divorce in Yasuj, Iran, who were referred to family counseling centers in the first three months of 2023. …”
Get full text

Cloning and Analysis of the Expansin Gene BdEXP1 from Migration Plant parasitic Nematode (Bursaphelenchus doui) by Kaiyang GUO, Shifeng LIN, Rengang WANG, Li LI, Jie ZHANG, Shizhou YU, Zili WANG, Guoqin LIU

“…The BdEXP1 protein had the highest sequence similarity (64%) with the homologous protein of B. xylophilus, and contained a typical DPBB_SPI-like conservative domain and a signal peptide but no transmembrane structure, indicating that it was a secretory protein. …”
Get full text

Lipitension and cardiometabolic risk factors in young people by A. V. Sineglazova, A. Sh. Fakhrutdinova, T. Yu. Kim, S. D. Parve

“…In patients with lipitension, 43,8% were diagnosed with HTN, while the remaining 56,2% had BP ≥130/85 mm Hg. In the structure of dyslipidemia in lipitension, 79,2% had abnormalities in ≥2 lipid parameters, of which increased levels of low-density lipoprotein cholesterol (LDL-C) and hypercholesterolemia (78,3%) were most often detected. …”
Get full text

Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice by Ashish Kumar Tripathi, Sadaf Dabeer, Jun Song, Tatyana Vikulina, Susanne Roser-Page, Jessica A. Alvarez, David. R. Archer, M. Neale Weitzmann

“…To investigate HU action on SCD-related vertebral defects, we used HU-treated “Townes” mice, an SCD animal model and performed high-resolution micro-computed tomography (µCT) imaging to resolve bone volume and micro-architectural structure of cortical and trabecular bone, the two major compartments contributing to bone mass and strength. …”
Get full text

Mental health and life satisfaction of university students influenced by war by Yu. B. Melnyk, A. V. Stadnik, U. B. Mykhaylyshyn, J. Vveinhardt, C. M. De Frias, I. S. Pypenko

“…These methods should be comprehensive and involve the integration of psychological support into the structure of universities, including individual and group counselling, crisis intervention, psychological training, and student support programmes.…”
Get full text

Econometric predictive model for assessing the functional state of students during the examination period: a cross-sectional exploratory pilot study by I. S. Knyazhev, L. V. Karaulova, O. V. Reztsov, A. P. Spitsin

“…Mathematical modeling is widely used in medicine to analyze the body systems in terms of their structure, work and interrelations. The present study investigates factors associated with the adaptation potential of the cardiovascular system, develops multiple regression models for the dependence of the adaptive potential on these factors, and compares the significance of the linear model with non-linear ones. …”
Get full text

The Role of Premorbid Background in Tanatogenesis of Acute Poisonings with Psychoactive Drugs in Gerontological Patients by K. K. Ilyashenko, G. N. Sukhodolova, A. Y. Simonova, M. M. Potskhveriya, A. Y. Kluyev, L. N. Zimina, M. V. Barinova

“…Background Human aging is a universal and regular process characterized by uneven and steady progression, inevitably affecting to some extent all levels of biological organization. In the structure of acute exotoxicosis, patients of gerontological age range from 10.3 to 12.9%. …”
Get full text

Assessment of the quality of drinking water and basic water, sanitation, and hygiene conditions of urban street dwellers in Bangladesh by Dr Zenat Hossain, Md. Harun Or Rashid, Dipan Barai, Najmun Nahar, Dr. Anowara Begum

“…A survey was conducted using a semi structure questionnaire to collect data on demographic characteristics, WASH situation and health problems. …”
Get full text

Evaluation of the feasibility, appropriateness, and acceptability of an environmental cleaning program improvement toolkit at a tertiary care hospital in Nigeria by Cori Dennison, Matthew Hudson, Damilola Adeniyi, Folasade Ogunsola, Hanako Osuka, Lisa P. Oakley, Paul Malpiedi, Amber Vasquez, Molly Patrick

“…A deductive analytic process was used to code and analyze interview data based on constructs of appropriateness and acceptability. …”
Get full text